Immune responses in experimental allergic neuritis treated with corticosteroids.


:The preventive and suppressive effects of methylprednisolone (MP) were investigated in 22 rabbits immunized with peripheral nerve myelin. Cellular reactivity to bovine P2 protein (P2) and anti-P2 antibody were also examined serially in these animals, using the lymphocyte proliferation test or enzyme-linked immunosorbent assay. Seven animals (preventive group), given 15 mg/day of MP subcutaneously from Days 0-28, showed a significant reduction in maximal severity and a delay in onset in comparison with 8 control animals. The remaining 7 animals (suppressive group), given the same dose of MP from Days 11-28, also showed significantly milder clinical signs than those observed in the controls. However, cellular hypersensitivity to P2 were manifested at Day 14 (just after clinical onset) in the controls, as well as in the preventive or suppressive groups. Furthermore, anti-P2 antibody was detected in each group after Day 14. These results suggested that the interference of inflammatory processes of immune-mediated disease might respond to the preventive and suppressive effects of MP.


Acta Neurol Scand


Ohno R,Hamaguchi K,Nomura K,Sowa K,Tanaka H,Negishi T,Yamashita T




Has Abstract


1988-06-01 00:00:00












  • Comparison of concentration of orosomucoid in serum and cerebrospinal fluid in different neurological diseases.

    abstract::We compared orosomucoid levels in cerebrospinal fluid (CSF) in patients with aseptic meningitis, multiple sclerosis, ischemic and hemorrhagic stroke, CNS-affecting leukemia/lymphoma, and CNS-tumor with the levels in a reference group not having neurologic diseases. Because of possible blood brain barrier damage, we co...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章


    authors: Vrethem M,Ohman S,von Schenck H,Forsberg P,Olsson JE

    更新日期:1987-05-01 00:00:00

  • Algorithm for lamotrigine dose adjustment before, during, and after pregnancy.

    abstract:BACKGROUND:Treatment with lamotrigine (LTG) during pregnancy is associated with a pronounced risk of seizure deterioration, because pregnancy accelerates LTG elimination. The extent to which pregnancy affects LTG pharmacokinetics is unpredictable and varies considerably among patients. AIM:We propose an algorithm for ...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章


    authors: Sabers A

    更新日期:2012-07-01 00:00:00

  • Phosphomannosyl receptors of lysosomal enzymes of skeletal muscle in neuromuscular diseases.

    abstract::The phosphomannosyl receptor system is responsible for both the receptor-mediated endocytosis and the intracellular transport of lysosomal enzymes. In the present study this receptor system was examined in affected muscles of patients with various neuromuscular diseases. The total activity of beta-N-acetyl-glucosamini...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章


    authors: Salminen A,Marjomäki V,Tolonen U,Myllylä VV

    更新日期:1988-06-01 00:00:00

  • Immunological and genetic studies in primary generalized corticoreticular epilepsy.

    abstract::Serum immunoglobulin and HLA investigations were carried out in 21 probands with primary generalized corticoreticular epilepsy (PGCE) and in 26 of their first degree relatives. The mean serum levels of IgG, IgA and IgM in the epileptic probands were not significantly different from controls. In the relatives, however,...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章


    authors: Eeg-Olofsson O,Janjua NA,Andermann E,Guttmann RD,Osterland K

    更新日期:1986-12-01 00:00:00

  • Estimate of parkinsonism prevalence through drug prescription histories in the Province of Rome, Italy.

    abstract:INTRODUCTION:The objective of the study was to estimate the prevalence of parkinsonism in the Province of Rome using antiparkinsonian prescription histories from 1986 to 1991. METHODS:A subject was defined as a case of parkinsonism if he/she had received "specific" and "consistent" antiparkinsonian therapy in the stud...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章


    authors: Menniti-Ippolito F,Spila-Alegiani S,Vanacore N,Bonifati V,Diana G,Meco G,Raschetti R

    更新日期:1995-07-01 00:00:00

  • Selenium, vitamin E and copper in multiple sclerosis.

    abstract::There has been accumulation of the nutritional muscular dystrophy of the cattle in a certain western district of Finland where the prevalence of multiple sclerosis (MS) is also highest. This animal disease is due to lack of selenium (Se) and vitamin E. The Se content of whole blood was low (52.6 +/- 11.3 ng/ml) in MS ...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章


    authors: Wikström J,Westermarck T,Palo J

    更新日期:1976-09-01 00:00:00

  • Vaccine-associated contact paralytic poliomyelitis with atypical neurological presentation.

    abstract::Paralytic poliomyelitis presenting with quadriparesis, transient encephalitis and bulbar symptoms in 2 patients in close contact with recently vaccinated children with trivalent live oral polio vaccine is described. Symmetrical lower motor neuron involvement of deltoid muscles with electromyographic confirmation was f...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章


    authors: Arlazoroff A,Bleicher Z,Klein C,Vure E,Lahat E,Gross B,Handsher R

    更新日期:1987-09-01 00:00:00

  • Anterior ischaemic optic neuropathy secondary to cluster headache.

    abstract::This report describes a patient with cluster headache who developed anterior ischaemic optic neuropathy during an attack of headache, an association not previously described. A possible pathophysiologic mechanism based upon the understanding of optic disc physiology and ocular vascular pathology in headache syndromes ...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章


    authors: Toshniwal P

    更新日期:1986-02-01 00:00:00

  • Myelin glycosphingolipid immunoreactivity and CSF levels in multiple sclerosis.

    abstract:OBJECTIVES:Patients with multiple sclerosis were reported to harbour antibodies not only against proteins and glycoproteins but also against glycolipids, including sulfatide and galactosylceramide (GalCer), the two major glycosphingolipids of myelin. However, previous results were inconsistent concerning glycosphingoli...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章


    authors: Haghighi S,Lekman A,Nilsson S,Blomqvist M,Andersen O

    更新日期:2012-01-01 00:00:00

  • Dyscalculia in the early stages of Alzheimer's disease.

    abstract:OBJECTIVE:To study mathematical deficits in the early stages of Alzheimer's disease (AD). METHODS:Sixty-eight patients with mild AD and 242 normal controls (NC) received a standardized battery (EC 301-R) assessing number processing and calculation abilities. AD patients also received testing for language, memory, visu...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章


    authors: Carlomagno S,Iavarone A,Nolfe G,Bourène G,Martin C,Deloche G

    更新日期:1999-03-01 00:00:00

  • Cavernous hemangioma of the spinal cord - conservative or operative management?

    abstract::Once believed to be extremely uncommon, due to magnetic resonance imaging cavernous hemangiomas of the spinal cord are detected with increasing frequency. Management of both symptomatic and asymptomatic intramedullary cavernous hamangiomas is therefore of growing importance. However, experience with treatment and foll...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章


    authors: Kondziella D,Brodersen P,Laursen H,Hansen K

    更新日期:2006-10-01 00:00:00

  • Serum elevation of high density lipoprotein (HDL) cholesterol in epileptic patients taking carbamazepine or phenytoin.

    abstract::Serum lipids and the cholesterol concentration in the high density lipoprotein (HDL) fraction were measured in epileptic patients taking either carbamazepine or phenytoin as single drug treatment. There was a significant increase in HDL-cholesterol levels in patients taking both phenytoin and carbamazepine. Serum tota...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章


    authors: O'Neill B,Callaghan N,Stapleton M,Molloy W

    更新日期:1982-02-01 00:00:00

  • Conduction velocity study in type 1 diabetic patients.

    abstract::The role of metabolic abnormalities in the development of diabetic neuropathy is controversial. To investigate the peripheral nerve function and the influence of hyperglycemia on nerve conduction in insulin-dependent diabetes, a one-year neurophysiological study was carried out in 30 type 1 diabetic patients ranging i...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章


    authors: Meli F,Cardella F,Raimondo D,Modica A,Muscarella A,Fierro B

    更新日期:1989-11-01 00:00:00

  • Self-assessments and determinants of HRQoL in a German MS population.

    abstract:OBJECTIVES:The importance of health-related quality of life (HRQoL) in multiple sclerosis (MS) is widely acknowledged. In 2015, a multicenter study was launched to assess the HRQoL and coping styles of chronically ill persons in Germany. The aims of this paper were (i) to describe how persons affected by MS assess thei...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章,多中心研究


    authors: Nickel S,von dem Knesebeck O,Kofahl C

    更新日期:2018-02-01 00:00:00

  • Glucose metabolism in the brain in LMNB1-related autosomal dominant leukodystrophy.

    abstract:OBJECTIVE:LMNB1-related autosomal dominant leukodystrophy is caused by an overexpression of the protein lamin B1, usually due to a duplication of the LMNB1 gene. Symptoms start in 5th to 6th decade. This slowly progressive disease terminates with death. We studied brain glucose metabolism in this disease using 18 F-flu...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章


    authors: Finnsson J,Lubberink M,Savitcheva I,Fällmar D,Melberg A,Kumlien E,Raininko R

    更新日期:2019-02-01 00:00:00

  • "Numb, clumsy hands" and tactile agnosia secondary to high cervical spondylotic myelopathy: a clinical and electrophysiological correlation.

    abstract::Four patients presented with a distinctive syndrome of "numb, clumsy hand" and tactile agnosia. Myelography and computed tomographic myelography (CTM) of the cervical spine documented major spondylotic compressive lesions mainly between the C3 and C5 levels. The cortical responses of dermatomal somatosensory evoked po...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章


    authors: Chang MH,Liao KK,Cheung SC,Kong KW,Chang SP

    更新日期:1992-12-01 00:00:00

  • Effect of baclofen on gait in spastic MS patients.

    abstract:OBJECTIVES:To measure gait and postural stability by objective methods in spastic MS patients and to evaluate the effect of baclofen on gait and postural stability. PATIENTS AND METHODS:Fourteen spastic MS patients were examined in a placebo controlled double-blind, cross-over trial of oral baclofen treatment. The gai...

    journal_title:Acta neurologica Scandinavica

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Orsnes GB,Sørensen PS,Larsen TK,Ravnborg M

    更新日期:2000-04-01 00:00:00

  • In vivo microstructural white matter changes in early spinocerebellar ataxia 2.

    abstract:OBJECTIVE:White matter (WM) integrity of Spinocerebellar ataxia 2 (SCA2) is poorly understood, more so in the early stages of SCA2. In this study, we evaluated the microstructural integrity of the WM tracts with an emphasis on the nature of in vivo pathological involvement in early SCA2. MATERIALS AND METHODS:We evalu...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章


    authors: Stezin A,Bhardwaj S,Khokhar S,Hegde S,Jain S,Bharath RD,Saini J,Pal PK

    更新日期:2020-10-08 00:00:00

  • Cell-mediated immunity to viral antigens and tuberculin in multiple sclerosis.

    abstract::Lymphocyte transformation responses to measles, mumps, herpes simplex and parainfluenza virus antigens and purified protein derivative of tuberculin were determined in both 78 normal controls and 40 patients with multiple sclerosis, 16 of whom were studied serially. Patients with multiple sclerosis showed significantl...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章


    authors: Sagar HJ,Allonby ID,Hughes P

    更新日期:1981-02-01 00:00:00

  • Brain morphology in juvenile myoclonic epilepsy and absence seizures.

    abstract:OBJECTIVE:We evaluated the differences in brain morphology among patients with juvenile myoclonic epilepsy according to the occurrence of absence seizures. MATERIALS AND METHODS:Twenty-one juvenile myoclonic epilepsy patients with (n = 6) and without (n = 15) absence seizures were enrolled. We analyzed whole-brain T1-...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章


    authors: Park KM,Kim TH,Han YH,Mun CW,Shin KJ,Ha SY,Park JS,Kim SE

    更新日期:2016-02-01 00:00:00

  • Capsular infarcts: location, size and etiology of pure motor hemiparesis, sensorimotor stroke and ataxic hemiparesis.

    abstract::We investigated the types of syndrome, location, size and presumed causes of 72 patients with acute capsular lacunar infarction. Clinical syndromes were classified into pure motor hemiparesis (PM), sensorimotor stroke (SM) and ataxic hemiparesis (AH). Lesion sizes of AH were significantly smaller than those of PM (p <...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章


    authors: Tei H,Uchiyama S,Maruyama S

    更新日期:1993-10-01 00:00:00

  • Visually evoked potentials in respiratory chain disorders.

    abstract:OBJECTIVES:Little is known about the frequency of abnormal visually evoked potentials (VEPs) in patients with respiratory chain disorders (RCDs). We thus wanted to investigate the frequency of abnormal VEPs in RCDs, how often VEPs are abnormal despite normal visual acuity, and which of the VEP variables are most often ...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章


    authors: Finsterer J

    更新日期:2001-07-01 00:00:00

  • Subclinical cerebral lesion accumulation on serial magnetic resonance imaging (MRI) in patients with hypertension: risk factors.

    abstract:OBJECTIVES:We investigated the occurrence in hypertensive patients of new subclinical changes in the brain by serial magnetic resonance imaging (MRI). METHODS:MRI was performed serially in 98 hypertensive subjects without neurologic deficits at least once a year for 3 years. All received antihypertensive medicines Blo...

    journal_title:Acta neurologica Scandinavica

    pub_type: 临床试验,杂志文章


    authors: Shintani S,Shiigai T,Arinami T

    更新日期:1998-04-01 00:00:00

  • Probabilistic ictal EEG sources and temporal lobe epilepsy surgical outcome.

    abstract:OBJECTIVE:For patients with medication refractory medial temporal lobe epilepsy (MTLE), surgery offers the hope of a cure. However, up to 30% of patients with MTLE continue to experience disabling seizures after surgery. The reasons why some patients do not achieve seizure freedom are poorly understood. A promising the...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章


    authors: Breedlove J,Nesland T,Vandergrift WA 3rd,Betting LE,Bonilha L

    更新日期:2014-08-01 00:00:00

  • Incidence and significance of adverse effects of albendazole therapy in patients with a persistent solitary cysticercus granuloma.

    abstract:OBJECTIVE:To study the incidence of adverse reactions to albendazole therapy in patients presenting with seizures and a persistent (>3 months after diagnosis), solitary cysticercus granuloma and to determine whether the occurrence of adverse reactions predicted the response of the granuloma to therapy. MATERIAL AND ME...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章


    authors: Rajshekhar V

    更新日期:1998-08-01 00:00:00

  • B cell activation in multiple sclerosis.

    abstract::A microtechnique was established for the study of the limited numbers of cells available in CSF. The method allowed for the determination of the number of immunoglobulin-secreting cells (IgSC) as well as the quantitation of immunoglobulin or specific antibody secreted into the culture medium. Dose-response curves and ...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章


    authors: Sandberg M,Levinson AI,Zweiman B,Lisak RP

    更新日期:1986-12-01 00:00:00

  • Change of the melanocortin system caused by bilateral subthalamic nucleus stimulation in Parkinson's disease.

    abstract::OBJECTIVES - Determine whether bilateral subthalamic nucleus stimulation (STN-DBS) in Parkinson's disease (PD) is associated with an increase in neuropeptide Y (NPY) and/or resistance to inhibition by leptin in relation to post-surgery weight gain. MATERIALS AND METHODS - This prospective study included 20 patients wh...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章


    authors: Escamilla-Sevilla F,Pérez-Navarro MJ,Muñoz-Pasadas M,Sáez-Zea C,Jouma-Katati M,Piédrola-Maroto G,Ramírez-Navarro A,Mínguez-Castellanos A

    更新日期:2011-10-01 00:00:00

  • Public stroke awareness and intent to call 112 in Sweden.

    abstract:BACKGROUND AND AIMS:Recognition of stroke symptoms and activation of emergency services are essential in minimizing delay for acute stroke treatments. In this study, we assessed public stroke awareness in Sweden. METHODS:One thousand and five hundred residents aged 18-79 years participated in a telephone survey. Open-...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章


    authors: Nordanstig A,Jood K,Rosengren L

    更新日期:2014-12-01 00:00:00

  • Experimental studies and controlled clinical testing of valproate and vigabatrin.

    abstract::Gamma-aminobutyric acid (GABA) is the most important inhibitory transmitter, quantitatively, in the CNS. Evidence exists that decreased GABAergic neurotransmission may play a role in some forms of epilepsy. Consequently, manipulating the GABA system may be a therapeutic possibility in the treatment of this disease. In...

    journal_title:Acta neurologica Scandinavica

    pub_type: 临床试验,杂志文章,评审


    authors: Gram L

    更新日期:1988-10-01 00:00:00

  • Intrathecal interferon in subacute sclerosing panencephalitis.

    abstract::Three patients at Stage II of subacute sclerosing panencephalitis (SSPE) were treated with semipurified alpha-interferon (IFN) using different combinations of intrathecal and intravenous routes: 1 x 10(6) IU of alpha-IFN were given every other day up to a total of 15 x 10(6) IU. Transient improvement of neurological s...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章


    authors: Maimone D,Grimaldi LM,Incorpora G,Biondi R,Sofia V,Mancuso GR,Siciliano L,Ruscica M,Pavone L

    更新日期:1988-09-01 00:00:00