Mutations in the alpha-synuclein gene in Parkinson's disease among Indians.

Abstract:

OBJECTIVE:To investigate the prevalence of G88C, G209A and any other mutation(s) in exons 3 and 4 of the alpha-synuclein gene in Indian patients with Parkinson's disease (PD). METHODS:A total of 169 PD patients comprising 18 familial, 3 juvenile, 48 early onset and 100 sporadic cases were included in this study. Genomic DNA was amplified by PCR using primers specific for Exons 3 and 4. Mutations at G88C and G209A were screened following restriction enzyme digestion of the PCR product. Direct PCR product sequencing of entire exons 3 and 4 was carried out for at least one proband each from the 10 familial cases. RESULTS:Neither G88C and G209A mutations nor any other mutation in exons 3 and 4 was found in the PD patients analysed. CONCLUSION:The G88C and G209A mutations do not seem to be the predominant genetic determinant of PD among Indians.

journal_name

Acta Neurol Scand

authors

Nagar S,Juyal RC,Chaudhary S,Behari M,Gupta M,Rao SN,Thelma BK

doi

10.1034/j.1600-0404.2001.103002120.x

subject

Has Abstract

pub_date

2001-02-01 00:00:00

pages

120-2

issue

2

eissn

0001-6314

issn

1600-0404

journal_volume

103

pub_type

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