Effect of memantine on CBF and CMRO2 in patients with early Parkinson's disease.

Abstract:

OBJECTIVES:Parkinson's disease (PD) may be associated with increased energy metabolism in overactive regions of the basal ganglia. Therefore, we hypothesized that treatment with the N-methyl-d-aspartate receptor (NMDAR) antagonist memantine would decrease regional cerebral blood flow (rCBF) and oxygen metabolism in the basal ganglia of patients with early-stage PD. METHODS:Quantitative positron emission tomography (PET) recordings were obtained with 15O]water and 15O]oxygen in 10 patients, scanned first in a baseline condition, and again 6 weeks after treatment with a daily dose of 20 mg memantine. Dynamic PET data were analyzed using volume of interest and voxel-based approaches. RESULTS:The treatment evoked rCBF decreases in basal ganglia, and in several frontal cortical areas. The regional cerebral metabolic rate of oxygen (rCMRO2) did not decrease in any of the a priori defined regions, and consequently the oxygen extraction fraction was increased in these regions. Two peaks of significantly decreased rCMRO2 were detected near the frontal poles in both hemispheres, using a posteriori voxel-based analysis. CONCLUSIONS:Although we did not find the predicted decrease in basal ganglia oxygen consumption, our data suggest that treatment with memantine actively modulates neuronal activity and/or hemodynamic response in basal ganglia of PD patients. This finding may be relevant to the putative neuroprotective properties of NMDAR antagonists.

journal_name

Acta Neurol Scand

authors

Borghammer P,Vafaee M,Ostergaard K,Rodell A,Bailey C,Cumming P

doi

10.1111/j.1600-0404.2007.00943.x

subject

Has Abstract

pub_date

2008-05-01 00:00:00

pages

317-23

issue

5

eissn

0001-6314

issn

1600-0404

pii

ANE943

journal_volume

117

pub_type

临床试验,杂志文章
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    abstract::Ten patients with pseudotumor cerebri were studied. The diagnosis was based on bilateral papilledema and absence of intracranial masses and hydrocephalus. Based on the radiological findings, three groups of patients emerged: (A) Five patients with an empty sella. Four had an enlarged sella; (B) Two patients with a pit...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0404.1982.tb06869.x

    authors: Bjerre P,Lindholm J,Gyldensted C

    更新日期:1982-10-01 00:00:00

  • Plantar stimulation alters brain connectivity in idiopathic Parkinson's disease.

    abstract:OBJECTIVE:Individuals with Parkinson's disease (PD) and freezing of gait (FOG) present peripheral and central sensitivity disturbances that impair motor performance. This study aimed to investigate long-term effects of plantar sensory stimulation on brain activity, brain connectivity, and gait velocity of individuals w...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/ane.13253

    authors: Pagnussat AS,Salazar AP,Pinto C,Redivo Marchese R,Rieder CRM,Alves Filho JO,Franco AR,Kleiner AFR

    更新日期:2020-09-01 00:00:00

  • Paraneoplastic neurological syndrome due to burned-out testicular tumor showing hot cross-bun sign.

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    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/ane.12469

    authors: Ishikawa H,Kawada N,Taniguchi A,Odachi K,Mizutani A,Asahi M,Tomimoto H

    更新日期:2016-05-01 00:00:00

  • The neurotoxicity of ethanol.

    abstract::Alterations in nervous system functioning following acute and chronic ethanol exposure have been studied in a great number of experimental investigations. Results from many of these investigations can be difficult to interpret, particularly since a variety of techniques and exposure models are employed. This review em...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章,评审

    doi:10.1111/j.1600-0404.1983.tb04556.x

    authors: Melgaard B

    更新日期:1983-03-01 00:00:00

  • Oral choline in cerebellar ataxia.

    abstract::In a double-blind crossover pilot study with placebo, choline chloride, the physiologic precursor of acetylcholine, was tested in six patients with cerebellar ataxia. Neither subjectively nor objectively could any statistical significant difference be demonstrated. ...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0404.1980.tb03012.x

    authors: Sehested P,Lund HI,Kristensen O

    更新日期:1980-08-01 00:00:00

  • Oligoclonal bands in cerebrospinal fluid: a comparative study of isoelectric focusing, agarose gel electrophoresis and IgG index.

    abstract:OBJECTIVE:To compare the sensitivity and specificity of isoelectric focusing (IEF) with immunofixation, agarose gel electrophoresis (AGE) and the IgG index in detecting intrathecally synthesized IgG in multiple sclerosis (MS) and in other nervous system disorders. MATERIALS AND METHODS:Cerebrospinal fluid (CSF) and se...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1034/j.1600-0404.2000.102005322.x

    authors: Lunding J,Midgard R,Vedeler CA

    更新日期:2000-11-01 00:00:00

  • B cell activation in multiple sclerosis.

    abstract::A microtechnique was established for the study of the limited numbers of cells available in CSF. The method allowed for the determination of the number of immunoglobulin-secreting cells (IgSC) as well as the quantitation of immunoglobulin or specific antibody secreted into the culture medium. Dose-response curves and ...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0404.1986.tb07866.x

    authors: Sandberg M,Levinson AI,Zweiman B,Lisak RP

    更新日期:1986-12-01 00:00:00

  • M-wave analysis and passive tilt in patients with different degrees of carotid artery disease.

    abstract:BACKGROUND AND PURPOSE:Carotid artery disease (CAD) is able to critically impair cerebral autoregulation which increases the risk for stroke. As therapeutic strategy largely depends on the degree of CAD, we investigated whether this gradation is also related to significant changes in autoregulatory capacity. We applied...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1034/j.1600-0404.2003.00210.x

    authors: Haubrich C,Klemm A,Diehl RR,Möller-Hartmann W,Klötzsch C

    更新日期:2004-03-01 00:00:00

  • Genetic factors in temporal lobe epilepsy.

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    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0404.1975.tb05833.x

    authors: Jensen I

    更新日期:1975-11-01 00:00:00

  • Regional cerebral blood flow in various types of brain tumor. Effect of the space-occupying lesion on blood flow in brain tissue close to and remote from tumor site.

    abstract::Regional cerebral blood flow (rCBF) was measured in 23 patients with brain tumors using the 133Xe intra-carotid injection method and a 254 channel gamma camera. The glioblastomas (4) and astrocytomas (4) all showed hyperemia in the tumor and tumor-near region. This was also seen in several meningiomas (4 of 7 cases) i...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0404.1982.tb04513.x

    authors: Kuroda K,Skyhøj Olsen T,Lassen NA

    更新日期:1982-08-01 00:00:00

  • How broad is the phenotype of Hallervorden-Spatz disease?

    abstract::Magnetic resonance imaging (MRI) has enabled ante mortem diagnosis of Hallervorden Spatz disease (HSD). Childhood-onset cases are the most common type and usually present with progressive dystonia and dementia. The duration of illness is 15 to 20 years, leading to death. Presentation in adulthood and infancy have also...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1034/j.1600-0404.2001.103003201.x

    authors: Hickman SJ,Ward NS,Surtees RA,Stevens JM,Farmer SF

    更新日期:2001-03-01 00:00:00

  • Types of occult cancer in stroke and the relation to smoking.

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    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/ane.13299

    authors: Tybjerg AJ,Babore AD,Olsen TS,Andersen KK

    更新日期:2020-11-01 00:00:00

  • Cell-mediated immunity to viral antigens and tuberculin in multiple sclerosis.

    abstract::Lymphocyte transformation responses to measles, mumps, herpes simplex and parainfluenza virus antigens and purified protein derivative of tuberculin were determined in both 78 normal controls and 40 patients with multiple sclerosis, 16 of whom were studied serially. Patients with multiple sclerosis showed significantl...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0404.1981.tb00752.x

    authors: Sagar HJ,Allonby ID,Hughes P

    更新日期:1981-02-01 00:00:00

  • Cerebrospinal fluid and blood flow patterns in idiopathic normal pressure hydrocephalus.

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    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/ane.12636

    authors: Qvarlander S,Ambarki K,Wåhlin A,Jacobsson J,Birgander R,Malm J,Eklund A

    更新日期:2017-05-01 00:00:00

  • Advances in the pathophysiology of status epilepticus.

    abstract::Status epilepticus (SE) describes an enduring epileptic state during which seizures are unremitting and tend to be self-perpetuating. We describe the clinical phases of generalized convulsive SE, impending SE, established SE, and subtle SE. We discuss the physiological and biochemical cascades which characterize self-...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章,评审

    doi:10.1111/j.1600-0404.2007.00803.x

    authors: Chen JW,Naylor DE,Wasterlain CG

    更新日期:2007-04-01 00:00:00

  • Transcranial Doppler echo contrast studies using different colour processing modes.

    abstract:OBJECTIVES:To study the effects of different colour imaging modes on the contrast-medium-enhanced image of the intracranial cerebral arteries. METHODS:Twelve healthy volunteers were studied transcranially after administration of 10 ml BY963 successively with Power Doppler (p-TCCS) and with colour Doppler frequency ima...

    journal_title:Acta neurologica Scandinavica

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/j.1600-0404.1997.tb00225.x

    authors: Kaps M,Schaffer P,Beller KD,Seidel G,Wurst W

    更新日期:1997-06-01 00:00:00

  • Autosomal recessive paraparesis with amyotrophy of the hands and feet.

    abstract::We present 2 sibs with autosomal recessive spastic paraparesis and severe amyotrophy of the distal limb muscles. Elaborate neurophysiologic studies disclosed slight to moderate slowing of motor conduction, moderate to severe reduction of motor action potentials, denervation potentials, and increased distal motor laten...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0404.1993.tb04133.x

    authors: Bruyn RP,Scheltens P,Lycklama à Nijeholt J,de Jong JM

    更新日期:1993-06-01 00:00:00

  • High ratio of HTLV-1-infected cells in HTLV-1 associated myelopathy (HAM).

    abstract::Sixteen patients with HTLV-1 associated myelopathy (HAM) were examined for the presence of HTLV-1 provirus genome by Southern blot analysis of genomic DNA from peripheral blood mononuclear (PBM) cells. Random integration of the provirus was detected in 14 of 16 HAM patients. By contrast, the provirus genome could not ...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0404.1990.tb00968.x

    authors: Nishimura M,Adachi A,Akiguchi I,Shirahata N,Maeda M,Ishimoto A,Mezaki T,Kimura J

    更新日期:1990-03-01 00:00:00

  • Neuropsychological assessment in MS: clinical, neurophysiological and neuroradiological relationships.

    abstract::We assessed cognitive performance and its relationship with clinical and anatomic disease severity in MS with mild to moderate handicap; 34 definite MS and 18 healthy subjects matched for age and education were submitted to a neuropsychological test battery. Both groups were examined for anxiety. MS patients underwent...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0404.1992.tb05052.x

    authors: Maurelli M,Marchioni E,Cerretano R,Bosone D,Bergamaschi R,Citterio A,Martelli A,Sibilla L,Savoldi F

    更新日期:1992-08-01 00:00:00

  • Premature death in juvenile myoclonic epilepsy.

    abstract:OBJECTIVES:To report three cases of premature death in juvenile myoclonic epilepsy (JME), a benign form of idiopathic generalized epilepsy (IGE) in which no case of epilepsy-related death has been reported. MATERIAL AND METHODS:We retrospectively analyzed all medical records of JME patients first referred to two epile...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1034/j.1600-0404.2001.00003.x

    authors: Genton P,Gelisse P

    更新日期:2001-09-01 00:00:00

  • Neuroacanthocytosis--the variability of presenting symptoms in two siblings.

    abstract::Neuroacanthocytosis is a progressive multisystem disease with a wide range of symptoms. The involuntary movements mainly include chorea and orofaciolingual dyskinesias. The descriptive name of the disease refers to the presence of abnormal erythrocytes in peripheral blood. Two siblings are presented. One young female ...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0404.1999.tb00404.x

    authors: Aasly J,Skandsen T,Rø M

    更新日期:1999-11-01 00:00:00

  • Temporal arteritis: a decision-analytic approach to temporal artery biopsy.

    abstract::The clinical indications for temporal artery biopsy were explored using clinical decision analysis. The analysis indicated that biopsy is most useful in patients with a high likelihood of steroid side effects. It is nearly always useful when the pre-biopsy likelihood of temporal arteritis is low, but loses its value w...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0404.1988.tb03627.x

    authors: Nadeau SE

    更新日期:1988-08-01 00:00:00

  • Cognitive function in early adult and adult onset myotonic dystrophy.

    abstract:INTRODUCTION:Most studies revealing intellectual deficits in myotonic dystrophy (MyD) involved heterogeneous groups of patients with respect to intelligence and onset of disease. The present study was undertaken to investigate whether patients with early adult and adult MyD show subtle cognitive deficits despite a norm...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0404.1995.tb00446.x

    authors: Van Spaendonck KP,Ter Bruggen JP,Weyn Banningh EW,Maassen BA,Van de Biezenbos JB,Gabreëls FJ

    更新日期:1995-06-01 00:00:00

  • Pooled analysis of phase III with entacapone in Parkinson's disease.

    abstract:OBJECTIVES:To investigate efficacy and safety of entacapone across phase III studies in Parkinson's disease (PD) with wearing-off symptoms. METHODS:Retrospective, pooled analysis of four phase 3 randomized, double-blind, placebo-controlled studies with entacapone. RESULTS:475 of 808 patients with PD received entacapo...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章,meta分析

    doi:10.1111/ane.12278

    authors: Kuoppamäki M,Vahteristo M,Ellmén J,Kieburtz K

    更新日期:2014-10-01 00:00:00

  • Cerebrospinal fluid levels of cyclic nucleotides in meningitis and idiopathic polyneuritis.

    abstract::Cyclic adenosine 3',5'-monophosphate (cAMP) and cyclic guanosine 3',5'-monophosphate (cGMP) were measured in cerebrospinal fluid (CSF) and plasma from 7 patients with bacterial meningitis, 9 patients with serous meningitis, 5 patients with idiopathic polyneuritis and 15 reference patients. A significantly (P less than...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0404.1984.tb07796.x

    authors: Lerche A,Svenson M,Wiik A

    更新日期:1984-03-01 00:00:00

  • Vigabatrin-associated retinal damage: potential biochemical mechanisms.

    abstract::Vigabatrin (VGB), an irreversible inhibitor of gamma-aminobutyric acid (GABA) transaminase, is approved as adjunct treatment of refractory partial seizures as well as infantile spasms. Although VGB has been proven to be effective, its use is limited by the risk of retinopathy and associated peripheral visual field def...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章,评审

    doi:10.1111/j.1600-0404.2012.01684.x

    authors: Heim MK,Gidal BE

    更新日期:2012-10-01 00:00:00

  • Etiology and management of single small CT lesions in patients with seizures: understanding a controversy.

    abstract::Single, small (less than 1 cm) enhancing lesions are frequent findings on CT scans of Indian patients with seizures. These lesions have also been reported in patients from other parts of the world. They often resolve spontaneously and their etiology has been disputed for over a decade. Initially diagnosed in Indian pa...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章,评审

    doi:10.1111/j.1600-0404.1991.tb04996.x

    authors: Rajshekhar V

    更新日期:1991-12-01 00:00:00

  • Prostaglandin E2 is increased in amyotrophic lateral sclerosis patients.

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    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1034/j.1600-0404.2003.00102.x

    authors: Iłzecka J

    更新日期:2003-08-01 00:00:00

  • Long-term neuropsychological effects and MRI findings in patients with CS2 poisoning.

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    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1034/j.1600-0404.2002.01245.x

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    更新日期:2002-11-01 00:00:00

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    pub_type: 杂志文章,评审

    doi:10.1111/j.1600-0404.1993.tb05512.x

    authors: Villardita C

    更新日期:1993-04-01 00:00:00