Serum soluble interleukin-2 receptor levels in chronic progressive, stable and steroid-treated multiple sclerosis.

Abstract:

:Serum levels of the soluble interleukin-2 receptor (sIL-2R), an indicator of T cell activation, were significantly elevated in chronic progressive MS (CPMS) patients, clinically stable MS patients and in patients with other neurological diseases (OND) as compared to healthy controls. Levels of sIL-2R in steroid treated CPMS patients were markedly lower than in untreated CPMS patients and were comparable to healthy controls. Thus, systemic T cell activation occurs in MS during clinically stable and progressive disease stages and in other neurological disorders. The ability of oral corticosteroids to depress serum sIL-2R levels in vivo may be one mechanism by which they exert their therapeutic effect.

journal_name

Acta Neurol Scand

authors

Bansil S,Troiano R,Cook SD,Rohowsky-Kochan C

doi

10.1111/j.1600-0404.1991.tb04955.x

subject

Has Abstract

pub_date

1991-10-01 00:00:00

pages

282-5

issue

4

eissn

0001-6314

issn

1600-0404

journal_volume

84

pub_type

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