Antiepileptic monotherapy significantly impairs normative scores on common tests of executive functions.


BACKGROUND:Understanding how antiepileptic (AED) monotherapy influences normative test scores is of importance in the clinic for correct interpretation of neuropsychological profiles. Previous studies have primarily reported minor influence on neuropsychological raw scores, and the clinical relevance of these findings is unclear. AIM OF THE STUDY:To obtain a clinical valid answer to this question, we analysed changes in T-scores after AED withdrawal in a large group of well-controlled epilepsy patients, for tests previously shown to be sensitive to AED withdrawal. METHODS:We report outcomes on measures of choice reaction time from the California Computerized Assessment Package, on the Controlled Oral Word Association Test and on the Stroop Color-Word Interference Test. RESULTS:Significantly improved T-scores were revealed after AED withdrawal on five of the six tests of executive functions with mean improvement of 5 T-scores. Comparable results were achieved in the subgroup taking carbamazepine, with a mean improvement of 6.2 T-scores. CONCLUSION:The present results suggest that T-scores for computerized tests of choice reaction time and tests of verbal fluency and response inhibition may be significantly impaired as a consequence of AED monotherapy, and that careful interpretation of these scores is required in diagnostic assessment of patients receiving AED monotherapy.


Acta Neurol Scand


Hessen E,Lossius MI,Gjerstad L




Has Abstract


2009-03-01 00:00:00














  • Occipital intracerebral hemorrhage-clinical characteristics, outcome, and post-ICH epilepsy.

    abstract:OBJECTIVES:Posterior location affects the clinical presentation and outcome of ischemic stroke, but little is known about occipital intracerebral hemorrhage (ICH). We studied non-traumatic occipital ICH phenotype, outcome, and post-ICH epilepsy. MATERIALS AND METHODS:Occipital ICH patients were retrospectively identif...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章


    authors: Räty S,Sallinen H,Virtanen P,Haapaniemi E,Wu TY,Putaala J,Meretoja A,Tatlisumak T,Strbian D

    更新日期:2020-06-30 00:00:00

  • Parkinson's disease occurrence in Europe.

    abstract::Parkinson's disease (PD) surveys and death-record studies in European populations were reviewed. Particular attention was given to methodological aspects. Two sets of quality criteria were used. Four door-to-door surveys revealed underdiagnosis of prevalent idiopathic parkinsonism ranging from 30% to 71%. Quality surv...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章,meta分析


    authors: de Pedro-Cuesta J

    更新日期:1991-10-01 00:00:00

  • Lack of effect of clonazepam on serum levels of diphenylhydantoin, phenobarbital and carbamazepine.

    abstract::The influence of clonazepam on steady-state serum levels of diphenylhydantoin, phenobarbital and carbamazepine was studied in 22 patients with epilepsy receiving one or two of these drugs. Clonazepam was given in slowly increasing doses for 2 weeks until a maximum dose of 4-6 mg per day was reached; thereafter the dos...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章


    authors: Johannessen SI,Strandjord RE,Munthe-Kaas AW

    更新日期:1977-06-01 00:00:00

  • Cerebrospinal fluid and urinary biomarkers in multiple sclerosis.

    abstract:OBJECTIVES:Biomarkers with the potential for longitudinal measurements are needed in multiple sclerosis (MS). Urine is easy to collect, and repeated sampling is possible. METHODS:39 paired CSF and urine samples were taken. Oligoclonal bands (OCBs) were measured in CSF. Kappa and lambda free light chain (FLC), neopteri...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章


    authors: Dobson R,Topping J,Davis A,Thompson E,Giovannoni G

    更新日期:2013-11-01 00:00:00

  • The Gulf War era multiple sclerosis cohort: 3. Early clinical features.

    abstract:OBJECTIVES:To present clinical features at diagnosis for a large nationwide incident cohort of multiple sclerosis (MS) among those serving in the US military during the Gulf War era (GWE). MATERIALS & METHODS:Medical records and databases from the Department of Veterans Affairs (VA) for cases of MS with onset in or af...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章


    authors: Wallin MT,Culpepper WJ,Maloni H,Kurtzke JF

    更新日期:2018-01-01 00:00:00

  • Regional spinal cord blood flow in the rabbit, cat and monkey.

    abstract::Regional blood flow in the spinal cord was measured in rabbits, cats and monkeys with radioactively labelled microspheres. The reproducibility of the method was tested in rabbits by 3 consecutive determinations with differently labelled microspheres within the different cord regions, and was found to be good. In all 3...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章


    authors: Nyström B,Stjernschantz J,Smedegård G

    更新日期:1984-10-01 00:00:00

  • Multiple sclerosis and vitamin D during pregnancy and lactation.

    abstract:BACKGROUND:Both pregnancy and high vitamin D concentration seem to generate a protective environment against multiple sclerosis (MS) relapses. Longitudinal case-control analysis of vitamin D concentrations during pregnancy and lactation of MS mothers is lacking. AIMS OF THE STUDY:To examine serum 25-hydroxyvitamin-D3 ...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章


    authors: Jalkanen A,Kauko T,Turpeinen U,Hämäläinen E,Airas L

    更新日期:2015-01-01 00:00:00

  • Severe amphethamine-induced bruxism: treatment with botulinum toxin.

    abstract::While chewing and grinding movements have been observed in amphetamine addicts, recognition and management of this problem have rarely been highlighted. Botulinum toxin (BTX) has previously been demonstrated to be effective for bruxism associated with movement disorders, such as cranial-cervical dystonia. However, the...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章


    authors: See SJ,Tan EK

    更新日期:2003-02-01 00:00:00

  • Vascular risk factors for atherosclerotic lesions of the middle cerebral artery detected by magnetic resonance angiography (MRA).

    abstract:OBJECTIVES:To examine the relationship between atherosclerotic lesions of the middle cerebral artery (MCA) detected on MRA and vascular risk factors. MATERIAL AND METHODS:We retrospectively assessed 279 patients (mean age, 69.0+/-11.3 years) who visited the Department of Neurology of Masuda Red Cross Hospital and unde...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章


    authors: Takahashi K,Kitani M,Fukuda H,Kobayashi S

    更新日期:1999-12-01 00:00:00

  • Treatment of steroid-unresponsive optic neuritis with plasma exchange.

    abstract:OBJECTIVES:Until now, the significance of plasma exchange (PE) as a treatment for steroid-unresponsive optic neuritis (ON) is still unclear because placebo-controlled and larger studies are missing. We report our experience with 23 patients treated by PE due to steroid-unresponsive ON. MATERIALS AND METHODS:Patients w...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章


    authors: Roesner S,Appel R,Gbadamosi J,Martin R,Heesen C

    更新日期:2012-08-01 00:00:00

  • Etiology and management of single small CT lesions in patients with seizures: understanding a controversy.

    abstract::Single, small (less than 1 cm) enhancing lesions are frequent findings on CT scans of Indian patients with seizures. These lesions have also been reported in patients from other parts of the world. They often resolve spontaneously and their etiology has been disputed for over a decade. Initially diagnosed in Indian pa...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章,评审


    authors: Rajshekhar V

    更新日期:1991-12-01 00:00:00

  • Impaired cardiac uptake of meta-[123I]iodobenzylguanidine in Parkinson's disease with autonomic failure.

    abstract:OBJECTIVE:To selectively investigate postganglionic sympathetic cardiac neurons in patients with Parkinson's disease and autonomic failure. MATERIAL AND METHODS:Metaiodobenzylguanidine (MIBG) is a pharmacologically inactive analogue of noradrenaline, which is similarly metabolized in noradrenergic neurons. Therefore t...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章


    authors: Braune S,Reinhardt M,Bathmann J,Krause T,Lehmann M,Lücking CH

    更新日期:1998-05-01 00:00:00

  • Buccally absorbed vs intravenous prochlorperazine for treatment of migraines headaches.

    abstract:OBJECTIVE:To compare the efficacy of buccally absorbed prochlorperazine (BAP) to intravenous prochlorperazine (IVP) for the abortive treatment of migraine headaches. METHODS:Randomized double-blind trial. Eighty subjects aged 18-65 presenting with migraines to the ED of a safety-net, urban hospital. Subjects were rand...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章,随机对照试验


    authors: Fernando T,Lumanauw DD,Youn S,Shimada M,Yadav K,Chappell B,Horeczko T,Tanen DA

    更新日期:2019-07-01 00:00:00

  • Efficacy of a soft hand brace and a wrist splint for carpal tunnel syndrome: a randomized controlled study.

    abstract:OBJECTIVE:To examine, in a randomized, controlled, single blinded trial, the efficacy of a soft hand brace and a wrist splint for carpal tunnel syndrome (CTS). METHODS:We randomized 120 patients with CTS into a group wearing the soft hand brace MANU and into another group wearing the wrist splint CAMP TIELLE at night ...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章,随机对照试验


    authors: De Angelis MV,Pierfelice F,Di Giovanni P,Staniscia T,Uncini A

    更新日期:2009-01-01 00:00:00

  • Comparison of upright balance in stroke, Parkinson and multiple sclerosis.

    abstract:OBJECTIVE:Multiple sclerosis (MS), Parkinson's disease (PD) and stroke (ST) subjects show balance impairments due to damage of the balance control system. The objective of the study was to assess the impact of MS, PD and ST on upright posture in eyes open condition and when visual and/or proprioceptive inputs are alter...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章


    authors: Cattaneo D,Carpinella I,Aprile I,Prosperini L,Montesano A,Jonsdottir J

    更新日期:2016-05-01 00:00:00

  • Distribution of cerebral microembolism in the anterior and middle cerebral arteries.

    abstract:BACKGROUND AND PURPOSE:Cerebral infarcts occur more frequently along the middle (MCA) than the anterior cerebral artery (ACA) territory. The reason(s) for this difference remains speculative. The objective of this study was to investigate the distribution of cerebral microemboli as detected by transcranial Doppler ultr...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章


    authors: Wijman CA,Babikian VL,Winter MR,Pochay VE

    更新日期:2000-02-01 00:00:00

  • "To hundred and twenty4our": a study of transcoding in dementia.

    abstract::The ability to transcode integers from ideographic to alphabetic script was assessed in patients with dementia of Alzheimer type. Eleven of 13 consecutive patients made characteristic errors of intrusion. We propose that this may be a simple bedside test for dementia. ...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章


    authors: Tegnér R,Nybäck H

    更新日期:1990-02-01 00:00:00

  • Isolated seizures in rats do not cause neuronal injury.

    abstract:BACKGROUND:Previous studies have shown that status epilepticus can lead to neuronal injury. However, the effect of a small number of isolated seizures is uncertain. METHODS:We used structural MRI and neuropathology to study the effects of isolated seizures induced by kainic acid (KA), (RS)-2-amino-3-(3-hydroxy-5-tert-...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章


    authors: Acosta MT,Munashinge J,Zhang L,Guerron DA,Vortmeyer A,Theodore WH

    更新日期:2012-01-01 00:00:00

  • Determinants of post-stroke cognitive impairment: analysis from VISTA.

    abstract:BACKGROUND:Post-stroke cognitive impairment (PSCI) occurs commonly and is linked with development of dementia. We investigated the relationship between demographic, clinical and stroke symptoms at stroke onset and the presence of PSCI at 1 and 3 years after stroke. METHODS:We accessed anonymized data from the Virtual ...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章


    authors: Arba F,Quinn T,Hankey GJ,Inzitari D,Ali M,Lees KR,VISTA Collaboration.

    更新日期:2017-06-01 00:00:00

  • Pediatric frontal lobe epilepsy: white matter abnormalities and cognitive impairment.

    abstract:OBJECTIVES:Cognitive impairment is frequent in children with frontal lobe epilepsy (FLE). Its etiology remains unknown. With diffusion tensor imaging, we have studied cerebral white matter properties and associations with cognitive functioning in children with FLE and healthy controls. METHODS:Thirty children aged 8-1...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章


    authors: Braakman HM,Vaessen MJ,Jansen JF,Debeij-van Hall MH,de Louw A,Hofman PA,Vles JS,Aldenkamp AP,Backes WH

    更新日期:2014-04-01 00:00:00

  • Effects of MRI abnormalities on WAIS-R performance in solvent abusers.

    abstract:OBJECTIVE:To clarify how chronic solvent abuse affects cognitive function using magnetic resonance imaging as an index of brain damage. MATERIAL AND METHODS:A total of 25 chronic solvent abusers underwent magnetic resonance imaging with quantitative neurometry and Wechsler Adult Intelligence Scales revised. RESULTS:T...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章


    authors: Yamanouchi N,Okada S,Kodama K,Sakamoto T,Sekine H,Hirai S,Murakami A,Komatsu N,Sato T

    更新日期:1997-07-01 00:00:00

  • Cognitive impairments associated with periventricular white matter hyperintensities are mediated by cortical atrophy.

    abstract:BACKGROUND:Previous studies have shown that white matter lesions (WMLs) is an important risk factor for cognitive impairment, but the underlying mechanisms have not been clarified. OBJECTIVE:We tested the hypothesis that the cognitive impairments associated with periventricular white matter hyperintensities (PWMHs) on...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章


    authors: Zi W,Duan D,Zheng J

    更新日期:2014-09-01 00:00:00

  • The role of essential fatty acids in chronic fatigue syndrome. A case-controlled study of red-cell membrane essential fatty acids (EFA) and a placebo-controlled treatment study with high dose of EFA.

    abstract:OBJECTIVE:To replicate the treatment study by Behan et al. (1990) using current research criteria for Chronic Fatigue Syndrome (CFS). METHOD:Fifty patients who fulfilled the Oxford Criteria for CFS were randomly allocated to treatment with either Efamol Marine or placebo for 3 months. They were seen monthly and comple...

    journal_title:Acta neurologica Scandinavica

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Warren G,McKendrick M,Peet M

    更新日期:1999-02-01 00:00:00

  • Optimum trace count necessary for jitter calculation in single-fiber electromyography.

    abstract:OBJECTIVE:To clarify the optimum trace count for jitter calculation. MATERIALS AND METHODS:Single-fiber electromyography was performed during voluntary contraction (VC-SFEMG) of extensor digitorum muscle in six healthy and five myasthenic subjects. Twenty single-fiber action potential (SFAP) pairs were recorded from e...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章


    authors: Baslo MB,Yalinay P,Yildiz N,Ertaş M

    更新日期:2003-10-01 00:00:00

  • Cerebral hemodynamic changes at basilar artery in patients with obstructive sleep apnea syndrome. A case-control study.

    abstract:INTRODUCTION:Obstructive sleep apnea syndrome (OSAS) is characterized in polysomnography by recurrent airflow obstruction during sleep. The underlying pathogenic mechanisms of neuropsychological and cerebrovascular events in patients with OSAS have not been clarified unequivocally. MATERIAL AND METHODS:Case-control st...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章


    authors: Jiménez Caballero PE,Coloma Navarro R,Segura Martín T,Ayo Martín O

    更新日期:2014-02-01 00:00:00

  • Cognitive impairment in MS: rehabilitation approaches.

    abstract::Cognitive deficits have been reported in 45%-70% of patients with multiple sclerosis (MS). Like other symptoms of MS, cognitive deficits are highly variable. Slowed information processing and memory and learning dysfunction are regarded as the most frequent cognitive deficits in MS. Both white and gray matter damages ...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章,评审


    authors: Hämäläinen P,Rosti-Otajärvi E

    更新日期:2016-09-01 00:00:00

  • Musculoskeletal and central pain at 1 year post-stroke: associated factors and impact on quality of life.

    abstract:BACKGROUND AND PURPOSE:Pain is common in post-stroke patients and has been shown to be associated with depression, fatigue, and decreased quality of life (QOL). However, studies examining different types of post-stroke pain are scarce. We investigated differences in the related factors and their QOL impacts between mus...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章


    authors: Choi-Kwon S,Choi SH,Suh M,Choi S,Cho KH,Nah HW,Song H,Kim JS

    更新日期:2017-04-01 00:00:00

  • Transient acute renal failure and functional hemispheric depression after cerebral arteriography in diabetic patients.

    abstract::Cerebral angiography was carried out in two diabetic patients in the evaluation of minor vascular ischemic episodes. A transient acute renal failure following cerebral angiography was accompanied by a transient comatose episode with severe unilateral neurological deficits. A functional depression of the injected hemis...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章


    authors: Skyhøj Olsen T,Lund P,Praestholm J

    更新日期:1981-12-01 00:00:00

  • Subjective memory decline in healthy community-dwelling elders. What does this complain mean?

    abstract:OBJECTIVES:Subjective feelings of memory decline are fairly common among the elderly. The causes of this are heterogeneous, and may be related to both affective and cognitive disorders. We attempted to explore the associations between subjective and cognitive measures. MATERIALS AND METHODS:Healthy subjects were studi...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章


    authors: Balash Y,Mordechovich M,Shabtai H,Merims D,Giladi N

    更新日期:2010-03-01 00:00:00

  • Type-2 diabetes and cognitive function in a non-demented population.

    abstract:OBJECTIVES:To study if type-2 (non-insulin-dependent) diabetes mellitus (NIDDM) is associated with cognitive dysfunction independently of clinically diagnosed dementia in an elderly population. MATERIAL AND METHODS:Cognitive function was investigated with a brief neuropsychological test battery in a non-demented elder...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章


    authors: Vanhanen M,Kuusisto J,Koivisto K,Mykkänen L,Helkala EL,Hänninen T,Riekkinen P Sr,Soininen H,Laakso M

    更新日期:1999-08-01 00:00:00