Infections in patients with multiple sclerosis: Implications for disease-modifying therapy.

abstract：OBJECTIVES:Evaluate interim long-term tolerability, safety and efficacy of adjunctive perampanel, a novel α-amino-3-hydroxy-5-methyl-5-isoxazolepropionic acid (AMPA)-receptor antagonist, in patients with refractory partial-onset seizures. MATERIALS AND METHODS:Study 207, an open-label extension (OLE) study (ClinicalTr...

journal_title：Acta neurologica Scandinavica

authors： Rektor I,Krauss GL,Bar M,Biton V,Klapper JA,Vaiciene-Magistris N,Kuba R,Squillacote D,Gee M,Kumar D

更新日期：2012-10-01 00:00:00

abstract：:Serum and CSF from 53 vascular dementia (VD) patients and 50 controls were analysed to investigate the possibility of an intrathecal synthesis of IgG, defined as an elevated IgG index (greater than or equal to 7) and/or presence of oligoclonal IgG in cerebrospinal fluid (CSF), but not in serum. Five (9%) patients and ...

journal_title：Acta neurologica Scandinavica

authors： Wallin A,Blennow K,Fredman P,Gottfries CG,Karlsson I,Svennerholm L

更新日期：1990-02-01 00:00:00

abstract：:For patients with Parkinson's disease (PD), excessive daytime sleepiness (PD-EDS) is a debilitating non-motor symptom and may be affected by mood symptoms, especially depression and anxiety. Few neuroimaging works have attempted to identify the neural features of PD-EDS, but various findings were reported. The purpose...

journal_title：Acta neurologica Scandinavica

authors： Wen MC,Chan LL,Tan LCS,Tan EK

更新日期：2017-08-01 00:00:00

abstract：:We assessed cognitive performance and its relationship with clinical and anatomic disease severity in MS with mild to moderate handicap; 34 definite MS and 18 healthy subjects matched for age and education were submitted to a neuropsychological test battery. Both groups were examined for anxiety. MS patients underwent...

journal_title：Acta neurologica Scandinavica

authors： Maurelli M,Marchioni E,Cerretano R,Bosone D,Bergamaschi R,Citterio A,Martelli A,Sibilla L,Savoldi F

更新日期：1992-08-01 00:00:00

abstract：:A total of 24 asymptomatic HIV-infected patients (CDC II/III) and 27 HIV-negative controls were tested for speed of reaction and for general neuropsychological functioning. Reaction time was assessed with two computerized tests with differing levels of cognitive complexity. The results show that the asymptomatic HIV-p...

journal_title：Acta neurologica Scandinavica

authors： Karlsen NR,Reinvang I,Frøland SS

更新日期：1992-09-01 00:00:00

abstract：OBJECTIVES:To present clinical features at diagnosis for a large nationwide incident cohort of multiple sclerosis (MS) among those serving in the US military during the Gulf War era (GWE). MATERIALS & METHODS:Medical records and databases from the Department of Veterans Affairs (VA) for cases of MS with onset in or af...

journal_title：Acta neurologica Scandinavica

authors： Wallin MT,Culpepper WJ,Maloni H,Kurtzke JF

更新日期：2018-01-01 00:00:00

abstract：:Using organotypic cultures of ICR mouse cerebellum, we studied the effects of TNF-alpha on myelin formation, and its demyelinating effects. Mature, myelinated cultures were resistant to TNF-alpha, even at the highest concentration examined, 1 x 10(4) U/ml. However, when cultures were grown in medium containing TNF-alp...

journal_title：Acta neurologica Scandinavica

authors： Tsukamoto T,Ishikawa M,Yamamoto T

更新日期：1995-01-01 00:00:00

abstract：BACKGROUND:Variants in genes encoding enzymes involved in production, aggregation or degradation of beta-amyloid are potential risk factors for sporadic Alzheimer's disease (AD). METHODS:Meta-analyses on AD association with BACE1 exon 5, BACE1 intron 5, FE65 intron 13, CYP46 intron 2, alpha(1)-antichymotrypsine Ala17T...

journal_title：Acta neurologica Scandinavica

authors： Llorca J,Rodríguez-Rodríguez E,Dierssen-Sotos T,Delgado-Rodríguez M,Berciano J,Combarros O

更新日期：2008-01-01 00:00:00

abstract：:The prophylactic effect of a 5-HT uptake inhibitor, femoxetine, was compared with that of propranolol in a double-blind crossover study of 6-months duration. 29 patients commenced the experiment. 3 subjects withdrew because of side effects and 2 because the program was inconvenient for them. In the 24 patients who con...

journal_title：Acta neurologica Scandinavica

authors： Kangasniemi PJ,Nyrke T,Lang AH,Petersen E

更新日期：1983-10-01 00:00:00

abstract：OBJECTIVES:To describe clinical, electrophysiological and genetic data of five unrelated Sicilian pedigrees harbouring a heterozygous Ser78Leu mutation in the myelin protein zero (MPZ) extracellular domain. MATERIALS AND METHODS:Clinical, electrophysiological and genetic findings of 16 patients were reported. Polymorp...

journal_title：Acta neurologica Scandinavica

authors： Mazzeo A,Muglia M,Rodolico C,Toscano A,Patitucci A,Quattrone A,Messina C,Vita G

更新日期：2008-11-01 00:00:00

abstract：:The F response can provide a measure of motoneurone excitability (MNE) and so it may be used to investigate upper motoneurone disorders. This report studies the F-wave configuration in patients with stroke to evaluate the changes of the central excitability of the motoneurones at different times after an acute cerebra...

journal_title：Acta neurologica Scandinavica

authors： Fierro B,Raimondo D,Modica A

更新日期：1990-11-01 00:00:00

abstract：:A purified citric acid soluble extract from human skeletal muscle (AEMA) and a phosphate-buffered saline extract from rabbit muscle acetone powder (EMA) were used to coat polystyrene beads in an enzyme-linked immunosorbent assay (ELISA). From 54 patients with myasthenia gravis, positive results were observed in 14. Fi...

journal_title：Acta neurologica Scandinavica

authors： Viana VS,Bueno C,Marchiori PE,Oliveira RM,Assis JL,Scaff M,Cossermelli W

更新日期：1986-06-01 00:00:00

abstract：:Previously we have shown low levels of dystrophin immunoreactivity in muscle from patients with DMD. According to the "frame-shift hypothesis" DMD muscle should not synthesize any dystrophin through to the C-terminus and it has been suggested that the protein detected is not dystrophin, but a related autosomal homolog...

journal_title：Acta neurologica Scandinavica

authors： Nicholson LV,Johnson MA,Davison K,O'Donnell E,Falkous G,Barron M,Harris JB

更新日期：1992-07-01 00:00:00

abstract：INTRODUCTION:We planned a descriptive study on the incidence of intracranial gliomas spanning a 16-year period (1976-1991) in the Local Health Service 31 of Ferrara, Northern Italy. MATERIAL AND METHODS:We used a complete enumeration approach by reviewing all the possible sources of case collection available in the st...

journal_title：Acta neurologica Scandinavica

authors： Tola MR,Casetta I,Granieri E,Pinna L,Veronesi V,Tamarozzi R,Trapella G,Monetti VC,Paolino E,Govoni V

更新日期：1994-11-01 00:00:00

abstract：OBJECTIVE:To clarify the relationship between mitochondrial DNA (mtDNA) sequence variations and phenotypes in patients with A3243G mutation. MATERIALS AND METHODS:We studied whole mtDNA sequences in two families with A3243G mutation and characteristic clinical features. Two brothers in Family 1 had shown thiamine defi...

journal_title：Acta neurologica Scandinavica

authors： Morovvati S,Nakagawa M,Sato Y,Hamada K,Higuchi I,Osame M

更新日期：2002-08-01 00:00:00

abstract：INTRODUCTION:The objective of this study was to describe facial myokymia in experimental animals accompanying kainic acid affects on facial motor neurons. MATERIAL & METHODS:Anesthetized cats were injected with kainic acid into the pons adjacent to the facial nucleus. Facial movements appeared shortly after the inject...

journal_title：Acta neurologica Scandinavica

authors： Zaaroor M,Starr A

更新日期：1997-01-01 00:00:00

abstract：:This study aimed to systematically review the literature on the epidemiology of epilepsy in Iran and to provide analytical estimates of the prevalence of various epilepsy syndromes. MEDLINE, Scopus, and Embase from inception to 30 July 2020 were systematically searched. These key words were used: "epilepsy" OR "seizur...

journal_title：Acta neurologica Scandinavica

authors： Asadi-Pooya AA,Simani L

更新日期：2020-11-22 00:00:00

abstract：:Over last fifty years, intravenous (iv) phenytoin (PHT) loading dose has been the treatment of choice for patients with benzodiazepine-resistant convulsive status epilepticus and several guidelines recommended this treatment regimen with simultaneous iv diazepam. Clinical studies have never shown a better efficacy of ...

journal_title：Acta neurologica Scandinavica

authors： Zaccara G,Giorgi FS,Amantini A,Giannasi G,Campostrini R,Giovannelli F,Paganini M,Nazerian P,Tuscany study group on seizures in the emergency department and status epilepticus in adults.

更新日期：2018-06-01 00:00:00

abstract：:We present a 47-year-old white woman who had a definitive diagnosis of systemic lupus erythematosus (SLE), and developed cerebellar ataxia of sudden onset. MR imaging showed changes characteristics of cerebellar infarct. Due to the absence of vascular risk factors and to the previous diagnosis of SLE, we postulate tha...

journal_title：Acta neurologica Scandinavica

authors： Lancman ME,Pomeraniec C,Norscini J

更新日期：1992-10-01 00:00:00

abstract：:Parkinson's disease (PD) surveys and death-record studies in European populations were reviewed. Particular attention was given to methodological aspects. Two sets of quality criteria were used. Four door-to-door surveys revealed underdiagnosis of prevalent idiopathic parkinsonism ranging from 30% to 71%. Quality surv...

journal_title：Acta neurologica Scandinavica

authors： de Pedro-Cuesta J

更新日期：1991-10-01 00:00:00

abstract：BACKGROUND:No systematic study has been made to separate age-related clinical deterioration and dysfunctional brain areas from those associated with Parkinson's disease (PD). METHODS:This study included 73 de novo patients with PD and 43 age-matched controls. All subjects underwent [(18)F]-fluorodeoxy glucose (FDG) po...

journal_title：Acta neurologica Scandinavica

authors： Lee MS,Lyoo CH,Ryu YH,Lim HS,Nam CM,Kim HS,Rinne JO

更新日期：2011-09-01 00:00:00

abstract：BACKGROUND:It has been suggested that polymorphisms in the WT1 gene modulate the effect of IFN-β treatment in multiple sclerosis (MS) through regulation of the relationship between IFN-β and vitamin D. OBJECTIVE:To examine whether WT1 modulates the relationship between IFN-β and vitamin D in a longitudinal study with ...

journal_title：Acta neurologica Scandinavica

authors： Holmøy T,Esbensen QY,Torkildsen Ø,Wergeland S,Bjerve KS,Beiske AG,Midgard R,Šaltytė-Benth J,Hovdal H,Myhr KM

更新日期：2016-04-01 00:00:00

abstract：INTRODUCTION:In patients with cervical root syndromes, the relation between clinical findings and EMG results, the value of the registration of the H-reflex latency of the flexor carpi radial muscle (HFCR) and the rate of recovery of EMG abnormalities following surgery are unclear. METHODS:In 68 patients with cervical...

journal_title：Acta neurologica Scandinavica

authors： van den Bent MJ,Oosting J,Laman DM,van Duijn H

更新日期：1995-10-01 00:00:00

abstract：OBJECTIVE:We performed a systematic review and meta-analysis to evaluate the proposed association of restless legs syndrome (RLS) with cerebrovascular/cardiovascular outcomes. METHODS:We calculated the corresponding odds ratios on the prevalence of cerebrovascular/cardiovascular risk factors and standardized mean diff...

journal_title：Acta neurologica Scandinavica

authors： Katsanos AH,Kosmidou M,Konitsiotis S,Tsivgoulis G,Fiolaki A,Kyritsis AP,Giannopoulos S

更新日期：2018-01-01 00:00:00

abstract：:Twenty solvent-exposed workers, most of them painters, had been diagnosed as cases of toxic encephalopathy in 1978/79. Two years later they were re-examined with an extensive battery of neuropsychological tests. Their performance was unchanged on retesting. We have now compared their test results with those of non-exp...

journal_title：Acta neurologica Scandinavica

authors： Gade A,Mortensen EL,Bruhn P

更新日期：1988-04-01 00:00:00

abstract：INTRODUCTION:The aim of this study was to examine the coping strategies of 49 patients with amyotrophic lateral sclerosis (ALS) and their relationships with medical and demographic data. METHODS:A total of 49 subjects were asked to fill out a document that would provide their demographic and medical data. Then, each o...

journal_title：Acta neurologica Scandinavica

authors： Montel S,Albertini L,Spitz E

更新日期：2012-02-01 00:00:00

abstract：:A 23-year-old patient suffering from mental deterioration was referred for CT study following her first epileptic fit. The study disclosed generalized atrophy and diffuse symmetric white matter hypodensities. Similar findings were found in her 13-year-old retarded sister. The diagnosis of metachromatic leukodystrophy ...

journal_title：Acta neurologica Scandinavica

authors： Reider-Grosswasser I,Bornstein N

更新日期：1987-01-01 00:00:00

abstract：OBJECTIVES:This study aimed to investigate whether neurological disability status, heart rate variability (HRV), cardiorespiratory fitness (CRF) explained the variance in depressive symptoms in multiple sclerosis (MS). METHODS:Associations between CRF (via maximal oxygen uptake; VO2peak ), HRV indices of normalized ul...

journal_title：Acta neurologica Scandinavica

authors： Ensari I,Pilutti LA,Motl RW

更新日期：2017-11-01 00:00:00

abstract：:CSF cytology, immunocytochemistry and biochemical tumor markers were compared in 12 patients with a meningeal carcinomatosis regarding diagnostic significance and therapy control; 50 samples were investigated. Cytology was tumor-positive in 39 samples and immunocytochemistry in 45 samples. Intrathecally produced tumor...

journal_title：Acta neurologica Scandinavica

authors： Oschmann P,Kaps M,Völker J,Dorndorf W

更新日期：1994-05-01 00:00:00

abstract：:A three generation family is presented in which rapidly progressive, early-onset Creutzfeldt-Jakob disease without typical EEG changes segregates as an autosomal dominant disease. An aspartic acid to asparagine mutation at codon 178 of the prion gene, PRNP, co-segregates with the disease. As expected, the disease alle...

journal_title：Acta neurologica Scandinavica

authors： Holm IE,Abelskov K,Bojsen-Møller M,Nielsen AL,Jørgensen AL

更新日期：2001-03-01 00:00:00