Type-2 diabetes and cognitive function in a non-demented population.

Abstract:

OBJECTIVES:To study if type-2 (non-insulin-dependent) diabetes mellitus (NIDDM) is associated with cognitive dysfunction independently of clinically diagnosed dementia in an elderly population. MATERIAL AND METHODS:Cognitive function was investigated with a brief neuropsychological test battery in a non-demented elderly population consisting of 183 NIDDM (World Health Organization, 1985) patients and 732 non-diabetic subjects. RESULTS:Patients with NIDDM were impaired in the Trail-Making Test parts A and C, which may be a reflection of mildly affected frontal lobe/executive functions. Women with NIDDM performed better than non-diabetic subjects in the Mini-Mental State Examination. CONCLUSIONS:We conclude that NIDDM per se is not associated with impaired memory in the elderly, and the minor defects observed in tests of frontal lobe/executive functions are unlikely to affect daily living. In the non-demented population aged 69 78 years, NIDDM does not carry a significant risk of cognitive dysfunction, when compared to the non-diabetic subjects.

journal_name

Acta Neurol Scand

authors

Vanhanen M,Kuusisto J,Koivisto K,Mykkänen L,Helkala EL,Hänninen T,Riekkinen P Sr,Soininen H,Laakso M

doi

10.1111/j.1600-0404.1999.tb01045.x

subject

Has Abstract

pub_date

1999-08-01 00:00:00

pages

97-101

issue

2

eissn

0001-6314

issn

1600-0404

journal_volume

100

pub_type

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