Influence of adoptively transferred thioglycollate-elicited peritoneal macrophages on metastasis formation in mice with depressed or stimulated NK activity.

abstract：:It is recognised that stromal cells determine cancer progression. We have previously shown that active TGFbeta produced by rat colon carcinoma cells modulated NO production in rat endothelial cells. To elucidate the role of TGFbeta and NO in the mechanisms of interaction of colon carcinoma cells with stromal cells and...

journal_title：Clinical & experimental metastasis

authors： Lohm S,Peduto-Eberl L,Lagadec P,Renggli-Zulliger N,Dudler J,Jeannin JF,Juillerat-Jeanneret L

更新日期：2005-01-01 00:00:00

abstract：:Pulmonary metastasectomy (PM) is an accepted treatment modality in colorectal cancer (CRC) patients with pulmonary tumor spread. Positive intrathoracic lymph nodes at the time of PM are associated with a poor prognosis and 5-year survival rates of <20 %. Increased lymphangiogenesis in pulmonary metastases might repres...

journal_title：Clinical & experimental metastasis

authors： Schweiger T,Nikolowsky C,Graeter T,Seebacher G,Laufer J,Glueck O,Glogner C,Birner P,Lang G,Klepetko W,Ankersmit HJ,Hoetzenecker K

更新日期：2016-02-01 00:00:00

abstract：:The concurrent administration of Metrazol (60 mg/kg, i.v.) to anaesthetized rats enhances the cerebral penetration of the anticancer agent razoxane. Such an enhancement leads to an increase in the therapeutic efficacy of razoxane against intracerebrally sequestered L1210 leukaemia cells in mice. The combination of Met...

journal_title：Clinical & experimental metastasis

authors： Greig N,Newell D,Hellmann K

更新日期：1984-01-01 00:00:00

abstract：:Although in the past little attention has been paid to the influence of osteosarcoma cells in osteoclast function, recent studies suggest a close relationship between osteosarcoma aggressiveness and osteoclastic activity. The present study addresses the paracrine effects of MG63 cells, a human osteosarcoma-derived cel...

journal_title：Clinical & experimental metastasis

authors： Costa-Rodrigues J,Teixeira CA,Fernandes MH

更新日期：2011-08-01 00:00:00

abstract：:Tumour endothelial markers (TEMs) are a newly discovered family of endothelial markers associated with tumour specific angiogenesis. This study sought to examine the levels of expression for TEMs in human breast cancer. Breast cancer tissues (n = 120) together with normal background tissues (n = 33) were obtained afte...

journal_title：Clinical & experimental metastasis

authors： Davies G,Cunnick GH,Mansel RE,Mason MD,Jiang WG

更新日期：2004-01-01 00:00:00

abstract：:Human CD44 standard isoform (hCD44s) cDNA regulated by a high-expressing promoter was transfected into Balb/c 3T3 cells and the tumorigenic and metastatic capacities of the transfectants were investigated in nude mice at the subcutaneous site. One of three transfectants was tumorigenic. hCD44s expression was lost in t...

journal_title：Clinical & experimental metastasis

authors： Kogerman P,Sy MS,Culp LA

更新日期：1998-01-01 00:00:00

abstract：:Breast cancer (BC) is the most common cancer affecting women in the United States and metastatic breast cancer is the leading cause of death. The role estradiol plays in ER-positive BC is well-documented, but the way it contributes to ER-negative BC remains unclear. In the present study, we utilized an experimental mo...

journal_title：Clinical & experimental metastasis

authors： Yang X,Belosay A,Du M,Fan TM,Turner RT,Iwaniec UT,Helferich WG

更新日期：2013-08-01 00:00:00

abstract：:Radiation therapy is an effective means of achieving local control in a wide range of primary tumours, with the reduction in the size of the tumour(s) thought to mediate the observed reductions in metastatic spread in clinical trials. However, there is evidence to suggest that the complex changes induced by radiation ...

journal_title：Clinical & experimental metastasis

authors： Blyth BJ,Cole AJ,MacManus MP,Martin OA

更新日期：2018-04-01 00:00:00

abstract：:Pancreatic cancer demonstrates a strong resistance to anticancer drugs, presumably due to its resistance to drug induced apoptosis. Although gemcitabine (GEM) might be partially effective for treating advanced pancreatic cancer, its efficacy is still less than satisfactory. Galectin-3 (gal-3), a member of the β-galact...

journal_title：Clinical & experimental metastasis

authors： Kobayashi T,Shimura T,Yajima T,Kubo N,Araki K,Wada W,Tsutsumi S,Suzuki H,Kuwano H,Raz A

更新日期：2011-04-01 00:00:00

abstract：:We have used 5'-deoxy-5'-S isobutyl-thioadenosine (SIBA), an analog of S-adenosylhomocysteine, alone or in association with a methionine-depleted diet in order to obtain an antitumoral effect in two different tumor models: a transplantable rat rhabdomyosarcoma (RMS-J1) induced by i.m. injection of nickel and the well-...

journal_title：Clinical & experimental metastasis

authors： Breillout F,Poupon MF,Blanchard P,Lascaux V,Echinard-Garin P,Robert-Gero M

更新日期：1988-01-01 00:00:00

abstract：:Organ-specific metastasis of tumour cells may result from selective invasion and growth or from selective host cell responses. The present study demonstrates how selective interactions with the host affect the metastatic pattern of two murine T cell hybridoma lines, derived from the BW 5147 thymoma. Upon intravenous i...

journal_title：Clinical & experimental metastasis

authors： Schmidt C,Verschueren H,Toussaint-Demylle D,van den Berg T,Kraal G,De Baetselier P

更新日期：1994-03-01 00:00:00

abstract：:Single cell progenies (SCPs) inherit biological properties from their isogenetic mother cells. If a single cancer cell can give rise to progenies, which can be passaged sustainably in vitro and produce tumor in xenotransplantation, the cell should be cancer initiating cell. CD133 (Prominin-1, Prom1) is the marker of h...

journal_title：Clinical & experimental metastasis

authors： Li G,Liu C,Yuan J,Xiao X,Tang N,Hao J,Wang H,Bian X,Deng Y,Ding Y

更新日期：2010-10-01 00:00:00

abstract：:MicroRNAs have been identified as key players in the development and progression of osteosarcoma, which is the most common primary malignancy of bone. Sequencing-based miR-omic and quantitative real-time PCR analyses suggested that the expression of miR-193a-3p and miR-193a-5p was decreased by DNA methylation at their...

journal_title：Clinical & experimental metastasis

authors： Pu Y,Zhao F,Cai W,Meng X,Li Y,Cai S

更新日期：2016-04-01 00:00:00

abstract：:The complex process of tumor invasion requires the coordinated expression and activity of cell-substratum adhesive interactions and of cell-associated protease systems, which destroy the extracellular matrix (ECM), in order to enable the invading cells to simultaneously grip and destroy the anatomical barriers that co...

journal_title：Clinical & experimental metastasis

authors： Del Rosso M,Fibbi G,Pucci M,D'Alessio S,Del Rosso A,Magnelli L,Chiarugi V

更新日期：2002-01-01 00:00:00

abstract：:Cancer stem cells drive the metastatic cascade by undergoing epithelial to mesenchymal transition (EMT) and again mesenchymal to epithelial transition (MET). Using multiple breast cancer cell lines including cigarette smoke induced breast cancer cells and tumor derived primary cells from patient sample; we developed a...

journal_title：Clinical & experimental metastasis

authors： Siddharth S,Das S,Nayak A,Kundu CN

更新日期：2016-10-01 00:00:00

abstract：:The effects of the cyclooxygenase (COX)-2 inhibitor nimesulide on bombesin-enhanced peritoneal metastasis of azoxymethane (AOM)-induced intestinal adenocarcinomas were investigated in male Wistar rats. From the beginning of the study, the rats were given 10 weekly s.c. injections of AOM (7.4 mg/kg body weight) and s.c...

journal_title：Clinical & experimental metastasis

authors： Iishi H,Tatsuta M,Baba M,Yano H,Higashino K,Mukai M,Akedo H

更新日期：2003-01-01 00:00:00

abstract：BACKGROUND:One of the major clinical problems in breast cancer detection is the relatively high incidence of occult lymph node metastases undetectable by standard procedures. Since the ascertainment of breast cancer stage determines the following treatment, such a "hypo-diagnosis" leads to inadequate therapy, and hence...

journal_title：Clinical & experimental metastasis

authors： Afrimzon E,Deutsch A,Shafran Y,Zurgil N,Sandbank J,Pappo I,Deutsch M

更新日期：2008-01-01 00:00:00

abstract：:Several lines of evidence indicate that sialosyl Le(a), tumor-associated carbohydrate antigen present on human colon carcinoma cells, is involved in formation of metastases. To study the role of this carbohydrate structure in development of metastases, we have used the clone of human colon carcinoma CX-1 cells transfe...

journal_title：Clinical & experimental metastasis

authors： Opolski A,Laskowska A,Madej J,Wietrzyk J,Kłopocki A,Radzikowski C,Ugorski M

更新日期：1998-11-01 00:00:00

abstract：:Bone is the third most common site of cancer metastasis. Over 30 to 40% of lung cancers can develop skeletal metastasis and no effective curative therapy exists in clinic cases. Previously we screened the different expression of proteins between SBC-5 cells and SBC-3 cells by proteomic study methods (MALDI-TOF/TOF-MS)...

journal_title：Clinical & experimental metastasis

authors： Ma NQ,Liu LL,Min J,Wang JW,Jiang WF,Liu Y,Feng YG,Su HC,Feng YM,Zhang HL

更新日期：2011-12-01 00:00:00

abstract：:To evaluate the local control (LC), progression free survival (PFS), out-field PFS, overall survival (OS), toxicity and failure predictors of SRT in a series of various sites oligometastatic CRC patients. Patients with oligometastatic CRC disease were analyzed retrospectively. The SRT prescribed dose was dependent on ...

journal_title：Clinical & experimental metastasis

authors： Dell'Acqua V,Surgo A,Kraja F,Kobiela J,Zerella MA,Spychalski P,Gandini S,Francia CM,Ciardo D,Fodor C,Ferrari AM,Piperno G,Cattani F,Vigorito S,Pansini F,Petz W,Orecchia R,Leonardi MC,Jereczek-Fossa BA

更新日期：2019-08-01 00:00:00

abstract：:The combined therapeutic effect of natural killer T (NKT) cell ligand alpha-galactosylceramide (alpha-GalCer) and IL-12 against highly metastatic B16-BL6-HM melanoma cells was investigated. In comparison with a single administration of alpha-GalCer or IL-12, the combined treatment of tumor-bearing mice with alpha-GalC...

journal_title：Clinical & experimental metastasis

authors： Nakui M,Ohta A,Sekimoto M,Sato M,Iwakabe K,Yahata T,Kitamura H,Koda T,Kawano T,Makuuchi H,Taniguchi M,Nishimura T

更新日期：2000-01-01 00:00:00

abstract：:Clear cell renal cell carcinoma (ccRCC) is one of few cancers with rising incidence in North America. The prognosis of ccRCC is variable and difficult to predict. Stratification of patients according to disease aggressiveness can significantly improve patient management. We investigated the expression of the S100A11 p...

journal_title：Clinical & experimental metastasis

authors： Gabril M,Girgis H,Scorilas A,Rotondo F,Wala S,Bjarnason GA,Ding Q,Evans A,Tawedrous E,Pasic M,Finelli A,Al-Haddad S,Yousef GM

更新日期：2016-01-01 00:00:00

abstract：:Matrilysin is a member of the matrix metalloproteinase gene family which is believed to play an important role in tumor progression. Expression of matrilysin mRNA was examined by reverse transcription-polymerase chain reaction combined with Southern blot analysis in 46 human primary gastric cancers. Overexpression of ...

journal_title：Clinical & experimental metastasis

authors： Senota A,Itoh F,Yamamoto H,Adachi Y,Hinoda Y,Imai K

更新日期：1998-05-01 00:00:00

abstract：:ECA109 human oesophageal carcinoma cells were injected either subcutaneously or intraperitoneally into BALB/CATc 1-nu/nu mice. After 23 weeks tumours were examined histologically and by scanning electron microscopy. Subcutaneous ECA109 tumours were well-delineated without signs of invasion. By contrast, intra-abdomina...

journal_title：Clinical & experimental metastasis

authors： Gao J,Xue KX,Li BG,Dong HY,Wei LS,Zhang ZH,Tian S,Xu ZG

更新日期：1984-07-01 00:00:00

abstract：:This study was carried out to clarify the presentation, treatment options, and prognosis of renal cell carcinoma (RCC) metastasis to the bladder in which we do not yet have a comprehensive understanding. A systematic Medline, Web of Science, Embase, Google, and Ichushi Web search was performed to identify articles des...

journal_title：Clinical & experimental metastasis

authors： Matsumoto K,Hayakawa N,Nakamura S,Oya M

更新日期：2015-02-01 00:00:00

abstract：:It is generally accepted that recent advances in anticancer agents have contributed significantly to the improvement of both the disease-free survival and quality of life in cancer patients. However, in many instances, a favorable initial response to treatment changes afterwards, thereby leading to cancer relapse and ...

journal_title：Clinical & experimental metastasis

authors： Nikolaou M,Pavlopoulou A,Georgakilas AG,Kyrodimos E

更新日期：2018-04-01 00:00:00

abstract：:We have examined the role of platelet-endothelial cell adhesion molecule-1 (PECAM-1/CD31) during the transendothelial migration of melanoma cells using a novel in vitro system. Comparable studies have suggested the involvement of PECAM-1 in leukocyte transendothelial migration. Such studies have been confirmed using i...

journal_title：Clinical & experimental metastasis

authors： Voura EB,Chen N,Siu CH

更新日期：2000-01-01 00:00:00

abstract：:The growth of metastatic prostate cancer cells in the bone involves an intimate interaction between the tumor cells and various elements of the bone microenvironment, resulting in increased rate of bone turnover and rapid tumor growth. The alpha(v)beta3 integrin has been shown to play an important role in tumor growth...

journal_title：Clinical & experimental metastasis

authors： Nemeth JA,Cher ML,Zhou Z,Mullins C,Bhagat S,Trikha M

更新日期：2003-01-01 00:00:00

abstract：:Brain metastases are the most common intracranial tumors in adults, accounting for more than 50% of all such cases. The approach to and management of brain metastases have evolved significantly in recent years due to several reasons. These include advances in neurosurgical and radiotherapeutic techniques, improved sys...

journal_title：Clinical & experimental metastasis

authors： Thiagarajan A,Yamada Y

更新日期：2017-10-01 00:00:00

abstract：:To provide an investigative tool for the study of osteosarcoma (OSA) biology we have developed a syngeneic (balb/c) murine model of OSA, using cell lines derived from a spontaneously occurring murine OSA (Schmidt et al. Differentiation 1988; 39: 151-60). This model is characterized by orthotopic primary tumor growth, ...

journal_title：Clinical & experimental metastasis

authors： Khanna C,Prehn J,Yeung C,Caylor J,Tsokos M,Helman L

更新日期：2000-01-01 00:00:00