Site-dependence of invasiveness of ECA109 human oesophageal carcinoma cells in nude mice.

abstract：:The complex process of tumor invasion requires the coordinated expression and activity of cell-substratum adhesive interactions and of cell-associated protease systems, which destroy the extracellular matrix (ECM), in order to enable the invading cells to simultaneously grip and destroy the anatomical barriers that co...

journal_title：Clinical & experimental metastasis

authors： Del Rosso M,Fibbi G,Pucci M,D'Alessio S,Del Rosso A,Magnelli L,Chiarugi V

更新日期：2002-01-01 00:00:00

abstract：:Radiation therapy is an effective means of achieving local control in a wide range of primary tumours, with the reduction in the size of the tumour(s) thought to mediate the observed reductions in metastatic spread in clinical trials. However, there is evidence to suggest that the complex changes induced by radiation ...

journal_title：Clinical & experimental metastasis

authors： Blyth BJ,Cole AJ,MacManus MP,Martin OA

更新日期：2018-04-01 00:00:00

abstract：:We have previously reported that induction of MMP-2 activation by Concanavalin A (ConA) in MDA-MB-231 human breast cancer cells involves both transcriptional and post-transcriptional mechanisms, and that the continuous presence of ConA is required for MMP-2 activation (Yu et al. Cancer Res, 55, 3272-7, 1995). In an ef...

journal_title：Clinical & experimental metastasis

authors： Yu M,Sato H,Seiki M,Spiegel S,Thompson EW

更新日期：1998-02-01 00:00:00

abstract：:Considering recent findings that cyclooxygensase-2 (COX-2) is involved in the progression of colorectal carcinoma (CRC), the role of COX-2 in promoting invasion and angiogenesis was investigated by evaluating the relationship of COX-2 expression to various clinicopathological variables, including plasminogen activatin...

journal_title：Clinical & experimental metastasis

authors： Konno H,Baba M,Shoji T,Ohta M,Suzuki S,Nakamura S

更新日期：2002-01-01 00:00:00

abstract：:Although in the past little attention has been paid to the influence of osteosarcoma cells in osteoclast function, recent studies suggest a close relationship between osteosarcoma aggressiveness and osteoclastic activity. The present study addresses the paracrine effects of MG63 cells, a human osteosarcoma-derived cel...

journal_title：Clinical & experimental metastasis

authors： Costa-Rodrigues J,Teixeira CA,Fernandes MH

更新日期：2011-08-01 00:00:00

abstract：:We have examined the effects of the microenvironment on the frequency and generation of metastatic variant cells in both parental B16F1 melanoma cells and nascent clones. The metastatic abilities of cultured B16F1 cells were tested after a period of growth in the presence or absence of a second cell population separat...

journal_title：Clinical & experimental metastasis

authors： Harris JF,Chambers AF,Tam AS

更新日期：1991-03-01 00:00:00

abstract：:Tumor cell adhesion to the extracellular matrix (ECM) is closely linked with tumor cell invasion and metastasis. In this study, we demonstrate that low levels of adriamycin, a widely used anticancer drug, can inhibit the invasion of highly metastatic K1735-M2 mouse melanoma cells in vitro through a reconstituted basem...

journal_title：Clinical & experimental metastasis

authors： Repesh LA,Drake SR,Warner MC,Downing SW,Jyring R,Seftor EA,Hendrix MJ,McCarthy JB

更新日期：1993-01-01 00:00:00

abstract：:The function of tropomyosin receptor kinase (Trk) family including TrkA, TrkB, and TrkC in cancer remains unknown. The role of Trks in oral squamous cell carcinoma (OSCC) was examined. Knockdown of Trks provided inhibition of growth or invasion and decrease of apoptosis in OSCC cells, which expressed Trks at high leve...

journal_title：Clinical & experimental metastasis

authors： Sasahira T,Ueda N,Yamamoto K,Bhawal UK,Kurihara M,Kirita T,Kuniyasu H

更新日期：2013-02-01 00:00:00

abstract：:Proliferation capacity and MHC class I antigen expression of two Lewis lung carcinoma (3LL) metastatic variants (C87, BC215) grown under defined experimental conditions (serum-free defined medium or 10 per cent serum) have been studied following exposure to MoAb 135-13C which recognizes on these cells a tumor surface ...

journal_title：Clinical & experimental metastasis

authors： Sacchi A,Piaggio G,Rizzo MA,Falcioni R,Kennel SJ

更新日期：1989-01-01 00:00:00

abstract：:Although the loss of sulfomucins was known as an indicator of carcinogenesis and malignant progression of colonic epithelia, it was not known whether the loss was directly related to the malignant behavior of colon carcinoma cells. We have studied the biological properties of LS174T human colon carcinoma cells before ...

journal_title：Clinical & experimental metastasis

authors： Tsuiji H,Nakatsugawa S,Ishigaki T,Irimura T

更新日期：1999-03-01 00:00:00

abstract：:Accumulating evidences indicate that long non-coding RNAs (lncRNAs) play important roles in several biological processes and dysregulated lncRNAs are involved in different kinds of cancer and are associated with carcinogenesis, metastasis, and prognosis of cancer. The role of a new lncRNA LOC100130476 in gastric cardi...

journal_title：Clinical & experimental metastasis

authors： Guo W,Dong Z,Shi Y,Liu S,Liang J,Guo Y,Guo X,Shen S,Wang G

更新日期：2016-06-01 00:00:00

abstract：:Activation of nuclear factor-κB (NF-κB) has been implicated in metastasis of pancreatic cancer. We investigated the effects of the novel NF-κB inhibitor dehydroxymethylepoxyquinomicin (DHMEQ) on the inhibition of liver metastasis of pancreatic cancer in a mouse model of clinical liver metastasis. Nude mice were xenogr...

journal_title：Clinical & experimental metastasis

authors： Suzuki K,Aiura K,Matsuda S,Itano O,Takeuchi O,Umezawa K,Kitagawa Y

更新日期：2013-04-01 00:00:00

abstract：:Lung cancer often metastasizes to bone in patients with advanced disease. Identification of the factors involved in the interactions between lung cancer cells and bone will improve the prevention and treatment of bone metastases. We identified changes in metastasis-related gene expression of human HARA lung squamous c...

journal_title：Clinical & experimental metastasis

authors： Deng X,Tannehill-Gregg SH,Nadella MV,He G,Levine A,Cao Y,Rosol TJ

更新日期：2007-01-01 00:00:00

abstract：:The occurrence of metastases is the hallmark of cancer. Development of metastasis severely affects prognosis and survival. It limits or discourages therapeutic interventions since no therapies are available to block or prevent cancer invasion. In order to invade, epithelial cancer cells need to penetrate through the b...

journal_title：Clinical & experimental metastasis

authors： Giannelli G,Antonaci S

更新日期：2000-01-01 00:00:00

abstract：:Vascularization of solid tumors is thought to occur by sprouting or intussusceptive angiogenesis, co-option of existing vessels, and vasculogenic mimicry after the onset of tumor hypoxia, when the tumor radius exceeds the oxygen diffusion distance. In contrast, here we show that individual endothelial cells that are i...

journal_title：Clinical & experimental metastasis

authors： Elzarrad K,Haroon A,Reed D,Al-Mehdi AB

更新日期：2009-01-01 00:00:00

abstract：:Treating metastatic osteosarcoma (OS) remains a challenge in oncology. Current treatment strategies target the primary tumour rather than metastases and have a limited efficacy in the treatment of metastatic disease. Metastatic cells have specific features that render them less sensitive to therapy and targeting these...

journal_title：Clinical & experimental metastasis

authors： PosthumaDeBoer J,Witlox MA,Kaspers GJ,van Royen BJ

更新日期：2011-06-01 00:00:00

abstract：:CD147 is expressed at low levels in normal tissues but frequently highly expressed in a wide range of tumor types such as lung, breast, and liver and therefore it is a potentially unique therapeutic target for these diverse tumor types. We previously generated a murine antibody HAb18 which suppresses matrix met al.lop...

journal_title：Clinical & experimental metastasis

authors： Wang Y,Yuan L,Yang XM,Wei D,Wang B,Sun XX,Feng F,Nan G,Wang Y,Chen ZN,Bian H

更新日期：2015-01-01 00:00:00

abstract：:Blood samples, bone marrow, tumours and metastases where possible were collected from SCID mice bearing orthotopic xenografts of the triple-negative MDA-MB-468 cell line or a transplantable ER-positive patient derived xenograft (ED-03), and assessed using human-specific, tandem-nested RT-qPCR for markers relating to d...

journal_title：Clinical & experimental metastasis

authors： Tachtsidis A,Le AV,Blick T,Gunasinghe D,De Sousa E,Waltham M,Dobrovic A,Thompson EW

更新日期：2019-08-01 00:00:00

abstract：:Repeated administration of the hepatic lectin blocking agents D-galactose or arabinogalactan completely prevented the settling of metastatic cells of sarcoma L-1 tumor in the liver of Balb/c mice and greatly reduced the colonization process of highly metastatic ESb lymphoma cells of the liver of DBA/2 mice. Therefore,...

journal_title：Clinical & experimental metastasis

authors： Beuth J,Ko HL,Schirrmacher V,Uhlenbruck G,Pulverer G

更新日期：1988-03-01 00:00:00

abstract：:We have investigated the gelatinase profiles and invasiveness of clonal tumour sublines derived from a spontaneously arising mammary tumour in a Balb/cfC3H mouse. The 67NR. 66c14 and 4T1.2 sublines have low, intermediate and high metastatic potential respectively. In Boyden chamber studies, Matrigel invasion was seen ...

journal_title：Clinical & experimental metastasis

authors： Tester AM,Ruangpanit N,Anderson RL,Thompson EW

更新日期：2000-01-01 00:00:00

abstract：:Pancreatic cancer demonstrates a strong resistance to anticancer drugs, presumably due to its resistance to drug induced apoptosis. Although gemcitabine (GEM) might be partially effective for treating advanced pancreatic cancer, its efficacy is still less than satisfactory. Galectin-3 (gal-3), a member of the β-galact...

journal_title：Clinical & experimental metastasis

authors： Kobayashi T,Shimura T,Yajima T,Kubo N,Araki K,Wada W,Tsutsumi S,Suzuki H,Kuwano H,Raz A

更新日期：2011-04-01 00:00:00

abstract：:The mechanisms leading to rapid invasive growth of malignant gliomas are poorly understood. Expression of the hyaluronic acid (HA) receptor CD44 and adhesion to HA are involved in invasive properties. Our previous studies have shown that malignant glioma cells are able to adhere to extracellular HA. Here we investigat...

journal_title：Clinical & experimental metastasis

authors： Knüpfer MM,Poppenborg H,Hotfilder M,Kühnel K,Wolff JE,Domula M

更新日期：1999-02-01 00:00:00

abstract：:Tumor cells exposed to a growth stress such as low pH, glucose starvation and hypoxia have been shown to exhibit a transient increase in experimental metastatic potential, particularly when allowed to recover under normal growth conditions for a period of 24-48 h. In this study we examined whether this increase in met...

journal_title：Clinical & experimental metastasis

authors： Jang A,Hill RP

更新日期：1997-09-01 00:00:00

abstract：:Morbidity and mortality of breast cancer patients are drastically increased when primary tumor cells are able to spread to distant sites and proliferate to become secondary lesions. Effective treatment of metastatic disease has been limited; therefore, an increased molecular understanding to identify biomarkers and th...

journal_title：Clinical & experimental metastasis

authors： Cook LM,Cao X,Dowell AE,Debies MT,Edmonds MD,Beck BH,Kesterson RA,Desmond RA,Frost AR,Hurst DR,Welch DR

更新日期：2012-04-01 00:00:00

abstract：:A previous study from our laboratory suggested that prostate cancer metastasis to bone may be mediated, in part, by preferential adhesion to human bone marrow endothelial (HBME) cells. Tumor cell adhesion to endothelial cells may be modulated by the effect of cytokines on cell adhesion molecules (CAMs). Tumor necrosis...

journal_title：Clinical & experimental metastasis

authors： Cooper CR,Bhatia JK,Muenchen HJ,McLean L,Hayasaka S,Taylor J,Poncza PJ,Pienta KJ

更新日期：2002-01-01 00:00:00

abstract：:Human tissue factor pathway inhibitor-2 (TFPI-2), also known as placental protein (PP5) and matrix-associated serine protease inhibitor (MSPI), is a 32-kDa extracellular matrix (ECM) protein consisting of three tandomly arranged Kunitz-type domains that inhibits plasmin, trypsin, chymotrypsin, cathepsin G and plasma k...

journal_title：Clinical & experimental metastasis

authors： Konduri SD,Tasiou A,Chandrasekar N,Nicolson GL,Rao JS

更新日期：2000-01-01 00:00:00

abstract：:High grade serous ovarian tumors often metastasize transperitoneally, a process that begins when small tumor nodules de-adhere and are released into the fluid of the abdominal cavity where they float freely to reach new sites on the peritoneal wall. Podocalyxin, a small anti-adhesive sialomucin, has been shown to cont...

journal_title：Clinical & experimental metastasis

authors： Cipollone JA,Graves ML,Köbel M,Kalloger SE,Poon T,Gilks CB,McNagny KM,Roskelley CD

更新日期：2012-03-01 00:00:00

abstract：:To elucidate the development of bone metastasis in human neuroblastoma, bone marrow and bone metastases were analysed histologically in a hematogeneous metastasis model of murine neuroblastoma. The bone marrow metastasis occurred initially in the bone marrow sinusoid where tumor cells adhered and extravasated to bone ...

journal_title：Clinical & experimental metastasis

authors： Yoshino K,Tanabe M,Ohnuma N,Takahashi H

更新日期：1996-10-01 00:00:00

abstract：:Aromatic polyamidines containing two, three or four benzamidine residues inhibit proteinase activity and proliferation of different human tumor cell lines, including leukemic (K562, HEL), melanoma (Colo 38) and B-lymphoid (WI-L2) cell lines. In addition, the benzamidine derivatives analysed in the present study inhibi...

journal_title：Clinical & experimental metastasis

authors： Nastruzzi C,Feriotto G,Spandidos D,Ferroni R,Guarneri M,Barbieri R,Gambari R

更新日期：1989-01-01 00:00:00

abstract：BACKGROUND:One of the major clinical problems in breast cancer detection is the relatively high incidence of occult lymph node metastases undetectable by standard procedures. Since the ascertainment of breast cancer stage determines the following treatment, such a "hypo-diagnosis" leads to inadequate therapy, and hence...

journal_title：Clinical & experimental metastasis

authors： Afrimzon E,Deutsch A,Shafran Y,Zurgil N,Sandbank J,Pappo I,Deutsch M

更新日期：2008-01-01 00:00:00