Cerebrospinal neuron-specific enolase, S-100 and myelin basic protein in neurological disorders.

Abstract:

:In this study levels of neuron-specific enolase (NSE), S-100 protein (S-100) and myelin basic protein (MBP) in cerebrospinal fluid (CSF) of children and adults with distinct neurological disorders were examined. A previous study from our department demonstrated age related reference values for these brain-specific proteins in CSF. The median concentration level of the 3 proteins in 17 different neurological disease groups versus the reference group was compared. Significantly higher MBP values were observed in patients with multiple sclerosis (MS), cerebrovascular accident (CVA), metabolic disorder and infection. Furthermore, significantly higher values were demonstrated for S-100 in CVA and for NSE in metabolic diseases. In CVA, the NSE and S-100 values were significantly related with MBP values, whereas in MS the NSE and S-100 were not related with MBP values.

journal_name

Acta Neurol Scand

authors

Lamers KJ,van Engelen BG,Gabreëls FJ,Hommes OR,Borm GF,Wevers RA

doi

10.1111/j.1600-0404.1995.tb01696.x

subject

Has Abstract

pub_date

1995-09-01 00:00:00

pages

247-51

issue

3

eissn

0001-6314

issn

1600-0404

journal_volume

92

pub_type

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