Variation of therapeutic response in Parkinson's disease: a retrospective study.

Abstract:

:A retrospective study of variations of therapeutic response (dyskinesia and on-off phenomenon) in Parkinson's disease was conducted on 278 patients treated with levodopa for at least 6 months and hospitalized at National Neurological Institute "C. Besta" of Milan between 1974 and 1984. Variations of therapeutic response (TRV) were present in 105 of 278 patients; in this group, age at illness onset was significantly lower, while duration of levodopa treatment and also duration of illness were longer than in the group of patients without TRV. Multiple logistic regression analysis showed that the most important variables were age at illness onset and duration of treatment, but they were only modestly predictive. Other factors connected with progression of disease must also contribute to the TRV.

journal_name

Acta Neurol Scand

authors

Geminiani G,Cesana BM,Scigliano G,Soliveri P,Girotti F,Giovannini P,Caraceni T

doi

10.1111/j.1600-0404.1990.tb00983.x

subject

Has Abstract

pub_date

1990-05-01 00:00:00

pages

397-401

issue

5

eissn

0001-6314

issn

1600-0404

journal_volume

81

pub_type

杂志文章
  • Health-related quality of life in blepharospasm or hemifacial spasm.

    abstract:OBJECTIVES:Health-related quality of life (HRQL) has become an important outcome criterion of medical interventions, but was hardly studied in patients with facial spasms. MATERIALS AND METHODS:Patients with blepharospasm or hemifacial spasm treated with botulinum toxin were included. A healthy control group sociodemo...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0404.2004.00357.x

    authors: Reimer J,Gilg K,Karow A,Esser J,Franke GH

    更新日期:2005-01-01 00:00:00

  • Femoxetine - a new 5-HT uptake inhibitor - and propranolol in the prophylactic treatment of migraine.

    abstract::The prophylactic effect of a 5-HT uptake inhibitor, femoxetine, was compared with that of propranolol in a double-blind crossover study of 6-months duration. 29 patients commenced the experiment. 3 subjects withdrew because of side effects and 2 because the program was inconvenient for them. In the 24 patients who con...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0404.1983.tb04836.x

    authors: Kangasniemi PJ,Nyrke T,Lang AH,Petersen E

    更新日期:1983-10-01 00:00:00

  • Diffusion-weighted MR findings in a reversible case of acute Wernicke encephalopathy.

    abstract::We report a case of acute Wernicke encephalopathy (WE) in which apparent diffusion coefficient maps showed areas of increased diffusion in the bilateral medial thalami that corresponded to the hyperintense lesions on T2-weighted imaging. The hyperintense lesions on T2-weighted imaging disappeared with full recovery fr...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1034/j.1600-0404.2001.00098.x

    authors: Oka M,Terae S,Kobayashi R,Kudoh K,Chu BC,Kaneko K,Yoshida M,Kaneda M,Suzuki Y,Miyasaka K

    更新日期:2001-09-01 00:00:00

  • Carotid Doppler - costs and need after stroke or TIA.

    abstract:OBJECTIVES:To estimate the need for and the costs of carotid Doppler and carotid endarterectomy after stroke or TIA in non-selected hospitalized patients. MATERIAL AND METHODS:During 25 months hospitalized patients with stroke or TIA, in whom carotid endarterectomy could be relevant, were examined with carotid Doppler...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1034/j.1600-0404.2002.0o348.x

    authors: Jespersen HF,Jørgensen HS,Nakayama H,Reith J,Olsen TS

    更新日期:2002-01-01 00:00:00

  • Treatment of spatial neglect in clinical practice: A nationwide survey.

    abstract:OBJECTIVES:Clinical research has documented a range of evidence-based treatment approaches for spatial neglect (SN), but there is a lack of research on the implementation of treatment into clinical practice. The purpose of this study is to describe the current clinical practice of SN treatment across healthcare sectors...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/ane.13179

    authors: Evald L,Wilms IL,Nordfang M

    更新日期:2020-01-01 00:00:00

  • Effect of memantine on CBF and CMRO2 in patients with early Parkinson's disease.

    abstract:OBJECTIVES:Parkinson's disease (PD) may be associated with increased energy metabolism in overactive regions of the basal ganglia. Therefore, we hypothesized that treatment with the N-methyl-d-aspartate receptor (NMDAR) antagonist memantine would decrease regional cerebral blood flow (rCBF) and oxygen metabolism in the...

    journal_title:Acta neurologica Scandinavica

    pub_type: 临床试验,杂志文章

    doi:10.1111/j.1600-0404.2007.00943.x

    authors: Borghammer P,Vafaee M,Ostergaard K,Rodell A,Bailey C,Cumming P

    更新日期:2008-05-01 00:00:00

  • Measurement of glial fibrillary acidic protein (GFAP) and anti-GFAP antibodies by solid-phase radioimmunoassays.

    abstract::A solid-phase radioimmunoassay was developed for the detection of glial fibrillary acidic protein (GFAP) and GFAP-specific immunoglobulin G (IgG) antibodies. In antibody assays purified GFAP was absorbed onto polystyrene beads, followed by incubation in dilutions of serum. (125-I)-labelled human anti-IgG was used to q...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0404.1981.tb00783.x

    authors: Ruutiainen J,Newcombe J,Salmi A,Dahl D,Frey H

    更新日期:1981-05-01 00:00:00

  • Ondine's curse in listeria monocytogenes brain stem encephalitis.

    abstract::A case of necrotizing brain stem encephalitis due to listeria monocytogenes is described in a 48-year-old man who had brain stem encephalitis of complicated course and with selective destruction of the vasomotoric and respiratory centers. He developed that very rare Ondine's curse syndrome, being only able to breathe ...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0404.1988.tb05949.x

    authors: Jensen TH,Hansen PB,Brodersen P

    更新日期:1988-06-01 00:00:00

  • Optimum trace count necessary for jitter calculation in single-fiber electromyography.

    abstract:OBJECTIVE:To clarify the optimum trace count for jitter calculation. MATERIALS AND METHODS:Single-fiber electromyography was performed during voluntary contraction (VC-SFEMG) of extensor digitorum muscle in six healthy and five myasthenic subjects. Twenty single-fiber action potential (SFAP) pairs were recorded from e...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1034/j.1600-0404.2003.00120.x

    authors: Baslo MB,Yalinay P,Yildiz N,Ertaş M

    更新日期:2003-10-01 00:00:00

  • Phenytoin, phenobarbital, and midazolam fail to stop status epilepticus-like activity induced by low magnesium in rat entorhinal slices, but can prevent its development.

    abstract:OBJECTIVES:It was shown previously that low-Mg2+-induced epileptiform activity in rat entorhinal cortex slices changes with time from a pattern of serial seizure-like events (SLEs) to a state of continuously recurring epileptiform activity. Valproic acid blocked the early SLEs but not the late activity. It was proposed...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0404.1998.tb07286.x

    authors: Dreier JP,Zhang CL,Heinemann U

    更新日期:1998-09-01 00:00:00

  • Is there a lamotrigine withdrawal syndrome?

    abstract:OBJECTIVES:To report a peculiar observation of a patient who developed a psychomotor inhibition state after a rapid cessation of lamotrigine (LTG). RESULTS:This man was referred to us at the age of 26 years for presurgical evaluation. His treatment [valproate (VPA), 1200 mg/day and LTG, 200 mg/day] was quickly decreas...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1034/j.1600-0404.2002.1c220.x

    authors: Gelisse P,Kissani N,Crespel A,Jafari H,Baldy-Moulinier M

    更新日期:2002-03-01 00:00:00

  • Sensitivity of transcranial Doppler for confirming brain death: a prospective study of 270 cases.

    abstract:OBJECTIVE:The reported sensitivity of transcranial Doppler ultrasonography (TCD) for confirming brain death (BD) ranges from 91% to 100%. We assessed the frequency and causes of false-negative results in TCD examination in a series of patients with BD and in the literature. METHODS:We carried out a prospective TCD exa...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0404.2006.00645.x

    authors: de Freitas GR,André C

    更新日期:2006-06-01 00:00:00

  • Small vessel disease and clinical outcomes after IV rt-PA treatment.

    abstract:INTRODUCTION:Cerebral small vessel disease (SVD) contributes to dementia and disability in the elderly, and may negatively affect stroke outcomes. We aimed to evaluate to what extent single features and global burden of SVD detected with magnetic resonance (MR) are associated with worse outcomes in patients with ischae...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/ane.12745

    authors: Arba F,Inzitari D,Ali M,Warach SJ,Luby M,Lees KR,STIR\/VISTA Imaging Collaboration.

    更新日期:2017-07-01 00:00:00

  • Sarcoplasmic body myopathy--a rare hereditary myopathy with characteristic inclusions.

    abstract:OBJECTIVES:To characterise a Swedish family with a rare hereditary myopathy with unique sarcoplasmic inclusion bodies in the muscle biopsy. MATERIALS AND METHODS:Part of the pedigree was described in 1980. Nine new members of the included and the phenotype further characterised through clinical, neurophysiological and...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0404.2005.00475.x

    authors: Engvall M,Ahlberg G,Hedberg B,Edström L,Ansved T

    更新日期:2005-10-01 00:00:00

  • Impact of recently diagnosed multiple sclerosis on quality of life, anxiety, depression and distress of patients and partners.

    abstract:OBJECTIVES:Studies demonstrating reduced quality of life and psychological well-being in multiple sclerosis (MS) have typically investigated patients within more advanced stages of disease. The aim of the present paper was to evaluate the emotional burden and quality of life of recently diagnosed MS patients and their ...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1034/j.1600-0404.2003.00166.x

    authors: Janssens AC,van Doorn PA,de Boer JB,van der Meché FG,Passchier J,Hintzen RQ

    更新日期:2003-12-01 00:00:00

  • CD45RA+ ICAM-3+ lymphocytes in interferon-beta1b-treated and -untreated patients with relapsing-remitting multiple sclerosis.

    abstract:OBJECTIVES:Multiple sclerosis (MS) is believed to be an autoimmune disease of the human central nervous system mediated by autoreactive T cells. Interferon-beta1b (IFN-beta1b) has been shown to be effective in reducing disease activity defined by clinical and magnetic resonance imaging (MRI) criteria in relapsing-remit...

    journal_title:Acta neurologica Scandinavica

    pub_type: 临床试验,杂志文章

    doi:10.1111/j.1600-0404.2004.00346.x

    authors: Chatzimanolis N,Kraus J,Bauer R,Engelhardt B,Bregenzer T,Kuehne BS,Tofighi J,Laske C,Stolz E,Blaes F,Voigt K,Traupe H,Kaps M,Oschmann P

    更新日期:2004-12-01 00:00:00

  • Leber's hereditary optic neuropathy associated with a disorder indistinguishable from multiple sclerosis in a male harbouring the mitochondrial DNA 11778 mutation.

    abstract::This report describes a multiple sclerosis (MS)-like disorder in a male patient with Leber's hereditary optic neuropathy (LHON) harbouring the mitochondrial DNA 11778 base pair mutation. Given the population frequencies of MS and LHON, coincidental occurrence is unlikely. Hypothetically the mitochondrial mutation unde...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0404.1995.tb07016.x

    authors: Olsen NK,Hansen AW,Nørby S,Edal AL,Jørgensen JR,Rosenberg T

    更新日期:1995-05-01 00:00:00

  • Basal metabolic rate in patients with hydrocephalus. On the cause of lowered basal metabolic rate in myotonic dystrophy.

    abstract::Myotonic dystrophy seems to have a hypometabolism of non-thyroid origin. The hypometabolism could hypothetically be caused by : 1) reduction in muscle mass, 2) hydrocephalus ex vacuo, an integral part of the disorder, or 3) the basic disease process itself. Possibility 2) was explored by determining basal metabolic ra...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0404.1976.tb04344.x

    authors: Hidle I,Sjaastad O

    更新日期:1976-03-01 00:00:00

  • Restless legs syndrome and cerebrovascular/cardiovascular events: Systematic review and meta-analysis.

    abstract:OBJECTIVE:We performed a systematic review and meta-analysis to evaluate the proposed association of restless legs syndrome (RLS) with cerebrovascular/cardiovascular outcomes. METHODS:We calculated the corresponding odds ratios on the prevalence of cerebrovascular/cardiovascular risk factors and standardized mean diff...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章,meta分析,评审

    doi:10.1111/ane.12848

    authors: Katsanos AH,Kosmidou M,Konitsiotis S,Tsivgoulis G,Fiolaki A,Kyritsis AP,Giannopoulos S

    更新日期:2018-01-01 00:00:00

  • Medication adherence/persistence among patients with active multiple sclerosis in Finland.

    abstract:OBJECTIVES:To explore adherence, persistence, and treatment patterns in patients with multiple sclerosis (MS) in Finland treated with disease-modifying therapies (DMTs) for active MS in 2005-2018. MATERIALS AND METHODS:The study cohort was identified using the Drug Prescription Register of Social Insurance Institute, ...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/ane.13301

    authors: Lahdenperä S,Soilu-Hänninen M,Kuusisto HM,Atula S,Junnila J,Berglund A

    更新日期:2020-12-01 00:00:00

  • Body temperature and major neurological improvement in tPA-treated stroke patients.

    abstract:BACKGROUND:Major neurological improvement (MNI) at 24 hours represents a marker of early recanalization in ischaemic stroke. Although low body temperature is considered neuroprotective in cerebral ischaemia, some studies have suggested that higher body temperature may promote clot lysis in the acute phase of ischaemic ...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/ane.12184

    authors: Kvistad CE,Thomassen L,Waje-Andreassen U,Logallo N,Naess H

    更新日期:2014-05-01 00:00:00

  • Cerebral abscesses among Danish patients with hereditary haemorrhagic telangiectasia.

    abstract:BACKGROUND:Hereditary haemorrhagic telangiectasia (HHT) is a dominantly inherited disease characterized by a wide variety of clinical manifestations, including pulmonary arteriovenous malformations (PAVMs), which due to paradoxical embolization may cause cerebral abscess. OBJECTIVE:To estimate the risk of cerebral abs...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/ane.12167

    authors: Kjeldsen AD,Tørring PM,Nissen H,Andersen PE

    更新日期:2014-03-01 00:00:00

  • Neurofilament light protein levels in cerebrospinal fluid predict long-term disability of Guillain-Barré syndrome: A pilot study.

    abstract:OBJECTIVES:Although the recovery from Guillain-Barré syndrome (GBS) is good in most patients, some develop permanent severe disability or even die. Early predictors would increase the likelihood to identify patients at risk for poor outcome at the acute stage, allowing them intensified therapeutic intervention. MATERI...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/ane.12927

    authors: Axelsson M,Sjögren M,Andersen O,Blennow K,Zetterberg H,Lycke J

    更新日期:2018-08-01 00:00:00

  • Mutations in the alpha-synuclein gene in Parkinson's disease among Indians.

    abstract:OBJECTIVE:To investigate the prevalence of G88C, G209A and any other mutation(s) in exons 3 and 4 of the alpha-synuclein gene in Indian patients with Parkinson's disease (PD). METHODS:A total of 169 PD patients comprising 18 familial, 3 juvenile, 48 early onset and 100 sporadic cases were included in this study. Genom...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1034/j.1600-0404.2001.103002120.x

    authors: Nagar S,Juyal RC,Chaudhary S,Behari M,Gupta M,Rao SN,Thelma BK

    更新日期:2001-02-01 00:00:00

  • Localized outbreak of enteroviral meningitis in adults.

    abstract::During a thorough surveillance of viral infections of the central nervous system an outbreak of aseptic meningitis was discovered in the western part of Finland in late 1985. The 21 diseased young adults were carefully studied by different virological methods. A presumed viral etiology, in all cases of enteroviral ori...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0404.1987.tb05457.x

    authors: Kinnunen E,Hovi T,Stenvik M,Hellström O,Porras J,Kleemola M,Kantanen ML

    更新日期:1987-05-01 00:00:00

  • Spinal tumours associated with increased intracranial pressure. Report of two cases and a discussion on the pathophysiology.

    abstract::Two cases of increased intracranial pressure associated with lumbar intraspinal tumours are reported. On the basis of protein investigations and constant flow infusion manometric tests, the pathophysiology of the increased intracranial pressure is discussed. It is demonstrated that protein macromolecules leak from the...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:

    authors: Borgesen SE,Sorensen SC,Olesen J,Gjerris F

    更新日期:1977-09-01 00:00:00

  • Quality of life in Parkinson's disease: A gender-specific perspective.

    abstract:OBJECTIVES:The epidemiology, manifestations, and course of Parkinson's disease (PD) may differ in men and women. Assessments of severity of the illness and quality of life (QoL), and the burden on their caregivers (CG) may change as the disease advances. We determined gender differences in assessment by patients with P...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/ane.13095

    authors: Balash Y,Korczyn AD,Migirov AA,Gurevich T

    更新日期:2019-07-01 00:00:00

  • SPECT studies of regional cerebral blood flow in 8 patients with Japanese encephalitis in subacute and chronic stage.

    abstract:OBJECTIVE:There is a paucity of regional cerebral blood flow studies in Japanese encephalitis (JE). In this communication we report clinical, radiological and single photon emission computed tomography findings in subacute and chronic JE patients. MATERIAL AND METHODS:Eight JE patients whose ages ranged between 10 and...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0404.1999.tb07349.x

    authors: Kalita J,Das BK,Misra UK

    更新日期:1999-04-01 00:00:00

  • Evaluation of fatigue in Parkinson's disease patients with stimulated single fiber electromyography.

    abstract:OBJECTIVES:Fatigue is a disabling and dopa-resistant symptom in Parkinson's disease (PD). Pathological studies have shown that both peripheral and central cholinergic systems are involved in PD. Electrophysiological investigation showed decremental muscle responses following repetitive nerve stimulation (RNS). We hypot...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1034/j.1600-0404.2001.00046.x

    authors: Hwang WJ,Lin TS

    更新日期:2001-11-01 00:00:00

  • Oligoclonal immunoglobulin G in cerebrospinal fluid of myasthenia gravis patients.

    abstract::Immunoglobulin G (IgG) band patterns were investigated in cerebrospinal fluid (CSF) from 19 patients with myasthenia gravis (MG) in a search for abnormalities indicating central nervous system (CNS) involvement in this disorder. Using the isoelectric focusing (IEF) technique and antiserum immunoblotting against IgG, w...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0404.1990.tb00977.x

    authors: Mavra M,Apostolski S,Nikolic J,Thompson EJ

    更新日期:1990-03-01 00:00:00