Decreased plasma alanine and isoleucine in Huntington's disease.

abstract：OBJECTIVES:Mutations in the p150 subunit of the axonal transport protein dynactin (DCTN1) have been reported in patients with amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Given the common features of neurodegeneration in multiple sclerosis (MS), FTD and ALS, sequence variants of the DCTN1 gene...

journal_title：Acta neurologica Scandinavica

authors： Münch C,Meyer R,Linke P,Meyer T,Ludolph AC,Haas J,Hemmer B

更新日期：2007-10-01 00:00:00

abstract：:Mitochondrial DNA (mtDNA) deletions have been noted in small quantities in a handful of atypical cases of myotonic dystrophy and there are clinical and pathological parallels between this autosomal dominant disease and certain mitochondrial myopathies where such deletions are well recognised. We studied 20 individuals...

journal_title：Acta neurologica Scandinavica

authors： Thyagarajan D,Byrne E,Noer S,Lertrit P,Utthanophol P,Kapsa R,Marzuki S

更新日期：1993-01-01 00:00:00

abstract：OBJECTIVES:We investigated the relationship between C-reactive protein (CRP)-values in the acute phase of stroke and the risk of further fatal and non-fatal ischemic events. MATERIALS AND METHODS:We analysed 462 consecutive incident ischemic strokes. Patients were divided into two subgroups on the basis of a CRP cut-o...

journal_title：Acta neurologica Scandinavica

authors： Corso G,Bottacchi E,Brusa A,Benedetto MD,Giardini G,Lia C,Reggiani M,Veronese Morosini M

更新日期：2010-09-01 00:00:00

abstract：:The effect of a new peripherally acting muscle relaxant drug Dantrium, on spasticity tested on 11 hemiplegic patients. The effect was evaluated both with regular clinical examination and with electromyographic technique. The latter concerned a quantitative analysis of the patients' voluntary control of fine neuromuscu...

journal_title：Acta neurologica Scandinavica

authors： Jonsson B,Ladd H,Afzelius-Frisk I,Lindberg-Broman AM

更新日期：1975-05-01 00:00:00

abstract：BACKGROUND:The epidemiology, diagnosis, and treatment of motor neuron disease (MND) in Chinese patients are ill known. METHODS:A registered study of 461 MND patients was conducted across 10 facilities in 7 Chinese cities from February 2009 to March 2010. RESULTS:Patients were classified as amyotrophic lateral scleros...

journal_title：Acta neurologica Scandinavica

authors： Cui F,Liu M,Chen Y,Huang X,Cui L,Fan D,Pu C,Lu J,Zhou D,Zhang C,Yan C,Li C,Ding X,Liu Y,Li X,Jiang Y,Zhang J,Shang H,Yao X,Ding Y,Niu Q,Wang L

更新日期：2014-08-01 00:00:00

abstract：:IgG and IgM concentrations in tears of multiple sclerosis patients (n = 38) are increased compared to normal controls (n = 23). The occurrence of oligoclonal tear IgG bands (7.9%)--as determined by immunoblotting--did not differ between groups. Our findings suggest an altered reactivity of the secretory immune system ...

journal_title：Acta neurologica Scandinavica

authors： Liedtke W,Weller M,Wiethölter H,Dichgans J

更新日期：1992-03-01 00:00:00

abstract：:By a rapid PCR-based method to assess the 8344 mtDNA mutation associated with MERRF disease, we have studied DNA from blood samples of 10 individuals belonging to a family spanning four generations in which one patient showed the complete MERRF phenotype, three other members were less severely affected, while the rema...

journal_title：Acta neurologica Scandinavica

authors： Piccolo G,Focher F,Verri A,Spadari S,Banfi P,Gerosa E,Mazzarello P

更新日期：1993-12-01 00:00:00

abstract：:Twenty-three consecutive patients with hemifacial spasm were studied. Magnetic resonance imaging angiography of the brain was performed in 20 patients and 15 controls. The angiograms were evaluated by two independent observers and blinded for side-location of the spasm. Contact between an artery from the vertebrobasil...

journal_title：Acta neurologica Scandinavica

authors： Jespersen JH,Dupont E,Gelineck J,Lundorf E

更新日期：1996-01-01 00:00:00

abstract：OBJECTIVES:The GM2 gangliosidoses are a group of genetic disorders caused by the accumulation of ganglioside GM2 in neuronal cells. We examined the alpha- and beta-subunits of beta-hexosaminidases by a non-radioisotopes detecting system to evaluate whether it was a useful method for understanding of the pathophysiologi...

journal_title：Acta neurologica Scandinavica

authors： Utsumi K,Tsuji A,Kase R,Tanaka A,Tanaka T,Uyama E,Ozawa T,Sakuraba H,Komaba Y,Kawabe M,Iino Y,Katayama Y

更新日期：2002-06-01 00:00:00

abstract：:3-methoxy-4-hydroxyphenylglycol (MHPG) and 5-hydroxyindoleacetic acid (5-HIAA) as well as homovanillic acid (HVA) and cyclic AMP were estimated in the morning urine of 41 drug-free parkinsonian patients and 25 hospitalized controls. In 29 patients, the estimations were repeated after 2 weeks treatment with L-dopa plus...

journal_title：Acta neurologica Scandinavica

authors： Markianos M,Hadjikonstantinou M,Bistolaki E

更新日期：1982-08-01 00:00:00

abstract：OBJECTIVES:Many studies have shown that nitric oxide (NO) and growth factors including insulin growth factors (IGFs) may be involved in the pathogenesis of multiple sclerosis (MS) and neurodegenerative diseases. Our previous studies suggested a relationship between cerebrospinal fluid (CSF) NO metabolites (nitrates and...

journal_title：Acta neurologica Scandinavica

authors： Pirttilä T,Vanhatalo S,Turpeinen U,Riikonen R

更新日期：2004-05-01 00:00:00

abstract：BACKGROUND:Mild malformation of cortical dysplasia (mMCD) with oligodendroglial hyperplasia (MOGHE) is an epilepsy-related pathologic entity highlighted in post-surgical specimens of frontal lobe epilepsy (FLE) patients. AIMS OF THE STUDY:We present two temporal lobe epilepsy (TLE) cases with MOGHE and discuss clinica...

journal_title：Acta neurologica Scandinavica

authors： Garganis K,Kokkinos V,Zountsas B,Dinopoulos A,Coras R,Blümcke I

更新日期：2019-10-01 00:00:00

abstract：:The aim of this paper was to evaluate the outcome and the factors predictive for a good prognosis of resective surgery for intractable partial epilepsy guided by subdural electrode arrays (SEA's) and operative electrocorticography. Sixty-four patients, aged 8-52 years, were evaluated with chronic SEAs in order to reco...

journal_title：Acta neurologica Scandinavica

authors： Jennum P,Dhuna A,Davies K,Fiol M,Maxwell R

更新日期：1993-06-01 00:00:00

abstract：:Peripheral blood lymphocytes from 23 out of 27 (85%) patients with multiple sclerosis responded to MS brain homogenates by increased formation of active E-rosettes. Lymphocytes from only six out of 78 (8%) patients with other neurological diseases responded to MS brain homogenates. The possible value of the test in th...

journal_title：Acta neurologica Scandinavica

authors： Offner H,Fog T,Rastogi SC,Konat G,Clausen J

更新日期：1979-03-01 00:00:00

abstract：OBJECTIVES:Multiple sclerosis (MS) patients suffer from high levels of anxiety. However, it is unclear which factors are related to anxiety, since study results are inconsistent, and the associated factors have not been examined comprehensively. In this study, we investigated the demographic, disease-related and psycho...

journal_title：Acta neurologica Scandinavica

authors： Wallis O,Bol Y,Köhler S,van Heugten C

更新日期：2020-03-01 00:00:00

abstract：OBJECTIVE:To prospectively detect significant transient F wave abnormalities obtained after exercise in patients with peripheral arterial disease (PAD) and to assess the potential diagnostic sensitivity of dynamic F wave study in such a context. PATIENTS AND METHODS:A series of 40 electrical stimuli were delivered to ...

journal_title：Acta neurologica Scandinavica

authors： Argyriou AA,Tsolakis I,Papadoulas S,Polychronopoulos P,Gourzis P,Chroni E

更新日期：2007-02-01 00:00:00

abstract：OBJECTIVES:Patients with Parkinson's disease (PD) and essential tremor (ET) have a higher risk of cognitive impairment than age-matched controls. Only a few small studies (11-18 subjects per group) have directly compared the cognitive profile of these conditions. Our aim was to compare the cognitive profile of patients...

journal_title：Acta neurologica Scandinavica

authors： Sánchez-Ferro Á,Benito-León J,Louis ED,Contador I,Hernández-Gallego J,Puertas-Martín V,Bermejo-Pareja F

更新日期：2017-11-01 00:00:00

abstract：OBJECTIVES:The LRRK2-G2019S mutation is the most common cause of Parkinson's disease (PD) in North Africa. G2019S-PD has been described as similar to idiopathic with minor clinical differences. The aim of this study was to determine the G2019S-related phenotype and to investigate gender and gene dosage effects on clini...

journal_title：Acta neurologica Scandinavica

authors： Ben Romdhan S,Farhat N,Nasri A,Lesage S,Hdiji O,Ben Djebara M,Landoulsi Z,Stevanin G,Brice A,Damak M,Gouider R,Mhiri C

更新日期：2018-11-01 00:00:00

abstract：:Brivaracetam (BRV) is a new antiseizure medication (ASM) that is currently approved for adjunctive treatment in patients with focal onset seizures. Similarly to levetiracetam (LEV), BRV works by binding SV2A vesicles with a high affinity and a linear pharmacokinetic profile. Retrospective studies and randomized clinic...

journal_title：Acta neurologica Scandinavica

authors： Verrotti A,Grasso EA,Cacciatore M,Matricardi S,Striano P

更新日期：2020-09-23 00:00:00

abstract：:Three patients with well-defined clinical and radiographic lesions have been studied with somatosensory evoked potentials (SSEPs). The data indicate that the primary scalp potentials from stimulation of both the arm and leg (N20 and P40) can be lost with thalamic lesions and would be consistent with these potentials b...

journal_title：Acta neurologica Scandinavica

authors： Fisher MA,Perlik SJ

更新日期：1985-01-01 00:00:00

abstract：:Genetic investigation of 74 patients with temporal lobe epilepsy, resistant to medication, who underwent unilateral temporal lobectomy 1960-1969. Thirty per cent had a positive family history of epilepsy; 49 per cent of other neurological diseases; and 46 per cent of major psychiatric disorders. Neither of the genetic...

journal_title：Acta neurologica Scandinavica

authors： Jensen I

更新日期：1975-11-01 00:00:00

abstract：:Alzheimer's disease (AD) and vascular dementia (VD) are the two most common causes of dementia. As yet, no definitive biological antemortem marker has been established for differential diagnosis of AD or VD. In this study, proteins of cerebrospinal fluid (CSF) from AD, VD and control patients were analyzed by two-dime...

journal_title：Acta neurologica Scandinavica

authors： Mattila KM,Pirttilä T,Blennow K,Wallin A,Viitanen M,Frey H

更新日期：1994-03-01 00:00:00

abstract：OBJECTIVE:Association of leuko-araiosis (LA) with certain risk factors has been reported in Western patients. This is a case-control study to determine the risk factors and the type of stroke associated with LA in Saudi patients. DESIGN AND SETTING:398 consecutive Saudi patients with the diagnosis of stroke admitted o...

journal_title：Acta neurologica Scandinavica

authors： Awada A,Omojola MF

更新日期：1996-12-01 00:00:00

abstract：:In order to characterize the CSF (cerebrospinal fluid) lymphocytes in CNS (central nervous system) inflammation, we examined paired samples of CSF and PB (peripheral blood) of 19 patients with acute aseptic meningitis, performing the dual labelling method on flow cytometry. Significantly higher percentages of CD3+ (T ...

journal_title：Acta neurologica Scandinavica

authors： Uchihara T,Ikeda M,Takahashi H,Yoshida S,Tsukagoshi H

更新日期：1990-05-01 00:00:00

abstract：OBJECTIVE:The reported sensitivity of transcranial Doppler ultrasonography (TCD) for confirming brain death (BD) ranges from 91% to 100%. We assessed the frequency and causes of false-negative results in TCD examination in a series of patients with BD and in the literature. METHODS:We carried out a prospective TCD exa...

journal_title：Acta neurologica Scandinavica

authors： de Freitas GR,André C

更新日期：2006-06-01 00:00:00

abstract：:This study investigated whether there are predictors for initial severity of ideomotor apraxia (IMA) in focal left-hemisphere vascular patients. One hundred and twenty-nine subjects were examined between 15 and 30 days post-onset. Twenty-five patients with bilateral lesions were also studied in order to delineate the ...

journal_title：Acta neurologica Scandinavica

authors： Basso A,Capitani E,Della Sala S,Laiacona M,Spinnler H

更新日期：1987-08-01 00:00:00

abstract：:Neuropsychiatric symptoms such as delusions and misidentifications have been reported in dementia ranging from 10% to 73% in Alzheimer's disease (AD) patients and up to 40% in multi-infarct dementia (MID) patients. The aim of this study was to investigate in 61 AD and 31 MID patients both the frequency and the content...

journal_title：Acta neurologica Scandinavica

authors： Binetti G,Bianchetti A,Padovani A,Lenzi G,De Leo D,Trabucchi M

更新日期：1993-07-01 00:00:00

abstract：OBJECTIVES:Oxidative stress and glutamate-mediated excitotoxicity may play an important role in the etiopathogenesis of amyotrophic lateral sclerosis (ALS). Prostaglandin E2 (PGE2) activity can be associated with motor neuron death by inducing free radical formation and glutamate release from astrocytes. The aim of thi...

journal_title：Acta neurologica Scandinavica

authors： Iłzecka J

更新日期：2003-08-01 00:00:00

abstract：OBJECTIVE:To describe spinal epidural abscess after treatment with rituximab. METHODS:Report of a new case of cervical epidural spinal abscess after treatment with rituximab and review of the literature. RESULTS:Biologic agents are associated with an increased risk of serious infections, there are only few reports of...

journal_title：Acta neurologica Scandinavica

authors： Avila JD,Živković S

更新日期：2016-05-01 00:00:00

abstract：BACKGROUND:There has been a long-standing interest in the possible role of the hippocampus in autism and both postmortem brain and neuroimaging studies have documented varying abnormalities in this limbic system structure. AIMS:This study investigates the density of subsets of hippocampal interneurons, immunostained w...

journal_title：Acta neurologica Scandinavica

authors： Lawrence YA,Kemper TL,Bauman ML,Blatt GJ

更新日期：2010-02-01 00:00:00