Abstract：
:Multiple sclerosis (MS) is associated with autoimmune disorders (AIDs) in individual patients, and limited data suggest a possible familial association of MS and AIDs; however, no systematic study has been conducted on the occurrence of AIDs in the families of MS patients. Using a standardized interview focused on AIDs, we obtained the family histories of 357 consecutive patients from our MS clinic. Adequate information was obtained on 1971 first-degree relatives. Fifty-five patients (15.4%) had first-degree relatives with MS (n=22, 6.2%) another AID (n = 30, 8.4%), or both (n = 3, 0.8%). In 16 families (4.5%), at least 3 first-degree relatives had MS or another AID. MS, Grave's disease, rheumatoid arthritis, vitiligo, type 1 insulin-dependent diabetes mellitus, and uveitis, were the most common AIDs in these families. Such multiplex families (families with MS plus AID) are appropriate for identifying susceptibility genes that may be common to MS and other AIDs.
journal_name
Acta Neurol Scandjournal_title
Acta neurologica Scandinavicaauthors
Heinzlef O,Alamowitch S,Sazdovitch V,Chillet P,Joutel A,Tournier-Lasserve E,Roullet Edoi
10.1034/j.1600-0404.2000.101001036.xsubject
Has Abstractpub_date
2000-01-01 00:00:00pages
36-40issue
1eissn
0001-6314issn
1600-0404journal_volume
101pub_type
杂志文章abstract：:With the macrophage electrophoretic mobility (MEM) test of Field & Caspary, lymphocyte sensitization to thyroid antigen (F1-fraction) is demonstrable in all subjects--multiple sclerosis (MS) patients, those with other (destructive) neurological diseases (OND) and normals. The MEM-LAD test enables a further differentia...
journal_title：Acta neurologica Scandinavica
pub_type： 杂志文章
doi：10.1111/j.1600-0404.1976.tb04324.x
更新日期：1976-01-01 00:00:00
abstract：:One cause of ischemic brain injury is free radical formation during recirculation. Allopurinol inhibits xanthine oxidase, an important source of free oxygen radicals. It is known that allopurinol pre-treatment has a protective action during cerebral ischemia. In the present study we exposed slices from the rat hippoca...
journal_title：Acta neurologica Scandinavica
pub_type： 杂志文章
doi：10.1111/j.1600-0404.1991.tb04702.x
更新日期：1991-05-01 00:00:00
abstract：:EEG data obtained from 27 patients with presenile Alzheimer's disease (AD) and 28 patients with senile dementia of the Alzheimer type (SDAT) were compared with data from 30 age- and sex-matched controls. Both patient groups exhibited more pronounced delta and theta activity and less prominent alpha and beta activity t...
journal_title：Acta neurologica Scandinavica
pub_type： 杂志文章
doi：
更新日期：1994-01-01 00:00:00
abstract：:The death rate from Parkinson's disease (PD) were analyzed using Japanese vital statistics for 1950-1992. The age-adjusted PD death rate increased statistically significantly with the years between 1950 and 1992 for both sexes. However, decline in the PD death rate were observed among the population under 65 years old...
journal_title：Acta neurologica Scandinavica
pub_type： 杂志文章
doi：10.1111/j.1600-0404.1995.tb00428.x
更新日期：1995-03-01 00:00:00
abstract：:The urinary excretion of uronic acid and the electrophoretic composition of urinary glucosaminoglycans were studied in 10 members of a family, of which 3 had progressive familial myoclonus epilepsy. This seems to be the first detailed investigation of the excretion of urinary glucosaminoglycans in patients suffering f...
journal_title：Acta neurologica Scandinavica
pub_type： 杂志文章
doi：10.1111/j.1600-0404.1975.tb05776.x
更新日期：1975-09-01 00:00:00
abstract：OBJECTIVES:The aim of this study was to re-evaluate the clinical features of stroke in children, their outcome and the place of the different mechanisms, in the light of CT-scan and magnetic resonance imaging. METHODS:A 10-year review of the Dijon Childhood Neurology Clinic experience (1985-1995) identified 54 patient...
journal_title：Acta neurologica Scandinavica
pub_type： 杂志文章
doi：10.1111/j.1600-0404.1997.tb00306.x
更新日期：1997-12-01 00:00:00
abstract：:Neurotropin was found to reduce brain oedema in an experimental model of brain infarction in the guinea-pig. A randomized double-blind controlled trial with Neurotropin was performed in 220 patients admitted within 24 h after an acute ischemic stroke. 35 of the neurotropin and 41 of the placebo-randomized patients had...
journal_title：Acta neurologica Scandinavica
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1111/j.1600-0404.1994.tb02643.x
更新日期：1994-05-01 00:00:00
abstract：:Soleus H-reflexes during tonic contractions and isometric ramp contractions of the ankle extensors in spastic and healthy subjects were measured. During the tonic contractions, the H-reflex increased with the contraction level. The increase was highest in the patients (p < 0.001). The facilitation of the H-reflex duri...
journal_title：Acta neurologica Scandinavica
pub_type： 杂志文章
doi：10.1111/j.1600-0404.1993.tb05352.x
更新日期：1993-11-01 00:00:00
abstract：:We present a 47-year-old white woman who had a definitive diagnosis of systemic lupus erythematosus (SLE), and developed cerebellar ataxia of sudden onset. MR imaging showed changes characteristics of cerebellar infarct. Due to the absence of vascular risk factors and to the previous diagnosis of SLE, we postulate tha...
journal_title：Acta neurologica Scandinavica
pub_type： 杂志文章
doi：10.1111/j.1600-0404.1992.tb05111.x
更新日期：1992-10-01 00:00:00
abstract：OBJECTIVE:There is a paucity of regional cerebral blood flow studies in Japanese encephalitis (JE). In this communication we report clinical, radiological and single photon emission computed tomography findings in subacute and chronic JE patients. MATERIAL AND METHODS:Eight JE patients whose ages ranged between 10 and...
journal_title：Acta neurologica Scandinavica
pub_type： 杂志文章
doi：10.1111/j.1600-0404.1999.tb07349.x
更新日期：1999-04-01 00:00:00
abstract：OBJECTIVES:Evaluate interim long-term tolerability, safety and efficacy of adjunctive perampanel, a novel α-amino-3-hydroxy-5-methyl-5-isoxazolepropionic acid (AMPA)-receptor antagonist, in patients with refractory partial-onset seizures. MATERIALS AND METHODS:Study 207, an open-label extension (OLE) study (ClinicalTr...
journal_title：Acta neurologica Scandinavica
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1111/ane.12001
更新日期：2012-10-01 00:00:00
abstract：:Demented patients with Alzheimer's disease (AD) (n = 67), multi-infarct dementia (MID) (n = 77) and probable vascular dementia (PVD) (n = 45) were studied with electroencephalography (EEG). All patients underwent a routine EEG examination and quantitative EEG was recorded from 14 patients with AD, 20 with MID, and 12 ...
journal_title：Acta neurologica Scandinavica
pub_type： 杂志文章
doi：10.1111/j.1600-0404.1988.tb06971.x
更新日期：1988-01-01 00:00:00
abstract：OBJECTIVES:The well-being and physical function among patients with ALS and their next of kin was studied over time. MATERIALS AND METHODS:Thirty-five patients with ALS and their next of kin were studied with respect to physical, general and psychological well-being by the visual analogue scale (VAS) every 4-6 months....
journal_title：Acta neurologica Scandinavica
pub_type： 杂志文章
doi：10.1111/j.1600-0404.2009.01191.x
更新日期：2010-04-01 00:00:00
abstract：OBJECTIVES:To study the prevalence of antibodies of IgA class against tissue transglutaminase (tTG), endomysium (EMA) and gliadin (AGA) in patients with chronic idiopathic axonal polyneuropathy (CIAP) and to characterize the patients clinically and neurophysiologically. METHODS:Of 182 patients, 126 patients agreed to ...
journal_title：Acta neurologica Scandinavica
pub_type： 杂志文章
doi：10.1111/j.1600-0404.2012.01687.x
更新日期：2013-02-01 00:00:00
abstract：:A 23-year-old patient suffering from mental deterioration was referred for CT study following her first epileptic fit. The study disclosed generalized atrophy and diffuse symmetric white matter hypodensities. Similar findings were found in her 13-year-old retarded sister. The diagnosis of metachromatic leukodystrophy ...
journal_title：Acta neurologica Scandinavica
pub_type： 杂志文章
doi：10.1111/j.1600-0404.1987.tb07891.x
更新日期：1987-01-01 00:00:00
abstract：OBJECTIVES:We investigated whether mutation of mitochondrial DNA (mtDNA) affects the copy number of the mitochondrial genome in patients with mitochondrial myopathy encephalopathy with lactic acidosis and stroke-like episodes (MELAS) and those with myoclonic epilepsy with ragged-red fiber (MERRF) syndromes. MATERIALS ...
journal_title：Acta neurologica Scandinavica
pub_type： 杂志文章
doi：10.1111/j.1600-0404.2006.00586.x
更新日期：2006-05-01 00:00:00
abstract：OBJECTIVES:In this study the frequency of inherited thrombophilic risk factors in a population of German CVT patients and their influence on clinical outcome were evaluated. MATERIAL AND METHODS:Twenty-five patients (age 37.1 +/- 16.3 years) with CVT were screened for inherited coagulation disorders. All participants ...
journal_title：Acta neurologica Scandinavica
pub_type： 杂志文章
doi：10.1034/j.1600-0404.2000.102001031.x
更新日期：2000-07-01 00:00:00
abstract：:Reports on the incidence of alcoholic polyneuropathies are variable depending on diagnostic tools. In this study, 50 chronic alcoholics with positive MALT (Munich Alcoholism Test) and greater than seven years history of excessive alcohol abuse were examined neurologically. Tibial and peroneal motor and sural nerve con...
journal_title：Acta neurologica Scandinavica
pub_type： 杂志文章
doi：10.1111/j.1600-0404.1995.tb07026.x
更新日期：1995-05-01 00:00:00
abstract：OBJECTIVES:Although leukoaraosis (LA) is a common CT findings, its pathogenesis remains debated: if small-artery pathology may explain in some cases white matter changes, many other factors, such as hemodynamic perturbations, might also lead to LA. To test these hypothesis, we determined the types of cerebrovascular ri...
journal_title：Acta neurologica Scandinavica
pub_type： 杂志文章
doi：10.1111/j.1600-0404.1996.tb07044.x
更新日期：1996-08-01 00:00:00
abstract：:A patient with paraneoplastic encephalomyelitis (PEM) and small cell lung cancer had a clinical presentation of acute polyneuritis. The patient had an antibody (anti-Hu) restricted to nuclei of neurons identical to that reported in patients with subacute sensory neuronopathy and lung cancer. This finding further suppo...
journal_title：Acta neurologica Scandinavica
pub_type： 杂志文章
doi：10.1111/j.1600-0404.1987.tb07928.x
更新日期：1987-04-01 00:00:00
abstract：OBJECTIVE:To describe clinical features of a patient with secretions of atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) during an epileptic attack. PATIENT:A 65-year-old woman experienced frequent bouts of polyuria, pyrexia and general fatigue after several years of a cerebral contusion involving ...
journal_title：Acta neurologica Scandinavica
pub_type： 杂志文章
doi：10.1034/j.1600-0404.2002.01228.x
更新日期：2002-10-01 00:00:00
abstract：OBJECTIVES:The goal of this study was to evaluate the incidence of urological malignancies in MS patients using active screening. MATERIAL AND METHODS:A total of 495 MS patients (141 men, 354 women, age of 42±13.4) were included in the study. The duration of disease was 12.3±11 years, and the EDSS score was 4.3 (±2.5)...
journal_title：Acta neurologica Scandinavica
pub_type： 杂志文章
doi：10.1111/ane.12264
更新日期：2014-09-01 00:00:00
abstract：:Isoelectric focusing and agarose gel electrophoresis of CSF and serum revealed similar frequencies of oligoclonal bands in multiple sclerosis (100% with both methods), infectious CNS disorders (38 and 23%) and other neurological diseases (8 and 10%). In selected cases with unsure CSF oligoclonal bands on agarose gel e...
journal_title：Acta neurologica Scandinavica
pub_type： 杂志文章
doi：10.1111/j.1600-0404.1978.tb02874.x
更新日期：1978-09-01 00:00:00
abstract：OBJECTIVES:Differential diagnosis between vascular parkinsonism (VP) and Parkinson's Disease (PD) is often difficult, due to the overlap in clinical presentation and the lack of specificity at neuroimaging. Aim of the study was to identify a possible reliable marker at SPECT imaging useful to distinguish the two condit...
journal_title：Acta neurologica Scandinavica
pub_type： 杂志文章
doi：10.1111/j.1600-0404.2011.01583.x
更新日期：2012-07-01 00:00:00
abstract：OBJECTIVES:To explore adherence, persistence, and treatment patterns in patients with multiple sclerosis (MS) in Finland treated with disease-modifying therapies (DMTs) for active MS in 2005-2018. MATERIALS AND METHODS:The study cohort was identified using the Drug Prescription Register of Social Insurance Institute, ...
journal_title：Acta neurologica Scandinavica
pub_type： 杂志文章
doi：10.1111/ane.13301
更新日期：2020-12-01 00:00:00
abstract：BACKGROUND AND PURPOSE:The role of the natural anticoagulants, antithrombin III (AT III), protein C (PC), and protein S (PS), in patients with mild to moderate ischemic stroke remains uncertain. We aimed to find out whether their levels in peripheral blood correlated with the severity of neurological deficit or can pre...
journal_title：Acta neurologica Scandinavica
pub_type： 杂志文章
doi：10.1034/j.1600-0404.2002.1o112.x
更新日期：2002-02-01 00:00:00
abstract：BACKGROUND:The Danish National Patient Register, Landspatientregistret (LPR), is a register of all hospital discharges and outpatient treatments in Denmark. AIMS:It is increasingly used in research so it is important to understand to what extent this can be used as an accurate source of information. Virtually all pati...
journal_title：Acta neurologica Scandinavica
pub_type： 杂志文章
doi：10.1111/j.1600-0404.2011.01558.x
更新日期：2012-03-01 00:00:00
abstract：:In an attempt to establish the efficacy of the different diagnostic tests, 41 multiple sclerosis (MS) patients at different stages of the disease were studied by means of visual evoked potential (VEP) recording, T-lymphocyte subset determination cerebrospinal fluid (CSF) analysis and magnetic resonance (MR) imaging. M...
journal_title：Acta neurologica Scandinavica
pub_type： 杂志文章
doi：10.1111/j.1600-0404.1989.tb03900.x
更新日期：1989-11-01 00:00:00
abstract：:Forty-eight patients with a clinical diagnosis of Alzheimer's disease, 30 patients with cerebrovascular dementia, and 48 normal controls were assessed with a battery of neuropsychological tests designed to measure the following cognitive processes: orientation to time and place, memory, visual-perceptual and construct...
journal_title：Acta neurologica Scandinavica
pub_type： 杂志文章,评审
doi：10.1111/j.1600-0404.1993.tb05512.x
更新日期：1993-04-01 00:00:00
abstract：:The possibility of disturbed dopamine and serotonin metabolism in senile dementia of Alzheimer type was studied. The basal concentrations of homovanillic acid (HVA) and 5-hydroxyindoleacetic acid (5-HIAA) in cerebrospinal fluid (CSF) were studied in 28 patients with senile dementia of Alzheimer type and in 13 controls...
journal_title：Acta neurologica Scandinavica
pub_type： 杂志文章
doi：10.1111/j.1600-0404.1981.tb04392.x
更新日期：1981-08-01 00:00:00
