Cerebellar atrophy does not increase susceptibility to carbamazepine toxicity.

Abstract:

:Cerebellar atrophy (CA) is a frequent finding in patients with chronic epilepsy. To find out whether the existence of CA has an influence on the tolerance of high-dose monotherapy with carbamazepine, we compared the lowest individual toxic serum levels in patients with complex focal seizures, with CA (n = 27) and without CA (n = 20) in computerized tomography (CT). There was no statistical difference between the groups, even after separating patients with mild CA (n = 20) from those with more severe damage (n = 7). In addition, other clinical, EEG and CT data also seemed to have no influence on the individual toxic threshold serum levels of carbamazepine.

journal_name

Acta Neurol Scand

authors

Specht U,Rohde M,May T,Schmidt RC,Meencke HJ,Wolf P

doi

10.1111/j.1600-0404.1994.tb01622.x

subject

Has Abstract

pub_date

1994-01-01 00:00:00

pages

1-4

issue

1

eissn

0001-6314

issn

1600-0404

journal_volume

89

pub_type

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