Time to metastatic relapse and breast cancer cells dissemination in bone marrow at metastatic relapse.


:Breast cancer dissemination can be monitored in patients by detecting circulating and/or disseminated tumor cells. However, bone marrow disseminated tumor cells (BM DTC) may undergo a dormancy during several years before growing (or not) into clinically detectable metastases. We therefore hypothesized that breast cancers which have formed BM DTC in the course of their metastatic growth might exhibit a longer interval before metastatic relapse. We examined the association of DTC detection (cytokeratin 8, 18 or 19 positive epithelial cells with cancerous morphological features), at metastatic relapse, with the metastasis-free interval in breast cancer patients. In the 110 metastatic patients studied, 42% (n = 64/110) were classified as BM DTC-negative. These patients had a significantly shorter metastasis-free interval than BM DTC-positive patients (P = 0.02). In multivariate logistic regression analysis, the metastasis-free interval was an independent predictor of DTC detection (P = 0.02), together with bone metastasis (P = 0.0003) and low tumor grade (grade I or II, P = 0.05). We finally suggest that a faster metastatic process might skip in some patients the BM DTC-associated dormancy step. Dissemination of DTC in other host organ and/or epithelial-mesenchymal transition from cytokeratin-positive to cytokeratin-negative DTC may explain this observation.


Clin Exp Metastasis


Bidard FC,Vincent-Salomon A,Sigal-Zafrani B,Rodrigues M,Diéras V,Mignot L,Sastre-Garau X,Poupon MF,Pierga JY




Has Abstract


2008-01-01 00:00:00












  • Role of extracellular matrix proteins in regulation of human glioma cell invasion in vitro.

    abstract::Primary brain tumors lack the metastatic behavior that is in part believed to be promoted by the extracellular matrix (ECM) components of the basement membrane. This study was intended to examine the influence of the ECM components present in the basement membrane that may act as natural barriers to tumor cell invasio...

    journal_title:Clinical & experimental metastasis

    pub_type: 杂志文章


    authors: Chintala SK,Gokaslan ZL,Go Y,Sawaya R,Nicolson GL,Rao JS

    更新日期:1996-09-01 00:00:00

  • Increased lymphangiogenesis in lung metastases from colorectal cancer is associated with early lymph node recurrence and decreased overall survival.

    abstract::Pulmonary metastasectomy (PM) is an accepted treatment modality in colorectal cancer (CRC) patients with pulmonary tumor spread. Positive intrathoracic lymph nodes at the time of PM are associated with a poor prognosis and 5-year survival rates of <20 %. Increased lymphangiogenesis in pulmonary metastases might repres...

    journal_title:Clinical & experimental metastasis

    pub_type: 杂志文章,多中心研究


    authors: Schweiger T,Nikolowsky C,Graeter T,Seebacher G,Laufer J,Glueck O,Glogner C,Birner P,Lang G,Klepetko W,Ankersmit HJ,Hoetzenecker K

    更新日期:2016-02-01 00:00:00

  • SCUBE3 regulation of early lung cancer angiogenesis and metastatic progression.

    abstract::Signal peptide-CUB-EGF-like domain-containing protein 3 (SCUBE3) is strongly expressed in extremely invasive lung carcinoma. We showed in our previous study that SCUBE3 triggers the transforming growth factor-β pathway and subsequently promotes tumor angiogenesis and the epithelial-mesenchymal transition (EMT). Howeve...

    journal_title:Clinical & experimental metastasis

    pub_type: 杂志文章


    authors: Chou CH,Cheng YF,Siow TY,Kumar A,Peck K,Chang C

    更新日期:2013-08-01 00:00:00

  • Predictors of prognosis of synchronous brain metastases in small-cell lung cancer patients.

    abstract::Patients with small cell lung cancer (SCLC) are more likely to have synchronous brain metastasis (SBM) at the time of diagnosis than patients with any other extracranial primary malignancy. We sought to identify which factors predicted an increased risk of SBM in SCLC as well as which factors affected the prognosis of...

    journal_title:Clinical & experimental metastasis

    pub_type: 杂志文章


    authors: Reddy SP,Dowell JE,Pan E

    更新日期:2020-08-01 00:00:00

  • S100A11 is a potential prognostic marker for clear cell renal cell carcinoma.

    abstract::Clear cell renal cell carcinoma (ccRCC) is one of few cancers with rising incidence in North America. The prognosis of ccRCC is variable and difficult to predict. Stratification of patients according to disease aggressiveness can significantly improve patient management. We investigated the expression of the S100A11 p...

    journal_title:Clinical & experimental metastasis

    pub_type: 杂志文章


    authors: Gabril M,Girgis H,Scorilas A,Rotondo F,Wala S,Bjarnason GA,Ding Q,Evans A,Tawedrous E,Pasic M,Finelli A,Al-Haddad S,Yousef GM

    更新日期:2016-01-01 00:00:00

  • The meaning of the c-kit proto-oncogene product in malignant transformation in human mammary epithelium.

    abstract::To evaluate the relationship between the c-kit proto-oncogene product and malignant transformation of human breast tissue, we examined the immunohistochemical expression of the c-kit proto-oncogene product in both malignant and non-malignant breast tissues. The immunohistochemical expression of the c-kit proto-oncogen...

    journal_title:Clinical & experimental metastasis

    pub_type: 杂志文章


    authors: Ko CD,Kim JS,Ko BG,Son BH,Kang HJ,Yoon HS,Cho EY,Gong G,Ahn SH

    更新日期:2003-01-01 00:00:00

  • Leading malignant cells initiate collective epithelial cell invasion in a three-dimensional heterotypic tumor spheroid model.

    abstract::Solid tumors consist of genetically and phenotypically diverse subpopulations of cancer cells with unique capacities for growth, differentiation, and invasion. While the molecular and microenvironmental bases for heterogeneity are increasingly appreciated, the outcomes of such intratumor heterogeneity, particularly in...

    journal_title:Clinical & experimental metastasis

    pub_type: 杂志文章


    authors: Carey SP,Starchenko A,McGregor AL,Reinhart-King CA

    更新日期:2013-06-01 00:00:00

  • Matrix metalloproteinase 9 is induced by the Epstein-Barr virus BZLF1 transactivator.

    abstract::Type IV collagenases, matrix metalloproteinase (MMP) 2 and MMP9 are implicated in tumor invasion and metastasis. In patients with nasopharyngeal carcinoma (NPC), poor prognosis due to development of local and distant metastasis has been reported to be predicted by antibody titers against the Z protein which is an AP-1...

    journal_title:Clinical & experimental metastasis

    pub_type: 杂志文章


    authors: Yoshizaki T,Sato H,Murono S,Pagano JS,Furukawa M

    更新日期:1999-07-01 00:00:00

  • Lymphangiogenesis induced by VEGF-C and VEGF-D promotes metastasis and a poor outcome in breast carcinoma: a retrospective study of 61 cases.

    abstract:PURPOSE:To evaluate lymphangiogenesis in patients with breast carcinoma, explore the underlying mechanism, and study the relationship between lymphangiogenesis and progression of breast carcinoma. METHODS:Sixty-one cases of breast carcinoma with complete clinical and pathological data were analyzed. Using an anti-podo...

    journal_title:Clinical & experimental metastasis

    pub_type: 杂志文章


    authors: Gu Y,Qi X,Guo S

    更新日期:2008-01-01 00:00:00

  • IL-4 and TNF-alpha induce changes in integrin expression and adhesive properties and decrease the lung-colonizing potential of HT-29 colon carcinoma cells.

    abstract::The colon carcinoma cell line HT-29 was used to explore the potential of interleukin-4 (IL-4) and tumor necrosis factor alpha (TNF-alpha) to modify integrin expression and adhesive functions of tumor cells in vitro and to examine corresponding metastatic effects in vivo. Preincubation of HT-29 cells with 100 U/ml of I...

    journal_title:Clinical & experimental metastasis

    pub_type: 杂志文章


    authors: Herzberg F,Schöning M,Schirner M,Topp M,Thiel E,Kreuser ED

    更新日期:1996-03-01 00:00:00

  • Dual X-ray absorptiometry detects disease- and treatment-related alterations of bone density in prostate cancer patients.

    abstract::Metastatic bone disease is an important clinical problem which has proven difficult to study because of a lack of noninvasive investigative modalities. Here we show that dual-energy X-ray absorptiometry (DXA) scanning provides clinically useful information about the status of metastatic bone lesions in cancer patients...

    journal_title:Clinical & experimental metastasis

    pub_type: 临床试验,杂志文章


    authors: Smith GL,Doherty AP,Banks LM,Dutton J,Hanham LW,Christmas TJ,Epstein RJ

    更新日期:2000-01-01 00:00:00

  • Site-dependence of invasiveness of ECA109 human oesophageal carcinoma cells in nude mice.

    abstract::ECA109 human oesophageal carcinoma cells were injected either subcutaneously or intraperitoneally into BALB/CATc 1-nu/nu mice. After 23 weeks tumours were examined histologically and by scanning electron microscopy. Subcutaneous ECA109 tumours were well-delineated without signs of invasion. By contrast, intra-abdomina...

    journal_title:Clinical & experimental metastasis

    pub_type: 杂志文章


    authors: Gao J,Xue KX,Li BG,Dong HY,Wei LS,Zhang ZH,Tian S,Xu ZG

    更新日期:1984-07-01 00:00:00

  • The histological growth pattern of colorectal cancer liver metastases has prognostic value.

    abstract::Little is known about the biological characteristics that determine the prognosis of colorectal cancer (CRC) liver metastases. In previous work we reported three different histological patterns of the tumour-liver interface of CRC liver metastases, termed the pushing, replacement and desmoplastic growth pattern (GP). ...

    journal_title:Clinical & experimental metastasis

    pub_type: 杂志文章


    authors: Van den Eynden GG,Bird NC,Majeed AW,Van Laere S,Dirix LY,Vermeulen PB

    更新日期:2012-08-01 00:00:00

  • Inhibition of 'in vitro' tumor cell growth by aromatic polyamidines exhibiting antiproteinase activity.

    abstract::Aromatic polyamidines containing two, three or four benzamidine residues inhibit proteinase activity and proliferation of different human tumor cell lines, including leukemic (K562, HEL), melanoma (Colo 38) and B-lymphoid (WI-L2) cell lines. In addition, the benzamidine derivatives analysed in the present study inhibi...

    journal_title:Clinical & experimental metastasis

    pub_type: 杂志文章


    authors: Nastruzzi C,Feriotto G,Spandidos D,Ferroni R,Guarneri M,Barbieri R,Gambari R

    更新日期:1989-01-01 00:00:00

  • Involvement of cell-cell adhesion molecules in liver colonization by metastatic murine lymphoma/lymphosarcoma variants.

    abstract::Metastatic variant sublines of the murine RAW117 large cell lymphoma or lymphosarcoma have been established in vitro by sequential cycles of harvesting of liver tumor nodules after intravenous inoculation of tumor cell suspensions into syngeneic BALB/c mice. After five and ten in vivo selections for liver colonization...

    journal_title:Clinical & experimental metastasis

    pub_type: 杂志文章


    authors: McGuire EJ,Mascali JJ,Grady SR,Nicolson GL

    更新日期:1984-07-01 00:00:00

  • Editorial: Therapy-induced metastasis.

    abstract::The idea for this Special Issue originated from our recent review in Nature Reviews Clinical Oncology entitled "Does the mobilization of circulating tumour cells during cancer therapy cause metastasis?" Martin et al. (Nat Rev Clin Oncol 14:32-44, 2017). While preparing this review, it became evident that an overwhelmi...

    journal_title:Clinical & experimental metastasis

    pub_type: 社论


    authors: Martin OA,Anderson RL

    更新日期:2018-04-01 00:00:00

  • Resistance of the embryonic notochord to invasion by malignant neurogenic tumor cells in vitro.

    abstract::Very few tissues in vivo are resistant to invasion by malignant cells. In this paper, confrontation cultures consisting of chick embryonic notochord fragments and cell aggregates from three malignant neurogenic cell lines showed a resistance of the embryonic organ to malignant invasion by tumor cells. The mechanism of...

    journal_title:Clinical & experimental metastasis

    pub_type: 杂志文章


    authors: Schroyens W,Camon J,De Ridder L

    更新日期:1991-07-01 00:00:00

  • RANK expression on breast cancer cells promotes skeletal metastasis.

    abstract::RANK ligand (RANKL), acting through its cognate receptor RANK, is a key factor for bone remodeling and metastasis by regulating the differentiation, survival and activation of osteoclasts. RANKL is also crucial for the development of mouse mammary glands during pregnancy and has been recently linked to the etiology of...

    journal_title:Clinical & experimental metastasis

    pub_type: 杂志文章


    authors: Blake ML,Tometsko M,Miller R,Jones JC,Dougall WC

    更新日期:2014-02-01 00:00:00

  • Tumor cell surface beta 1-6 branched oligosaccharides and lung metastasis.

    abstract::NIH3T3 cells transfected with an activated Ha-ras oncogene were treated with L-PHA, the leukoagglutinin from red kidney beans. Cell lines resistant to L-PHA-mediated cytotoxicity were isolated and found to contain reduced levels of L-PHA-binding oligosaccharides. The levels of N-acetylglucosaminyltransferase V, the en...

    journal_title:Clinical & experimental metastasis

    pub_type: 杂志文章


    authors: Lu Y,Pelling JC,Chaney WG

    更新日期:1994-01-01 00:00:00

  • Bladder metastasis from renal cell carcinoma: retrospective analysis of 65 reported cases.

    abstract::This study was carried out to clarify the presentation, treatment options, and prognosis of renal cell carcinoma (RCC) metastasis to the bladder in which we do not yet have a comprehensive understanding. A systematic Medline, Web of Science, Embase, Google, and Ichushi Web search was performed to identify articles des...

    journal_title:Clinical & experimental metastasis

    pub_type: 杂志文章,评审


    authors: Matsumoto K,Hayakawa N,Nakamura S,Oya M

    更新日期:2015-02-01 00:00:00

  • Tumor cell adhesion to frozen lymph node sections--an in vitro correlate of lymphatic metastasis.

    abstract::Two variant sublines of the murine 3LL carcinoma with divergent potentials for lymphatic metastasis were used to assess the relationship between tumor cell potential for lymphatic metastasis and its ability to adhere specifically to lymphatic tissue. Using fresh cryostat sections of lymph nodes and spleens, it was fou...

    journal_title:Clinical & experimental metastasis

    pub_type: 杂志文章


    authors: Brodt P

    更新日期:1989-05-01 00:00:00

  • Platelet-derived growth factor (PDGF) BB acts as a chemoattractant for human malignant mesothelioma cells via PDGF receptor beta-integrin alpha3beta1 interaction.

    abstract::Platelet-derived growth factor BB (PDGF BB) and the PDGF receptor beta are expressed on mesothelioma cells, but their biological function has not yet been defined. In the present study we used Boyden chambers fitted with filters coated with the adhesive matrix proteins fibronectin, laminin, collagen type IV or the non...

    journal_title:Clinical & experimental metastasis

    pub_type: 杂志文章


    authors: Klominek J,Baskin B,Hauzenberger D

    更新日期:1998-08-01 00:00:00

  • KiSS1 suppresses metastasis in human ovarian cancer via inhibition of protein kinase C alpha.

    abstract::Metastasis is a vital target for cancer treatment, since the majority of cancer patients die from metastatic, rather than the primary disease. KiSS1 has been identified as a metastasis suppressor gene in melanoma and breast carcinomas. We show here that KiSS1 is also a metastasis suppressor in human ovarian cancer. Ov...

    journal_title:Clinical & experimental metastasis

    pub_type: 杂志文章


    authors: Jiang Y,Berk M,Singh LS,Tan H,Yin L,Powell CT,Xu Y

    更新日期:2005-01-01 00:00:00

  • Neurosurgical management of brain metastases.

    abstract::Brain metastases present a significant public health issue, affecting more than 100,000 patients per year in the U.S. and result in significant morbidity. Brain metastases can occur in a variety of clinical situations ranging from multiple brain metastases with uncontrolled systemic disease to a solitary metastasis in...

    journal_title:Clinical & experimental metastasis

    pub_type: 杂志文章,评审


    authors: Ferguson SD,Wagner KM,Prabhu SS,McAleer MF,McCutcheon IE,Sawaya R

    更新日期:2017-10-01 00:00:00

  • Expression and functional analysis of the WAP four disulfide core domain 1 gene in human melanoma.

    abstract::The exact cellular and molecular mechanisms involved in melanoma tumorigenesis remain obscure. Previous gene expression profiling analyses performed upon NHEM and human melanoma samples identified WFDC1 as one of the most frequently down-regulated genes. Here we further showed that NHEM readily express WFDC1 but expre...

    journal_title:Clinical & experimental metastasis

    pub_type: 杂志文章


    authors: Liu S,Howell P,Ren S,Fodstad O,Zhang G,Samant R,Shevde L,Xi Y,Pannell LK,Riker AI

    更新日期:2009-01-01 00:00:00

  • Naturally occurring resistance of bone marrow mononuclear and metastatic cancer cells to anticancer agents.

    abstract::Numerous cancer patients fail standard chemotherapy or develop resistance to chemotherapy during the course of treatment. The purpose of this study is to elucidate the overall response of cells obtained from cancer patients and from normal individuals to chemotherapeutic agents. We analysed the chemosensitivity of can...

    journal_title:Clinical & experimental metastasis

    pub_type: 杂志文章


    authors: Richard C,Yau J,Th'ng JP,Duivenvoorden WC

    更新日期:2006-01-01 00:00:00

  • miR-200c inhibits invasion and migration in human colon cancer cells SW480/620 by targeting ZEB1.

    abstract::MicroRNAs are a class of ≈22-nt noncoding single-strand RNAs regulating gene expression postscriptionally. Metastasis caused poor prognosis in colorectal cancer patients and half of the patients developed metastatic lesions when admission. Here we investigated the possible roles of microRNAs in regulating metastasis i...

    journal_title:Clinical & experimental metastasis

    pub_type: 杂志文章


    authors: Chen ML,Liang LS,Wang XK

    更新日期:2012-06-01 00:00:00

  • Cancer initiation and progression within the cancer microenvironment.

    abstract::Within the cancer microenvironment, the growth and proliferation of cancer cells in the primary site as well as in the metastatic site represent a global biological phenomenon. To understand the growth, proliferation and progression of cancer either by local expansion and/or metastasis, it is important to understand t...

    journal_title:Clinical & experimental metastasis

    pub_type: 杂志文章,评审


    authors: Leong SP,Aktipis A,Maley C

    更新日期:2018-08-01 00:00:00

  • Isolation and characterization of a low metastatic variant from EL-4 mouse T-lymphoma.

    abstract::A variant cell line (EL-4ad) which adhered to a tissue culture dish was isolated from highly metastatic EL-4 murine T-lymphoma. The experimental and spontaneous metastatic ability of EL-4ad was lower than that of the EL-4 parent cell line. The cell surface phenotypes of both cell lines were CD2+3+4-8-45+TCR alpha beta...

    journal_title:Clinical & experimental metastasis

    pub_type: 杂志文章


    authors: Ota T,Tanino M,Kohno H,Funamoto H,Odashima S

    更新日期:1992-09-01 00:00:00

  • Dendritic cells recruitment in melanoma metastasis treated by electrochemotherapy.

    abstract::Electrochemotherapy (ECT) is a novel treatment for recurrent or in-transit unresectable melanoma metastases based on the administration of anti-neoplastic drugs followed by cancer cell electroporation. Whether ECT can also induce anti-tumour immunity is unclear. We addressed this issue investigating the presence of de...

    journal_title:Clinical & experimental metastasis

    pub_type: 杂志文章


    authors: Gerlini G,Sestini S,Di Gennaro P,Urso C,Pimpinelli N,Borgognoni L

    更新日期:2013-01-01 00:00:00