Diagnostic investigations in MS: which is the most sensitive?

abstract：:We present clinical and virological data on 9 patients, 7 women and 2 men aged 31-56 years, with recurrent aseptic meningitis (Mollaret's meningitis). Polymerase chain reaction detected Herpes simplex virus type 2 DNA in cerebrospinal fluid samples from all patients collected during their latest attacks of meningitis....

journal_title：Acta neurologica Scandinavica

authors： Jensenius M,Myrvang B,Størvold G,Bucher A,Hellum KB,Bruu AL

更新日期：1998-09-01 00:00:00

abstract：:Supernatants of peripheral blood lymphocytes (PBL), containing lymphokines, isolated from MS patients and healthy subjects were tested for demyelinating activity in organotypic culture of the rat cerebellum. PBL were isolated on Ficoll-paque gradient and cultures in RPMI 1640 medium for 72 h with or without phytohemag...

journal_title：Acta neurologica Scandinavica

authors： Selmaj K,Renkawek K,Alam R,Kida E,Maszewska M,Rozniecki J

更新日期：1986-09-01 00:00:00

abstract：:Patients with multiple sclerosis have an increased risk of infections compared to the general population. The increased risk has been described for decades and is not alone attributed to the use of disease-modifying drugs, but secondary to the disability. The introduction of more potent immunomodulatory drugs may caus...

journal_title：Acta neurologica Scandinavica

authors： Celius EG

更新日期：2017-11-01 00:00:00

abstract：OBJECTIVE:To compare the mortality rate in Parkinson's disease (PD) with a control group without PD, and to assess the relationship between mortality and features of PD. MATERIAL AND METHODS:Ninety PD patients and 50 controls, mortality ascertained at 11 years follow-up. RESULTS:The hazard ratio (HR) for mortality in...

journal_title：Acta neurologica Scandinavica

authors： Hughes TA,Ross HF,Mindham RH,Spokes EG

更新日期：2004-08-01 00:00:00

abstract：:The first case of benign IgAK monoclonal gammopathy associated with peripheral neuropathy is described. Dysautonomia is an unusual, yet prominent, manifestation of neuropathy in this patient. Electrodiagnostic testing and nerve biopsy were compatible with demyelination and axonal loss. Myelin sheath, perineural, and e...

journal_title：Acta neurologica Scandinavica

authors： Bailey RO,Ritaccio AL,Bishop MB,Wu AY

更新日期：1986-06-01 00:00:00

abstract：:This article reports the case of a man who developed a pure motor paraplegia following epidural anesthesia with a pattern of slow recovery over subsequent months. Reviewing the available literature on post-epidural paraplegia we noted a number of potential etiologies and analyzed their role in its causation. On the ba...

journal_title：Acta neurologica Scandinavica

authors： Skouen JS,Wainapel SF,Willock MM

更新日期：1985-10-01 00:00:00

abstract：OBJECTIVES:To study if type-2 (non-insulin-dependent) diabetes mellitus (NIDDM) is associated with cognitive dysfunction independently of clinically diagnosed dementia in an elderly population. MATERIAL AND METHODS:Cognitive function was investigated with a brief neuropsychological test battery in a non-demented elder...

journal_title：Acta neurologica Scandinavica

authors： Vanhanen M,Kuusisto J,Koivisto K,Mykkänen L,Helkala EL,Hänninen T,Riekkinen P Sr,Soininen H,Laakso M

更新日期：1999-08-01 00:00:00

abstract：OBJECTIVES:The goal of this study was to evaluate the incidence of urological malignancies in MS patients using active screening. MATERIAL AND METHODS:A total of 495 MS patients (141 men, 354 women, age of 42±13.4) were included in the study. The duration of disease was 12.3±11 years, and the EDSS score was 4.3 (±2.5)...

journal_title：Acta neurologica Scandinavica

authors： Krhut J,Hradilek P,Nemec D,Tvrdik J,Zapletalova O,Zvara P

更新日期：2014-09-01 00:00:00

abstract：:Three patients with well-defined clinical and radiographic lesions have been studied with somatosensory evoked potentials (SSEPs). The data indicate that the primary scalp potentials from stimulation of both the arm and leg (N20 and P40) can be lost with thalamic lesions and would be consistent with these potentials b...

journal_title：Acta neurologica Scandinavica

authors： Fisher MA,Perlik SJ

更新日期：1985-01-01 00:00:00

abstract：:Cerebellar atrophy (CA) is a frequent finding in patients with chronic epilepsy. To find out whether the existence of CA has an influence on the tolerance of high-dose monotherapy with carbamazepine, we compared the lowest individual toxic serum levels in patients with complex focal seizures, with CA (n = 27) and with...

journal_title：Acta neurologica Scandinavica

authors： Specht U,Rohde M,May T,Schmidt RC,Meencke HJ,Wolf P

更新日期：1994-01-01 00:00:00

abstract：OBJECTIVE:In a previous study, we found that nine of the 47 siblings to multiple sclerosis (MS) patients with a normal neurologic examination carry an intrathecal oligoclonal immunopathy with limited specificity, a condition we termed MS immunopathic trait. Here we searched for neurological dysfunction with increased s...

journal_title：Acta neurologica Scandinavica

authors： Haghighi S,Frisén L,Odén A,Andersen O

更新日期：2003-11-01 00:00:00

abstract：:The present communication is devoted to investigating the possibility that in myotonic dystrophy (MyD) a decreased ATP utilization by the membrane may produce modifications in glycoprotein structure and/or in the supramolecular arrangement of some membrane proteins. The study was carried out a) by determining the memb...

journal_title：Acta neurologica Scandinavica

authors： Sandrini G,Bottiroli G,Nappi G,Balduini C,Brovelli A

更新日期：1982-06-01 00:00:00

abstract：:The intrathecal production (ITP) of the immunoglobulins (Ig) G, A, M and D was examined in untreated patients with multiple sclerosis (MS) and controls. Sensitive sandwich enzyme-linked immunosorbent assay systems were applied to the determination of IgA, IgM and IgD levels in the cerebrospinal fluid and plasma from a...

journal_title：Acta neurologica Scandinavica

authors： Lolli F,Halawa I,Link H

更新日期：1989-09-01 00:00:00

abstract：OBJECTIVES:To compare intravenous phenytoin (PHT) and intravenous lacosamide (LCM) for treatment of status epilepticus after failure of the first and second drug. METHODS:We retrospectively identified patients from a large community hospital in northern Germany who had been diagnosed with SE between August 2008 and De...

journal_title：Acta neurologica Scandinavica

authors： Kellinghaus C,Berning S,Stögbauer F

更新日期：2014-05-01 00:00:00

abstract：:We investigated the types of syndrome, location, size and presumed causes of 72 patients with acute capsular lacunar infarction. Clinical syndromes were classified into pure motor hemiparesis (PM), sensorimotor stroke (SM) and ataxic hemiparesis (AH). Lesion sizes of AH were significantly smaller than those of PM (p <...

journal_title：Acta neurologica Scandinavica

authors： Tei H,Uchiyama S,Maruyama S

更新日期：1993-10-01 00:00:00

abstract：OBJECTIVES:Little is known about the frequency of abnormal visually evoked potentials (VEPs) in patients with respiratory chain disorders (RCDs). We thus wanted to investigate the frequency of abnormal VEPs in RCDs, how often VEPs are abnormal despite normal visual acuity, and which of the VEP variables are most often ...

journal_title：Acta neurologica Scandinavica

authors： Finsterer J

更新日期：2001-07-01 00:00:00

abstract：:63 patients with alcoholic-nutritional peripheral neuropathy were given neurologic, electrophysiologic and nutritional examinations. 24 of these patients were reexamined later in the course of their disease, after from 2 to 72 months (mean 33). Alcoholic-nutritional neuropathy appeared and worsened after bouts of heav...

journal_title：Acta neurologica Scandinavica

authors： Hawley RJ,Kurtzke JF,Armbrustmacher VW,Saini N,Manz H

更新日期：1982-11-01 00:00:00

abstract：:Regional cerebral blood flow (rCBF) was measured in 23 patients with brain tumors using the 133Xe intra-carotid injection method and a 254 channel gamma camera. The glioblastomas (4) and astrocytomas (4) all showed hyperemia in the tumor and tumor-near region. This was also seen in several meningiomas (4 of 7 cases) i...

journal_title：Acta neurologica Scandinavica

authors： Kuroda K,Skyhøj Olsen T,Lassen NA

更新日期：1982-08-01 00:00:00

abstract：:EEG data obtained from 27 patients with presenile Alzheimer's disease (AD) and 28 patients with senile dementia of the Alzheimer type (SDAT) were compared with data from 30 age- and sex-matched controls. Both patient groups exhibited more pronounced delta and theta activity and less prominent alpha and beta activity t...

journal_title：Acta neurologica Scandinavica

authors： Miyauchi T,Hagimoto H,Ishii M,Endo S,Tanaka K,Kajiwara S,Endo K,Kajiwara A,Kosaka K

更新日期：1994-01-01 00:00:00

abstract：:We studied a Becker muscular dystrophy (BMD) family with a manifesting carrier. Proximal muscle weakness, pseudohypertrophy of the calves, significantly elevated serum creatine kinase and dystrophic alterations in the muscle biopsy were the characteristic phenotypical features of this manifesting carrier. The recombin...

journal_title：Acta neurologica Scandinavica

authors： Ionasescu VV,Searby CC,Ionasescu R

更新日期：1989-06-01 00:00:00

abstract：OBJECTIVES:Baseline brain single-photon emission computed tomography (SPECT) can predict mild cognitive impairment (MCI) patients at risk for progressive MCI (PMCI). METHODS:Twenty-eight subjects [12 MCI, 6 with probable Alzheimer's Disease (AD), and 10 normal subjects] underwent baseline brain SPECT and were clinical...

journal_title：Acta neurologica Scandinavica

authors： Ishiwata A,Sakayori O,Minoshima S,Mizumura S,Kitamura S,Katayama Y

更新日期：2006-08-01 00:00:00

abstract：:A 54 year-old woman showed the unusual association of a Guillain-Barré syndrome and opsoclonus, a rare eye movement characterized by involuntary bursts of jerking, ataxic and multidirectional saccades, without an intersaccadic interval. Since opsoclonus is a phenomenon described exclusively in CNS diseases, the case r...

journal_title：Acta neurologica Scandinavica

authors： Nicolai A,Lazzarino LG

更新日期：1992-05-01 00:00:00

abstract：:A purified citric acid soluble extract from human skeletal muscle (AEMA) and a phosphate-buffered saline extract from rabbit muscle acetone powder (EMA) were used to coat polystyrene beads in an enzyme-linked immunosorbent assay (ELISA). From 54 patients with myasthenia gravis, positive results were observed in 14. Fi...

journal_title：Acta neurologica Scandinavica

authors： Viana VS,Bueno C,Marchiori PE,Oliveira RM,Assis JL,Scaff M,Cossermelli W

更新日期：1986-06-01 00:00:00

abstract：BACKGROUND:Thirty patients with glioblastoma multiforme (GBM) were treated by boron neutron capture therapy (BNCT) at the Studsvik facility in Sweden, in a clinical trial exploring a procedure in which 900 mg p-boronophenylalanine (BPA) per kilo body weight was infused in 6 h. OBJECTIVE:The present study was designed ...

journal_title：Acta neurologica Scandinavica

authors： H-Stenstam B,Pellettieri L,Sköld K,Rezaei A,Brun A

更新日期：2007-09-01 00:00:00

abstract：OBJECTIVE:To evaluate the efficacy and tolerability of the treatment with valproic acid (VPA) in patients with status epilepticus (SE) or acute repetitive seizures (ARS) comparing it with phenytoin (PHT) treatment. MATERIALS AND METHODS:Patients with SE or ARS were treated in a consecutive manner with either VPA or PH...

journal_title：Acta neurologica Scandinavica

authors： Gilad R,Izkovitz N,Dabby R,Rapoport A,Sadeh M,Weller B,Lampl Y

更新日期：2008-11-01 00:00:00

abstract：OBJECTIVES:To examine differences in cerebrovascular reactivity between multi-infarct and Alzheimer types of dementia. PATIENTS AND METHODS:Using transcranial Doppler, measurements of flow velocity in the middle cerebral arteries during apnea, thumb-to-finger opposition and verbal and design discrimination tasks were ...

journal_title：Acta neurologica Scandinavica

authors： Matteis M,Silvestrini M,Troisi E,Bragoni M,Vernieri F,Caltagirone C

更新日期：1998-06-01 00:00:00

abstract：OBJECTIVES:Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease. There is evidence that oxidative stress is implicated in the pathophysiology of the neurodegenerative disorders, including ALS. Data from the literature suggests that the receptor for advanced glycation end products (RAGE) partic...

journal_title：Acta neurologica Scandinavica

authors： Iłzecka J

更新日期：2009-08-01 00:00:00

abstract：:Over last fifty years, intravenous (iv) phenytoin (PHT) loading dose has been the treatment of choice for patients with benzodiazepine-resistant convulsive status epilepticus and several guidelines recommended this treatment regimen with simultaneous iv diazepam. Clinical studies have never shown a better efficacy of ...

journal_title：Acta neurologica Scandinavica

authors： Zaccara G,Giorgi FS,Amantini A,Giannasi G,Campostrini R,Giovannelli F,Paganini M,Nazerian P,Tuscany study group on seizures in the emergency department and status epilepticus in adults.

更新日期：2018-06-01 00:00:00

abstract：:Isoelectric focusing and agarose gel electrophoresis of CSF and serum revealed similar frequencies of oligoclonal bands in multiple sclerosis (100% with both methods), infectious CNS disorders (38 and 23%) and other neurological diseases (8 and 10%). In selected cases with unsure CSF oligoclonal bands on agarose gel e...

journal_title：Acta neurologica Scandinavica

authors： Laurenzi MA,Link H

更新日期：1978-09-01 00:00:00

abstract：OBJECTIVES:To gain insight into the main advantages and disadvantages that might result from valproate being unavailable for women who intend to become pregnant. MATERIALS AND METHODS:Analysis of data from the Australian Pregnancy Register concerning pregnancies exposed to valproate (N = 501) and pregnancies where pre...

journal_title：Acta neurologica Scandinavica

authors： Vajda FJE,O'Brien TJ,Graham JE,Hitchcock AA,Lander CM,Eadie MJ

更新日期：2019-01-01 00:00:00