Immune responses in experimental allergic neuritis treated with corticosteroids.


:The preventive and suppressive effects of methylprednisolone (MP) were investigated in 22 rabbits immunized with peripheral nerve myelin. Cellular reactivity to bovine P2 protein (P2) and anti-P2 antibody were also examined serially in these animals, using the lymphocyte proliferation test or enzyme-linked immunosorbent assay. Seven animals (preventive group), given 15 mg/day of MP subcutaneously from Days 0-28, showed a significant reduction in maximal severity and a delay in onset in comparison with 8 control animals. The remaining 7 animals (suppressive group), given the same dose of MP from Days 11-28, also showed significantly milder clinical signs than those observed in the controls. However, cellular hypersensitivity to P2 were manifested at Day 14 (just after clinical onset) in the controls, as well as in the preventive or suppressive groups. Furthermore, anti-P2 antibody was detected in each group after Day 14. These results suggested that the interference of inflammatory processes of immune-mediated disease might respond to the preventive and suppressive effects of MP.


Acta Neurol Scand


Ohno R,Hamaguchi K,Nomura K,Sowa K,Tanaka H,Negishi T,Yamashita T




Has Abstract


1988-06-01 00:00:00












  • Benign monomelic amyotrophy of lower limb: report of three cases.

    abstract::Three patients with wasting confined to a single lower limb are reported. The characteristic features were: sporadic occurrence, insidious onset with slow progression and in 2 cases arrested course for at least 4 years, wasting out of proportion with disability, absence of sensory, pyramidal tract or bulbar signs. CK,...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章


    authors: Uncini A,Servidei S,Delli Pizzi C,Cutarella R,Di Muzio A,Gambi D,Tonali P

    更新日期:1992-06-01 00:00:00

  • Carotid Doppler - costs and need after stroke or TIA.

    abstract:OBJECTIVES:To estimate the need for and the costs of carotid Doppler and carotid endarterectomy after stroke or TIA in non-selected hospitalized patients. MATERIAL AND METHODS:During 25 months hospitalized patients with stroke or TIA, in whom carotid endarterectomy could be relevant, were examined with carotid Doppler...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章


    authors: Jespersen HF,Jørgensen HS,Nakayama H,Reith J,Olsen TS

    更新日期:2002-01-01 00:00:00

  • Benign muscular dystrophy with contractures: a new syndrome?

    abstract::Three patients are described with muscular dystrophy and contractures. Although this disorder bears similarities to Emery-Dreifuss disease and variants previously described, absence of cardiomyopathy is a distinguishing feature. Electrodiagnostic testing and muscle biopsy are consistent with a myopathy. An autosomal d...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章


    authors: Bailey RO,Dentinger MP,Toms ME,Hans MB

    更新日期:1986-04-01 00:00:00

  • Immunological and genetic studies in primary generalized corticoreticular epilepsy.

    abstract::Serum immunoglobulin and HLA investigations were carried out in 21 probands with primary generalized corticoreticular epilepsy (PGCE) and in 26 of their first degree relatives. The mean serum levels of IgG, IgA and IgM in the epileptic probands were not significantly different from controls. In the relatives, however,...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章


    authors: Eeg-Olofsson O,Janjua NA,Andermann E,Guttmann RD,Osterland K

    更新日期:1986-12-01 00:00:00

  • Amino acid incorporation into brain subcellular fractions in experimental allergic encephalomyelitis.

    abstract::The in vitro protein synthetic capactiy of brain slices from guinea-pigs in the late stage (17-18 days post-induction) of experimental allergic encephalomyelitis was increased over that of Freund's adjuvant injected controls, as determined by the rate of (14C)-leucine incorporation into both tris-soluble and tris-inso...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章


    authors: Babitch JA,Blomstrand C,Hamberger A

    更新日期:1975-03-01 00:00:00

  • Models for studying long-term recovery following forebrain ischemia in the rat. 2. A 2-vessel occlusion model.

    abstract::A model is described in which transient ischemia is induced in rats anaesthetized with N2O:O2 (70:30) by bilateral carotid artery clamping combined with a lowering of mean arterial blood pressure to 50 mm Hg, the latter being achieved by bleeding, or by bleeding supplemented with administration of trimetaphan or phent...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章


    authors: Smith ML,Bendek G,Dahlgren N,Rosén I,Wieloch T,Siesjö BK

    更新日期:1984-06-01 00:00:00

  • Depression in the early phase of MS: influence of functional disability, cognitive impairment and brain abnormalities.

    abstract::This study investigated the relationship between depression, physical disability, cognitive deficit and brain abnormalities on magnetic resonance imaging (MRI) in patients with early MS. Eighteen relapsing-remitting MS patients were evaluated: depression was diagnosed according to DSM-III R and measured by the MMPI de...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章


    authors: Millefiorini E,Padovani A,Pozzilli C,Loriedo C,Bastianello S,Buttinelli C,Di Piero V,Fieschi C

    更新日期:1992-10-01 00:00:00

  • Musculoskeletal and central pain at 1 year post-stroke: associated factors and impact on quality of life.

    abstract:BACKGROUND AND PURPOSE:Pain is common in post-stroke patients and has been shown to be associated with depression, fatigue, and decreased quality of life (QOL). However, studies examining different types of post-stroke pain are scarce. We investigated differences in the related factors and their QOL impacts between mus...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章


    authors: Choi-Kwon S,Choi SH,Suh M,Choi S,Cho KH,Nah HW,Song H,Kim JS

    更新日期:2017-04-01 00:00:00

  • Muscular cramps: proposals for a new classification.

    abstract::Muscle cramps are involuntary, painful, sudden contractions of the skeletal muscles. They are present in normal subjects under certain conditions (during a strong voluntary contraction, sleep, sports, pregnancy) and in several pathologies such as myopathies, neuropathies, motoneuron diseases, metabolic disorders, hydr...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章,评审


    authors: Parisi L,Pierelli F,Amabile G,Valente G,Calandriello E,Fattapposta F,Rossi P,Serrao M

    更新日期:2003-03-01 00:00:00

  • Anxiety in multiple sclerosis is related to depressive symptoms and cognitive complaints.

    abstract:OBJECTIVES:Multiple sclerosis (MS) patients suffer from high levels of anxiety. However, it is unclear which factors are related to anxiety, since study results are inconsistent, and the associated factors have not been examined comprehensively. In this study, we investigated the demographic, disease-related and psycho...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章


    authors: Wallis O,Bol Y,Köhler S,van Heugten C

    更新日期:2020-03-01 00:00:00

  • A study of right unilateral spatial neglect in left hemispheric lesions: the difference between right-handed and non-right-handed post-stroke patients.

    abstract::We report 20 cases of right unilateral spatial neglect caused by lesions in the left cerebral hemisphere. Differences in neuropsychological symptoms and lesions sites are discussed in connection with handedness. Of the right-handed patients, 6 had severe aphasia, 4 had Gerstmann's syndrome, and 1 had pure agraphia, bu...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章


    authors: Maeshima S,Shigeno K,Dohi N,Kajiwara T,Komai N

    更新日期:1992-06-01 00:00:00

  • Can we face the challenge of expanding use of intravenous immunoglobulin in neurology?

    abstract::The use of high-dose polyclonal intravenous immunoglobulin (IVIG) in the treatment of autoimmune neurological diseases has expanded over the last decade. Based on controlled clinical trials IVIG can be considered currently as the first-line treatment in Guillain-Barré syndrome, chronic inflammatory demyelinating polyn...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章,评审


    authors: Elovaara I,Hietaharju A

    更新日期:2010-11-01 00:00:00

  • Lack of difference in the intimal medial thickness between the left and right carotid arteries in the young.

    abstract:BACKGROUND:Carotid intimal medial thickening (c-IMT) is an established surrogate marker for atherosclerosis. There have been sporadic reports about an increase of c-IMT on the left carotid artery among populations with a mean age of +/-50 years. OBJECTIVE:The purpose of this study was to evaluate whether there is a di...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章


    authors: Arbel Y,Maharshak N,Gal-Oz A,Shapira I,Berliner S,Bornstein NM

    更新日期:2007-06-01 00:00:00

  • Cerebrospinal fluid findings in mycoplasma pneumoniae infections with neurological complications.

    abstract::The cerebrospinal fluid (CSF) findings of 16 patients with mycoplasma pneumoniae infections and different neurologic complications are presented. In acute meningitis there was predominantly a mononuclear cell reaction remitting in accordance with the improvement of the clinical symptoms. An early switch from IgM to Ig...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章


    authors: Maida E,Kristoferitsch W

    更新日期:1982-05-01 00:00:00

  • TPA for ischemic stroke in patients ≥80 years.

    abstract:OBJECTIVE:Although patients >80 years were excluded in RCTs for tPA treatment of acute ischemic stroke (AIS), many centers treat old patients. We wanted to examine whether age ≥80 years is an independent predictor of outcome after tPA. MATERIALS:We included 77 consecutive patients ≥80 years and 83 patients <80 years t...

    journal_title:Acta neurologica Scandinavica

    pub_type: 临床试验,杂志文章


    authors: Henriksen EH,Ljøstad U,Tveiten A,Naess H,Thomassen L,Mygland A

    更新日期:2013-05-01 00:00:00

  • No associations between five polymorphisms in COMT gene and migraine.

    abstract:OBJECTIVES:The pathophysiology of migraine headaches is not clearly understood yet. The dopaminergic system has been hypothesized to be involved in migraine pathogenesis. The aim of this study was to investigate catechol-O-methyltransferase (COMT) polymorphisms and chronic headaches. We analyzed five single nucleotide ...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章


    authors: Takigawa H,Kowa H,Nakashima K

    更新日期:2017-02-01 00:00:00

  • Circulating nociceptin and CGRP in medication-overuse headache.

    abstract:BACKGROUND:Previous studies found low serum levels of nociceptin in migraine patients but high serum levels of calcitonin gene-related peptide (CGRP). CGRP can elicit migraine-like headache. Medication-Overuse Headache (MOH) often has migraine features and can mimic chronic migraine. We therefore hypothesized that as i...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章


    authors: Munksgaard SB,Ertsey C,Frandsen E,Bendtsen L,Tekes K,Jensen RH

    更新日期:2019-03-01 00:00:00

  • Blood pressure variability and leukoaraiosis amount in cerebral small-vessel disease.

    abstract:OBJECTIVES:To analyze the correlation between blood pressure (BP) variability and leukoaraiosis (LA) amount in patients with symptomatic cerebral small-vessel disease. MATERIALS AND METHODS:We included 25 hypertensive patients: 13 with Binswanger's disease (BD) and 12 with a first-ever lacunar infarction (LI). Baselin...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章


    authors: Martí-Fàbregas J,Valencia C,Pujol J,García-Sánchez C,Roca-Cusachs A,López-Contreras J,Solé MJ,Martí-Vilalta JL

    更新日期:2001-12-01 00:00:00

  • Retraction: 'Sunlight exposure is important for preventing hip fractures in patients with Alzheimer's disease, Parkinson's disease, or stroke' by J. Iwamoto, T. Takeda and H. Matsumoto.

    abstract::The above article from Acta Neurologica Scandinavica, published online on 18 June 2011 in Wiley Online Library ( and in Volume 125, pp. 279-284, has been retracted by agreement between the authors, the Journal Editor-in-Chief Elinor Ben-Menachem and John Wiley & Sons Ltd. The Retraction h...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章,撤回出版物



    更新日期:2018-06-01 00:00:00

  • Depressive symptomology in multiple sclerosis: Disability, cardiorespiratory fitness and heart rate variability.

    abstract:OBJECTIVES:This study aimed to investigate whether neurological disability status, heart rate variability (HRV), cardiorespiratory fitness (CRF) explained the variance in depressive symptoms in multiple sclerosis (MS). METHODS:Associations between CRF (via maximal oxygen uptake; VO2peak ), HRV indices of normalized ul...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章


    authors: Ensari I,Pilutti LA,Motl RW

    更新日期:2017-11-01 00:00:00

  • A follow-up study of neuropsychological function in asymptomatic HIV-infected patients.

    abstract::A group of asymptomatic HIV-infected patients (CDC II and III) was followed-up over a two year period with semi-annual neuropsychological testing. Of the total sample of 36 subjects, all were retested at test two (T2), 19 at test three (T3) and 13 at test four (T4). A subgroup of subjects was further tested on a simpl...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章


    authors: Karlsen NR,Reinvang I,Frøland SS

    更新日期:1993-02-01 00:00:00

  • Failure of allopurinol to protect against cerebral injury when given after the start of hypoxia.

    abstract::One cause of ischemic brain injury is free radical formation during recirculation. Allopurinol inhibits xanthine oxidase, an important source of free oxygen radicals. It is known that allopurinol pre-treatment has a protective action during cerebral ischemia. In the present study we exposed slices from the rat hippoca...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章


    authors: Hegstad E,Berg-Johnsen J,Langmoen IA

    更新日期:1991-05-01 00:00:00

  • Rhesus anti-D immunoglobulin in chronic autoimmune neuropathy.

    abstract:OBJECTIVE:To investigate the effect of Rhesus anti-D immunoglobulin (anti-D) in patients with an autoimmune demyelinating neuropathy. MATERIAL AND METHODS:Three patients with an autoimmune mediated neuropathy received 1000 IU anti-D weekly for 2 months. RESULTS:Two patients worsened gradually during the treatment and...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章


    authors: de Jager AE,Hazenberg CA,van der Hoeven JH

    更新日期:1998-07-01 00:00:00

  • Unchanged striatal dopamine transporter availability in narcolepsy: a PET study with [11C]-CFT.

    abstract:OBJECTIVE:To investigate dopamine reuptake sites (dopamine transporter) in the caudate nucleus and putamen in narcolepsy. PATIENTS AND METHODS:Ten patients with narcolepsy and 15 controls were studied with positron emission tomography. A cocaine analogue [11C]-CFT was used as a radioligand. RESULTS:The uptake of[11C]...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章


    authors: Rinne JO,Hublin C,Någren K,Helenius H,Partinen M

    更新日期:2004-01-01 00:00:00

  • Scalp EMG in brain death electroencephalogram.

    abstract::Electromyograms (EMGs) are usually considered artifacts during electroencephalographic (EEG) recording for determination of electrocerebral silence (ECS). Appearance of scalp motor unit activity, however, may reflect residual brainstem function and can introduce difficulty in establishing a secure diagnosis of brain d...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章


    authors: Wee AS

    更新日期:1986-08-01 00:00:00

  • Clinical and neurophysiological abnormalities before and after reconstruction of the anterior cruciate ligament of the knee.

    abstract:OBJECTIVES:We aimed to study knee proprioception and somatosensory evoked potentials (SEPs) to stimulation of the common peroneal nerve (CPN) in 7 patients with lesion of the anterior cruciate ligament (ACL) before and after ACL reconstruction. MATERIALS AND METHODS:We recorded the spinal N14 and scalp P27 potentials ...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章


    authors: Valeriani M,Restuccia D,Di Lazzaro V,Franceschi F,Fabbriciani C,Tonali P

    更新日期:1999-05-01 00:00:00

  • CT and MRI in late-onset metachromatic leukodystrophy.

    abstract::A 23-year-old patient suffering from mental deterioration was referred for CT study following her first epileptic fit. The study disclosed generalized atrophy and diffuse symmetric white matter hypodensities. Similar findings were found in her 13-year-old retarded sister. The diagnosis of metachromatic leukodystrophy ...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章


    authors: Reider-Grosswasser I,Bornstein N

    更新日期:1987-01-01 00:00:00

  • Cognitive impairment in MS: rehabilitation approaches.

    abstract::Cognitive deficits have been reported in 45%-70% of patients with multiple sclerosis (MS). Like other symptoms of MS, cognitive deficits are highly variable. Slowed information processing and memory and learning dysfunction are regarded as the most frequent cognitive deficits in MS. Both white and gray matter damages ...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章,评审


    authors: Hämäläinen P,Rosti-Otajärvi E

    更新日期:2016-09-01 00:00:00

  • Variation of therapeutic response in Parkinson's disease: a retrospective study.

    abstract::A retrospective study of variations of therapeutic response (dyskinesia and on-off phenomenon) in Parkinson's disease was conducted on 278 patients treated with levodopa for at least 6 months and hospitalized at National Neurological Institute "C. Besta" of Milan between 1974 and 1984. Variations of therapeutic respon...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章


    authors: Geminiani G,Cesana BM,Scigliano G,Soliveri P,Girotti F,Giovannini P,Caraceni T

    更新日期:1990-05-01 00:00:00

  • Motor compensation and recovery for reaching in stroke patients.

    abstract:OBJECTIVES:To examine the mechanisms of alternative strategies developed by stroke patients to compensate their motor impairment and their role in recovery. MATERIAL AND METHODS:The three-dimensional kinematics of the upper limb were quantified during unconstrained reaching movements in seven healthy individuals and i...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章


    authors: Roby-Brami A,Feydy A,Combeaud M,Biryukova EV,Bussel B,Levin MF

    更新日期:2003-05-01 00:00:00