Failure of allopurinol to protect against cerebral injury when given after the start of hypoxia.

Abstract:

:One cause of ischemic brain injury is free radical formation during recirculation. Allopurinol inhibits xanthine oxidase, an important source of free oxygen radicals. It is known that allopurinol pre-treatment has a protective action during cerebral ischemia. In the present study we exposed slices from the rat hippocampus to 9 minutes of hypoxia to test whether it is sufficient that allopurinol is present in the tissue at the time of reoxygenation. Forty-six slices loaded with allopurinol (10(-5) M) prior to reoxygenation (during hypoxia) were compared to 34 control slices. The response of the pyramidal cell population to orthodromic stimulation was reduced in both groups and there was not a significant difference between the two groups.

journal_name

Acta Neurol Scand

authors

Hegstad E,Berg-Johnsen J,Langmoen IA

doi

10.1111/j.1600-0404.1991.tb04702.x

subject

Has Abstract

pub_date

1991-05-01 00:00:00

pages

286-8

issue

5

eissn

0001-6314

issn

1600-0404

journal_volume

83

pub_type

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