Resistance of the embryonic notochord to invasion by malignant neurogenic tumor cells in vitro.

abstract：:A previous study from our laboratory suggested that prostate cancer metastasis to bone may be mediated, in part, by preferential adhesion to human bone marrow endothelial (HBME) cells. Tumor cell adhesion to endothelial cells may be modulated by the effect of cytokines on cell adhesion molecules (CAMs). Tumor necrosis...

journal_title：Clinical & experimental metastasis

authors： Cooper CR,Bhatia JK,Muenchen HJ,McLean L,Hayasaka S,Taylor J,Poncza PJ,Pienta KJ

更新日期：2002-01-01 00:00:00

abstract：:We have compared the pattern of surface antigen expression, as detected by monoclonal antibodies (mAbs), in plasma membranes vs shed membrane vesicles of two human breast carcinoma cell lines, MCF-7 and 8701-BC. Antigen expression was detected on cells by immunofluorescence (IF) analysis, whilst, due to their small di...

journal_title：Clinical & experimental metastasis

authors： Dolo V,Adobati E,Canevari S,Picone MA,Vittorelli ML

更新日期：1995-07-01 00:00:00

abstract：:Recently the concept that gap junctions play a role in cancer cell metastasis has emerged. However, the mechanism by which this might occur is unknown. To examine this issue a metastatic breast cancer cell line, MDA-MB-435, was stably transfected with human Cx43 cDNA. Four clones of 435 transfectants (435/Cx43(+) c1, ...

journal_title：Clinical & experimental metastasis

authors： Li Z,Zhou Z,Welch DR,Donahue HJ

更新日期：2008-01-01 00:00:00

abstract：:Brain metastases present a significant public health issue, affecting more than 100,000 patients per year in the U.S. and result in significant morbidity. Brain metastases can occur in a variety of clinical situations ranging from multiple brain metastases with uncontrolled systemic disease to a solitary metastasis in...

journal_title：Clinical & experimental metastasis

authors： Ferguson SD,Wagner KM,Prabhu SS,McAleer MF,McCutcheon IE,Sawaya R

更新日期：2017-10-01 00:00:00

abstract：:Lymphangiogenesis plays a crucial role in promoting cancer metastasis to sentinel lymph nodes (LNs) and beyond. Increasing data have shown that simvastatin, a cholesterol-lowering medication for the prevention of cardiovascular diseases, is involved in tumor growth and dissemination, and endothelial functions. This st...

journal_title：Clinical & experimental metastasis

authors： Ji RC,Eshita Y,Kobayashi T,Hidano S,Kamiyama N,Onishi Y

更新日期：2018-12-01 00:00:00

abstract：:Melanoma is an aggressive cutaneous malignancy with rapidly rising incidence. Diagnosis of controversial melanocytic lesions, correct prognostication of patients, selection of appropriate adjuvant and systemic therapies, and prediction of response to a given therapy remain very real challenges. Despite these challenge...

journal_title：Clinical & experimental metastasis

authors： Ankeny JS,Labadie B,Luke J,Hsueh E,Messina J,Zager JS

更新日期：2018-08-01 00:00:00

abstract：:Cell motility is an important factor in the process of invasion and metastasis of tumor. In this study, the relationship between cell motility and experimental metastatic potential was examined using two human pancreatic cancer cell lines, SW1990 and PANC-1. Serum-free conditioned medium from the highly metastatic cel...

journal_title：Clinical & experimental metastasis

authors： Sakurai Y,Sawada T,Chung YS,Funae Y,Sowa M

更新日期：1997-05-01 00:00:00

abstract：:Breast cancer (BC) is the most common cancer affecting women in the United States and metastatic breast cancer is the leading cause of death. The role estradiol plays in ER-positive BC is well-documented, but the way it contributes to ER-negative BC remains unclear. In the present study, we utilized an experimental mo...

journal_title：Clinical & experimental metastasis

authors： Yang X,Belosay A,Du M,Fan TM,Turner RT,Iwaniec UT,Helferich WG

更新日期：2013-08-01 00:00:00

abstract：:Matrilysin is a member of the matrix metalloproteinase gene family which is believed to play an important role in tumor progression. Expression of matrilysin mRNA was examined by reverse transcription-polymerase chain reaction combined with Southern blot analysis in 46 human primary gastric cancers. Overexpression of ...

journal_title：Clinical & experimental metastasis

authors： Senota A,Itoh F,Yamamoto H,Adachi Y,Hinoda Y,Imai K

更新日期：1998-05-01 00:00:00

abstract：:We have previously reported that transfection of mouse interferon gamma (IFN-gamma) in H-2Kk-positive BW variants (BW-Sp3) abolishes tumorigenicity and reduces metastatic capacity. To further increase the immunogenicity of BW-Sp3 cells, the gene for human interleukin 2 (huIL-2) was transfected in these cancer cells. S...

journal_title：Clinical & experimental metastasis

authors： Geldhof AB,Van Ginderachter J,Vandersteen P,Raes G,De Baetselier P

更新日期：1998-07-01 00:00:00

abstract：:Extrathyroidal extension (ETE) of papillary thyroid carcinoma (PTC) is common and clinical presentation can vary from minimal to extensive locoregional involvement. Although PTC is generally considered the most benign among all thyroid carcinomas, it may present with local invasion with poor prognosis. Our retrospecti...

journal_title：Clinical & experimental metastasis

authors： Lin JD,Hsueh C,Chao TC

更新日期：2016-08-01 00:00:00

abstract：:It is recognised that stromal cells determine cancer progression. We have previously shown that active TGFbeta produced by rat colon carcinoma cells modulated NO production in rat endothelial cells. To elucidate the role of TGFbeta and NO in the mechanisms of interaction of colon carcinoma cells with stromal cells and...

journal_title：Clinical & experimental metastasis

authors： Lohm S,Peduto-Eberl L,Lagadec P,Renggli-Zulliger N,Dudler J,Jeannin JF,Juillerat-Jeanneret L

更新日期：2005-01-01 00:00:00

abstract：:Previous studies from our laboratory have demonstrated that metastatic propensity is significantly influenced by the genetic background upon which tumors arise. We have also established that human gene expression profiles predictive of metastasis are not only present in mouse tumors with both high and low metastatic c...

journal_title：Clinical & experimental metastasis

authors： Yang H,Crawford N,Lukes L,Finney R,Lancaster M,Hunter KW

更新日期：2005-01-01 00:00:00

abstract：:Recombinant murine interferon beta (MuIFN-beta) given i.v. efficiently inhibited both pulmonary arrest and formation of lung colonies of NL-17, a highly metastatic variant of mouse colon adenocarcinoma 26. NL-17 was rather resistant to MuIFN-beta in vitro and was highly resistant to natural killer cells of mice even t...

journal_title：Clinical & experimental metastasis

authors： Tsuruo T,Saito H,Watanabe M,Sugimoto Y,Yamori T,Oh-Hara T

更新日期：1990-03-01 00:00:00

abstract：:This study compared phenotype and behaviour of seven head and neck squamous cell carcinoma (HNSCC) cell lines and normal epithelial cells. Indications were found that in HNSCC cells: 1) loss of the cell-cell adhesion molecule E-cadherin was correlated with loss of epithelioid cell morphology but not with loss of cell-...

journal_title：Clinical & experimental metastasis

authors： Tomson AM,Scholma J,Meijer B,Koning JG,de Jong KM,van der Werf M

更新日期：1996-11-01 00:00:00

abstract：:The anti-metastatic efficacy and safety of a newly-developed matrix metalloproteinase (MMP) inhibitor were examined. MMI-166, a N-sulfonylamino acid derivative, inhibited the enzyme activity of MMP-2, 9, and 14 but not MMP-1, 3 or 7. Daily oral administration of MMI-166 resulted in potent inhibition of metastatic lung...

journal_title：Clinical & experimental metastasis

authors： Maekawa R,Maki H,Wada T,Yoshida H,Nishida-Nishimoto K,Okamoto H,Matsumoto Y,Tsuzuki H,Yoshioka T

更新日期：2000-01-01 00:00:00

abstract：:We aimed to define the clinicopathologic characteristics of breast cancer (BC) patients with brain metastasis (BM) and to investigate the effect of these parameters on survival. Seventy-nine patients diagnosed with BC and symptomatic BM between 1995 and 2011 were retrospectively evaluated. The relationship between cli...

journal_title：Clinical & experimental metastasis

authors： Tarhan MO,Demir L,Somali I,Yigit S,Erten C,Alacacioglu A,Ellidokuz H,Seseogullari O,Kucukzeybek Y,Can A,Dirican A,Bayoglu V,Akyol M

更新日期：2013-02-01 00:00:00

abstract：:The urokinase-type plasminogen activator (UPA) and its inhibitor PAI-1 are thought to play an important part in gastric cancer (GC) invasion and metastasis. Little is known about the behavior and prognostic impact of the receptor for UPA (UPAR). The aims of the present study were: (1) to measure UPAR, UPA and PAI-1 le...

journal_title：Clinical & experimental metastasis

authors： Plebani M,Herszènyi L,Carraro P,De Paoli M,Roveroni G,Cardin R,Tulassay Z,Naccarato R,Farinati F

更新日期：1997-07-01 00:00:00

abstract：:The complex process of tumor invasion requires the coordinated expression and activity of cell-substratum adhesive interactions and of cell-associated protease systems, which destroy the extracellular matrix (ECM), in order to enable the invading cells to simultaneously grip and destroy the anatomical barriers that co...

journal_title：Clinical & experimental metastasis

authors： Del Rosso M,Fibbi G,Pucci M,D'Alessio S,Del Rosso A,Magnelli L,Chiarugi V

更新日期：2002-01-01 00:00:00

abstract：:The growth and metastatic behavior of three human tumor cell lines and a human colon carcinoma previously passaged in vivo were compared between nude mice and scid mice after xenotransplantation. The three human tumor lines included a bladder carcinoma (T24B), a melanoma (RPMI 7931) and a lacZ gene-transduced breast c...

journal_title：Clinical & experimental metastasis

authors： Xie X,Brünner N,Jensen G,Albrectsen J,Gotthardsen B,Rygaard J

更新日期：1992-05-01 00:00:00

abstract：:Cancer cells with the surface marker profile CD44+/CD24- have previously been described to possess cancer stem cell-like properties. This manuscript evaluates those properties in ovarian cancer cell lines. The proportion of CD44+/CD24- cells corresponded to the clinical aggressiveness of each ovarian cancer cell line ...

journal_title：Clinical & experimental metastasis

authors： Meng E,Long B,Sullivan P,McClellan S,Finan MA,Reed E,Shevde L,Rocconi RP

更新日期：2012-12-01 00:00:00

abstract：:The chemokine CXCL12/SDF-1 and its receptors CXCR4 and CXCR7 play a major role in tumor invasion, proliferation and metastasis. Since both receptors are overexpressed on distinct tumor cells and on the tumor vasculature, we evaluated their potential as targets for detection of cancers by molecular imaging. We synthesi...

journal_title：Clinical & experimental metastasis

authors： Meincke M,Tiwari S,Hattermann K,Kalthoff H,Mentlein R

更新日期：2011-12-01 00:00:00

abstract：:Radiotherapy induces untargeted effects on normal tissues such as bone marrow. So alteration of microenvironment by ionizing irradiation is supposed to influence dynamic host-cancer ecosystem affecting cancer behavior including metastasis. Herein, the incidence of lung metastasis after high-dose irradiation has been i...

journal_title：Clinical & experimental metastasis

authors： Shin JW,Son JY,Raghavendran HR,Chung WK,Kim HG,Park HJ,Jang SS,Son CG

更新日期：2011-12-01 00:00:00

abstract：:Cancer metastasis shows great diversity in target organs, routes and molecular mechanisms depending on the type of cancer and even on the individual patients. To identify key molecules involved in metastasis, we constructed a murine model system including multiple sublines with different organotropism and pathways of ...

journal_title：Clinical & experimental metastasis

authors： Sugino T,Ichikawa-Tomikawa N,Tanaka M,Shishito N,Miura T,Abe M,Muramatsu K,Oishi T,Kakuda Y,Kawata T,Akiyama Y

更新日期：2019-08-01 00:00:00

abstract：:Patients with small cell lung cancer (SCLC) are more likely to have synchronous brain metastasis (SBM) at the time of diagnosis than patients with any other extracranial primary malignancy. We sought to identify which factors predicted an increased risk of SBM in SCLC as well as which factors affected the prognosis of...

journal_title：Clinical & experimental metastasis

authors： Reddy SP,Dowell JE,Pan E

更新日期：2020-08-01 00:00:00

abstract：:The abilities of tumor cells to extravasate from the blood vessel system and to migrate through the connective tissue are prerequisites in metastasis formation. Both processes are chiefly mediated by integrins, which mediate both cell-cell and cell-matrix interactions. We investigated the role of integrin subunits in ...

journal_title：Clinical & experimental metastasis

authors： Heyder C,Gloria-Maercker E,Hatzmann W,Niggemann B,Zänker KS,Dittmar T

更新日期：2005-01-01 00:00:00

abstract：:Lung cancer is the most frequent and one of the most deadly cancer types and is classified into small cell lung cancer and non-small cell lung cancer (NSCLC). Transforming growth factor beta (TGFβ) regulates a wide array of cell functions and plays a major role in lung diseases, including NSCLC. TGFβ signals through t...

journal_title：Clinical & experimental metastasis

authors： Vázquez PF,Carlini MJ,Daroqui MC,Colombo L,Dalurzo ML,Smith DE,Grasselli J,Pallotta MG,Ehrlich M,Bal de Kier Joffé ED,Puricelli L

更新日期：2013-12-01 00:00:00

abstract：:We have examined the role of platelet-endothelial cell adhesion molecule-1 (PECAM-1/CD31) during the transendothelial migration of melanoma cells using a novel in vitro system. Comparable studies have suggested the involvement of PECAM-1 in leukocyte transendothelial migration. Such studies have been confirmed using i...

journal_title：Clinical & experimental metastasis

authors： Voura EB,Chen N,Siu CH

更新日期：2000-01-01 00:00:00

abstract：:The concurrent administration of Metrazol (60 mg/kg, i.v.) to anaesthetized rats enhances the cerebral penetration of the anticancer agent razoxane. Such an enhancement leads to an increase in the therapeutic efficacy of razoxane against intracerebrally sequestered L1210 leukaemia cells in mice. The combination of Met...

journal_title：Clinical & experimental metastasis

authors： Greig N,Newell D,Hellmann K

更新日期：1984-01-01 00:00:00

abstract：:Activation of nuclear factor-κB (NF-κB) has been implicated in metastasis of pancreatic cancer. We investigated the effects of the novel NF-κB inhibitor dehydroxymethylepoxyquinomicin (DHMEQ) on the inhibition of liver metastasis of pancreatic cancer in a mouse model of clinical liver metastasis. Nude mice were xenogr...

journal_title：Clinical & experimental metastasis

authors： Suzuki K,Aiura K,Matsuda S,Itano O,Takeuchi O,Umezawa K,Kitagawa Y

更新日期：2013-04-01 00:00:00