Abstract：
OBJECTIVE:Association of leuko-araiosis (LA) with certain risk factors has been reported in Western patients. This is a case-control study to determine the risk factors and the type of stroke associated with LA in Saudi patients. DESIGN AND SETTING:398 consecutive Saudi patients with the diagnosis of stroke admitted over a 6-year period were evaluated for presence or absence of LA on cranial computed tomography. LA and non-LA groups were compared with regards to the presence of certain risk factors such as type of stroke, age, brain atrophy, systemic hypertension and history of cardiac disease or diabetes mellitus. The odds ratio and its 95% confidence interval (CI) were used to estimate the strength of association between the different parameters. RESULTS:The mean age in the LA group was 67.8 +/- 8.5 years as compared to 61.2 +/- 13.2 years in the non-LA group. No patient younger than 40 years had LA on CT. Incidence of LA increased with age. Forty-seven percent of the LA group were over 70 years of age compared to 31% of the non-LA group (OR = 2, CI 1.26-3.15). Generalised atrophy was detected in 40% of patients with LA compared to 20% of non-LA group (OR 2.7, CI 1.65-4.39). Sixty-nine percent of patients in the LA group had lacunar infarct compare to 39% in the non-LA group (OR 3.4, CI 2.15-5.59). The difference was not significant between the two groups in relation to the frequency of cerebral hemorrhage or larger infarcts. Systemic hypertension was also significantly associated with the presence of LA (OR 2.15, CI 1.34-3.43). CONCLUSION:LA is associated mainly with lacunar infarcts, cerebral atrophy, systemic hypertension and advanced age in Saudi patients.
journal_name
Acta Neurol Scandjournal_title
Acta neurologica Scandinavicaauthors
Awada A,Omojola MFdoi
10.1111/j.1600-0404.1996.tb00054.xsubject
Has Abstractpub_date
1996-12-01 00:00:00pages
415-8issue
6eissn
0001-6314issn
1600-0404journal_volume
94pub_type
杂志文章abstract：OBJECTIVES:The aim of this study was to re-evaluate the clinical features of stroke in children, their outcome and the place of the different mechanisms, in the light of CT-scan and magnetic resonance imaging. METHODS:A 10-year review of the Dijon Childhood Neurology Clinic experience (1985-1995) identified 54 patient...
journal_title：Acta neurologica Scandinavica
pub_type： 杂志文章
doi：10.1111/j.1600-0404.1997.tb00306.x
更新日期：1997-12-01 00:00:00
abstract：:We studied a Becker muscular dystrophy (BMD) family with a manifesting carrier. Proximal muscle weakness, pseudohypertrophy of the calves, significantly elevated serum creatine kinase and dystrophic alterations in the muscle biopsy were the characteristic phenotypical features of this manifesting carrier. The recombin...
journal_title：Acta neurologica Scandinavica
pub_type： 杂志文章
doi：10.1111/j.1600-0404.1989.tb03821.x
更新日期：1989-06-01 00:00:00
abstract：BACKGROUND AND PURPOSE:The purpose of this study was to examine the effects of D-amphetamine (D-amph) and physical therapy separately or combined on fine motor performance, gross motor performance and cognition after middle cerebral artery thromboembolization in rats. METHODS:Seventy-four rats were trained in appropri...
journal_title：Acta neurologica Scandinavica
pub_type： 杂志文章
doi：10.1111/j.1600-0404.2005.00547.x
更新日期：2006-03-01 00:00:00
abstract：:The catabolism of orally and subcutaneously administered 14C histamine was studied in myotonic dystrophy patients. No definite abnormalities were observed as for subcutaneously administered histamine. The catabolism of orally administered histamine followed two distinct patterns: In patients with a relatively low endo...
journal_title：Acta neurologica Scandinavica
pub_type： 杂志文章
doi：10.1111/j.1600-0404.1977.tb01449.x
更新日期：1977-11-01 00:00:00
abstract：:Levodopa (LD) sales from wholesalers to pharmacies during the periods, 1977-1989 in Denmark, 1981-1989 in Greenland, and April 1988-May 1989 in Danish counties and the Faroe Islands, were evaluated using a reported method and a procedure expressly developed for assessment of random variation comparative levodopa use (...
journal_title：Acta neurologica Scandinavica
pub_type： 杂志文章
doi：10.1111/j.1600-0404.1995.tb00413.x
更新日期：1995-02-01 00:00:00
abstract：OBJECTIVE:To explore the relationship between motor subtypes and drooling, and other risk factors associated with drooling in a large cohort of Chinese patients with Parkinson's disease (PD). METHODS:A total of 586 PD patients were enrolled in this study. Unified Parkinson's disease rating scale (UPDRS) and Hoehn & Ya...
journal_title：Acta neurologica Scandinavica
pub_type： 杂志文章
doi：10.1111/ane.12893
更新日期：2018-05-01 00:00:00
abstract：OBJECTIVES:Strokes represent the most common etiology of epilepsy in patients over the age of 60 years, with an incidence of 2-4% occurring in different studies. MATERIALS AND METHODS:In this observational study, 1,428 patients were included who had stroke and were admitted to our Stroke Unit between the years 1996 an...
journal_title：Acta neurologica Scandinavica
pub_type： 杂志文章
doi：10.1111/j.1600-0404.2006.00642.x
更新日期：2006-07-01 00:00:00
abstract：OBJECTIVES:To examine the clinical characteristics of autoimmune encephalitis associated with the glutamate decarboxylase 65 (GAD 65) antibody. MATERIALS AND METHODS:Medical records of all patients that diagnosed with GAD 65 antibody-associated encephalitis were retrospectively analyzed. Data regarding demographics an...
journal_title：Acta neurologica Scandinavica
pub_type： 杂志文章
doi：10.1111/ane.13281
更新日期：2020-09-01 00:00:00
abstract：INTRODUCTION:Cognitive impairment is a common and disabling consequence of stroke. Its prevalence, the best way to screen for it in the acute setting, and its relation with premorbid status have not been thoroughly clarified. MATERIALS AND METHODS:Ischemic and hemorrhagic stroke patients admitted to our stroke unit un...
journal_title：Acta neurologica Scandinavica
pub_type： 杂志文章
doi：10.1111/ane.13319
更新日期：2020-10-01 00:00:00
abstract：OBJECTIVES:The objective was to investigate the incidence of multiple sclerosis (MS) as well as estimate the prevalence as of 1 January 2014 in the southeastern Norwegian county of Buskerud. MATERIALS AND METHODS:All patients with MS living in Buskerud county in Norway between 01 January 2003 and 01 January 2014 were ...
journal_title：Acta neurologica Scandinavica
pub_type： 杂志文章
doi：10.1111/ane.12615
更新日期：2017-04-01 00:00:00
abstract：OBJECTIVES:Botulinum neurotoxin (BoNT) injections in the salivary glands and radiotherapy (RT) on these glands are commonly used to alleviate severe drooling in patients with amyotrophic lateral sclerosis (ALS). This study compares BoNT type A with RT based on patient-rated evaluations. MATERIALS & METHODS:A prospecti...
journal_title：Acta neurologica Scandinavica
pub_type： 杂志文章,随机对照试验
doi：10.1111/ane.12559
更新日期：2016-09-01 00:00:00
abstract：:Electrophysiological examinations were done on 20 patients aged 40-71 years with recently diagnosed high grade non-Hodgkin's lymphomas. General chemotherapy and intrathecal chemotherapy in order to prevent central nervous system (CNS) involvement were begun. On the first day of chemotherapeutic cycle patients received...
journal_title：Acta neurologica Scandinavica
pub_type： 杂志文章
doi：10.1111/j.1600-0404.1996.tb07065.x
更新日期：1996-10-01 00:00:00
abstract：BACKGROUND:Subcutaneous immunoglobulin (SCIG) is effective treatment of chronic inflammatory demyelinating polyneuropathy (CIDP). Quality of life (QoL) increases following switch from intravenous administration to SCIG, but its correlation with clinical functioning is sparsely studied. AIMS OF THE STUDY:The aim of thi...
journal_title：Acta neurologica Scandinavica
pub_type： 杂志文章
doi：10.1111/ane.13322
更新日期：2020-12-01 00:00:00
abstract：OBJECTIVE:For patients with medication refractory medial temporal lobe epilepsy (MTLE), surgery offers the hope of a cure. However, up to 30% of patients with MTLE continue to experience disabling seizures after surgery. The reasons why some patients do not achieve seizure freedom are poorly understood. A promising the...
journal_title：Acta neurologica Scandinavica
pub_type： 杂志文章
doi：10.1111/ane.12253
更新日期：2014-08-01 00:00:00
abstract：OBJECTIVES:Health-related quality of life (HRQL) has become an important outcome criterion of medical interventions, but was hardly studied in patients with facial spasms. MATERIALS AND METHODS:Patients with blepharospasm or hemifacial spasm treated with botulinum toxin were included. A healthy control group sociodemo...
journal_title：Acta neurologica Scandinavica
pub_type： 杂志文章
doi：10.1111/j.1600-0404.2004.00357.x
更新日期：2005-01-01 00:00:00
abstract：:This study investigated whether there are predictors for initial severity of ideomotor apraxia (IMA) in focal left-hemisphere vascular patients. One hundred and twenty-nine subjects were examined between 15 and 30 days post-onset. Twenty-five patients with bilateral lesions were also studied in order to delineate the ...
journal_title：Acta neurologica Scandinavica
pub_type： 杂志文章
doi：10.1111/j.1600-0404.1987.tb03557.x
更新日期：1987-08-01 00:00:00
abstract：:The influence of clonazepam on steady-state serum levels of diphenylhydantoin, phenobarbital and carbamazepine was studied in 22 patients with epilepsy receiving one or two of these drugs. Clonazepam was given in slowly increasing doses for 2 weeks until a maximum dose of 4-6 mg per day was reached; thereafter the dos...
journal_title：Acta neurologica Scandinavica
pub_type： 杂志文章
doi：10.1111/j.1600-0404.1977.tb07629.x
更新日期：1977-06-01 00:00:00
abstract：:We studied clinically and electrophysiologically 8 patients affected by orthostatic tremor (OT), which is an unusual movement disorder consisting of shaking movements of the legs and trunk in the standing position. We failed to find any cause in 6 of the 8 cases. In 2 patients OT was clearly secondary to neurologic di...
journal_title：Acta neurologica Scandinavica
pub_type： 杂志文章
doi：10.1111/j.1600-0404.1990.tb00944.x
更新日期：1990-02-01 00:00:00
abstract：OBJECTIVES:A highly adaptive aspect of human memory is the enhancement of explicit, consciously accessible memory by emotional stimuli. We studied the performance of Alzheimer's disease (AD) patients and elderly controls using a memory battery with emotional content, and we correlated these results with the amygdala an...
journal_title：Acta neurologica Scandinavica
pub_type： 杂志文章
doi：10.1111/j.1600-0404.2008.01132.x
更新日期：2009-08-01 00:00:00
abstract：OBJECTIVE:To evaluate the efficacy and tolerability of the treatment with valproic acid (VPA) in patients with status epilepticus (SE) or acute repetitive seizures (ARS) comparing it with phenytoin (PHT) treatment. MATERIALS AND METHODS:Patients with SE or ARS were treated in a consecutive manner with either VPA or PH...
journal_title：Acta neurologica Scandinavica
pub_type： 临床试验,杂志文章
doi：10.1111/j.1600-0404.2008.01097.x
更新日期：2008-11-01 00:00:00
abstract：OBJECTIVES:We aimed to study knee proprioception and somatosensory evoked potentials (SEPs) to stimulation of the common peroneal nerve (CPN) in 7 patients with lesion of the anterior cruciate ligament (ACL) before and after ACL reconstruction. MATERIALS AND METHODS:We recorded the spinal N14 and scalp P27 potentials ...
journal_title：Acta neurologica Scandinavica
pub_type： 杂志文章
doi：10.1111/j.1600-0404.1999.tb00680.x
更新日期：1999-05-01 00:00:00
abstract：:Carotid stenoses of ≥50% account for about 15-20% of strokes. Their degree may be moderate (50-69%) or severe (70-99%). Current diagnostic methods include ultrasound, MR- or CT-angiography. Stenosis severity, irregular plaque surface, and presence of microembolic signals detected by transcranial Doppler predict the ea...
journal_title：Acta neurologica Scandinavica
pub_type： 杂志文章,评审
doi：10.1111/j.1600-0404.2012.01672.x
更新日期：2012-11-01 00:00:00
abstract：:Bulbar dysfunction resulting from corticobulbar pathway or brainstem neuron degeneration is one of the most important clinical problems encountered in motor neuron disease (MND) and contributes to various respiratory complications which are major causes of morbidity and mortality. Chronic malnutrition as a consequence...
journal_title：Acta neurologica Scandinavica
pub_type： 杂志文章,评审
doi：
更新日期：2001-04-01 00:00:00
abstract：OBJECTIVES:To study if type-2 (non-insulin-dependent) diabetes mellitus (NIDDM) is associated with cognitive dysfunction independently of clinically diagnosed dementia in an elderly population. MATERIAL AND METHODS:Cognitive function was investigated with a brief neuropsychological test battery in a non-demented elder...
journal_title：Acta neurologica Scandinavica
pub_type： 杂志文章
doi：10.1111/j.1600-0404.1999.tb01045.x
更新日期：1999-08-01 00:00:00
abstract：OBJECTIVES:We examined whether the apolipoprotein E (ApoE) allele epsilon4 influences imaging findings in stroke as assessed by diffusion- (DWI) and perfusion-weighted (PWI) magnetic resonance imaging, and MR angiography (MRA). METHODS:Eight ApoE epsilon4 carriers and 15 non-carriers with acute ischemic stroke in the ...
journal_title：Acta neurologica Scandinavica
pub_type： 杂志文章
doi：10.1111/j.1600-0404.2006.00654.x
更新日期：2006-11-01 00:00:00
abstract：OBJECTIVES:To analyze the correlation between blood pressure (BP) variability and leukoaraiosis (LA) amount in patients with symptomatic cerebral small-vessel disease. MATERIALS AND METHODS:We included 25 hypertensive patients: 13 with Binswanger's disease (BD) and 12 with a first-ever lacunar infarction (LI). Baselin...
journal_title：Acta neurologica Scandinavica
pub_type： 杂志文章
doi：10.1034/j.1600-0404.2001.00082.x
更新日期：2001-12-01 00:00:00
abstract：OBJECTIVES:To investigate acute effects of intra-amygdalar excitatory amino acid administration on blood flow, relaxation time and apparent diffusion coefficient in rat brain. MATERIALS AND METHODS:Several days after MR-compatible cannula placement in right basolateral amygdala, anesthetized rats were imaged at 7 T. R...
journal_title：Acta neurologica Scandinavica
pub_type： 杂志文章
doi：10.1111/j.1600-0404.2009.01188.x
更新日期：2010-03-01 00:00:00
abstract：:The frequency of post-lumbar puncture headache (PLPH) was registered prospectively in 395 consecutive demented patients at a dementia diagnostic unit. The incidence of PLPH was low, occurring in only 8 patients (2.0%), the severity was mild, and the duration was less than 2 days in all cases but one. The reasons for t...
journal_title：Acta neurologica Scandinavica
pub_type： 杂志文章
doi：10.1111/j.1600-0404.1993.tb04221.x
更新日期：1993-09-01 00:00:00
abstract：BACKGROUND AND PURPOSE:Pain is common in post-stroke patients and has been shown to be associated with depression, fatigue, and decreased quality of life (QOL). However, studies examining different types of post-stroke pain are scarce. We investigated differences in the related factors and their QOL impacts between mus...
journal_title：Acta neurologica Scandinavica
pub_type： 杂志文章
doi：10.1111/ane.12617
更新日期：2017-04-01 00:00:00
abstract：OBJECTIVES:We aimed to investigate associations between neuropsychological indices and normalized volumes of supratentorial structures, and the area of the corpus callosum. MATERIALS AND METHODS:We studied 40 patients with clinically definite MS, using 3D-acquired MRI (MPRAGE, Magnetization Prepared Rapid Acquisition ...
journal_title：Acta neurologica Scandinavica
pub_type： 杂志文章
doi：10.1034/j.1600-0404.2001.00270.x
更新日期：2001-10-01 00:00:00
