Autonomic dysfunction in experimental allergic neuritis.

Abstract:

:Beat-to-beat variation (R-R variation) in the electrocardiogram was studied in experimental allergic neuritis in the Sprague-Dawley rat. Reduced R-R variations were found in 2 of 10 animals, probably as a sign of autonomic dysfunction. The vagal nerves from these two animals, studied in vitro, showed disturbed conduction. In one animal prolonged conduction latencies to supramaximal electrical stimuli were found. Vagal nerves from controls and from animals without clinical symptoms showed normal conduction. Histologically, the vagal nerves from affected animals showed a slight inflammatory cell infiltration and signs of demyelination but there was no evidence of involvement of the brainstem vasomotor nuclei. Thus, we suggest that the autonomic dysfunction in experimental allergic neuritis, measured as reduced R-R variations, is caused by a peripheral vagal neuropathy.

journal_name

Acta Neurol Scand

authors

Solders G,Persson A,Kristensson K,Hansson S

doi

10.1111/j.1600-0404.1985.tb01542.x

subject

Has Abstract

pub_date

1985-07-01 00:00:00

pages

18-25

issue

1

eissn

0001-6314

issn

1600-0404

journal_volume

72

pub_type

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