Turns-amplitude analysis and motor unit potential analysis in myasthenia gravis.

Abstract:

OBJECTIVES:The aims of this study were to investigate myopathic changes in myasthenia gravis (MG) by using turns-amplitude analysis (TAA) and quantitative motor unit potential duration analysis (MUPan), to correlate myopathic changes with severity and duration of the disease and the results of diagnostic tests including repetitive nerve stimulation test (RNS), single fiber electromyography (SFEMG), and anti-acetylcholine receptor antibody (AChR-ab), and to compare the sensitivities of these two methods in detecting myopathic changes in MG. MATERIALS AND METHODS:We studied both MUPan and TAA in 32 patients with MG. RESULTS:The MUPan study showed myopathic changes in 12 patients (37.5%); TAA revealed a myopathic pattern in 4 (12.5%) and a neurogenic pattern in 4 cases (12.5%). Two of the 4 patients with a myopathic change by TAA also had short-duration mean MUP on the MUPan. No statistically significant association was found between the myopathic changes either by MUPan or TAA, and the various clinical and laboratory features. CONCLUSION:We conclude that MUPan is a more sensitive method than TAA in showing myopathic changes in MG, and that TAA is of limited help in demonstrating them.

journal_name

Acta Neurol Scand

authors

Odabasi Z,Kuruoglu R,Oh SJ

doi

10.1034/j.1600-0404.2000.90303.x

subject

Has Abstract

pub_date

2000-05-01 00:00:00

pages

315-20

issue

5

eissn

0001-6314

issn

1600-0404

journal_volume

101

pub_type

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