Altered blood-brain-barrier function in Alzheimer's disease?

Abstract:

:Alzheimer's disease (AD) and vascular dementia (VD) are the two most common causes of dementia. As yet, no definitive biological antemortem marker has been established for differential diagnosis of AD or VD. In this study, proteins of cerebrospinal fluid (CSF) from AD, VD and control patients were analyzed by two-dimensional (2-D) electrophoresis with immobilized pH gradients in the first dimension. No specific changes for AD or VD could be detected in the 2-D CSF patterns. However, a spot of haptoglobin alpha-1 chains (13.5 kDa; approximate pI 4.6) was found to be present in the majority of 2-D CSF maps from the dementia cases, suggesting a high-molecular-weight transudate type of alteration in the blood-brain barrier with considerable frequency in AD.

journal_name

Acta Neurol Scand

authors

Mattila KM,Pirttilä T,Blennow K,Wallin A,Viitanen M,Frey H

doi

10.1111/j.1600-0404.1994.tb01660.x

subject

Has Abstract

pub_date

1994-03-01 00:00:00

pages

192-8

issue

3

eissn

0001-6314

issn

1600-0404

journal_volume

89

pub_type

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