The effect of age on motor deficits and cerebral glucose metabolism of Parkinson's disease.

abstract：OBJECTIVES:Cerebrospinal fluid (CSF) from some patients with amyotrophic lateral sclerosis (ALS) has been demonstrated to significantly reduce the neuronal viability of primary cell cultures of motor neurons. We aimed to study the potential clinical consequences associated with the cytotoxicity of CSF in a cohort of pa...

journal_title：Acta neurologica Scandinavica

authors： Galán L,Matías-Guiu J,Matias-Guiu JA,Yáñez M,Pytel V,Guerrero-Sola A,Vela-Souto A,Arranz-Tagarro JA,Gómez-Pinedo U,García AG

更新日期：2017-09-01 00:00:00

abstract：:Patients with multiple sclerosis have an increased risk of infections compared to the general population. The increased risk has been described for decades and is not alone attributed to the use of disease-modifying drugs, but secondary to the disability. The introduction of more potent immunomodulatory drugs may caus...

journal_title：Acta neurologica Scandinavica

authors： Celius EG

更新日期：2017-11-01 00:00:00

abstract：OBJECTIVES:Fatigue and apathy are two of the most common and most disabling non-motor symptoms of Parkinson's disease (PD). They have a high coincidence and can often be confused; moreover, their relationship is not fully understood. The aim of our study was to describe the coincidence of apathy with different fatigue ...

journal_title：Acta neurologica Scandinavica

authors： Skorvanek M,Gdovinova Z,Rosenberger J,Saeedian RG,Nagyova I,Groothoff JW,van Dijk JP

更新日期：2015-02-01 00:00:00

abstract：OBJECTIVES:Sparse information on dose-response characteristics for initial antiepileptic drug monotherapy in children with idiopathic generalized epilepsy (IGE) is available. The aim of this study is to characterize the therapeutic dose of valproate in children with newly diagnosed IGE. MATERIALS AND METHODS:Effect of...

journal_title：Acta neurologica Scandinavica

authors： Holland KD,Monahan S,Morita D,Vartzelis G,Glauser TA

更新日期：2010-03-01 00:00:00

abstract：BACKGROUND:The Multiple Sclerosis Functional Composite (MSFC) is a multidimensional measurement tool for multiple sclerosis (MS) including a measure of ambulation (Timed 25-foot Walk [TWT]), arm function (Nine-Hole Peg Test [9HPT]) and cognition (Paced Auditory Serial Addition Test [PASAT]). OBJECTIVES:To assess the r...

journal_title：Acta neurologica Scandinavica

authors： Rosti-Otajärvi E,Hämäläinen P,Koivisto K,Hokkanen L

更新日期：2008-06-01 00:00:00

abstract：BACKGROUND:Neuropsychiatric symptoms are common in Parkinson's disease and may precede onset of motor symptoms. They are also known to increase caregiver's burden. OBJECTIVE:The aim of this study was to assess neuropsychiatric symptoms in a cohort of Nigerian patients with idiopathic Parkinson's disease and compare wi...

journal_title：Acta neurologica Scandinavica

authors： Ojagbemi AA,Akinyemi RO,Baiyewu O

更新日期：2013-07-01 00:00:00

abstract：OBJECTIVES:Therapy of acute relapses in multiple sclerosis with corticosteroids (CC) remains uncertain with respect to route, dosage and effectiveness. This makes the treatment of relapses a clinical field where 'shared decision-making (SDM)' could be of advantage for the patients. A prerequisite for SDM is the provisi...

journal_title：Acta neurologica Scandinavica

authors： Köpke S,Heesen C,Kasper J,Mühlhauser I

更新日期：2004-07-01 00:00:00

abstract：:Multiple system atrophy (MSA) is a heterogeneous group of central neurological degenerations often associated with diffuse deterioration of the hypothalamic cholinergic neurons. In the hypothesis of an altered cholinergic regulation of vasopressin release, we evaluated vasopressin response to metoclopramide (20 mg i.v...

journal_title：Acta neurologica Scandinavica

authors： Norbiato G,Bevilacqua M,Righini V,Chebat E,Vago T,Bertora P,Castelli L,Mangoni A

更新日期：1992-04-01 00:00:00

abstract：:Intrathecal IgG synthesis and CSF oligoclonal bands were reexamined after 18-24 months in 66 patients with multiple sclerosis; 40 of them received azathioprine (AZA) 2.5 mg/Kg/die; all received a course of dexamethasone (DEXA) during clinical relapses. The IgG Index was significantly reduced in the group treated with ...

journal_title：Acta neurologica Scandinavica

authors： Caputo D,Zaffaroni M,Ghezzi A,Cazzullo CL

更新日期：1987-02-01 00:00:00

abstract：:sHLA are secreted by B and T lymphocytes upon activation. These antigens are present in serum and cerebrospinal fluid (CSF). The establishment of a sHLA index, IH = (CSF sHLA/serum sHLA)/(CSF albumin/serum albumin) helped us to define that values above 9.7 reflect an intrathecal synthesis of these proteins. IH was sig...

journal_title：Acta neurologica Scandinavica

authors： Alvarez-Cermeño JC,Casado C,Villar LM,Ferreira A,Varela JM,Dominguez M,Bootello A,Najera R,Gonzalez-Porque P

更新日期：1990-07-01 00:00:00

abstract：OBJECTIVES:To assess the correlation of diffusion-weighted (DWI) and perfusion-weighted imaging (PWI) findings with the severity of acute neurologic deficit and their ability to predict short and long-term clinical outcomes of stroke. The ability of DWI and PWI to predict the outcome was compared with the ability of cl...

journal_title：Acta neurologica Scandinavica

authors： Nuutinen J,Liu Y,Laakso MP,Karonen JO,Roivainen R,Vanninen RL,Partanen K,Østergaard L,Sivenius J,Aronen HJ

更新日期：2006-02-01 00:00:00

abstract：OBJECTIVES:A highly adaptive aspect of human memory is the enhancement of explicit, consciously accessible memory by emotional stimuli. We studied the performance of Alzheimer's disease (AD) patients and elderly controls using a memory battery with emotional content, and we correlated these results with the amygdala an...

journal_title：Acta neurologica Scandinavica

authors： Schultz RR,de Castro CC,Bertolucci PH

更新日期：2009-08-01 00:00:00

abstract：OBJECTIVES:To investigate the frequency of ECG abnormalities suggestive of myocardial ischaemia in patients with severe drug resistant epilepsy and without any indication of previous cardiac disease, assuming that these changes may be of significance for the group of epileptic patients with sudden unexpected death. MA...

journal_title：Acta neurologica Scandinavica

authors： Tigaran S,Rasmussen V,Dam M,Pedersen S,Høgenhaven H,Friberg B

更新日期：1997-08-01 00:00:00

abstract：INTRODUCTION:Cognitive impairment is a common and disabling consequence of stroke. Its prevalence, the best way to screen for it in the acute setting, and its relation with premorbid status have not been thoroughly clarified. MATERIALS AND METHODS:Ischemic and hemorrhagic stroke patients admitted to our stroke unit un...

journal_title：Acta neurologica Scandinavica

authors： Cova I,Mele F,Zerini F,Maggiore L,Cucumo V,Brambilla M,Rosa S,Bertora P,Salvadori E,Pomati S,Pantoni L

更新日期：2020-10-01 00:00:00

abstract：:Reports on the incidence of alcoholic polyneuropathies are variable depending on diagnostic tools. In this study, 50 chronic alcoholics with positive MALT (Munich Alcoholism Test) and greater than seven years history of excessive alcohol abuse were examined neurologically. Tibial and peroneal motor and sural nerve con...

journal_title：Acta neurologica Scandinavica

authors： Hilz MJ,Zimmermann P,Claus D,Neundörfer B

更新日期：1995-05-01 00:00:00

abstract：:Decompressive craniectomy is a neurosurgical technique in which a portion of the skull is removed to reduce intracranial pressure. The rationale for this procedure is based on the Monro-Kellie Doctrine; expanding the physical space confining edematous brain tissue after traumatic brain injury will reduce intracranial ...

journal_title：Acta neurologica Scandinavica

authors： Quinn TM,Taylor JJ,Magarik JA,Vought E,Kindy MS,Ellegala DB

更新日期：2011-04-01 00:00:00

abstract：:Regional cerebral blood flow (rCBF) was measured in 23 patients with brain tumors using the 133Xe intra-carotid injection method and a 254 channel gamma camera. The glioblastomas (4) and astrocytomas (4) all showed hyperemia in the tumor and tumor-near region. This was also seen in several meningiomas (4 of 7 cases) i...

journal_title：Acta neurologica Scandinavica

authors： Kuroda K,Skyhøj Olsen T,Lassen NA

更新日期：1982-08-01 00:00:00

abstract：OBJECTIVES:Myotonic dystrophy type 1 (DM1) is caused by large expansions of cytosine-thymine-guanine (CTG)-repeats in myotonic dystrophy protein kinase (DMPK)-gene. This gene is highly polymorphic in healthy individuals. It has been proposed that expanded alleles originated from the group of large sized normal alleles....

journal_title：Acta neurologica Scandinavica

authors： Culjković B,Stojković O,Vukosavić S,Savić D,Rakocevic V,Apostolski S,Romac S

更新日期：2002-01-01 00:00:00

abstract：:We prospectively investigated 131 consecutive cases (both in- and outpatients) of suspected dementia to evaluate the relative frequency of different types of dementia in Chinese patients. Dementia was confirmed in 110 cases (84.0%). In contrast to the Western series, vascular dementia (39.1%) was slightly more frequen...

journal_title：Acta neurologica Scandinavica

authors： Liu HC,Tsou HK,Lin KN,Yan SH,Guo NW,Wang CL,Chiang BN

更新日期：1991-11-01 00:00:00

abstract：:Twenty-three consecutive patients with hemifacial spasm were studied. Magnetic resonance imaging angiography of the brain was performed in 20 patients and 15 controls. The angiograms were evaluated by two independent observers and blinded for side-location of the spasm. Contact between an artery from the vertebrobasil...

journal_title：Acta neurologica Scandinavica

authors： Jespersen JH,Dupont E,Gelineck J,Lundorf E

更新日期：1996-01-01 00:00:00

abstract：BACKGROUND:There has been a long-standing interest in the possible role of the hippocampus in autism and both postmortem brain and neuroimaging studies have documented varying abnormalities in this limbic system structure. AIMS:This study investigates the density of subsets of hippocampal interneurons, immunostained w...

journal_title：Acta neurologica Scandinavica

authors： Lawrence YA,Kemper TL,Bauman ML,Blatt GJ

更新日期：2010-02-01 00:00:00

abstract：OBJECTIVE:Multiple sclerosis (MS), Parkinson's disease (PD) and stroke (ST) subjects show balance impairments due to damage of the balance control system. The objective of the study was to assess the impact of MS, PD and ST on upright posture in eyes open condition and when visual and/or proprioceptive inputs are alter...

journal_title：Acta neurologica Scandinavica

authors： Cattaneo D,Carpinella I,Aprile I,Prosperini L,Montesano A,Jonsdottir J

更新日期：2016-05-01 00:00:00

abstract：:Gamma-aminobutyric acid (GABA) is the most important inhibitory transmitter, quantitatively, in the CNS. Evidence exists that decreased GABAergic neurotransmission may play a role in some forms of epilepsy. Consequently, manipulating the GABA system may be a therapeutic possibility in the treatment of this disease. In...

journal_title：Acta neurologica Scandinavica

authors： Gram L

更新日期：1988-10-01 00:00:00

abstract：OBJECTIVES:To measure gait and postural stability by objective methods in spastic MS patients and to evaluate the effect of baclofen on gait and postural stability. PATIENTS AND METHODS:Fourteen spastic MS patients were examined in a placebo controlled double-blind, cross-over trial of oral baclofen treatment. The gai...

journal_title：Acta neurologica Scandinavica

authors： Orsnes GB,Sørensen PS,Larsen TK,Ravnborg M

更新日期：2000-04-01 00:00:00

abstract：BACKGROUND:Delayed-release dimethyl fumarate (DMF) treatment can be associated with reduced lymphocyte and leucocyte counts, which might persist after DMF discontinuation. CASE PRESENTATION:We report the case of a patient with severe disease reactivation despite prolonged lymphopenia after DMF discontinuation. We desc...

journal_title：Acta neurologica Scandinavica

authors： Zecca C,Antozzi CG,Torri Clerici V,Ferrazzini M,Mantegazza RE,Rossi S,Gobbi C

更新日期：2018-06-01 00:00:00

abstract：OBJECTIVES:Neuropsychiatric symptoms commonly found after aneurysmal SAH are covered in the astheno-emotional disorder (AED) of Lindqvist & Malmgrens diagnostic system for organic psychiatry. This study aims to describe the reliability and symptomatology of AED and its relationship with social outcome. MATERIAL AND ME...

journal_title：Acta neurologica Scandinavica

authors： Rödholm M,Starmark JE,Svensson E,Von Essen C

更新日期：2001-06-01 00:00:00

abstract：:Magnetic resonance imaging (MRI) has enabled ante mortem diagnosis of Hallervorden Spatz disease (HSD). Childhood-onset cases are the most common type and usually present with progressive dystonia and dementia. The duration of illness is 15 to 20 years, leading to death. Presentation in adulthood and infancy have also...

journal_title：Acta neurologica Scandinavica

authors： Hickman SJ,Ward NS,Surtees RA,Stevens JM,Farmer SF

更新日期：2001-03-01 00:00:00

abstract：:Soleus H-reflexes during tonic contractions and isometric ramp contractions of the ankle extensors in spastic and healthy subjects were measured. During the tonic contractions, the H-reflex increased with the contraction level. The increase was highest in the patients (p < 0.001). The facilitation of the H-reflex duri...

journal_title：Acta neurologica Scandinavica

authors： Toft E,Sinkjaer T

更新日期：1993-11-01 00:00:00

abstract：BACKGROUND:Elevated levels of the cerebrospinal fluid (CSF) neuronal injury markers (neurofilament light chain [NF-L] and total tau protein [t-tau]) and of the astroglial marker glial fibrillary acidic protein (GFAP) are found in etiologically different neurological disorders affecting the peripheral and the central ne...

journal_title：Acta neurologica Scandinavica

authors： Constantinescu R,Mahamud U,Constantinescu C,Eriksson B,Novakova L,Olsson B,Rosengren L,Blennow K,Axelsson M

更新日期：2019-09-01 00:00:00

abstract：OBJECTIVES:Little is known about the frequency of abnormal visually evoked potentials (VEPs) in patients with respiratory chain disorders (RCDs). We thus wanted to investigate the frequency of abnormal VEPs in RCDs, how often VEPs are abnormal despite normal visual acuity, and which of the VEP variables are most often ...

journal_title：Acta neurologica Scandinavica

authors： Finsterer J

更新日期：2001-07-01 00:00:00