Opsoclonus in a patient with Guillain-Barré syndrome.

Abstract:

:A 54 year-old woman showed the unusual association of a Guillain-Barré syndrome and opsoclonus, a rare eye movement characterized by involuntary bursts of jerking, ataxic and multidirectional saccades, without an intersaccadic interval. Since opsoclonus is a phenomenon described exclusively in CNS diseases, the case reported supports the hypothesis of CNS involvement in some cases of Guillain-Barré syndrome. The latter is generally considered an immune-mediated disease and an immune pathogenesis is also supposed in opsoclonus associated with systemic malignancies; besides, in the patient reported, the self-limiting nature of the disturbance and the lack of MRI lesions suggest that opsoclonus may result from an immune-related phenomenon causing a functional and transitory dysfunction of the CNS.

journal_name

Acta Neurol Scand

authors

Nicolai A,Lazzarino LG

doi

10.1111/j.1600-0404.1992.tb04061.x

subject

Has Abstract

pub_date

1992-05-01 00:00:00

pages

363-4

issue

5

eissn

0001-6314

issn

1600-0404

journal_volume

85

pub_type

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