CSF neurotransmitter metabolites and short-term outcome of patients in coma after head injury.

Abstract:

:The main metabolites of the neurotransmitters noradrenaline, dopamine, and serotonin, methoxy-hydroxyphenylglycol (MHPG), homovanillic acid (HVA), and 5-hydroxyindoleacetic acid (5HIAA) respectively, were estimated by HPLC with electrochemical detection in CSF samples from 24 patients in coma after head injury, 1 to 12 (mean 3.0) days from accident, and from 24 age- and sex-matched subjects undergoing myelography for possible herniated disk. Analysis of variance with age as covariate, revealed significantly elevated levels of all three metabolites in the patients group. The concentrations of 5HIAA were negatively correlated to the score in the Glasgow Coma Scale. Fourteen patients who recovered with no or minor neurological deficits, had significantly lower CSF 5HIAA levels compared to the ten patients who had a bad outcome (death), while there were no differences regarding HVA or MHPG concentrations. The possibility of a connection of the high neurotransmitter turnover during coma to the development of post-traumatic depression is discussed.

journal_name

Acta Neurol Scand

authors

Markianos M,Seretis A,Kotsou S,Baltas I,Sacharogiannis H

doi

10.1111/j.1600-0404.1992.tb05064.x

subject

Has Abstract

pub_date

1992-08-01 00:00:00

pages

190-3

issue

2

eissn

0001-6314

issn

1600-0404

journal_volume

86

pub_type

杂志文章
  • Blood-brain barrier disturbance in patients with Alzheimer's disease is related to vascular factors.

    abstract::To investigate the blood-brain barrier (BBB function), serum and cerebrospinal fluid (CSF) from 118 patients with Alzheimer's disease (AD) and 50 healthy controls was analyzed with regard to albumin concentrations. For the AD group, clinical vascular factors were also recorded. The CSF/serum albumin ratio was used as ...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0404.1990.tb01563.x

    authors: Blennow K,Wallin A,Fredman P,Karlsson I,Gottfries CG,Svennerholm L

    更新日期:1990-04-01 00:00:00

  • Severe amphethamine-induced bruxism: treatment with botulinum toxin.

    abstract::While chewing and grinding movements have been observed in amphetamine addicts, recognition and management of this problem have rarely been highlighted. Botulinum toxin (BTX) has previously been demonstrated to be effective for bruxism associated with movement disorders, such as cranial-cervical dystonia. However, the...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1034/j.1600-0404.2003.02086.x

    authors: See SJ,Tan EK

    更新日期:2003-02-01 00:00:00

  • Prevalence and risk of thyroid diseases in myasthenia gravis.

    abstract:OBJECTIVES:To estimate the prevalence of thyroid diseases and the cumulative risk of thyroid diseases during a follow-up period after myasthenia gravis (MG) diagnosis compared with non-MG controls. MATERIALS AND METHODS:We used the Taiwan National Health Insurance Database linked to Registry of Catastrophic Illness da...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/ane.13254

    authors: Chou CC,Huang MH,Lan WC,Kong SS,Kuo CF,Chou IJ

    更新日期:2020-09-01 00:00:00

  • Outcome following occlusion of the middle cerebral artery.

    abstract::Outcome was studied prospectively in 28 consecutive patients with occlusion of the middle cerebral artery (MCA). They comprise a subgroup of 101 consecutive patients with TIA or stroke less than or equal to 75 years of age, admitted within 72 h after the stroke. Cerebral angiography and CT-scan were performed within 1...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0404.1991.tb04692.x

    authors: Olsen TS

    更新日期:1991-04-01 00:00:00

  • Algorithm for lamotrigine dose adjustment before, during, and after pregnancy.

    abstract:BACKGROUND:Treatment with lamotrigine (LTG) during pregnancy is associated with a pronounced risk of seizure deterioration, because pregnancy accelerates LTG elimination. The extent to which pregnancy affects LTG pharmacokinetics is unpredictable and varies considerably among patients. AIM:We propose an algorithm for ...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0404.2011.01627.x

    authors: Sabers A

    更新日期:2012-07-01 00:00:00

  • Capsular infarcts: location, size and etiology of pure motor hemiparesis, sensorimotor stroke and ataxic hemiparesis.

    abstract::We investigated the types of syndrome, location, size and presumed causes of 72 patients with acute capsular lacunar infarction. Clinical syndromes were classified into pure motor hemiparesis (PM), sensorimotor stroke (SM) and ataxic hemiparesis (AH). Lesion sizes of AH were significantly smaller than those of PM (p <...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0404.1993.tb04233.x

    authors: Tei H,Uchiyama S,Maruyama S

    更新日期:1993-10-01 00:00:00

  • Carotid artery stenting: Current state of evidence and future directions.

    abstract::Both carotid endarterectomy (CEA) and carotid artery stenting (CAS) are common treatments for carotid artery stenosis. Several randomized controlled trials (RCTs) have compared CEA to CAS in the treatment of carotid artery stenosis. These studies have suggested that CAS is more strongly associated with periprocedural ...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章,评审

    doi:10.1111/ane.13062

    authors: Lamanna A,Maingard J,Barras CD,Kok HK,Handelman G,Chandra RV,Thijs V,Brooks DM,Asadi H

    更新日期:2019-04-01 00:00:00

  • Neuropathy and impaired glucose tolerance: an updated review of the evidence.

    abstract::There has been considerable interest in the possible association between impaired glucose tolerance (IGT) and neuropathy. A systematic literature search (Medline) and review was here performed. Twenty-three studies were evaluated. Fourteen investigated for the presence of neuropathy in patients with IGT. Nine studied ...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章,评审

    doi:10.1111/j.1600-0404.2010.01425.x

    authors: Rajabally YA

    更新日期:2011-07-01 00:00:00

  • Long-term epidemiology of multiple sclerosis in the Northern Seville District.

    abstract:OBJECTIVES:Comprehensive epidemiologic data for multiple sclerosis (MS) in Spain are limited. The aim of this study was to collect epidemiologic data on MS in the Northern Seville District of Spain. MATERIALS AND METHODS:This longitudinal study identified possible MS cases every year from nine centres between 1 Januar...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章,多中心研究

    doi:10.1111/ane.12363

    authors: Izquierdo G,Venegas A,Sanabria C,Navarro G

    更新日期:2015-08-01 00:00:00

  • Perampanel, an AMPA receptor antagonist: From clinical research to practice in clinical settings.

    abstract::Epileptic seizures are refractory to treatment in approximately one-third of patients despite the recent introduction of many newer antiepileptic drugs (AEDs). Development of novel AEDs therefore remains a high priority. Perampanel is a first-in-class non-competitive selective AMPA receptor antagonist with a unique me...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章,评审

    doi:10.1111/ane.12879

    authors: Tsai JJ,Wu T,Leung H,Desudchit T,Tiamkao S,Lim KS,Dash A

    更新日期:2018-04-01 00:00:00

  • Acute disseminated encephalomyelitis following nephropathia epidemica.

    abstract::Acute disseminated encephalomyelitis (ADEM) is an acute monophasic inflammatory and demyelinating disease of the central nervous system (CNS) occurring days to weeks after a virus infection or vaccination. Nephropathia epidemica (NE) is a haemorrhagic fever with renal syndrome caused by Puumala virus, with endemic reg...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1034/j.1600-0404.2002.1c168.x

    authors: Toivanen AL,Valanne L,Tatlisumak T

    更新日期:2002-04-01 00:00:00

  • Parvalbumin-, calbindin-, and calretinin-immunoreactive hippocampal interneuron density in autism.

    abstract:BACKGROUND:There has been a long-standing interest in the possible role of the hippocampus in autism and both postmortem brain and neuroimaging studies have documented varying abnormalities in this limbic system structure. AIMS:This study investigates the density of subsets of hippocampal interneurons, immunostained w...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0404.2009.01234.x

    authors: Lawrence YA,Kemper TL,Bauman ML,Blatt GJ

    更新日期:2010-02-01 00:00:00

  • Is there progressive cognitive dysfunction in Sjögren Syndrome? A preliminary study.

    abstract:OBJECTIVE:The aim of this study was to determine the progression of cognitive dysfunction in primary Sjögren Syndrome (SS). METHODS:Twelve subjects with SS were compared with ten subjects with migraine and ten healthy controls on neuropsychological, mood and fatigue tests at baseline and 8 years later. RESULTS:At fol...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0404.2009.01293.x

    authors: Martínez S,Cáceres C,Mataró M,Escudero D,Latorre P,Dávalos A

    更新日期:2010-09-01 00:00:00

  • Outcome of resective surgery for intractable partial epilepsy guided by subdural electrode arrays.

    abstract::The aim of this paper was to evaluate the outcome and the factors predictive for a good prognosis of resective surgery for intractable partial epilepsy guided by subdural electrode arrays (SEA's) and operative electrocorticography. Sixty-four patients, aged 8-52 years, were evaluated with chronic SEAs in order to reco...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0404.1993.tb04131.x

    authors: Jennum P,Dhuna A,Davies K,Fiol M,Maxwell R

    更新日期:1993-06-01 00:00:00

  • Computerized cognition assessment during acetylcholinesterase inhibitor treatment in Alzheimer's disease.

    abstract:OBJECTIVES:Alzheimer's disease assessment scale-cognitive subscale (ADAS-Cog) has become a standard clinical trials outcome for cognition, but has been recognized as deficient in areas including coverage of cognitive domains, sensitivity and standardization. Computerized test batteries may address some of these issues....

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0404.2009.01309.x

    authors: Wesnes K,Edgar C,Andreasen N,Annas P,Basun H,Lannfelt L,Zetterberg H,Blennow K,Minthon L

    更新日期:2010-10-01 00:00:00

  • Clinical benefits of scalp EEG studies in intractable seizure disorders.

    abstract::Intractable seizure disorder is a clinical as well as a diagnostic problem. We evaluated the clinical role of extensive EEGs among patients (n = 64) considered to suffer from intractable paroxysmal neurologic symptoms. By reducing antiepileptic medication, ictal events were recorded in 89% of the cases. From the clini...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0404.1992.tb04024.x

    authors: Nousiainen U,Suomalainen T,Mervaala E

    更新日期:1992-03-01 00:00:00

  • Temporal lobe "plus" epilepsy associated with oligodendroglial hyperplasia (MOGHE).

    abstract:BACKGROUND:Mild malformation of cortical dysplasia (mMCD) with oligodendroglial hyperplasia (MOGHE) is an epilepsy-related pathologic entity highlighted in post-surgical specimens of frontal lobe epilepsy (FLE) patients. AIMS OF THE STUDY:We present two temporal lobe epilepsy (TLE) cases with MOGHE and discuss clinica...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/ane.13142

    authors: Garganis K,Kokkinos V,Zountsas B,Dinopoulos A,Coras R,Blümcke I

    更新日期:2019-10-01 00:00:00

  • Abnormalities of mitochondrial enzymes in hereditary ataxias.

    abstract::The activity of 7 mitochondrial enzymes, fumarase, NAD-malate dehydrogenase (MDH), citrate synthase (CS), valine dehydrogenase (VDH), succinate dehydrogenase (SDH), glutamate dehydrogenase (GDH), pyruvate dehydrogenase complex (PDHC) has been measured in platelet preparations from patients affected by Friedreich's ata...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0404.1989.tb03849.x

    authors: Sorbi S,Piacentini S,Fani C,Tonini S,Marini P,Amaducci L

    更新日期:1989-08-01 00:00:00

  • Vigabatrin-associated retinal damage: potential biochemical mechanisms.

    abstract::Vigabatrin (VGB), an irreversible inhibitor of gamma-aminobutyric acid (GABA) transaminase, is approved as adjunct treatment of refractory partial seizures as well as infantile spasms. Although VGB has been proven to be effective, its use is limited by the risk of retinopathy and associated peripheral visual field def...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章,评审

    doi:10.1111/j.1600-0404.2012.01684.x

    authors: Heim MK,Gidal BE

    更新日期:2012-10-01 00:00:00

  • Nasal spray desmopressin treatment of bladder dysfunction in patients with multiple sclerosis.

    abstract::Bladder dysfunction with increased voiding frequency and incontinence is a common problem in patients with multiple sclerosis (MS). In the present study, the effect of the synthetic vasopressin analogue, desmopressin, was evaluated on the voiding frequency in 26 patients with MS suffering from socially handicapping vo...

    journal_title:Acta neurologica Scandinavica

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/j.1600-0404.1996.tb00035.x

    authors: Fredrikson S

    更新日期:1996-07-01 00:00:00

  • A non-syndromic hearing loss caused by very low levels of the mtDNA A3243G mutation.

    abstract::We described a patient with progressive non-syndromic hearing loss (NSHL) harboring the A3243G mutation in the mitochondrial DNA (mtDNA). Muscle biopsy showed scattered ragged-red, cytochrome c oxidase negative fibers, whereas the biochemical analysis of the mitochondrial respiratory chain complexes was normal. Restri...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0404.2004.00254.x

    authors: Mancuso M,Filosto M,Forli F,Rocchi A,Berrettini S,Siciliano G,Murri L

    更新日期:2004-07-01 00:00:00

  • Determinants of post-stroke cognitive impairment: analysis from VISTA.

    abstract:BACKGROUND:Post-stroke cognitive impairment (PSCI) occurs commonly and is linked with development of dementia. We investigated the relationship between demographic, clinical and stroke symptoms at stroke onset and the presence of PSCI at 1 and 3 years after stroke. METHODS:We accessed anonymized data from the Virtual ...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/ane.12637

    authors: Arba F,Quinn T,Hankey GJ,Inzitari D,Ali M,Lees KR,VISTA Collaboration.

    更新日期:2017-06-01 00:00:00

  • Autosomal dominant cortical tremor, myoclonus and epilepsy: many syndromes, one phenotype.

    abstract::The association of cortical tremor, myoclonus and epileptic seizures has been reported in many Japanese and European families with different acronyms. We reviewed the familial cases presenting the clinical picture of autosomal dominant cortical tremor, myoclonus and epilepsy and analysed the phenotypic differences bet...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0404.2005.00385.x

    authors: Striano P,Zara F,Striano S

    更新日期:2005-04-01 00:00:00

  • Glial and neuronal alteration in the corpus striatum or fats with CCl4--induced liver disease. A quantitative morphological study using an electronic image analyzer.

    abstract::The density and size of astrocyte-, oligodendrocyte-and neurone nuclei in corpus striatum were determined in rats with CCl4-induced liver encephalopathy by means of an electronic image analyzer. After 8 weeks of CCl4-administration, the astrocyte number had nearly doubled, and astrocytes with increased nuclear size qp...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:

    authors: Diemer NH

    更新日期:1977-01-01 00:00:00

  • Dystrophin or a "related protein" in Duchenne muscular dystrophy?

    abstract::Previously we have shown low levels of dystrophin immunoreactivity in muscle from patients with DMD. According to the "frame-shift hypothesis" DMD muscle should not synthesize any dystrophin through to the C-terminus and it has been suggested that the protein detected is not dystrophin, but a related autosomal homolog...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0404.1992.tb08046.x

    authors: Nicholson LV,Johnson MA,Davison K,O'Donnell E,Falkous G,Barron M,Harris JB

    更新日期:1992-07-01 00:00:00

  • Azathioprine reduces intrathecal IgG synthesis in multiple sclerosis.

    abstract::Intrathecal IgG synthesis and CSF oligoclonal bands were reexamined after 18-24 months in 66 patients with multiple sclerosis; 40 of them received azathioprine (AZA) 2.5 mg/Kg/die; all received a course of dexamethasone (DEXA) during clinical relapses. The IgG Index was significantly reduced in the group treated with ...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0404.1987.tb07899.x

    authors: Caputo D,Zaffaroni M,Ghezzi A,Cazzullo CL

    更新日期:1987-02-01 00:00:00

  • FPL 57787 and migraine prophylaxis. A double-blind cross-over study.

    abstract::In a double-blind cross-over trial with placebo, FPL 57787, a chromone derivate, was tested on 15 patients as a prophylactic against migraine. There was found to be no effect. ...

    journal_title:Acta neurologica Scandinavica

    pub_type: 临床试验,杂志文章

    doi:10.1111/j.1600-0404.1979.tb02923.x

    authors: Koch-Henriksen N,Sehested P

    更新日期:1979-03-01 00:00:00

  • Ex vivo release of eicosanoids after aneurysmal subarachnoid hemorrhage: a preliminary experience in humans.

    abstract::Authors addressed the question whether the byosynthesis and the release of specific eicosanoids may occur in human brain cortex, and if the qualitative pattern of arachidonic acid metabolism is similar to that observed in experimental SAH. Human brain samples from 18 patients operated on for anterior communicating art...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0404.1992.tb05063.x

    authors: Gaetani P,Marzatico F,Rodriguez y Baena R

    更新日期:1992-08-01 00:00:00

  • B cell activation in multiple sclerosis.

    abstract::A microtechnique was established for the study of the limited numbers of cells available in CSF. The method allowed for the determination of the number of immunoglobulin-secreting cells (IgSC) as well as the quantitation of immunoglobulin or specific antibody secreted into the culture medium. Dose-response curves and ...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0404.1986.tb07866.x

    authors: Sandberg M,Levinson AI,Zweiman B,Lisak RP

    更新日期:1986-12-01 00:00:00

  • Coping strategies as related to medical and demographic data in amyotrophic lateral sclerosis.

    abstract:INTRODUCTION:The aim of this study was to examine the coping strategies of 49 patients with amyotrophic lateral sclerosis (ALS) and their relationships with medical and demographic data. METHODS:A total of 49 subjects were asked to fill out a document that would provide their demographic and medical data. Then, each o...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0404.2011.01513.x

    authors: Montel S,Albertini L,Spitz E

    更新日期:2012-02-01 00:00:00