TNF-alpha, TNF-beta and IL-4 gene polymorphisms in Iranian patients with multiple sclerosis.

Abstract:

OBJECTIVES:To investigate the association between tumor necrosis factor-alpha (TNF-alpha) G-308A, tumor necrosis factor-beta (TNF-beta) G+252A and interleukin-4 (IL-4) C-590T polymorphisms and susceptibility to multiple sclerosis (MS) development and clinical course of the disease. MATERIALS AND METHODS:Two hundred and seventy patients with MS and 542 sex and ethnic matched controls were enrolled in the present study. An allele-specific oligonucleotide polymerase chain reaction was used to detect the polymorphism at position -308 of the TNF-alpha gene. The genotypes of TNF-beta and IL-4 were determined by polymerase chain reaction-restriction fragment length polymorphism. RESULTS:Allelic and genotypic frequencies for these polymorphisms were similar in patients with MS and population controls or among different types of the disease. CONCLUSION:The results of the present study suggest that the three mentioned functional polymorphisms are not likely to cause susceptibility to MS in the Iranian population.

journal_name

Acta Neurol Scand

authors

Kamali-Sarvestani E,Nikseresht A,Aflaki E,Sarvari J,Gharesi-Fard B

doi

10.1111/j.1600-0404.2006.00743.x

subject

Has Abstract

pub_date

2007-03-01 00:00:00

pages

161-6

issue

3

eissn

0001-6314

issn

1600-0404

pii

ANE743

journal_volume

115

pub_type

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