Granulocyte-macrophage colony-stimulating factor activity in cerebrospinal fluid.

Abstract:

OBJECTIVES:The purpose of this study was to analyse the presence of the granulocyte-macrophage colony-stimulating factor (GM-CSF) in human cerebrospinal fluid (SF) of patients affected by multiple sclerosis (MS) in comparison with non-inflammatory neurological diseases. MATERIAL AND METHODS:All SFs were collected from 59 patients for diagnostic purpose. The presence of GM-CSF was revealed by measuring its activity and by immunoassay. The data obtained were statistically evaluated. RESULTS:We found that GM-CSF is constitutively present in human SF; this presence was confirmed by its stimulating activity of colony-forming-unit granulocyte-macrophage (CFU-GM) production. No significant changes of the GM-CSF concentration in the SFs were observed among different neurological disorders (degenerative or vascular) and MS. CONCLUSION:Our data suggest that GM-CSF is a constitutive component of human SF, relatively uninfluenced by the different morbid conditions of the nervous system.

journal_name

Acta Neurol Scand

authors

Leonardi A,Penco S,Gramigni C,Bason C,Ribizzi G,Gazzola P,Mancardi GL,Bianchi-Scarrà G,Abbruzzese M,Garrè C

doi

10.1111/j.1600-0404.1999.tb00394.x

subject

Has Abstract

pub_date

1999-10-01 00:00:00

pages

274-7

issue

4

eissn

0001-6314

issn

1600-0404

journal_volume

100

pub_type

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