Abstract：
:Radiotherapy induces untargeted effects on normal tissues such as bone marrow. So alteration of microenvironment by ionizing irradiation is supposed to influence dynamic host-cancer ecosystem affecting cancer behavior including metastasis. Herein, the incidence of lung metastasis after high-dose irradiation has been investigated using mice model having real-time condition of leucopenia. C57BL/6 mice were pre-exposed to a X-irradiation dose of 6 Gy on previous days 2, 5, 7, 10. Complete hematological parameters including lymphocyte subpopulation in blood and lung tissues were analyzed. Additionally, a group of mice including a non-irradiated group were inoculated with B16F10 cells (3 × 10(5)/200 μl) via tail vein at the same day, and lung metastasized colonies were compared among groups at day 14 of post-inoculation. We observed that (i) total leucocytes and platelet were gradually depleted by day 10; (ii) lung tissue showed gradual infiltration of leucocytes including neutrophils and lymphocytes; (iii) pulmonary colonies were maximum and minimum on day 5 and 10 respectively; (iv) lymphocyte subpopulation analysis showed most number of natural killer (NK) cells in lung tissues on day 10; (v) gene expression of platelet/endothelial cell adhesion molecule (PECAM) in lung tissues peaked on day 5. To sum-up the study, severity of leucopenia did not influence the incidence of metastasis but blood platelets and microenvironment alteration of targeting tissue may be responsible factors for lung metastasis in our experimental model.
journal_name
Clin Exp Metastasisjournal_title
Clinical & experimental metastasisauthors
Shin JW,Son JY,Raghavendran HR,Chung WK,Kim HG,Park HJ,Jang SS,Son CGdoi
10.1007/s10585-011-9411-ysubject
Has Abstractpub_date
2011-12-01 00:00:00pages
803-10issue
8eissn
0262-0898issn
1573-7276journal_volume
28pub_type
杂志文章abstract：:The idea for this Special Issue originated from our recent review in Nature Reviews Clinical Oncology entitled "Does the mobilization of circulating tumour cells during cancer therapy cause metastasis?" Martin et al. (Nat Rev Clin Oncol 14:32-44, 2017). While preparing this review, it became evident that an overwhelmi...
journal_title：Clinical & experimental metastasis
pub_type： 社论
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journal_title：Clinical & experimental metastasis
pub_type： 临床试验,杂志文章
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journal_title：Clinical & experimental metastasis
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journal_title：Clinical & experimental metastasis
pub_type： 杂志文章,评审
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journal_title：Clinical & experimental metastasis
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更新日期：2016-06-01 00:00:00
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pub_type： 杂志文章
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更新日期：2007-01-01 00:00:00
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journal_title：Clinical & experimental metastasis
pub_type： 杂志文章
doi：10.1007/BF01753837
更新日期：1994-07-01 00:00:00
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journal_title：Clinical & experimental metastasis
pub_type： 杂志文章
doi：10.1007/s10585-013-9594-5
更新日期：2013-12-01 00:00:00
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journal_title：Clinical & experimental metastasis
pub_type： 杂志文章
doi：10.1007/s10585-014-9689-7
更新日期：2015-01-01 00:00:00
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journal_title：Clinical & experimental metastasis
pub_type： 杂志文章
doi：10.1007/BF01784377
更新日期：1988-11-01 00:00:00
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journal_title：Clinical & experimental metastasis
pub_type： 杂志文章,多中心研究
doi：10.1007/s10585-014-9685-y
更新日期：2015-01-01 00:00:00
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journal_title：Clinical & experimental metastasis
pub_type： 杂志文章
doi：10.1023/a:1006783330996
更新日期：1999-01-01 00:00:00
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journal_title：Clinical & experimental metastasis
pub_type： 杂志文章
doi：10.1007/s10585-007-9059-9
更新日期：2007-01-01 00:00:00
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journal_title：Clinical & experimental metastasis
pub_type： 杂志文章
doi：10.1023/a:1006540824969
更新日期：1998-04-01 00:00:00
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pub_type： 杂志文章
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pub_type： 杂志文章,评审
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pub_type： 杂志文章,评审
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pub_type： 杂志文章
doi：10.1007/s10585-012-9547-4
更新日期：2013-04-01 00:00:00
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journal_title：Clinical & experimental metastasis
pub_type： 杂志文章
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更新日期：1988-03-01 00:00:00
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journal_title：Clinical & experimental metastasis
pub_type： 杂志文章
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更新日期：2000-01-01 00:00:00
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journal_title：Clinical & experimental metastasis
pub_type： 杂志文章
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更新日期：2002-01-01 00:00:00
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journal_title：Clinical & experimental metastasis
pub_type： 杂志文章
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pub_type： 杂志文章
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更新日期：1994-11-01 00:00:00
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journal_title：Clinical & experimental metastasis
pub_type： 杂志文章
doi：10.1007/s10585-014-9674-1
更新日期：2014-12-01 00:00:00
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journal_title：Clinical & experimental metastasis
pub_type： 杂志文章
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更新日期：2007-01-01 00:00:00
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journal_title：Clinical & experimental metastasis
pub_type： 历史文章,杂志文章
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更新日期：2011-03-01 00:00:00
