The EIF4G1 gene and Parkinson's disease.


:Variants in the EIF4G1 gene have been recently identified to be responsible for autosomal dominant PD (PARK18), but its role in the PD-related neurodegeneration is unclear. Several EIF4G1 mutation/variants were found to be associated with PD, and functional studies have suggested that these variants may impair the ability of cells to rapidly and dynamically respond to stress, thus probably participating in the development of PD, and these indicated that EIF4G1 variants may play an important role in pathogenicity of PD, although the frequency is low. Further studies involving large sample size of patients with PD from diverse populations, as well as studies of EIF4G1 expression and in scaffold function, are warranted.


Acta Neurol Scand


Deng H,Wu Y,Jankovic J




Has Abstract


2015-08-01 00:00:00












  • Effects of using dexamethasone and placebo in the treatment of prolapsed lumbar disc.

    abstract::Previous reports concerning the treatment of symptoms deriving from prolapsed lumbar disc with systemic administration of the potent steroid dexamethasone, have shown favourable results. The present clinical study includes 39 patients with symptoms of prolapsed lumbar disc, treated in a controlled double-blind investi...

    journal_title:Acta neurologica Scandinavica

    pub_type: 临床试验,杂志文章


    authors: Hedeboe J,Buhl M,Ramsing P

    更新日期:1982-01-01 00:00:00

  • Advances in the pathophysiology of status epilepticus.

    abstract::Status epilepticus (SE) describes an enduring epileptic state during which seizures are unremitting and tend to be self-perpetuating. We describe the clinical phases of generalized convulsive SE, impending SE, established SE, and subtle SE. We discuss the physiological and biochemical cascades which characterize self-...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章,评审


    authors: Chen JW,Naylor DE,Wasterlain CG

    更新日期:2007-04-01 00:00:00

  • R-R interval variation in Parkinson's disease and multiple system atrophy.

    abstract:OBJECTIVE:To investigate whether the cardiac R-R interval variation (RRIV) is of value in differentiating patients with Parkinson's disease (PD) from multiple system atrophy (MSA). BACKGROUND:RRIV assessment is a simple procedure, reflecting mainly vagal efferent activity. Reduced RRIV was reported in MSA. METHODS:RR...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章


    authors: Gurevich TY,Groozman GB,Giladi N,Drory VE,Hausdorff JM,Korczyn AD

    更新日期:2004-04-01 00:00:00

  • Basal metabolic rate in patients with hydrocephalus. On the cause of lowered basal metabolic rate in myotonic dystrophy.

    abstract::Myotonic dystrophy seems to have a hypometabolism of non-thyroid origin. The hypometabolism could hypothetically be caused by : 1) reduction in muscle mass, 2) hydrocephalus ex vacuo, an integral part of the disorder, or 3) the basic disease process itself. Possibility 2) was explored by determining basal metabolic ra...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章


    authors: Hidle I,Sjaastad O

    更新日期:1976-03-01 00:00:00

  • Phenotypes and mitochondrial DNA substitutions in families with A3243G mutation.

    abstract:OBJECTIVE:To clarify the relationship between mitochondrial DNA (mtDNA) sequence variations and phenotypes in patients with A3243G mutation. MATERIALS AND METHODS:We studied whole mtDNA sequences in two families with A3243G mutation and characteristic clinical features. Two brothers in Family 1 had shown thiamine defi...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章


    authors: Morovvati S,Nakagawa M,Sato Y,Hamada K,Higuchi I,Osame M

    更新日期:2002-08-01 00:00:00

  • Failure of allopurinol to protect against cerebral injury when given after the start of hypoxia.

    abstract::One cause of ischemic brain injury is free radical formation during recirculation. Allopurinol inhibits xanthine oxidase, an important source of free oxygen radicals. It is known that allopurinol pre-treatment has a protective action during cerebral ischemia. In the present study we exposed slices from the rat hippoca...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章


    authors: Hegstad E,Berg-Johnsen J,Langmoen IA

    更新日期:1991-05-01 00:00:00

  • CTG repeat polymorphism in DMPK gene in healthy Yugoslav population.

    abstract:OBJECTIVES:Myotonic dystrophy type 1 (DM1) is caused by large expansions of cytosine-thymine-guanine (CTG)-repeats in myotonic dystrophy protein kinase (DMPK)-gene. This gene is highly polymorphic in healthy individuals. It has been proposed that expanded alleles originated from the group of large sized normal alleles....

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章


    authors: Culjković B,Stojković O,Vukosavić S,Savić D,Rakocevic V,Apostolski S,Romac S

    更新日期:2002-01-01 00:00:00

  • Neuropsychiatric symptoms in Nigerian patients with Parkinson's disease.

    abstract:BACKGROUND:Neuropsychiatric symptoms are common in Parkinson's disease and may precede onset of motor symptoms. They are also known to increase caregiver's burden. OBJECTIVE:The aim of this study was to assess neuropsychiatric symptoms in a cohort of Nigerian patients with idiopathic Parkinson's disease and compare wi...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章


    authors: Ojagbemi AA,Akinyemi RO,Baiyewu O

    更新日期:2013-07-01 00:00:00

  • Cerebrospinal fluid nitrate levels in patients with Parkinson's disease.

    abstract::It has been suggested that nitric oxide could be implicated in the neuronal degeneration of substantia nigra compacta in patients with Parkinson's disease. Recently, it has been reported decreased CSF nitrate levels (oxidation product that provides an indirect estimation of nitric oxide) in Parkinson's disease patient...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章


    authors: Molina JA,Jiménez-Jiménez FJ,Navarro JA,Vargas C,Gómez P,Benito-León J,Ortí-Pareja M,Cisneros E,Arenas J

    更新日期:1996-02-01 00:00:00

  • Motor subtypes and other risk factors associated with drooling in Parkinson's disease patients.

    abstract:OBJECTIVE:To explore the relationship between motor subtypes and drooling, and other risk factors associated with drooling in a large cohort of Chinese patients with Parkinson's disease (PD). METHODS:A total of 586 PD patients were enrolled in this study. Unified Parkinson's disease rating scale (UPDRS) and Hoehn & Ya...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章


    authors: Mao CJ,Xiong YT,Wang F,Yang YP,Yuan W,Zhu C,Chen J,Liu CF

    更新日期:2018-05-01 00:00:00

  • Studies on the clustering of multiple sclerosis in Finland I: Comparison between the domiciles and places of birth in selected subpopulations.

    abstract::Further studies pm yjr rofr,op;phu pg ,i;yo;r dv;rtpdod (MS) IN Finland were carried out in three different types of geographical unit: in counties, combined clerical districts, and single clerical district. For longitudinal studies, the prevalence of MS by present domicile was compared to that by place of birth, and ...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章


    authors: Wikström J,Palo J

    更新日期:1975-02-01 00:00:00

  • Epilepsy with impulsive petit mal (juvenile myoclonic epilepsy).

    abstract::Juvenile myoclonic epilepsy (JME) is a special syndrome within the primary generalized epilepsies which is characterized clinically by irregular jerks of shoulders and arms (so-called impulsive petit mal) after awakening and electroencephalographically by bilateral-synchronous 4-6/s spike-wave complexes, often in the ...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章,评审


    authors: Janz D

    更新日期:1985-11-01 00:00:00

  • Psychometric evaluation of ADAS-Cog and NTB for measuring drug response.

    abstract:AIMS:To conduct a psychometric analysis to determine the adequacy of instruments that measure cognition in Alzheimer's disease trials. BACKGROUND:Both the Alzheimer's Disease Assessment Scale - Cognition (ADAS-Cog) and the Neuropsychological Test Battery (NTB) are validated outcome measures for clinical trials in Alzh...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章


    authors: Karin A,Hannesdottir K,Jaeger J,Annas P,Segerdahl M,Karlsson P,Sjögren N,von Rosen T,Miller F

    更新日期:2014-02-01 00:00:00

  • Epidemiology of multiple sclerosis in western Poland--a comparison between prevalence rates in 1965 and 1981.

    abstract::An epidemiological survey of multiple sclerosis was carried out in the western part of Poland. The estimated prevalence rate on December 31, 1981 was compared with that established on the same territory on January 1, 1965. The disease was less frequent in 1981. The prevalence rate for definite cases was only 42.87 ver...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章


    authors: Wender M,Pruchnik-Grabowska D,Hertmanowska H,Kowal P,Zielińska M,Namysł I,Marcinkowski J

    更新日期:1985-08-01 00:00:00

  • Phenytoin, phenobarbital, and midazolam fail to stop status epilepticus-like activity induced by low magnesium in rat entorhinal slices, but can prevent its development.

    abstract:OBJECTIVES:It was shown previously that low-Mg2+-induced epileptiform activity in rat entorhinal cortex slices changes with time from a pattern of serial seizure-like events (SLEs) to a state of continuously recurring epileptiform activity. Valproic acid blocked the early SLEs but not the late activity. It was proposed...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章


    authors: Dreier JP,Zhang CL,Heinemann U

    更新日期:1998-09-01 00:00:00

  • Surgery in primary supratentorial intracerebral hematoma: a meta-analysis of randomized trials.

    abstract:OBJECTIVES:To examine through a meta-analysis whether a treatment strategy of surgery plus the routine medical management saves lives and reduces disability in survivors of primary supratentorial intracerebral hematoma compared to routine medical management alone. MATERIAL AND METHODS:Computerized bibliographic search...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章,meta分析


    authors: Prasad K,Browman G,Srivastava A,Menon G

    更新日期:1997-02-01 00:00:00

  • The epidemiology of post-stroke epilepsy according to stroke subtypes.

    abstract:OBJECTIVES:Strokes represent the most common etiology of epilepsy in patients over the age of 60 years, with an incidence of 2-4% occurring in different studies. MATERIALS AND METHODS:In this observational study, 1,428 patients were included who had stroke and were admitted to our Stroke Unit between the years 1996 an...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章


    authors: Benbir G,Ince B,Bozluolcay M

    更新日期:2006-07-01 00:00:00

  • Urinary noradrenaline and serotonin metabolites in drug-free Parkinson patients and the effect of L-dopa treatment.

    abstract::3-methoxy-4-hydroxyphenylglycol (MHPG) and 5-hydroxyindoleacetic acid (5-HIAA) as well as homovanillic acid (HVA) and cyclic AMP were estimated in the morning urine of 41 drug-free parkinsonian patients and 25 hospitalized controls. In 29 patients, the estimations were repeated after 2 weeks treatment with L-dopa plus...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章


    authors: Markianos M,Hadjikonstantinou M,Bistolaki E

    更新日期:1982-08-01 00:00:00

  • Postural control in persons with late effects of polio.

    abstract:BACKGROUND:Persons who have suffered from acute poliomyelitis may decades later experience reduction of balance and gait capacity due to muscle weakness, fatigue and/or pain. This may affect the activity level in daily life of these persons. AIMS OF THE STUDY:The aim of this study was to describe observer assessed and...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章


    authors: Lehmann K,Sunnerhagen KS,Willén C

    更新日期:2006-01-01 00:00:00

  • Benign muscular dystrophy with contractures: a new syndrome?

    abstract::Three patients are described with muscular dystrophy and contractures. Although this disorder bears similarities to Emery-Dreifuss disease and variants previously described, absence of cardiomyopathy is a distinguishing feature. Electrodiagnostic testing and muscle biopsy are consistent with a myopathy. An autosomal d...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章


    authors: Bailey RO,Dentinger MP,Toms ME,Hans MB

    更新日期:1986-04-01 00:00:00

  • Assessing the outcome of stroke: a comparison between MRI and clinical stroke scales.

    abstract:OBJECTIVES:To assess the correlation of diffusion-weighted (DWI) and perfusion-weighted imaging (PWI) findings with the severity of acute neurologic deficit and their ability to predict short and long-term clinical outcomes of stroke. The ability of DWI and PWI to predict the outcome was compared with the ability of cl...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章


    authors: Nuutinen J,Liu Y,Laakso MP,Karonen JO,Roivainen R,Vanninen RL,Partanen K,Østergaard L,Sivenius J,Aronen HJ

    更新日期:2006-02-01 00:00:00

  • Isolated seizures in rats do not cause neuronal injury.

    abstract:BACKGROUND:Previous studies have shown that status epilepticus can lead to neuronal injury. However, the effect of a small number of isolated seizures is uncertain. METHODS:We used structural MRI and neuropathology to study the effects of isolated seizures induced by kainic acid (KA), (RS)-2-amino-3-(3-hydroxy-5-tert-...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章


    authors: Acosta MT,Munashinge J,Zhang L,Guerron DA,Vortmeyer A,Theodore WH

    更新日期:2012-01-01 00:00:00

  • Acute disseminated encephalomyelitis following nephropathia epidemica.

    abstract::Acute disseminated encephalomyelitis (ADEM) is an acute monophasic inflammatory and demyelinating disease of the central nervous system (CNS) occurring days to weeks after a virus infection or vaccination. Nephropathia epidemica (NE) is a haemorrhagic fever with renal syndrome caused by Puumala virus, with endemic reg...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章


    authors: Toivanen AL,Valanne L,Tatlisumak T

    更新日期:2002-04-01 00:00:00

  • Burden and cost of neurological diseases: a European North-South comparison.

    abstract:OBJECTIVES:To address the relationship between years lived with a disability (YLDs), prevalence and cost of neurological diseases, and to test whether there is a European North-South gradient for national health expenditure, disability, costs and prevalence of neurological diseases. MATERIALS AND METHODS:Information o...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章


    authors: Raggi A,Leonardi M

    更新日期:2015-07-01 00:00:00

  • Diffusion-weighted MR findings in a reversible case of acute Wernicke encephalopathy.

    abstract::We report a case of acute Wernicke encephalopathy (WE) in which apparent diffusion coefficient maps showed areas of increased diffusion in the bilateral medial thalami that corresponded to the hyperintense lesions on T2-weighted imaging. The hyperintense lesions on T2-weighted imaging disappeared with full recovery fr...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章


    authors: Oka M,Terae S,Kobayashi R,Kudoh K,Chu BC,Kaneko K,Yoshida M,Kaneda M,Suzuki Y,Miyasaka K

    更新日期:2001-09-01 00:00:00

  • Prior poliomyelitis: an immunohistochemical study of cytoskeletal proteins and a marker for muscle fibre regeneration in relation to usage of remaining motor units.

    abstract::Patients with prior poliomyelitis with paresis and excessive use (n = 8) and low use (n = 6) of residual anterior tibial motor units (MUs) during walking were subjected to muscle biopsy of the anterior tibial muscle (TA). Antibodies directed against cytoskeletal proteins, spectrin and desmin, and against Leu-19, a myo...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章


    authors: Borg K,Edström L

    更新日期:1993-02-01 00:00:00

  • Neurophysiologic evaluation of cyclosporine toxicity associated with bone marrow transplantation.

    abstract:INTRODUCTION:Cortical blindness, a rare form of cyclosporine (CSA) neurotoxicity, has previously been described in only nine bone marrow transplant (BMT) recipients. METHODS:Our institution averages 35 allogeneic BMT's per year. In the past year we have seen two women with reversible cortical blindness secondary to CS...

    journal_title:Acta neurologica Scandinavica

    pub_type: 更正并重新发布的文章,杂志文章,评审


    authors: Edwards LL,Wszolek ZK,Normand MM

    更新日期:1996-11-01 00:00:00

  • A comprehensive electrophysiological evaluation of phrenic nerve injury related to open-heart surgery.

    abstract::A prospective electrophysiological study of phrenic nerve was performed in 59 subjects undergoing open-heart surgery. The nerve was stimulated percutaneously at the neck and the diaphragmatic response was recorded with surface electrodes placed over the 8th intercostal space. The latency, amplitude, duration and area ...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章


    authors: Chroni E,Patel RL,Taub N,Venn GE,Howard RS,Panayiotopoulos CP

    更新日期:1995-04-01 00:00:00

  • Genetic factors in temporal lobe epilepsy.

    abstract::Genetic investigation of 74 patients with temporal lobe epilepsy, resistant to medication, who underwent unilateral temporal lobectomy 1960-1969. Thirty per cent had a positive family history of epilepsy; 49 per cent of other neurological diseases; and 46 per cent of major psychiatric disorders. Neither of the genetic...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章


    authors: Jensen I

    更新日期:1975-11-01 00:00:00

  • The POEMS syndrome among Chinese: association with Castleman's disease and some immunological abnormalities.

    abstract::POEMS or Crow-Fukase syndrome is a multisystemic, clinically malignant disorder of obscure etiology. Peripheral neuropathy and plasma cell dyscrasia are central features. The authors now report 7 Chinese patients with this syndrome in which PCD or paraproteinemia were absent in 6, and 2 had a lymph node histology rese...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章


    authors: Thajeb P,Chee CY,Lo SF,Lee N

    更新日期:1989-12-01 00:00:00