当前位置： SCI文献检索 > CLINICAL & EXPERIMENTAL METASTASIS期刊下所有文献 > CNTO 95, a fully human anti alphav integrin antibody, inhibits cell signaling, migration, invasion, and spontaneous metastasis of human breast cancer cells.

CNTO 95, a fully human anti alphav integrin antibody, inhibits cell signaling, migration, invasion, and spontaneous metastasis of human breast cancer cells.

Abstract：

:CNTO 95 is a fully human monoclonal antibody that recognizes alphav integrins. Previous studies have shown that CNTO 95 exhibits both anti-tumor and anti-angiogenic activities (Trikha M et al., Int J Cancer 110:326-335, 2004). In this study we investigated the biological activities of CNTO 95 on breast tumor cells both in vitro and in vivo. In vitro treatment with CNTO 95 decreased the viability of breast tumor cells adhering to vitronectin. CNTO 95 inhibited tumor cell adhesion, migration, and invasion in vitro. CNTO 95 treatment also induced tyrosine dephosphorylation of focal adhesion kinase (FAK), and the docking protein paxillin that recruits both structural and signaling molecules to focal adhesions (Turner CE, Int J Biochem Cell Biol 30:955-959, 1998; O'Neil GM et al., Trends Cell Biol 10:111-119, 2000). These results suggest that CNTO 95 inhibits breast tumor cell growth, migration and invasion by interruption of alphav integrin mediated focal adhesions and cell motility signals. In vivo studies of CNTO 95 were conducted in an orthotopic breast tumor xenograft model. Treatment with CNTO 95 resulted in significant inhibition of both tumor growth and spontaneous metastasis of MDA-MB-231 cells to the lungs. CNTO 95 also inhibited lung metastasis in a separate experimental (tail vein injection) model of metastasis. The results presented here demonstrate the anti-tumor and anti-metastatic activities of CNTO 95 in breast cancer models and provide insight into the cellular and molecular mechanisms mediating its inhibitory effects on metastasis.

journal_name

Clin Exp Metastasis

journal_title

Clinical & experimental metastasis

authors

Chen Q,Manning CD,Millar H,McCabe FL,Ferrante C,Sharp C,Shahied-Arruda L,Doshi P,Nakada MT,Anderson GM

doi

10.1007/s10585-007-9132-4

subject

Has Abstract

pub_date

2008-01-01 00:00:00

pages

139-48

issue

2

eissn

0262-0898

issn

1573-7276

journal_volume

25

pub_type

杂志文章

相关文献

CLINICAL & EXPERIMENTAL METASTASIS文献大全
  • Role of simvastatin in tumor lymphangiogenesis and lymph node metastasis.

    abstract：:Lymphangiogenesis plays a crucial role in promoting cancer metastasis to sentinel lymph nodes (LNs) and beyond. Increasing data have shown that simvastatin, a cholesterol-lowering medication for the prevention of cardiovascular diseases, is involved in tumor growth and dissemination, and endothelial functions. This st...

    journal_title：Clinical & experimental metastasis

    pub_type： 杂志文章

    doi：10.1007/s10585-018-9940-8

    authors： Ji RC,Eshita Y,Kobayashi T,Hidano S,Kamiyama N,Onishi Y

    更新日期：2018-12-01 00:00:00

  • Angiogenesis and the role of epigenetics in metastasis.

    abstract：:The major obstacle to devising effective ways to treat cancer is its heterogeneity and genetic instability. It was originally postulated that targeting the process of tumor angiogenesis could circumvent this problem, as it involves genetically stable epigenetically controlled host stroma. Thus, anti-angiogenic approac...

    journal_title：Clinical & experimental metastasis

    pub_type： 杂志文章,评审

    doi：10.1023/a:1022935117193

    authors： Coomber BL,Yu JL,Fathers KE,Plumb C,Rak JW

    更新日期：2003-01-01 00:00:00

  • Dunning rat prostate adenocarcinomas and alternative splicing reporters: powerful tools to study epithelial plasticity in prostate tumors in vivo.

    abstract：:Using alternative splicing reporters we have previously observed mesenchymal epithelial transitions in Dunning AT3 rat prostate tumors. We demonstrate here that the Dunning DT and AT3 cells, which express epithelial and mesenchymal markers, respectively, represent an excellent model to study epithelial transitions sin...

    journal_title：Clinical & experimental metastasis

    pub_type： 杂志文章

    doi：10.1007/s10585-008-9186-y

    authors： Oltean S,Febbo PG,Garcia-Blanco MA

    更新日期：2008-01-01 00:00:00

  • The anti-adhesive mucin podocalyxin may help initiate the transperitoneal metastasis of high grade serous ovarian carcinoma.

    abstract：:High grade serous ovarian tumors often metastasize transperitoneally, a process that begins when small tumor nodules de-adhere and are released into the fluid of the abdominal cavity where they float freely to reach new sites on the peritoneal wall. Podocalyxin, a small anti-adhesive sialomucin, has been shown to cont...

    journal_title：Clinical & experimental metastasis

    pub_type： 杂志文章

    doi：10.1007/s10585-011-9446-0

    authors： Cipollone JA,Graves ML,Köbel M,Kalloger SE,Poon T,Gilks CB,McNagny KM,Roskelley CD

    更新日期：2012-03-01 00:00:00

  • Tamoxifen resistance in breast cancer cells is accompanied by an enhanced motile and invasive phenotype: inhibition by gefitinib ('Iressa', ZD1839).

    abstract：:Despite an initial response to antihormonal therapies, the development of resistance will occur in a significant number of breast cancer patients. The mechanisms that underlie acquired resistance are not yet clear. Using a previously established in vitro cell model of tamoxifen resistance in MCF7 cells, shown to displ...

    journal_title：Clinical & experimental metastasis

    pub_type： 杂志文章

    doi：10.1023/b:clin.0000037697.76011.1d

    authors： Hiscox S,Morgan L,Barrow D,Dutkowskil C,Wakeling A,Nicholson RI

    更新日期：2004-01-01 00:00:00

  • The protein kinase C inhibitor, H7, inhibits tumor cell invasion and metastasis in mouse melanoma via suppression of ERK1/2.

    abstract：:Protein kinase C (PKC) has been shown to be a signal transducer during tumorigenesis, tumor cell invasion, and metastasis. Recent studies have reported that the PKC inhibitor, 7-hydroxystaurosporine, inhibits tumor cell invasion. However, the molecular mechanisms of this inhibition of invasion and metastasis are not w...

    journal_title：Clinical & experimental metastasis

    pub_type： 杂志文章

    doi：10.1007/s10585-007-9080-z

    authors： Tsubaki M,Matsuoka H,Yamamoto C,Kato C,Ogaki M,Satou T,Itoh T,Kusunoki T,Tanimori Y,Nishida S

    更新日期：2007-01-01 00:00:00

  • Selective antimetastatic effect of heparins in preclinical human melanoma models is based on inhibition of migration and microvascular arrest.

    abstract：:Use of heparin derivatives in several cancer types revealed that anticoagulant therapies have a beneficiary side effect: delay of tumor progression. Since there are no data on human melanoma, we have analyzed the effect of heparins in preclinical models. Neither unfractionated heparin (UFH), nor its low molecular weig...

    journal_title：Clinical & experimental metastasis

    pub_type： 杂志文章

    doi：10.1007/s10585-005-3859-6

    authors： Bereczky B,Gilly R,Rásó E,Vágó A,Tímár J,Tóvári J

    更新日期：2005-01-01 00:00:00

  • Establishment of highly metastatic tumor clones derived from a skin squamous cell carcinoma (SqC-NH), D-1 and F-3, with distinct features of pulmonary metastases.

    abstract：:We have established two highly metastatic tumor clones, D-1 and F-3, which have the distinct features of undergoing pulmonary metastases. Both clones were derived from a skin squamous cell carcinoma (SqC-NH), which had spontaneously occurred in DS-Nh mice. F-3 was morphologically spindle-shaped in tumor mass and adher...

    journal_title：Clinical & experimental metastasis

    pub_type： 杂志文章

    doi：10.1007/BF00058055

    authors： Maekawa R,Kishimoto Y,Sato K,Homma M

    更新日期：1993-07-01 00:00:00

  • CD44 expression and hyaluronic acid binding of malignant glioma cells.

    abstract：:The mechanisms leading to rapid invasive growth of malignant gliomas are poorly understood. Expression of the hyaluronic acid (HA) receptor CD44 and adhesion to HA are involved in invasive properties. Our previous studies have shown that malignant glioma cells are able to adhere to extracellular HA. Here we investigat...

    journal_title：Clinical & experimental metastasis

    pub_type： 杂志文章

    doi：10.1023/a:1026425519497

    authors： Knüpfer MM,Poppenborg H,Hotfilder M,Kühnel K,Wolff JE,Domula M

    更新日期：1999-02-01 00:00:00

  • Salvage treatment for recurrences after first resection of colorectal liver metastases: the impact of histopathological growth patterns.

    abstract：:The majority of patients recur after resection of colorectal liver metastases (CRLM). Patients with CRLM displaying a desmoplastic histopathological growth pattern (dHGP) have a better prognosis and lower probability of recurrence than patients with non-dHGP CRLM. The current study evaluates the impact of HGP type on ...

    journal_title：Clinical & experimental metastasis

    pub_type： 杂志文章

    doi：10.1007/s10585-019-09960-7

    authors： Nierop PMH,Galjart B,Höppener DJ,van der Stok EP,Coebergh van den Braak RRJ,Vermeulen PB,Grünhagen DJ,Verhoef C

    更新日期：2019-04-01 00:00:00

  • Platelet-derived growth factor (PDGF) BB acts as a chemoattractant for human malignant mesothelioma cells via PDGF receptor beta-integrin alpha3beta1 interaction.

    abstract：:Platelet-derived growth factor BB (PDGF BB) and the PDGF receptor beta are expressed on mesothelioma cells, but their biological function has not yet been defined. In the present study we used Boyden chambers fitted with filters coated with the adhesive matrix proteins fibronectin, laminin, collagen type IV or the non...

    journal_title：Clinical & experimental metastasis

    pub_type： 杂志文章

    doi：10.1023/a:1006542301794

    authors： Klominek J,Baskin B,Hauzenberger D

    更新日期：1998-08-01 00:00:00

  • Predicting brain metastases for non-small cell lung cancer based on magnetic resonance imaging.

    abstract：:In this study the relationship between brain structure and brain metastases (BM) occurrence was analyzed. A model for predicting the time of BM onset in patients with non-small cell lung cancer (NSCLC) was proposed. Twenty patients were used to develop the model, whereas the remaining 69 were used for independent vali...

    journal_title：Clinical & experimental metastasis

    pub_type： 杂志文章

    doi：10.1007/s10585-016-9833-7

    authors： Yin G,Li C,Chen H,Luo Y,Orlandini LC,Wang P,Lang J

    更新日期：2017-02-01 00:00:00

  • A novel in vitro assay system for transendothelial tumor cell invasion: significance of E-selectin and alpha 3 integrin in the transendothelial invasion by HT1080 fibrosarcoma cells.

    abstract：:The interaction of tumor cells with endothelial cells is a key event in tumor metastasis. We established an in vitro invasion assay system, in which the invasion of tumor cells after interaction with endothelial cells can be examined. Two chamber culture wells separated by porous membrane were used. Human umbilical ve...

    journal_title：Clinical & experimental metastasis

    pub_type： 杂志文章

    doi：10.1007/BF01753837

    authors： Okada T,Okuno H,Mitsui Y

    更新日期：1994-07-01 00:00:00

  • Control of pulmonary metastases of rat mammary cancer by inhibition of uPA and COX-2, singly and in combination.

    abstract：:Tumor cell metastasis can be suppressed by the attenuation of proteolytic and angiogenic events that are mediated by tumor and endothelial cells. Combinations of specific inhibitors directed to separate stages of the metastatic cascade may improve the potential for adjuvant therapies. Amiloride is an effective plasmin...

    journal_title：Clinical & experimental metastasis

    pub_type： 杂志文章

    doi：10.1023/b:clin.0000046140.19131.19

    authors： Evans DM,Sloan Stakleff KD

    更新日期：2004-01-01 00:00:00

  • Inhibition of prostate cancer metastasis by administration of a tissue vaccine.

    abstract：:Immunotherapy by vaccination represents a novel method for treatment of cancer. In this regard, vaccines with the broadest possible menu of relevant antigens stand the greatest chance of success. Tissue vaccines are composed of material harvested directly from tumors and contain not only antigens associated with neopl...

    journal_title：Clinical & experimental metastasis

    pub_type： 杂志文章

    doi：10.1007/s10585-008-9213-z

    authors： Suckow MA,Wolter WR,Sailes VT

    更新日期：2008-01-01 00:00:00

  • Near-infrared molecular imaging of tumors via chemokine receptors CXCR4 and CXCR7.

    abstract：:The chemokine CXCL12/SDF-1 and its receptors CXCR4 and CXCR7 play a major role in tumor invasion, proliferation and metastasis. Since both receptors are overexpressed on distinct tumor cells and on the tumor vasculature, we evaluated their potential as targets for detection of cancers by molecular imaging. We synthesi...

    journal_title：Clinical & experimental metastasis

    pub_type： 杂志文章

    doi：10.1007/s10585-011-9403-y

    authors： Meincke M,Tiwari S,Hattermann K,Kalthoff H,Mentlein R

    更新日期：2011-12-01 00:00:00

  • Effects of dietary fat on spontaneous metastasis of Lewis lung carcinoma in mice.

    abstract：:The present study assessed the effects of dietary fat on spontaneous metastasis of Lewis lung carcinoma in mice. Three-week old male C57BL/6 mice were fed the AIN-93G diet or a 45% fat diet (% kcal.) for 7 weeks before they were subcutaneously injected with 2.5 × 10⁵ viable carcinoma cells. The primary tumor was resec...

    journal_title：Clinical & experimental metastasis

    pub_type： 杂志文章

    doi：10.1007/s10585-010-9347-7

    authors： Yan L,DeMars LC

    更新日期：2010-12-01 00:00:00

  • Enhanced cell surface CD44 variant (v6, v9) expression by osteopontin in breast cancer epithelial cells facilitates tumor cell migration: novel post-transcriptional, post-translational regulation.

    abstract：:Osteopontin (OPN) is a glycosylated, secreted phosphoprotein that functions both as a cell attachment and chemotactic factor. Elevated expression of OPN confers enhanced metastatic ability on transformed cells, suggesting that OPN may contribute to the malignant progression of tumors. Migration of mammary carcinoma ce...

    journal_title：Clinical & experimental metastasis

    pub_type： 杂志文章

    doi：10.1007/s10585-006-9007-0

    authors： Khan SA,Cook AC,Kappil M,Günthert U,Chambers AF,Tuck AB,Denhardt DT

    更新日期：2005-01-01 00:00:00

  • Control pathways of the 67 kDa laminin binding protein: surface expression and activity of a new ligand binding domain.

    abstract：:A number of papers have been published on the clinical correlation of the expression of the 67 kDa laminin binding protein (LBP) with the metastatic potential of solid tumors. Both mRNA and protein expression levels have been reported, but both the relationship between them and the molecular nature of the 67 kDa surfa...

    journal_title：Clinical & experimental metastasis

    pub_type： 杂志文章

    doi：10.1007/BF00121912

    authors： Landowski TH,Uthayakumar S,Starkey JR

    更新日期：1995-09-01 00:00:00

  • The clinicopathological evaluation of the breast cancer patients with brain metastases: predictors of survival.

    abstract：:We aimed to define the clinicopathologic characteristics of breast cancer (BC) patients with brain metastasis (BM) and to investigate the effect of these parameters on survival. Seventy-nine patients diagnosed with BC and symptomatic BM between 1995 and 2011 were retrospectively evaluated. The relationship between cli...

    journal_title：Clinical & experimental metastasis

    pub_type： 杂志文章

    doi：10.1007/s10585-012-9528-7

    authors： Tarhan MO,Demir L,Somali I,Yigit S,Erten C,Alacacioglu A,Ellidokuz H,Seseogullari O,Kucukzeybek Y,Can A,Dirican A,Bayoglu V,Akyol M

    更新日期：2013-02-01 00:00:00

  • Adriamycin-induced inhibition of melanoma cell invasion is correlated with decreases in tumor cell motility and increases in focal contact formation.

    abstract：:Tumor cell adhesion to the extracellular matrix (ECM) is closely linked with tumor cell invasion and metastasis. In this study, we demonstrate that low levels of adriamycin, a widely used anticancer drug, can inhibit the invasion of highly metastatic K1735-M2 mouse melanoma cells in vitro through a reconstituted basem...

    journal_title：Clinical & experimental metastasis

    pub_type： 杂志文章

    doi：10.1007/BF00880070

    authors： Repesh LA,Drake SR,Warner MC,Downing SW,Jyring R,Seftor EA,Hendrix MJ,McCarthy JB

    更新日期：1993-01-01 00:00:00

  • Improvements in population-based survival of patients presenting with metastatic rectal cancer in the south of the Netherlands, 1992-2008.

    abstract：:We analysed population-based treatment and survival data of patients who presented with metastatic rectal cancer. All patients diagnosed with primary synchronous metastatic rectal cancer between 1992 and 2008 in the Eindhoven Cancer Registry area were included. Date of diagnosis was divided into three periods (1992-19...

    journal_title：Clinical & experimental metastasis

    pub_type： 历史文章,杂志文章

    doi：10.1007/s10585-010-9370-8

    authors： Lemmens VE,de Haan N,Rutten HJ,Martijn H,Loosveld OJ,Roumen RM,Creemers GJ

    更新日期：2011-03-01 00:00:00

  • Inhibition of metastasis in a murine 4T1 breast cancer model by liposomes preventing tumor cell-platelet interactions.

    abstract：:The interaction between circulating tumor cells and blood components, mainly platelets, plays an important role during metastasis. In this study, we prepared liposomes containing the platelet aggregation inhibitor Cilostazol (Cil-L). The objective of this study was to investigate the effect of this Cil-L on platelet a...

    journal_title：Clinical & experimental metastasis

    pub_type： 杂志文章

    doi：10.1007/s10585-009-9299-y

    authors： Wenzel J,Zeisig R,Fichtner I

    更新日期：2010-01-01 00:00:00

  • Expression of activated gelatinase in human invasive breast carcinoma.

    abstract：:The expression of both 92- and 72-kDa gelatinases has been studied in 20 samples of human breast carcinoma by the technique of gelatin zymography. This technique allowed the relative amount of each gelatinase to be determined in small samples of tissue (< 10 mg). More importantly, active and latent forms of the two ge...

    journal_title：Clinical & experimental metastasis

    pub_type： 杂志文章

    doi：10.1007/BF00114976

    authors： Brown PD,Bloxidge RE,Anderson E,Howell A

    更新日期：1993-03-01 00:00:00

  • An orthotopic model of murine osteosarcoma with clonally related variants differing in pulmonary metastatic potential.

    abstract：:To provide an investigative tool for the study of osteosarcoma (OSA) biology we have developed a syngeneic (balb/c) murine model of OSA, using cell lines derived from a spontaneously occurring murine OSA (Schmidt et al. Differentiation 1988; 39: 151-60). This model is characterized by orthotopic primary tumor growth, ...

    journal_title：Clinical & experimental metastasis

    pub_type： 杂志文章

    doi：10.1023/a:1006767007547

    authors： Khanna C,Prehn J,Yeung C,Caylor J,Tsokos M,Helman L

    更新日期：2000-01-01 00:00:00

  • Mitogen activated protein kinase pathway is involved in RhoC GTPase induced motility, invasion and angiogenesis in inflammatory breast cancer.

    abstract：:Inflammatory breast cancer (IBC) is the most lethal form of locally advanced breast cancer known. IBC carries a guarded prognosis primarily due to rapid onset of disease, typically within six months, and the propensity of tumor emboli to invade the dermal lymphatics and spread systemically. Although the clinical manif...

    journal_title：Clinical & experimental metastasis

    pub_type： 杂志文章

    doi：10.1023/a:1015518114931

    authors： van Golen KL,Bao LW,Pan Q,Miller FR,Wu ZF,Merajver SD

    更新日期：2002-01-01 00:00:00

  • A critical review of vascular endothelial growth factor (VEGF) analysis in peripheral blood: is the current literature meaningful?

    abstract：:Vascular endothelial growth factor (VEGF) is a potent angiogenic growth factor with a key role in many physiological and pathological processes. Investigation into the implications of circulating levels of this cytokine is progressing at an exponential rate. However, there are important inconsistencies between reports...

    journal_title：Clinical & experimental metastasis

    pub_type： 杂志文章,评审

    doi：10.1023/a:1021379811308

    authors： Hormbrey E,Gillespie P,Turner K,Han C,Roberts A,McGrouther D,Harris AL

    更新日期：2002-01-01 00:00:00

  • Overview and update of the phase III Multicenter Selective Lymphadenectomy Trials (MSLT-I and MSLT-II) in melanoma.

    abstract：:This short review offers an update on the first and second Multicenter Selective Lymphadenectomy Trials (MSLT-I and MSLT-II) for patients with melanoma, and briefly traces the development of intraoperative lymphatic mapping and sentinel node biopsy. ...

    journal_title：Clinical & experimental metastasis

    pub_type： 杂志文章,多中心研究,评审

    doi：10.1007/s10585-012-9503-3

    authors： Morton DL

    更新日期：2012-10-01 00:00:00

  • Mapping protein signal pathway interaction in sarcoma bone metastasis: linkage between rank, metalloproteinases turnover and growth factor signaling pathways.

    abstract：:We applied reverse phase protein microarrays technology to map signal pathway interactions in a discovery set of 34 soft tissue sarcoma (STS) bone metastases compared to healthy bone. Proteins associated with matrix remodeling (MMP), adhesion (FAK Y576/577, Syndecan-1), and growth/survival (IGF1R Y1135/1136, PI3K, EGF...

    journal_title：Clinical & experimental metastasis

    pub_type： 杂志文章

    doi：10.1007/s10585-013-9605-6

    authors： Conti A,Espina V,Chiechi A,Magagnoli G,Novello C,Pazzaglia L,Quattrini I,Picci P,Liotta LA,Benassi MS

    更新日期：2014-01-01 00:00:00

  • SCUBE3 regulation of early lung cancer angiogenesis and metastatic progression.

    abstract：:Signal peptide-CUB-EGF-like domain-containing protein 3 (SCUBE3) is strongly expressed in extremely invasive lung carcinoma. We showed in our previous study that SCUBE3 triggers the transforming growth factor-β pathway and subsequently promotes tumor angiogenesis and the epithelial-mesenchymal transition (EMT). Howeve...

    journal_title：Clinical & experimental metastasis

    pub_type： 杂志文章

    doi：10.1007/s10585-013-9575-8

    authors： Chou CH,Cheng YF,Siow TY,Kumar A,Peck K,Chang C

    更新日期：2013-08-01 00:00:00