R-R interval variation in Parkinson's disease and multiple system atrophy.

Abstract:

OBJECTIVE:To investigate whether the cardiac R-R interval variation (RRIV) is of value in differentiating patients with Parkinson's disease (PD) from multiple system atrophy (MSA). BACKGROUND:RRIV assessment is a simple procedure, reflecting mainly vagal efferent activity. Reduced RRIV was reported in MSA. METHODS:RRIV at rest and after 120 s of deep breathing was assessed blindly to clinical diagnosis in 22 PD and 20 MSA patients. The results were compared with data from 23 age-matched healthy subjects. RESULTS:RRIV at rest was 7.1 +/- 2.7% in PD and 9.7 +/- 7.2% in MSA, increasing after deep breathing to 11.2 +/- 6.3 and 12.3 +/- 6.6% correspondingly. The frequency of the RRIV abnormalities in the PD group (4/22, 18.2%) and MSA (6/20, 30%) were higher than among controls (P < 0.004). CONCLUSIONS:RRIV, either at rest or after deep breathing, may be abnormal both in PD and MSA, but does not distinguish between these disorders.

journal_name

Acta Neurol Scand

authors

Gurevich TY,Groozman GB,Giladi N,Drory VE,Hausdorff JM,Korczyn AD

doi

10.1111/j.1600-0404.2004.00226.x

subject

Has Abstract

pub_date

2004-04-01 00:00:00

pages

276-9

issue

4

eissn

0001-6314

issn

1600-0404

pii

226

journal_volume

109

pub_type

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