Recovering optic neuritis during systemic cisplatin and carboplatin chemotherapy.

Abstract:

INTRODUCTION:We describe bilateral optic neuropathy in a patient affected by ovarian carcinoma treated with cis-platin 160 mg/m2 and carboplatin, 640 mg/m2. The patient was followed for 1 year, when recovery appeared. The few previous descriptions of CDDP optic nerve toxicity did not report recovery. METHODS:Computerized visual field, visual evoked potentials, pattern electroretinograms, full field flash electroretinograms were recorded during follow-up. RESULTS:Optic neuritis appeared 13 weeks after cis-platin discontinuation, with right eye central scotoma; 2 days later the patient became bilaterally blind. Visual evoked potentials were initially absent, reappeared, with delayed latencies to left eye stimuli at 6 months, in both eyes at 9 months. At 1 year delayed VEPs were recorded with right eye stimuli, normal VEPs were recorded for left eye. CONCLUSION:Cis-platin can induce delayed optic neuritis, that can recover in 1 year.

journal_name

Acta Neurol Scand

authors

Caraceni A,Martini C,Spatti G,Thomas A,Onofrj M

doi

10.1111/j.1600-0404.1997.tb00280.x

subject

Has Abstract

pub_date

1997-10-01 00:00:00

pages

260-1

issue

4

eissn

0001-6314

issn

1600-0404

journal_volume

96

pub_type

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