Temporal lobe "plus" epilepsy associated with oligodendroglial hyperplasia (MOGHE).

Abstract:

BACKGROUND:Mild malformation of cortical dysplasia (mMCD) with oligodendroglial hyperplasia (MOGHE) is an epilepsy-related pathologic entity highlighted in post-surgical specimens of frontal lobe epilepsy (FLE) patients. AIMS OF THE STUDY:We present two temporal lobe epilepsy (TLE) cases with MOGHE and discuss clinical, neurophysiological, and neuroimaging features that may be indicative of surgical outcome. METHODS:We identified two cases with MOGHE out of 30 temporal lobe epilepsy (TLE) surgical patient cohort, whose pathological distribution spared the hippocampal structures. RESULTS:The TLE cases shared common features with the FLE series in terms of patient profiles, MRI findings and post-surgical outcome. TLE plus seizure semiology combined with extratemporal scalp electroencephalographic (EEG) and electrocorticographic (ECoG) epileptiform elements at a distance from the imaging lesion were suggestive of an underlying multifocal pathology. CONCLUSIONS:MOGHE pathology has to be considered in the decision-making process for TLE epilepsy surgery when this constellation of features is met.

journal_name

Acta Neurol Scand

authors

Garganis K,Kokkinos V,Zountsas B,Dinopoulos A,Coras R,Blümcke I

doi

10.1111/ane.13142

subject

Has Abstract

pub_date

2019-10-01 00:00:00

pages

296-300

issue

4

eissn

0001-6314

issn

1600-0404

journal_volume

140

pub_type

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