Abstract：
INTRODUCTION:Cognitive impairment is a common and disabling consequence of stroke. Its prevalence, the best way to screen for it in the acute setting, and its relation with premorbid status have not been thoroughly clarified. MATERIALS AND METHODS:Ischemic and hemorrhagic stroke patients admitted to our stroke unit underwent a baseline assessment that included a clinical and neuroimaging assessment, two cognitive tests (clock-drawing test, CDT; Montreal Cognitive Assessment-Basic, MoCA-B) and measures of premorbid function (including the Clinical Dementia Rating Scale). A follow-up examination was repeated 3-4 months after the acute event. RESULTS:Two hundred and twenty-three patients (52.5% women, mean age ± SD 75.8 years ± 12.3) were evaluated. Prestroke cognitive impairment was present in 91 patients (40.8%). At follow-up, the prevalence of cognitive impairment was 49%, while its incidence among patients who did not have any prestroke cognitive impairment was 38.8%. Of the originally admitted 223 patients (71 were lost to follow-up), only 60 (26.9%) were still cognitively intact at follow-up. On regression analysis, age and baseline CDT were associated with worsening of cognitive status at follow-up. In patients without cognitive impairment at baseline, a cutoff of 23 for MoCA-B and of 8.7 for CDT scores predicted the diagnosis of post-stroke cognitive impairment with sufficient accuracy. DISCUSSION AND CONCLUSION:Prestroke and post-stroke cognitive impairment affect a large proportion of patients with stroke. Our findings suggest that a neuropsychological screening during the acute phase might be predictive of the development of post-stroke cognitive impairment.
journal_name
Acta Neurol Scandjournal_title
Acta neurologica Scandinavicaauthors
Cova I,Mele F,Zerini F,Maggiore L,Cucumo V,Brambilla M,Rosa S,Bertora P,Salvadori E,Pomati S,Pantoni Ldoi
10.1111/ane.13319subject
Has Abstractpub_date
2020-10-01 00:00:00pages
377-384issue
4eissn
0001-6314issn
1600-0404journal_volume
142pub_type
杂志文章abstract：OBJECTIVE:To clarify the optimum trace count for jitter calculation. MATERIALS AND METHODS:Single-fiber electromyography was performed during voluntary contraction (VC-SFEMG) of extensor digitorum muscle in six healthy and five myasthenic subjects. Twenty single-fiber action potential (SFAP) pairs were recorded from e...
journal_title：Acta neurologica Scandinavica
pub_type： 杂志文章
doi：10.1034/j.1600-0404.2003.00120.x
更新日期：2003-10-01 00:00:00
abstract：:Over last fifty years, intravenous (iv) phenytoin (PHT) loading dose has been the treatment of choice for patients with benzodiazepine-resistant convulsive status epilepticus and several guidelines recommended this treatment regimen with simultaneous iv diazepam. Clinical studies have never shown a better efficacy of ...
journal_title：Acta neurologica Scandinavica
pub_type： 杂志文章,评审
doi：10.1111/ane.12928
更新日期：2018-06-01 00:00:00
abstract：:Single, small (less than 1 cm) enhancing lesions are frequent findings on CT scans of Indian patients with seizures. These lesions have also been reported in patients from other parts of the world. They often resolve spontaneously and their etiology has been disputed for over a decade. Initially diagnosed in Indian pa...
journal_title：Acta neurologica Scandinavica
pub_type： 杂志文章,评审
doi：10.1111/j.1600-0404.1991.tb04996.x
更新日期：1991-12-01 00:00:00
abstract：INTRODUCTION:Cerebrospinal fluid (CSF) may provide markers of severity and outcome of optic neuritis. MATERIAL AND METHODS:We examined the CSF from 29 patients with acute monosymptomatic optic neuritis (AMON) for content of myelin basic protein-like material (MBPLM) and correlated the levels with results of cranial ma...
journal_title：Acta neurologica Scandinavica
pub_type： 杂志文章
doi：10.1111/j.1600-0404.1996.tb07070.x
更新日期：1996-11-01 00:00:00
abstract：:The catabolism of orally and subcutaneously administered 14C histamine was studied in myotonic dystrophy patients. No definite abnormalities were observed as for subcutaneously administered histamine. The catabolism of orally administered histamine followed two distinct patterns: In patients with a relatively low endo...
journal_title：Acta neurologica Scandinavica
pub_type： 杂志文章
doi：10.1111/j.1600-0404.1977.tb01449.x
更新日期：1977-11-01 00:00:00
abstract：OBJECTIVE:Multiple sclerosis (MS), Parkinson's disease (PD) and stroke (ST) subjects show balance impairments due to damage of the balance control system. The objective of the study was to assess the impact of MS, PD and ST on upright posture in eyes open condition and when visual and/or proprioceptive inputs are alter...
journal_title：Acta neurologica Scandinavica
pub_type： 杂志文章
doi：10.1111/ane.12466
更新日期：2016-05-01 00:00:00
abstract：OBJECTIVE:To investigate whether the cardiac R-R interval variation (RRIV) is of value in differentiating patients with Parkinson's disease (PD) from multiple system atrophy (MSA). BACKGROUND:RRIV assessment is a simple procedure, reflecting mainly vagal efferent activity. Reduced RRIV was reported in MSA. METHODS:RR...
journal_title：Acta neurologica Scandinavica
pub_type： 杂志文章
doi：10.1111/j.1600-0404.2004.00226.x
更新日期：2004-04-01 00:00:00
abstract：:Sixteen patients with HTLV-1 associated myelopathy (HAM) were examined for the presence of HTLV-1 provirus genome by Southern blot analysis of genomic DNA from peripheral blood mononuclear (PBM) cells. Random integration of the provirus was detected in 14 of 16 HAM patients. By contrast, the provirus genome could not ...
journal_title：Acta neurologica Scandinavica
pub_type： 杂志文章
doi：10.1111/j.1600-0404.1990.tb00968.x
更新日期：1990-03-01 00:00:00
abstract：:A patient with paraneoplastic encephalomyelitis (PEM) and small cell lung cancer had a clinical presentation of acute polyneuritis. The patient had an antibody (anti-Hu) restricted to nuclei of neurons identical to that reported in patients with subacute sensory neuronopathy and lung cancer. This finding further suppo...
journal_title：Acta neurologica Scandinavica
pub_type： 杂志文章
doi：10.1111/j.1600-0404.1987.tb07928.x
更新日期：1987-04-01 00:00:00
abstract：BACKGROUND:Major neurological improvement (MNI) at 24 hours represents a marker of early recanalization in ischaemic stroke. Although low body temperature is considered neuroprotective in cerebral ischaemia, some studies have suggested that higher body temperature may promote clot lysis in the acute phase of ischaemic ...
journal_title：Acta neurologica Scandinavica
pub_type： 杂志文章
doi：10.1111/ane.12184
更新日期：2014-05-01 00:00:00
abstract：OBJECTIVES:The cost-effectiveness of available pharmacological treatments for narcolepsy is largely unknown. Available pharmacological treatments are associated with tolerability, abuse, and adherence issues. Pitolisant is the first inverse agonist of the histamine H3 receptor to be prescribed for the treatment of narc...
journal_title：Acta neurologica Scandinavica
pub_type： 杂志文章
doi：10.1111/ane.13202
更新日期：2020-04-01 00:00:00
abstract：:Alzheimer's disease (AD) is an irreversible and progressive neurodegenerative disorder. AD is the most common cause of dementia worldwide, and its incidence is increasing in line with population aging. The primary feature of AD is progressive cognitive decline, and severe AD is characterized by reduced communication s...
journal_title：Acta neurologica Scandinavica
pub_type： 杂志文章,评审
doi：10.1111/ane.12386
更新日期：2015-05-01 00:00:00
abstract：:We prospectively investigated 131 consecutive cases (both in- and outpatients) of suspected dementia to evaluate the relative frequency of different types of dementia in Chinese patients. Dementia was confirmed in 110 cases (84.0%). In contrast to the Western series, vascular dementia (39.1%) was slightly more frequen...
journal_title：Acta neurologica Scandinavica
pub_type： 杂志文章
doi：10.1111/j.1600-0404.1991.tb04981.x
更新日期：1991-11-01 00:00:00
abstract：:The effect of methylprednisolone (MP) on neurologic recovery and spinal cord blood flow (SCBF) was investigated up to 4 days after a spinal cord compression injury in rats. The injury was produced at midthoracic level by applying a load of 35 g on a 2.2 x 5.0 mm compression plate for 5 min, which resulted in transient...
journal_title：Acta neurologica Scandinavica
pub_type： 杂志文章
doi：10.1111/j.1600-0404.1990.tb01589.x
更新日期：1990-07-01 00:00:00
abstract：OBJECTIVE:Machado-Joseph disease (MJD)/spinocerebellar ataxia type 3 is an autosomal dominant spinocerebellar degeneration, for which there is no effective treatment. PATIENTS AND METHODS:This study involved the clinical response of lamotrigine (LTG) on six MJD patients with early truncal ataxia and the effect of LTG ...
journal_title：Acta neurologica Scandinavica
pub_type： 临床试验,杂志文章
doi：10.1111/j.1600-0404.2005.00405.x
更新日期：2005-06-01 00:00:00
abstract：OBJECTIVE:We wanted to describe the use of thrombolytic treatment for stroke in Scandinavia, to assess stroke doctors' opinions on this treatment, to identify barriers against treatment, and to suggest improvements to overcome these barriers. METHODS:We sent questionnaires to 493 Scandinavian doctors, who were involve...
journal_title：Acta neurologica Scandinavica
pub_type： 杂志文章
doi：10.1111/j.1600-0404.2009.01162.x
更新日期：2009-10-01 00:00:00
abstract：BACKGROUND:Presence of mild cognitive impairment (MCI) as a predictor for Parkinson's disease dementia (PDD) has been discussed from a clinical perspective. Recently, a Movement Disorder Society (MDS) commissioned Task Force published guidelines for PD-MCI. However, long-term follow-ups of the PD-MCI guidelines for the...
journal_title：Acta neurologica Scandinavica
pub_type： 杂志文章
doi：10.1111/ane.12375
更新日期：2015-08-01 00:00:00
abstract：:Thirty-eight demented patients were clinically investigated and classified into a multi-infarct dementia (MID) and senile dementia (SD) group. Total protein, albumin, immunoglobulin G, agar gel electrophoretic protein and iso-electric focusing pattern were determined in CSF and serum as well as the lactate dehydrogena...
journal_title：Acta neurologica Scandinavica
pub_type： 杂志文章
doi：10.1111/j.1600-0404.1981.tb04380.x
更新日期：1981-07-01 00:00:00
abstract：:Using the macrophage electrophoretic mobility (MEM) test, the in vitro effects of oleic, linoleic and arachidonic acid, as well as Naudicell oil and methyl gamma-linolenate, on lymphocyte response to various antigens (PPD, thyroid antigen and EF) were studied in patients with mutiple sclerosis, patients with other neu...
journal_title：Acta neurologica Scandinavica
pub_type： 杂志文章
doi：10.1111/j.1600-0404.1975.tb05766.x
更新日期：1975-08-01 00:00:00
abstract：:The ability to transcode integers from ideographic to alphabetic script was assessed in patients with dementia of Alzheimer type. Eleven of 13 consecutive patients made characteristic errors of intrusion. We propose that this may be a simple bedside test for dementia. ...
journal_title：Acta neurologica Scandinavica
pub_type： 杂志文章
doi：
更新日期：1990-02-01 00:00:00
abstract：:The main metabolites of the neurotransmitters noradrenaline, dopamine, and serotonin, methoxy-hydroxyphenylglycol (MHPG), homovanillic acid (HVA), and 5-hydroxyindoleacetic acid (5HIAA) respectively, were estimated by HPLC with electrochemical detection in CSF samples from 24 patients in coma after head injury, 1 to 1...
journal_title：Acta neurologica Scandinavica
pub_type： 杂志文章
doi：10.1111/j.1600-0404.1992.tb05064.x
更新日期：1992-08-01 00:00:00
abstract：:Genetic investigation of 74 patients with temporal lobe epilepsy, resistant to medication, who underwent unilateral temporal lobectomy 1960-1969. Thirty per cent had a positive family history of epilepsy; 49 per cent of other neurological diseases; and 46 per cent of major psychiatric disorders. Neither of the genetic...
journal_title：Acta neurologica Scandinavica
pub_type： 杂志文章
doi：10.1111/j.1600-0404.1975.tb05833.x
更新日期：1975-11-01 00:00:00
abstract：OBJECTIVE:The aim was to investigate risk factors separately and in sum in relation to long-term mortality after arterial cerebral infarction in young adults. MATERIALS AND METHODS:Mortality in relation to the number of risk factors (smoking, hypertension, hypercholesterolemia, diabetes mellitus, myocardial infarction...
journal_title：Acta neurologica Scandinavica
pub_type： 杂志文章
doi：10.1111/j.1600-0404.2012.01681.x
更新日期：2013-02-01 00:00:00
abstract：OBJECTIVE:To evaluate the epidemiological and clinical features of motor neuron disease (MND) in a region (835,000 inhabitants) of south-western Greece. PATIENTS AND METHODS:The medical records of all patients diagnosed with adult-onset MND at the Department of Neurology of the University Hospital of Patras from 1990 ...
journal_title：Acta neurologica Scandinavica
pub_type： 杂志文章
doi：10.1111/j.1600-0404.2004.00362.x
更新日期：2005-02-01 00:00:00
abstract：:The cerebrospinal fluid (CSF) findings of 16 patients with mycoplasma pneumoniae infections and different neurologic complications are presented. In acute meningitis there was predominantly a mononuclear cell reaction remitting in accordance with the improvement of the clinical symptoms. An early switch from IgM to Ig...
journal_title：Acta neurologica Scandinavica
pub_type： 杂志文章
doi：10.1111/j.1600-0404.1982.tb03107.x
更新日期：1982-05-01 00:00:00
abstract：:Treatment with intraventricular pentosan polysulphate (PPS) might be beneficial in patients with Creutzfeldt-Jakob disease. We report a 68-year-old woman with sporadic Creutzfeldt-Jakob disease who received continuous intraventricular PPS infusion (1-120 microg/kg/day) for 17 months starting 10 months after the onset ...
journal_title：Acta neurologica Scandinavica
pub_type： 杂志文章
doi：10.1111/j.1600-0404.2009.01272.x
更新日期：2010-02-01 00:00:00
abstract：OBJECTIVES:To investigate the association between tumor necrosis factor-alpha (TNF-alpha) G-308A, tumor necrosis factor-beta (TNF-beta) G+252A and interleukin-4 (IL-4) C-590T polymorphisms and susceptibility to multiple sclerosis (MS) development and clinical course of the disease. MATERIALS AND METHODS:Two hundred an...
journal_title：Acta neurologica Scandinavica
pub_type： 杂志文章
doi：10.1111/j.1600-0404.2006.00743.x
更新日期：2007-03-01 00:00:00
abstract：:This study concerns the distribution of T-cell subsets as determined by specific monoclonal antibodies in 50 individuals with complex partial seizures (31) and primary generalized tonic-clonic seizures (19), and in 30 healthy controls. The epileptic group had significantly fewer circulating T4 "helper" lymphocytes and...
journal_title：Acta neurologica Scandinavica
pub_type： 杂志文章
doi：10.1111/j.1600-0404.1985.tb00855.x
更新日期：1985-08-01 00:00:00
abstract：:We present a 47-year-old white woman who had a definitive diagnosis of systemic lupus erythematosus (SLE), and developed cerebellar ataxia of sudden onset. MR imaging showed changes characteristics of cerebellar infarct. Due to the absence of vascular risk factors and to the previous diagnosis of SLE, we postulate tha...
journal_title：Acta neurologica Scandinavica
pub_type： 杂志文章
doi：10.1111/j.1600-0404.1992.tb05111.x
更新日期：1992-10-01 00:00:00
abstract：OBJECTIVES:We used an electrical conditioning stimulation followed by transcranial magnetic stimulation (TMS) to facilitate the occurrence of long latency potentials (LLPs) in order to study the relationship between primary motor evoked potentials (MEPs) and LLPs in the lower limbs. MATERIALS AND METHODS:The study gro...
journal_title：Acta neurologica Scandinavica
pub_type： 杂志文章
doi：10.1111/j.1600-0404.1998.tb07323.x
更新日期：1998-12-01 00:00:00
