Diseases associated with multiple sclerosis and epilepsy. A population cohort study of 159,200 middle-aged, urban, native Swedes observed over 10 years (1970-79).

Abstract:

:A defined general population of 159,200 male and female native Swedes born in the period 1911-1940 from an urban catchment area of the then only general hospital, was followed over a decade (1970-79) with regard to in-patient hospitalization for all kinds of diagnoses. As a part of this population cohort study, multiple sclerosis cases (n = 351) and epilepsy cases (n = 648) were studied for association with other diseases. Unexpectedly, a cluster of diseases encompassing tuberculosis, bronchial asthma, diabetes mellitus and myocardial infarction, among the diseases associated with multiple sclerosis, also forms a gradient; this suggests a quantitative rather than a qualitative multifactorial model of disease for the understanding of the pathogenesis of MS. In epilepsy, heterogeneity was suggested as being mainly linked to the presence or absence of co-existing alcoholism. Brain tumours in cases of epilepsy were found almost exclusively in the latter subset and prevailing among younger people independent of sex (with an almost 100-fold excess rate of that disease combination as expected by chance only).

journal_name

Acta Neurol Scand

authors

Lindegård B

subject

Has Abstract

pub_date

1985-04-01 00:00:00

pages

267-77

issue

4

eissn

0001-6314

issn

1600-0404

journal_volume

71

pub_type

杂志文章
  • Muscular cramps: proposals for a new classification.

    abstract::Muscle cramps are involuntary, painful, sudden contractions of the skeletal muscles. They are present in normal subjects under certain conditions (during a strong voluntary contraction, sleep, sports, pregnancy) and in several pathologies such as myopathies, neuropathies, motoneuron diseases, metabolic disorders, hydr...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章,评审

    doi:10.1034/j.1600-0404.2003.01289.x

    authors: Parisi L,Pierelli F,Amabile G,Valente G,Calandriello E,Fattapposta F,Rossi P,Serrao M

    更新日期:2003-03-01 00:00:00

  • Impaired cardiac uptake of meta-[123I]iodobenzylguanidine in Parkinson's disease with autonomic failure.

    abstract:OBJECTIVE:To selectively investigate postganglionic sympathetic cardiac neurons in patients with Parkinson's disease and autonomic failure. MATERIAL AND METHODS:Metaiodobenzylguanidine (MIBG) is a pharmacologically inactive analogue of noradrenaline, which is similarly metabolized in noradrenergic neurons. Therefore t...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0404.1998.tb05958.x

    authors: Braune S,Reinhardt M,Bathmann J,Krause T,Lehmann M,Lücking CH

    更新日期:1998-05-01 00:00:00

  • Long-term effect of intravenous immunoglobulin on anti-MuSK antibody-positive myasthenia gravis.

    abstract::Anti-muscle-specific receptor tyrosine kinase (MuSK) antibody-positive myasthenia gravis (MG) patients show various responses to conventional immunosuppressive treatment and some patients are resistant to these therapies. We report a 50-year-old Japanese man with anti-MuSK antibody-positive MG, who showed no or poor r...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0404.2007.00877.x

    authors: Shibata-Hamaguchi A,Samuraki M,Furui E,Iwasa K,Yoshikawa H,Hayashi S,Yamada M

    更新日期:2007-12-01 00:00:00

  • Restless legs syndrome and cerebrovascular/cardiovascular events: Systematic review and meta-analysis.

    abstract:OBJECTIVE:We performed a systematic review and meta-analysis to evaluate the proposed association of restless legs syndrome (RLS) with cerebrovascular/cardiovascular outcomes. METHODS:We calculated the corresponding odds ratios on the prevalence of cerebrovascular/cardiovascular risk factors and standardized mean diff...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章,meta分析,评审

    doi:10.1111/ane.12848

    authors: Katsanos AH,Kosmidou M,Konitsiotis S,Tsivgoulis G,Fiolaki A,Kyritsis AP,Giannopoulos S

    更新日期:2018-01-01 00:00:00

  • Left ventricular failure and pulmonary edema in acute multiple sclerosis.

    abstract::We describe a young woman who developed left ventricular failure and pulmonary edema during fulminant onset of multiple sclerosis. One of the numerous plaques was located in the left inferior cerebellar peduncle near the dorsal motor vagal and solitary tract nuclei. Within two days pulmonary edema had cleared, and wit...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0404.1996.tb00002.x

    authors: Melin J,Usenius JP,Fogelholm R

    更新日期:1996-05-01 00:00:00

  • CSF lymphocyte subsets in aseptic meningitis: dual-labelling analysis with flow cytometry.

    abstract::In order to characterize the CSF (cerebrospinal fluid) lymphocytes in CNS (central nervous system) inflammation, we examined paired samples of CSF and PB (peripheral blood) of 19 patients with acute aseptic meningitis, performing the dual labelling method on flow cytometry. Significantly higher percentages of CD3+ (T ...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0404.1990.tb00997.x

    authors: Uchihara T,Ikeda M,Takahashi H,Yoshida S,Tsukagoshi H

    更新日期:1990-05-01 00:00:00

  • Motor subtypes and other risk factors associated with drooling in Parkinson's disease patients.

    abstract:OBJECTIVE:To explore the relationship between motor subtypes and drooling, and other risk factors associated with drooling in a large cohort of Chinese patients with Parkinson's disease (PD). METHODS:A total of 586 PD patients were enrolled in this study. Unified Parkinson's disease rating scale (UPDRS) and Hoehn & Ya...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/ane.12893

    authors: Mao CJ,Xiong YT,Wang F,Yang YP,Yuan W,Zhu C,Chen J,Liu CF

    更新日期:2018-05-01 00:00:00

  • Cerebrospinal fluid myelin basic protein-like material in acute monosymptomatic optic neuritis.

    abstract:INTRODUCTION:Cerebrospinal fluid (CSF) may provide markers of severity and outcome of optic neuritis. MATERIAL AND METHODS:We examined the CSF from 29 patients with acute monosymptomatic optic neuritis (AMON) for content of myelin basic protein-like material (MBPLM) and correlated the levels with results of cranial ma...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0404.1996.tb07070.x

    authors: Frederiksen JL,Whitaker JN

    更新日期:1996-11-01 00:00:00

  • Migraine without aura: comparison with cervicogenic headache. Vågå study of headache epidemiology.

    abstract:OBJECTIVES:To study migraine without aura (MwoA) prevalence in the commune of Vågå, Norway; 1838 (18- to 65-year-old) individuals were included. A special search was made for cervicogenic characteristics in MwoA, as it has been claimed that such characteristics may frequently be present. A comparison with cervicogenic ...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0404.2007.00966.x

    authors: Sjaastad O,Bakketeig LS

    更新日期:2008-06-01 00:00:00

  • Spinal tumours associated with increased intracranial pressure. Report of two cases and a discussion on the pathophysiology.

    abstract::Two cases of increased intracranial pressure associated with lumbar intraspinal tumours are reported. On the basis of protein investigations and constant flow infusion manometric tests, the pathophysiology of the increased intracranial pressure is discussed. It is demonstrated that protein macromolecules leak from the...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:

    authors: Borgesen SE,Sorensen SC,Olesen J,Gjerris F

    更新日期:1977-09-01 00:00:00

  • Natural anticoagulants (antithrombin III, protein C, and protein S) in patients with mild to moderate ischemic stroke.

    abstract:BACKGROUND AND PURPOSE:The role of the natural anticoagulants, antithrombin III (AT III), protein C (PC), and protein S (PS), in patients with mild to moderate ischemic stroke remains uncertain. We aimed to find out whether their levels in peripheral blood correlated with the severity of neurological deficit or can pre...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1034/j.1600-0404.2002.1o112.x

    authors: Haapaniemi E,Tatlisumak T,Soinne L,Syrjälä M,Kaste M

    更新日期:2002-02-01 00:00:00

  • Seizures as a presenting feature of late onset metachromatic leukodystrophy.

    abstract:OBJECTIVES:We describe 2 patients with epilepsy as an early manifestation of late onset metachromatic leukodystrophy (MLD). METHODS AND RESULTS:The first patient presented with epileptic seizures at the age of 34 years while neurological and cognitive abnormalities appeared later. MRI findings were compatible with leu...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1034/j.1600-0404.2000.102003192.x

    authors: Bostantjopoulou S,Katsarou Z,Michelakaki H,Kazis A

    更新日期:2000-09-01 00:00:00

  • Decreased plasma alanine and isoleucine in Huntington's disease.

    abstract::Amino acid concentrations in plasma of patients with Huntington's disease (HD) were determined in 16 patients and 21 age- and sex-matched healthy controls. Alanine and isoleucine were significantly decreased in HD plasma whereas arginine, histidine, leucine, lysine, ornithine, proline, serine, threonine, tyrosine, and...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0404.1995.tb00438.x

    authors: Reilmann R,Rolf LH,Lange HW

    更新日期:1995-03-01 00:00:00

  • Chronic experimental allergic neuritis (EAN) in juvenile guinea pigs: immunological comparison with acute EAN in adult guinea pigs.

    abstract::In order to approach the mechanism of chronic or relapsing course in human chronic inflammatory demyelinating polyradiculoneuropathy, we established a chronic model of experimental allergic neuritis (EAN) in juvenile guinea pigs, and investigated the underlying cellular immune phenomenon in comparison with acute EAN i...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0404.1985.tb03214.x

    authors: Suzumura A,Sobue G,Sugimura K,Matsuoka Y,Sobue I

    更新日期:1985-05-01 00:00:00

  • Cerebrospinal fluid and blood flow patterns in idiopathic normal pressure hydrocephalus.

    abstract:OBJECTIVES:Increased aqueduct cerebrospinal fluid (CSF) flow pulsatility and, recently, a reversed CSF flow in the aqueduct have been suggested as hallmarks of idiopathic normal pressure hydrocephalus (INPH). However, these findings have not been adequately confirmed. Our objective was to investigate the flow of blood ...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/ane.12636

    authors: Qvarlander S,Ambarki K,Wåhlin A,Jacobsson J,Birgander R,Malm J,Eklund A

    更新日期:2017-05-01 00:00:00

  • Unchanged striatal dopamine transporter availability in narcolepsy: a PET study with [11C]-CFT.

    abstract:OBJECTIVE:To investigate dopamine reuptake sites (dopamine transporter) in the caudate nucleus and putamen in narcolepsy. PATIENTS AND METHODS:Ten patients with narcolepsy and 15 controls were studied with positron emission tomography. A cocaine analogue [11C]-CFT was used as a radioligand. RESULTS:The uptake of[11C]...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1034/j.1600-0404.2003.00175.x

    authors: Rinne JO,Hublin C,Någren K,Helenius H,Partinen M

    更新日期:2004-01-01 00:00:00

  • Nicotinic α4β2 acetylcholine receptors and cognitive function in Parkinson's disease.

    abstract:BACKGROUND:Idiopathic Parkinson's disease (IPD) is characterized by the clinical motor symptoms of hypokinesia, rigidity, and tremor. Apart from these motor symptoms, cognitive deficits often occur in IPD. The positive effect of cholinesterase inhibitors on cognitive deficits in IPD and findings of earlier molecular im...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/ane.12259

    authors: Lorenz R,Samnick S,Dillmann U,Schiller M,Ong MF,Faßbender K,Buck A,Spiegel J

    更新日期:2014-09-01 00:00:00

  • Variants in the genes DCTN2, DNAH10, LRIG3, and MYO1A are associated with intermediate Charcot-Marie-Tooth disease in a Norwegian family.

    abstract:INTRODUCTION:Charcot-Marie-Tooth disease (CMT) is a heterogeneous inherited neuropathy. The number of known CMT genes is rapidly increasing mainly due to next-generation sequencing technology, at present more than 70 CMT-associated genes are known. We investigated whether variants in the DCTN2 could cause CMT. MATERIA...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/ane.12515

    authors: Braathen GJ,Høyer H,Busk ØL,Tveten K,Skjelbred CF,Russell MB

    更新日期:2016-07-01 00:00:00

  • Effects of psychological group therapy in patients with multiple sclerosis.

    abstract:OBJECTIVES:The aim of this pilot study was to evaluate a psychological therapy program used in the treatment of multiple sclerosis (MS) and including cognitive/behavioral strategies, relaxation training and physical exercise. MATERIAL AND METHODS:The participants were 29 patients with MS recruited from an outpatient u...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1034/j.1600-0404.2003.00077.x

    authors: Tesar N,Baumhackl U,Kopp M,Günther V

    更新日期:2003-06-01 00:00:00

  • The p150 subunit of dynactin (DCTN1) gene in multiple sclerosis.

    abstract:OBJECTIVES:Mutations in the p150 subunit of the axonal transport protein dynactin (DCTN1) have been reported in patients with amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Given the common features of neurodegeneration in multiple sclerosis (MS), FTD and ALS, sequence variants of the DCTN1 gene...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0404.2007.00884.x

    authors: Münch C,Meyer R,Linke P,Meyer T,Ludolph AC,Haas J,Hemmer B

    更新日期:2007-10-01 00:00:00

  • Relation between angiographic cerebral vasospasm and regional CBF in patients with SAH.

    abstract::The relation between angiographically determined cerebral vasospasm following a subarachnoid hemorrhage and regional cerebral blood flow (CBF) was studied in 63 investigations of 45 patients. The CBF was measured using the intra-arterial 133-Xe clearance technique within one hour of angiography. A positive correlation...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0404.1990.tb01598.x

    authors: Jakobsen M,Overgaard J,Marcussen E,Enevoldsen EM

    更新日期:1990-08-01 00:00:00

  • Intravenous lacosamide or phenytoin for treatment of refractory status epilepticus.

    abstract:OBJECTIVES:To compare intravenous phenytoin (PHT) and intravenous lacosamide (LCM) for treatment of status epilepticus after failure of the first and second drug. METHODS:We retrospectively identified patients from a large community hospital in northern Germany who had been diagnosed with SE between August 2008 and De...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/ane.12174

    authors: Kellinghaus C,Berning S,Stögbauer F

    更新日期:2014-05-01 00:00:00

  • Painful legs and moving toes. A report of 3 cases with neurophysiological studies.

    abstract::3 patients with the condition of "painful legs and moving toes" are reported. The etiology was unknown in 2 of them, but in 1 patient the symptoms were temporarily relieved by surgery for a lumbar herniated disc. The movements restarted 6 months after surgery. EMG studies showed near rhythmical muscle action potential...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0404.1982.tb04526.x

    authors: Wulff CH

    更新日期:1982-08-01 00:00:00

  • Alterations in polyadenylic acid-containing messenger RNA synthesis of brain polysomes after seizures of seizure-susceptible E1 mice.

    abstract::The effect of seizures on synthesis of the polyadenylic acid (poly(A]-containing messenger RNA (mRNA) isolated from brain polysomes in a genetically seizure-susceptible E1 mouse was studied in vivo. The seizure in the E1 mice was induced by tossed-up stimulation. Immediately after the seizure ceased, the labeled oroti...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0404.1989.tb03888.x

    authors: Yamagami S,Onishi H,Kawakita Y

    更新日期:1989-10-01 00:00:00

  • Cerebrospinal fluid findings in mycoplasma pneumoniae infections with neurological complications.

    abstract::The cerebrospinal fluid (CSF) findings of 16 patients with mycoplasma pneumoniae infections and different neurologic complications are presented. In acute meningitis there was predominantly a mononuclear cell reaction remitting in accordance with the improvement of the clinical symptoms. An early switch from IgM to Ig...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0404.1982.tb03107.x

    authors: Maida E,Kristoferitsch W

    更新日期:1982-05-01 00:00:00

  • Age at onset: the major determinant of outcome in Parkinson's disease.

    abstract::Factors at presentation which influenced the course of the disease and response to treatment were assessed in 125 de novo patients with Parkinson's disease. Ninety-eight patients were available for re-assessment at 5 years. Older patients presented earlier after the onset of symptoms, deteriorated more rapidly, and we...

    journal_title:Acta neurologica Scandinavica

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1111/j.1600-0404.1995.tb00480.x

    authors: Hely MA,Morris JG,Reid WG,O'Sullivan DJ,Williamson PM,Broe GA,Adena MA

    更新日期:1995-12-01 00:00:00

  • The role of essential fatty acids in chronic fatigue syndrome. A case-controlled study of red-cell membrane essential fatty acids (EFA) and a placebo-controlled treatment study with high dose of EFA.

    abstract:OBJECTIVE:To replicate the treatment study by Behan et al. (1990) using current research criteria for Chronic Fatigue Syndrome (CFS). METHOD:Fifty patients who fulfilled the Oxford Criteria for CFS were randomly allocated to treatment with either Efamol Marine or placebo for 3 months. They were seen monthly and comple...

    journal_title:Acta neurologica Scandinavica

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/j.1600-0404.1999.tb00667.x

    authors: Warren G,McKendrick M,Peet M

    更新日期:1999-02-01 00:00:00

  • Abnormalities of mitochondrial enzymes in hereditary ataxias.

    abstract::The activity of 7 mitochondrial enzymes, fumarase, NAD-malate dehydrogenase (MDH), citrate synthase (CS), valine dehydrogenase (VDH), succinate dehydrogenase (SDH), glutamate dehydrogenase (GDH), pyruvate dehydrogenase complex (PDHC) has been measured in platelet preparations from patients affected by Friedreich's ata...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0404.1989.tb03849.x

    authors: Sorbi S,Piacentini S,Fani C,Tonini S,Marini P,Amaducci L

    更新日期:1989-08-01 00:00:00

  • Comparison between agarose gel electrophoresis and isoelectric focusing of CSF for demonstration of oligoclonal immunoglobulin bands in neurological disorders.

    abstract::Isoelectric focusing and agarose gel electrophoresis of CSF and serum revealed similar frequencies of oligoclonal bands in multiple sclerosis (100% with both methods), infectious CNS disorders (38 and 23%) and other neurological diseases (8 and 10%). In selected cases with unsure CSF oligoclonal bands on agarose gel e...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0404.1978.tb02874.x

    authors: Laurenzi MA,Link H

    更新日期:1978-09-01 00:00:00

  • Effect of the alpha-adrenergic blocking agent thymoxamine on the neurogenic bladder and urethra.

    abstract::The effect of the alpha-adrenergic blocking agent thymoxamine by intravenous administration was studied in 25 patients with spastic paraplegia and uninhibited neurogenic bladder. By cystometry a shift to the right of the first desire to void, the threshold of the first uninhibited contraction and a reduction of the pr...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0404.1980.tb01472.x

    authors: Pedersen E,Tørring J,Klemar B

    更新日期:1980-02-01 00:00:00