Polyautoimmunity in a Greek cohort of multiple sclerosis.

Abstract:

OBJECTIVES:The aim of this study was to assess the existence of polyautoimmunity in a Greek cohort of multiple sclerosis (MS), particularly multiple autoimmune syndrome (MAS), i.e., the presence of three or more distinct autoimmune disorders (ADs) in the same individual. METHODS:Cross-sectional control study. RESULTS:The overall prevalence of polyautoimmunity in 2140 MS patients (female to male ratio: 2.1:1) was 8.3% (vs 6.07% in 1580 matched control participants, P = 0.008) mainly due to differences in autoimmune thyroid disorders (AITD) and vitiligo. The prevalence of MAS was 1.0%. The most frequent diseases encountered in MS were organ-specific ADs. There was no statistical difference in the total rates of ADs between female and male MS patients. There were higher rates of AITD in women (P = 0.004) and higher rates of iritis (P = 0.039) and ankylosing spondylitis (P = 0.003) in men. MS was diagnosed in the same year with AD in 7.4% of patients with additional ADs, earlier than AD in 42.0% and later than AD in 50.6%. CONCLUSION:Polyautoimmunity and particularly MAS occur more frequently in MS patients than in control participants indicating that MS may be part of a generalized susceptibility to autoimmunity. Therefore, polyautoimmunity may be implicated in the etiopathogenesis of MS-related ADs, with a potential impact on relative therapeutic strategies.

journal_name

Acta Neurol Scand

authors

Deretzi G,Kountouras J,Polyzos SA,Koutlas E,Pelidou SH,Xeromerisiou G,Zavos C,Tsiptsios I

doi

10.1111/ane.12308

subject

Has Abstract

pub_date

2015-04-01 00:00:00

pages

225-30

issue

4

eissn

0001-6314

issn

1600-0404

journal_volume

131

pub_type

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