Abstract：
OBJECTIVE:To explore the long-term effectiveness of rufinamide in managing Lennox-Gastaut Syndrome (LGS), other epileptic encephalopathies, and intractable focal epilepsies in adults and children in routine clinical practice. METHODS:A multicentre, retrospective chart review of patients prescribed adjunctive rufinamide at seven Spanish epilepsy centres, with assessments at six and 12 months. RESULTS:We evaluated data from 58 patients (40 male, age range 7-57 years), 25 of whom were diagnosed with LGS, 12 with other epileptic encephalopathies and 21 of whom were diagnosed with focal epilepsies, mainly frontal lobe. The mean daily rufinamide dose was 32.0 mg/kg (range 12.5-66.7 mg/kg) in children and 24.7 mg/kg (range 5.0-47.0 mg/kg) in adults, and the most commonly used concomitant antiepileptic drugs were levetiracetam and valproate. Rufinamide was discontinued in 25 patients (43.1%) during the 1-year follow-up, and the most common reason was lack of effectiveness (n = 12, 20.7% of total). The frequency of generalized tonic-clonic seizures was significantly reduced from baseline at 6 and 12 months (P = 0.001), both in patients with generalized epilepsies and in patients with focal epilepsies. Significant seizure frequency reduction from baseline was observed at 12 months (P = 0.01) for tonic/atonic seizures and at 6 months (P = 0.001) for focal seizures. Side effects were reported in 21 patients (36.2%): nausea, vomiting and weight loss were most frequent. CONCLUSIONS:Rufinamide was well tolerated and was effective in reducing frequency of generalized tonic-clonic, tonic/atonic and focal seizures in both children and adults with severe refractory epilepsies, primarily LGS.
journal_name
Acta Neurol Scandjournal_title
Acta neurologica Scandinavicaauthors
Jaraba S,Santamarina E,Miró J,Toledo M,Molins A,Burcet J,Becerra JL,Raspall M,Pico G,Miravet E,Cano A,Fossas P,Fernández S,Falip Mdoi
10.1111/ane.12572subject
Has Abstractpub_date
2017-01-01 00:00:00pages
122-128issue
1eissn
0001-6314issn
1600-0404journal_volume
135pub_type
杂志文章,多中心研究abstract：:The density and size of astrocyte-, oligodendrocyte-and neurone nuclei in corpus striatum were determined in rats with CCl4-induced liver encephalopathy by means of an electronic image analyzer. After 8 weeks of CCl4-administration, the astrocyte number had nearly doubled, and astrocytes with increased nuclear size qp...
journal_title：Acta neurologica Scandinavica
pub_type： 杂志文章
doi：
更新日期：1977-01-01 00:00:00
abstract：:N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, MPTP, is a neurotoxic substance known to induce a parkinsonian syndrome in primates. The distribution of intravenously injected 11C-labelled MPTP (11C-MPTP) in the head of Rhesus monkeys was studied by means of positron emission tomography, PET. The influence of pretreatme...
journal_title：Acta neurologica Scandinavica
pub_type： 杂志文章
doi：10.1111/j.1600-0404.1986.tb04618.x
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abstract：:The effect of seizures on synthesis of the polyadenylic acid (poly(A]-containing messenger RNA (mRNA) isolated from brain polysomes in a genetically seizure-susceptible E1 mouse was studied in vivo. The seizure in the E1 mice was induced by tossed-up stimulation. Immediately after the seizure ceased, the labeled oroti...
journal_title：Acta neurologica Scandinavica
pub_type： 杂志文章
doi：10.1111/j.1600-0404.1989.tb03888.x
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abstract：:Authors addressed the question whether the byosynthesis and the release of specific eicosanoids may occur in human brain cortex, and if the qualitative pattern of arachidonic acid metabolism is similar to that observed in experimental SAH. Human brain samples from 18 patients operated on for anterior communicating art...
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pub_type： 杂志文章
doi：10.1111/j.1600-0404.1992.tb05063.x
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abstract：OBJECTIVE:We wanted to describe the use of thrombolytic treatment for stroke in Scandinavia, to assess stroke doctors' opinions on this treatment, to identify barriers against treatment, and to suggest improvements to overcome these barriers. METHODS:We sent questionnaires to 493 Scandinavian doctors, who were involve...
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pub_type： 杂志文章
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abstract：OBJECTIVE:To evaluate the clinical course of patients with myasthenia gravis (MG) up to 3 months after double filtration plasmapheresis (DFP). MATERIAL AND METHODS:We recorded the MG score and measured the level of acetylcholine receptor antibody (AchRAb) at baseline and day 1 (D1), week 1 (W1), 1 month (M1), 2 (M2) a...
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pub_type： 杂志文章
doi：10.1034/j.1600-0404.2003.00107.x
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abstract：BACKGROUND:Previous studies have shown that status epilepticus can lead to neuronal injury. However, the effect of a small number of isolated seizures is uncertain. METHODS:We used structural MRI and neuropathology to study the effects of isolated seizures induced by kainic acid (KA), (RS)-2-amino-3-(3-hydroxy-5-tert-...
journal_title：Acta neurologica Scandinavica
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abstract：OBJECTIVES:To examine the relationship between atherosclerotic lesions of the middle cerebral artery (MCA) detected on MRA and vascular risk factors. MATERIAL AND METHODS:We retrospectively assessed 279 patients (mean age, 69.0+/-11.3 years) who visited the Department of Neurology of Masuda Red Cross Hospital and unde...
journal_title：Acta neurologica Scandinavica
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journal_title：Acta neurologica Scandinavica
pub_type： 杂志文章
doi：10.1034/j.1600-0404.2001.00167.x
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journal_title：Acta neurologica Scandinavica
pub_type： 杂志文章
doi：10.1034/j.1600-0404.2000.101002122.x
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journal_title：Acta neurologica Scandinavica
pub_type： 杂志文章
doi：10.1111/ane.12752
更新日期：2017-11-01 00:00:00
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journal_title：Acta neurologica Scandinavica
pub_type： 杂志文章
doi：10.1111/ane.12745
更新日期：2017-07-01 00:00:00
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journal_title：Acta neurologica Scandinavica
pub_type： 杂志文章
doi：10.1111/j.1600-0404.1987.tb07899.x
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journal_title：Acta neurologica Scandinavica
pub_type： 杂志文章
doi：10.1111/ane.12167
更新日期：2014-03-01 00:00:00
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journal_title：Acta neurologica Scandinavica
pub_type： 杂志文章
doi：10.1111/j.1600-0404.1992.tb05100.x
更新日期：1992-10-01 00:00:00
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doi：10.1034/j.1600-0404.2003.00010.x
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journal_title：Acta neurologica Scandinavica
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journal_title：Acta neurologica Scandinavica
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doi：10.1111/j.1600-0404.1999.tb00680.x
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journal_title：Acta neurologica Scandinavica
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doi：10.1111/j.1600-0404.2006.00624.x
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journal_title：Acta neurologica Scandinavica
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doi：10.1111/j.1600-0404.2005.00550.x
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journal_title：Acta neurologica Scandinavica
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doi：10.1111/j.1600-0404.1992.tb08046.x
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journal_title：Acta neurologica Scandinavica
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doi：10.1111/j.1600-0404.1993.tb04221.x
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journal_title：Acta neurologica Scandinavica
pub_type： 杂志文章,评审
doi：10.1111/j.1600-0404.1993.tb05512.x
更新日期：1993-04-01 00:00:00
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doi：10.1034/j.1600-0404.2002.1o112.x
更新日期：2002-02-01 00:00:00
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pub_type： 杂志文章
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更新日期：2017-04-01 00:00:00
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journal_title：Acta neurologica Scandinavica
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doi：10.1111/ane.13191
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journal_title：Acta neurologica Scandinavica
pub_type： 杂志文章
doi：10.1111/j.1600-0404.1986.tb03302.x
更新日期：1986-04-01 00:00:00
abstract：:This study concerns the distribution of T-cell subsets as determined by specific monoclonal antibodies in 50 individuals with complex partial seizures (31) and primary generalized tonic-clonic seizures (19), and in 30 healthy controls. The epileptic group had significantly fewer circulating T4 "helper" lymphocytes and...
journal_title：Acta neurologica Scandinavica
pub_type： 杂志文章
doi：10.1111/j.1600-0404.1985.tb00855.x
更新日期：1985-08-01 00:00:00
