Evaluating the use and limitations of the Danish National Patient Register in register-based research using an example of multiple sclerosis.

abstract：OBJECTIVES:A confident and accurate diagnosis of multiple sclerosis (MS) is important, but a specific diagnostic test for the disease does not exist. The traditional diagnostic criteria of Poser et al. were published in 1983, and recently, McDonald et al. recommended new criteria for the diagnosis of MS. PATIENTS AND ...

journal_title：Acta neurologica Scandinavica

authors： Fangerau T,Schimrigk S,Haupts M,Kaeder M,Ahle G,Brune N,Klinkenberg K,Kotterba S,Möhring M,Sindern E,Multiple Sclerosis Study Group.

更新日期：2004-06-01 00:00:00

abstract：:The effects of L-threo-3,4-dihydroxyphenylserine (L-threo-DOPS), an unnatural norepinephrine precursor, on alpha 2-adrenergic receptors in platelet membranes were investigated in a patient with familial amyloidotic polyneuropathy, two patients with multiple system atrophy, and two patients with Parkinson's disease. Ea...

journal_title：Acta neurologica Scandinavica

authors： Azuma T,Suzuki T,Sakoda S,Mizuno R,Tsujino S,Kobayashi T,Kishimoto S,Hiraga T,Matsubara T,Yoshida S

更新日期：1991-07-01 00:00:00

abstract：:The mode of action of dantrolene sodium was studied in 11 multiple sclerosis patients with spastic paresis of the legs by measurements of changes in electromyographic and mechanomyographic proprioceptive reflex responses and in voluntary power. Dantrolene sodium 0.5 mg per kg body weight given intravenously clearly re...

journal_title：Acta neurologica Scandinavica

authors： Mai J,Pedersen E

更新日期：1979-06-01 00:00:00

abstract：OBJECTIVES:To examine the relationship between atherosclerotic lesions of the middle cerebral artery (MCA) detected on MRA and vascular risk factors. MATERIAL AND METHODS:We retrospectively assessed 279 patients (mean age, 69.0+/-11.3 years) who visited the Department of Neurology of Masuda Red Cross Hospital and unde...

journal_title：Acta neurologica Scandinavica

authors： Takahashi K,Kitani M,Fukuda H,Kobayashi S

更新日期：1999-12-01 00:00:00

abstract：OBJECTIVES:The well-being and physical function among patients with ALS and their next of kin was studied over time. MATERIALS AND METHODS:Thirty-five patients with ALS and their next of kin were studied with respect to physical, general and psychological well-being by the visual analogue scale (VAS) every 4-6 months....

journal_title：Acta neurologica Scandinavica

authors： Olsson AG,Markhede I,Strang S,Persson LI

更新日期：2010-04-01 00:00:00

abstract：:This article reports the case of a man who developed a pure motor paraplegia following epidural anesthesia with a pattern of slow recovery over subsequent months. Reviewing the available literature on post-epidural paraplegia we noted a number of potential etiologies and analyzed their role in its causation. On the ba...

journal_title：Acta neurologica Scandinavica

authors： Skouen JS,Wainapel SF,Willock MM

更新日期：1985-10-01 00:00:00

abstract：:Carotid stenoses of ≥50% account for about 15-20% of strokes. Their degree may be moderate (50-69%) or severe (70-99%). Current diagnostic methods include ultrasound, MR- or CT-angiography. Stenosis severity, irregular plaque surface, and presence of microembolic signals detected by transcranial Doppler predict the ea...

journal_title：Acta neurologica Scandinavica

authors： Momjian-Mayor I,Burkhard P,Murith N,Mugnai D,Yilmaz H,Narata AP,Lovblad K,Pereira V,Righini M,Bounameaux H,Sztajzel RF

更新日期：2012-11-01 00:00:00

abstract：OBJECTIVES:We studied the in vitro production of variably MS-related cytokines from Sardinian MS and healthy donors bearing the two "Sardinian" MS-associated HLA-DR alleles: DR3 and DR4, with the purpose to evidentiate possible differences in their immune response. MATERIALS AND METHODS:ELISA were used for detection o...

journal_title：Acta neurologica Scandinavica

authors： Sotgiu S,Serra C,Marrosu MG,Dolei A,Pugliatti M,Murgia B,Aiello I,Rosati G

更新日期：1998-11-01 00:00:00

abstract：OBJECTIVE:Ultrasonographic assessment of carotid artery plaque morphology is widely used to identify patients at high risk for stroke. However, the reliability of plaque analysis in high-grade stenosis is uncertain. We determined the interrater reliability of sonographic plaque morphology analysis in patients with seve...

journal_title：Acta neurologica Scandinavica

authors： Hartmann A,Mohr JP,Thompson JL,Ramos O,Mast H

更新日期：1999-01-01 00:00:00

abstract：OBJECTIVE:Cerebrospinal fluid (CSF) pressure-volume compensation may change over time as part of normal ageing, where the resistance to CSF outflow increases and the formation of CSF decreases with age. Is CSF compensation dependent on duration of symptoms in idiopathic normal pressure hydrocephalus (iNPH)? METHODS:We...

journal_title：Acta neurologica Scandinavica

authors： Czosnyka Z,Owler B,Keong N,Santarius T,Baledent O,Pickard JD,Czosnyka M

更新日期：2011-06-01 00:00:00

abstract：OBJECTIVES:The purpose of this study was to analyse the presence of the granulocyte-macrophage colony-stimulating factor (GM-CSF) in human cerebrospinal fluid (SF) of patients affected by multiple sclerosis (MS) in comparison with non-inflammatory neurological diseases. MATERIAL AND METHODS:All SFs were collected from...

journal_title：Acta neurologica Scandinavica

authors： Leonardi A,Penco S,Gramigni C,Bason C,Ribizzi G,Gazzola P,Mancardi GL,Bianchi-Scarrà G,Abbruzzese M,Garrè C

更新日期：1999-10-01 00:00:00

abstract：OBJECTIVES:The aims of this study were to investigate myopathic changes in myasthenia gravis (MG) by using turns-amplitude analysis (TAA) and quantitative motor unit potential duration analysis (MUPan), to correlate myopathic changes with severity and duration of the disease and the results of diagnostic tests includin...

journal_title：Acta neurologica Scandinavica

authors： Odabasi Z,Kuruoglu R,Oh SJ

更新日期：2000-05-01 00:00:00

abstract：BACKGROUND:Understanding how antiepileptic (AED) monotherapy influences normative test scores is of importance in the clinic for correct interpretation of neuropsychological profiles. Previous studies have primarily reported minor influence on neuropsychological raw scores, and the clinical relevance of these findings ...

journal_title：Acta neurologica Scandinavica

authors： Hessen E,Lossius MI,Gjerstad L

更新日期：2009-03-01 00:00:00

abstract：OBJECTIVES:To address the relationship between years lived with a disability (YLDs), prevalence and cost of neurological diseases, and to test whether there is a European North-South gradient for national health expenditure, disability, costs and prevalence of neurological diseases. MATERIALS AND METHODS:Information o...

journal_title：Acta neurologica Scandinavica

authors： Raggi A,Leonardi M

更新日期：2015-07-01 00:00:00

abstract：:Only 15% of patients with severe epilepsy with frequent partial seizures achieve any improvement in their seizure frequency by further drug treatment. As we know that epileptic seizures result in neuron loss with early development of mental deterioration, that the mortality rate of patients with epilepsy is increased ...

journal_title：Acta neurologica Scandinavica

authors： Dam M

更新日期：1996-08-01 00:00:00

abstract：:In 30 ischemic stroke patients, divided into 2 groups depending on the side of their hemispheric cerebral lesion, the authors evaluated the levels of CSF homovanillic acid (HVA) and 5-hydroxyindoleacetic acid (5-HIAA). The changes of these metabolites in CSF samples collected 3, 14 and 25 days after stroke have been c...

journal_title：Acta neurologica Scandinavica

authors： Ferrarese C,Bassi S,Frattola L,Locatelli P,Piolti R,Trabucchi M

更新日期：1986-06-01 00:00:00

abstract：:Patients with homocystinuria excrete a large amount of metal in their urine. Homocysteine similar to penicillamine, administration to methylmercury treated rats resulted in a large amount of urinary methylmercury excretion. These results suggested that the total metal amounts in the whole body of patients with homocys...

journal_title：Acta neurologica Scandinavica

authors： Yoshida Y,Nakano A,Hamada R,Kamitsuchibashi H,Yamamoto K,Akagi H,Kitazono M,Osame M

更新日期：1992-11-01 00:00:00

abstract：OBJECTIVE:To describe clinical features of a patient with secretions of atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) during an epileptic attack. PATIENT:A 65-year-old woman experienced frequent bouts of polyuria, pyrexia and general fatigue after several years of a cerebral contusion involving ...

journal_title：Acta neurologica Scandinavica

authors： Obi T,Takatsu M,Konishi T,Mizoguchi K,Nishimura Y

更新日期：2002-10-01 00:00:00

abstract：:Attempts were made to trace a possible retrovirus in multiple sclerosis (MS) by means of polymerase chain reaction. The primers derived from conserved sequences in the genome of human T cell leukemia/lymphoma virus type I (HTLV-I) and the amplifications were carried out at varying stringency conditions (i.a. annealing...

journal_title：Acta neurologica Scandinavica

authors： Rasmussen HB,Clausen J

更新日期：1992-07-01 00:00:00

abstract：:The density and size of astrocyte-, oligodendrocyte-and neurone nuclei in corpus striatum were determined in rats with CCl4-induced liver encephalopathy by means of an electronic image analyzer. After 8 weeks of CCl4-administration, the astrocyte number had nearly doubled, and astrocytes with increased nuclear size qp...

journal_title：Acta neurologica Scandinavica

authors： Diemer NH

更新日期：1977-01-01 00:00:00

abstract：:We present a 47-year-old white woman who had a definitive diagnosis of systemic lupus erythematosus (SLE), and developed cerebellar ataxia of sudden onset. MR imaging showed changes characteristics of cerebellar infarct. Due to the absence of vascular risk factors and to the previous diagnosis of SLE, we postulate tha...

journal_title：Acta neurologica Scandinavica

authors： Lancman ME,Pomeraniec C,Norscini J

更新日期：1992-10-01 00:00:00

abstract：OBJECTIVES:To provide an update on recent research concerning obstructive sleep apnea syndrome (OSAS) and executive functions. METHODS:A systematic review was carried out on reports drawn from MEDLINE and PSYCHLIT (January 1990-December 2005) and identified from lists of references in these reports. The selection crit...

journal_title：Acta neurologica Scandinavica

authors： Saunamäki T,Jehkonen M

更新日期：2007-01-01 00:00:00

abstract：:Cognitive deficits have been reported in 45%-70% of patients with multiple sclerosis (MS). Like other symptoms of MS, cognitive deficits are highly variable. Slowed information processing and memory and learning dysfunction are regarded as the most frequent cognitive deficits in MS. Both white and gray matter damages ...

journal_title：Acta neurologica Scandinavica

authors： Hämäläinen P,Rosti-Otajärvi E

更新日期：2016-09-01 00:00:00

abstract：OBJECTIVES:To evaluate the presence of the afterdischarge activity following M- and F-waves in patients with peripheral neuropathies with or without muscle cramps. MATERIAL AND METHODS:Ten patients with peripheral neuropathies complaining of frequent muscle leg cramps (Group 1) and 14 patients with peripheral neuropat...

journal_title：Acta neurologica Scandinavica

authors： Parisi L,Serrao M,Rossi P,Valente G,Fattapposta F,Pierelli F,Amabile G

更新日期：2000-12-01 00:00:00

abstract：OBJECTIVE:Although patients >80 years were excluded in RCTs for tPA treatment of acute ischemic stroke (AIS), many centers treat old patients. We wanted to examine whether age ≥80 years is an independent predictor of outcome after tPA. MATERIALS:We included 77 consecutive patients ≥80 years and 83 patients <80 years t...

journal_title：Acta neurologica Scandinavica

authors： Henriksen EH,Ljøstad U,Tveiten A,Naess H,Thomassen L,Mygland A

更新日期：2013-05-01 00:00:00

abstract：OBJECTIVES:To examine the factors that influence acute and total length of stay (LOS) for stroke patients. MATERIALS AND METHODS:The basis of this investigation was a population-based cohort of first-ever stroke patients (n = 388). Subjects were survivors of the initial hospitalization (n = 295). Age, sex, social fact...

journal_title：Acta neurologica Scandinavica

authors： Appelros P

更新日期：2007-07-01 00:00:00

abstract：OBJECTIVES:An oral dispersible microtablet formulation of levodopa/carbidopa 5/1.25 mg (LC-5) was developed for individualized repeated dosing. The aim was to compare pharmacokinetic profiles of LC-5 and levodopa/carbidopa/entacapone (LCE). MATERIALS AND METHODS:A randomized, crossover study was carried out in 11 heal...

journal_title：Acta neurologica Scandinavica

authors： Nyholm D,Ehrnebo M,Lewander T,Trolin CG,Bäckström T,Panagiotidis G,Spira J,Nyström C,Aquilonius SM

更新日期：2013-02-01 00:00:00

abstract：OBJECTIVES:To examine through a meta-analysis whether a treatment strategy of surgery plus the routine medical management saves lives and reduces disability in survivors of primary supratentorial intracerebral hematoma compared to routine medical management alone. MATERIAL AND METHODS:Computerized bibliographic search...

journal_title：Acta neurologica Scandinavica

authors： Prasad K,Browman G,Srivastava A,Menon G

更新日期：1997-02-01 00:00:00

abstract：:The prescriptions of antiepileptic drugs in the years 1985 and 1986 were used to identify all possible cases of epilepsy in a population of about 50,000 people. The general practitioners of the study area filled out a questionnaire for each user of antiepileptic drugs registered as a patient of theirs. This informatio...

journal_title：Acta neurologica Scandinavica

authors： Giuliani G,Terziani S,Senigaglia AR,Luccioni G,Foschi N,Maffei C

更新日期：1992-01-01 00:00:00

abstract：OBJECTIVES:To investigate the frequency of ECG abnormalities suggestive of myocardial ischaemia in patients with severe drug resistant epilepsy and without any indication of previous cardiac disease, assuming that these changes may be of significance for the group of epileptic patients with sudden unexpected death. MA...

journal_title：Acta neurologica Scandinavica

authors： Tigaran S,Rasmussen V,Dam M,Pedersen S,Høgenhaven H,Friberg B

更新日期：1997-08-01 00:00:00