Loco-regional thrombolysis in the treatment of cerebral venous and sinus thrombosis: report of two cases.

Abstract:

:Although intravenous (i.v.) heparin is widely used as the first line treatment for cerebral venous and sinus thrombosis (CVST), the most appropriate therapy for this disease is still controversial. We report 2 cases of CVST who were successfully treated by means of loco-regional thrombolysis with urokinase. In the first case we chose this treatment instead of i.v. heparin because clinical conditions of the patient appeared critical for life on hospital admission; in the second case loco-regional thrombolysis was performed because a full-dose heparin treatment over 8 days failed to improve the clinical picture of the patient. In the literature, there are no established criteria for the use of loco-regional thrombolysis in CVST. On the basis of our own experience and few previous reports on the matter, we suggest that loco-regional thrombolysis should be considered an appropriate treatment for CVST when patients are at life risk, when an involvement of deep cerebral veins is present or when, after full heparinization, patients are doing poorly clinically.

journal_name

Acta Neurol Scand

authors

Buccino G,Scoditti U,Pini M,Menozzi R,Piazza P,Zuccoli P,Mancia D

doi

10.1034/j.1600-0404.2001.00058.x

subject

Has Abstract

pub_date

2001-01-01 00:00:00

pages

59-63

issue

1

eissn

0001-6314

issn

1600-0404

journal_volume

103

pub_type

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