Serum sAPO-1/Fas levels in multiple sclerosis.

Abstract:

UNLABELLED:Soluble APO-1 (sAPO-1) may prevent apoptosis of lymphocytes induced by activation of the APO-1/Fas receptor. OBJECTIVES:To determine sAPO-1 levels in the serum of multiple sclerosis (MS) patients and controls in order to investigate if abnormal lymphocyte apoptosis occurs in this disease. METHODS:Serum samples from patients with MS, other neurological diseases, systemic lupus erythematosus and healthy controls were determined by enzyme-linked immunosorbent assay. RESULTS:We did not detect differences in mean serum sAPO-1 levels between patients with multiple sclerosis and controls. CONCLUSIONS:This preliminary study suggests that resistance of peripheral blood lymphocytes to apoptosis mediated by sAPO-1 is not likely to be a major factor in the development of autoreactive cells in MS.

journal_name

Acta Neurol Scand

authors

Bansil S,Holtz CR,Cook SD,Rohowsky-Kochan C

doi

10.1111/j.1600-0404.1997.tb00100.x

subject

Has Abstract

pub_date

1997-04-01 00:00:00

pages

208-10

issue

4

eissn

0001-6314

issn

1600-0404

journal_volume

95

pub_type

杂志文章
  • Failure of allopurinol to protect against cerebral injury when given after the start of hypoxia.

    abstract::One cause of ischemic brain injury is free radical formation during recirculation. Allopurinol inhibits xanthine oxidase, an important source of free oxygen radicals. It is known that allopurinol pre-treatment has a protective action during cerebral ischemia. In the present study we exposed slices from the rat hippoca...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0404.1991.tb04702.x

    authors: Hegstad E,Berg-Johnsen J,Langmoen IA

    更新日期:1991-05-01 00:00:00

  • Cognitive function in stroke survivors: A 10-year follow-up study.

    abstract:OBJECTIVES:Post-stroke cognitive impairment (PSCI) has considerable impact on patients and society. However, long-term studies on PSCI are scarce and may be influenced by assessment methods and selection bias. We aimed to (i) assess the prevalence of long-term PSCI; (ii) compare two common cognitive assessment instrume...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/ane.12709

    authors: Delavaran H,Jönsson AC,Lövkvist H,Iwarsson S,Elmståhl S,Norrving B,Lindgren A

    更新日期:2017-09-01 00:00:00

  • Public stroke awareness and intent to call 112 in Sweden.

    abstract:BACKGROUND AND AIMS:Recognition of stroke symptoms and activation of emergency services are essential in minimizing delay for acute stroke treatments. In this study, we assessed public stroke awareness in Sweden. METHODS:One thousand and five hundred residents aged 18-79 years participated in a telephone survey. Open-...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/ane.12293

    authors: Nordanstig A,Jood K,Rosengren L

    更新日期:2014-12-01 00:00:00

  • Long-term epidemiology of multiple sclerosis in the Northern Seville District.

    abstract:OBJECTIVES:Comprehensive epidemiologic data for multiple sclerosis (MS) in Spain are limited. The aim of this study was to collect epidemiologic data on MS in the Northern Seville District of Spain. MATERIALS AND METHODS:This longitudinal study identified possible MS cases every year from nine centres between 1 Januar...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章,多中心研究

    doi:10.1111/ane.12363

    authors: Izquierdo G,Venegas A,Sanabria C,Navarro G

    更新日期:2015-08-01 00:00:00

  • Risk factor burden predicts long-term mortality in young patients with arterial cerebral infarction.

    abstract:OBJECTIVE:The aim was to investigate risk factors separately and in sum in relation to long-term mortality after arterial cerebral infarction in young adults. MATERIALS AND METHODS:Mortality in relation to the number of risk factors (smoking, hypertension, hypercholesterolemia, diabetes mellitus, myocardial infarction...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0404.2012.01681.x

    authors: Naess H,Waje-Andreassen U,Nyland H

    更新日期:2013-02-01 00:00:00

  • The Gulf War era multiple sclerosis cohort: 3. Early clinical features.

    abstract:OBJECTIVES:To present clinical features at diagnosis for a large nationwide incident cohort of multiple sclerosis (MS) among those serving in the US military during the Gulf War era (GWE). MATERIALS & METHODS:Medical records and databases from the Department of Veterans Affairs (VA) for cases of MS with onset in or af...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/ane.12810

    authors: Wallin MT,Culpepper WJ,Maloni H,Kurtzke JF

    更新日期:2018-01-01 00:00:00

  • Variation of therapeutic response in Parkinson's disease: a retrospective study.

    abstract::A retrospective study of variations of therapeutic response (dyskinesia and on-off phenomenon) in Parkinson's disease was conducted on 278 patients treated with levodopa for at least 6 months and hospitalized at National Neurological Institute "C. Besta" of Milan between 1974 and 1984. Variations of therapeutic respon...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0404.1990.tb00983.x

    authors: Geminiani G,Cesana BM,Scigliano G,Soliveri P,Girotti F,Giovannini P,Caraceni T

    更新日期:1990-05-01 00:00:00

  • "To hundred and twenty4our": a study of transcoding in dementia.

    abstract::The ability to transcode integers from ideographic to alphabetic script was assessed in patients with dementia of Alzheimer type. Eleven of 13 consecutive patients made characteristic errors of intrusion. We propose that this may be a simple bedside test for dementia. ...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:

    authors: Tegnér R,Nybäck H

    更新日期:1990-02-01 00:00:00

  • A non-syndromic hearing loss caused by very low levels of the mtDNA A3243G mutation.

    abstract::We described a patient with progressive non-syndromic hearing loss (NSHL) harboring the A3243G mutation in the mitochondrial DNA (mtDNA). Muscle biopsy showed scattered ragged-red, cytochrome c oxidase negative fibers, whereas the biochemical analysis of the mitochondrial respiratory chain complexes was normal. Restri...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0404.2004.00254.x

    authors: Mancuso M,Filosto M,Forli F,Rocchi A,Berrettini S,Siciliano G,Murri L

    更新日期:2004-07-01 00:00:00

  • Scalp EMG in brain death electroencephalogram.

    abstract::Electromyograms (EMGs) are usually considered artifacts during electroencephalographic (EEG) recording for determination of electrocerebral silence (ECS). Appearance of scalp motor unit activity, however, may reflect residual brainstem function and can introduce difficulty in establishing a secure diagnosis of brain d...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0404.1986.tb04638.x

    authors: Wee AS

    更新日期:1986-08-01 00:00:00

  • The linoleic acid depression (LAD) test for multiple sclerosis using the macrophage electrophoretic mobility (MEM) test.

    abstract::With the macrophage electrophoretic mobility (MEM) test of Field & Caspary, lymphocyte sensitization to thyroid antigen (F1-fraction) is demonstrable in all subjects--multiple sclerosis (MS) patients, those with other (destructive) neurological diseases (OND) and normals. The MEM-LAD test enables a further differentia...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0404.1976.tb04324.x

    authors: Jenssen HL,Meyer-Rienecker HJ,Köhler H,Günther JK

    更新日期:1976-01-01 00:00:00

  • Amino acid incorporation into brain subcellular fractions in experimental allergic encephalomyelitis.

    abstract::The in vitro protein synthetic capactiy of brain slices from guinea-pigs in the late stage (17-18 days post-induction) of experimental allergic encephalomyelitis was increased over that of Freund's adjuvant injected controls, as determined by the rate of (14C)-leucine incorporation into both tris-soluble and tris-inso...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0404.1975.tb07602.x

    authors: Babitch JA,Blomstrand C,Hamberger A

    更新日期:1975-03-01 00:00:00

  • Inhibitory effect of unsaturated fatty acids on lymphocyte-antigen interaction with special reference to multiple sclerosis.

    abstract::Using the macrophage electrophoretic mobility (MEM) test, the in vitro effects of oleic, linoleic and arachidonic acid, as well as Naudicell oil and methyl gamma-linolenate, on lymphocyte response to various antigens (PPD, thyroid antigen and EF) were studied in patients with mutiple sclerosis, patients with other neu...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0404.1975.tb05766.x

    authors: Field EJ,Shenton BK

    更新日期:1975-08-01 00:00:00

  • Mutations in the alpha-synuclein gene in Parkinson's disease among Indians.

    abstract:OBJECTIVE:To investigate the prevalence of G88C, G209A and any other mutation(s) in exons 3 and 4 of the alpha-synuclein gene in Indian patients with Parkinson's disease (PD). METHODS:A total of 169 PD patients comprising 18 familial, 3 juvenile, 48 early onset and 100 sporadic cases were included in this study. Genom...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1034/j.1600-0404.2001.103002120.x

    authors: Nagar S,Juyal RC,Chaudhary S,Behari M,Gupta M,Rao SN,Thelma BK

    更新日期:2001-02-01 00:00:00

  • European neuroborreliosis: quality of life 30 months after treatment.

    abstract:OBJECTIVES:The prognosis after Lyme neuroborreliosis (LNB) is debated. The aim of this study was to assess health-related Quality of Life (QoL) and neurological symptoms 30 months after treatment in European patients with LNB. MATERIALS AND METHODS:In a prospective case-control designed study, we investigated 50 well-...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0404.2010.01482.x

    authors: Eikeland R,Mygland A,Herlofson K,Ljøstad U

    更新日期:2011-11-01 00:00:00

  • Re-evaluation of the dysequilibrium syndrome.

    abstract:OBJECTIVES:To re-evaluate middle-aged Swedish patients diagnosed with dysequilibrium syndrome (DES) in childhood and to compare their clinical and neuroimaging features to DES with VLDLR gene mutations (DES-VLDR). MATERIALS AND METHODS:Six patients from five families underwent neurological examination and magnetic res...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0404.2010.01335.x

    authors: Melberg A,Orlén H,Raininko R,Entesarian M,Dahlqvist J,Gustavson KH,Dahl N

    更新日期:2011-01-01 00:00:00

  • Severe multiple sclerosis reactivation during prolonged lymphopenia after dimethyl fumarate discontinuation.

    abstract:BACKGROUND:Delayed-release dimethyl fumarate (DMF) treatment can be associated with reduced lymphocyte and leucocyte counts, which might persist after DMF discontinuation. CASE PRESENTATION:We report the case of a patient with severe disease reactivation despite prolonged lymphopenia after DMF discontinuation. We desc...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章,评审

    doi:10.1111/ane.12882

    authors: Zecca C,Antozzi CG,Torri Clerici V,Ferrazzini M,Mantegazza RE,Rossi S,Gobbi C

    更新日期:2018-06-01 00:00:00

  • Intravenous lacosamide or phenytoin for treatment of refractory status epilepticus.

    abstract:OBJECTIVES:To compare intravenous phenytoin (PHT) and intravenous lacosamide (LCM) for treatment of status epilepticus after failure of the first and second drug. METHODS:We retrospectively identified patients from a large community hospital in northern Germany who had been diagnosed with SE between August 2008 and De...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/ane.12174

    authors: Kellinghaus C,Berning S,Stögbauer F

    更新日期:2014-05-01 00:00:00

  • A further study on the prevalence of multiple sclerosis in Sicily: Caltanissetta city.

    abstract::The prevalence of probable multiple sclerosis (MS) in Caltanissetta city, Sicily, is at least 51 per 100,000. If possible multiple sclerosis patients are included, it is 54 per 100,000. This value is similar to that found in other cities in Sicily: Enna, Monreale and Agrigento. The high prevalence of multiple sclerosi...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0404.1986.tb03243.x

    authors: Savettieri G,Elian M,Giordano D,Grimaldi G,Ventura A,Dean G

    更新日期:1986-01-01 00:00:00

  • Restless legs syndrome in Wilson's disease: frequency, characteristics, and mimics.

    abstract:OBJECTIVE:To determine characteristics, clinical significance, frequency, and mimics of restless legs syndrome (RLS) in a cohort of Wilson's disease (WD, n = 42/f = 18), compared to healthy, matched controls. MATERIALS AND METHODS:Structured clinical interviews (patients and caregiving family members), repeated neurol...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/ane.12585

    authors: Trindade MC,Bittencourt T,Lorenzi-Filho G,Alves RC,de Andrade DC,Fonoff ET,Bor-Seng-Shu E,Machado AA,Teixeira MJ,Barbosa ER,Tribl GG

    更新日期:2017-02-01 00:00:00

  • Evoked potentials and CSF-immunoglobulins in MS: relationship to disease duration, disability, and functional status.

    abstract::In 100 MS patients, BAEP and tibial SEP abnormality rates increased significantly with disease duration and clinical disability. VEP correlated non-linearly with disease duration, and median nerve SEP correlated with disability. In multifactorial analysis, however, BAEP correlated significantly only with clinical brai...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0404.1990.tb04491.x

    authors: Sand T,Sulg IA

    更新日期:1990-09-01 00:00:00

  • Optic atrophy in experimental vitamin B12 deficiency in monkeys.

    abstract::The clinical findings and pathological changes of the visual pathway of vitamin B12 deficient monkeys have been described. The cellular morphology and counts of the peripheral blood and bone marrow remained normal during the study (nine deficient, three controls: one still alive in each group). Visual impairment was n...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0404.1980.tb02991.x

    authors: Chester EM,Agamanolis DP,Harris JW,Victor M,Hines JD,Kark JA

    更新日期:1980-01-01 00:00:00

  • Incidence of aneurysmal subarachnoid hemorrhage in Norway, 1999-2007.

    abstract:OBJECTIVE:To investigate changes and regional variations in annual incidence rates of aneurysmal subarachnoid hemorrhage (SAH) in Norway between 1999 and 2007. METHODS:The authors retrospectively reviewed data from the Norwegian Patient Register for the period 1999-2007. RESULTS:Crude incidence of aneurysmal SAH was ...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0404.2010.01336.x

    authors: Lindekleiv HM,Njølstad I,Ingebrigtsen T,Mathiesen EB

    更新日期:2011-01-01 00:00:00

  • Anti-GM1 ganglioside antibodies in Parkinson's disease.

    abstract:OBJECTIVES:To determine whether anti-GM1 antibodies are increased in Parkinson's disease (PD). METHODS:Serum immunoglobulin M (IgM) and IgG anti-GM1 antibodies were detected by enzyme-linked immunosorbent assay (ELISA) in 147 patients with PD and in 186 age-matched normal control subjects. Sera were assayed at initial...

    journal_title:Acta neurologica Scandinavica

    pub_type: 临床试验,杂志文章

    doi:10.1034/j.1600-0404.2002.01240.x

    authors: Zappia M,Crescibene L,Bosco D,Arabia G,Nicoletti G,Bagalà A,Bastone L,Napoli ID,Caracciolo M,Bonavita S,Di Costanzo A,Gambardella A,Quattrone A

    更新日期:2002-07-01 00:00:00

  • Tourette's syndrome associated with restless legs syndrome and akathisia in a family.

    abstract::A family with coincidence of a restless leg syndrome (RLS) in the mother and a Gilles de la Tourette syndrome (GTS) in the son who also shows increased vulnerability to neuroleptic induced akathisia (NIA) is presented. Since these diseases show parallels from a genetic, pathogenetic and clinical point of view, the fam...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0404.1994.tb02661.x

    authors: Müller N,Voderholzer U,Kurtz G,Straube A

    更新日期:1994-06-01 00:00:00

  • Measurement of glial fibrillary acidic protein (GFAP) and anti-GFAP antibodies by solid-phase radioimmunoassays.

    abstract::A solid-phase radioimmunoassay was developed for the detection of glial fibrillary acidic protein (GFAP) and GFAP-specific immunoglobulin G (IgG) antibodies. In antibody assays purified GFAP was absorbed onto polystyrene beads, followed by incubation in dilutions of serum. (125-I)-labelled human anti-IgG was used to q...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0404.1981.tb00783.x

    authors: Ruutiainen J,Newcombe J,Salmi A,Dahl D,Frey H

    更新日期:1981-05-01 00:00:00

  • Composition of free amino acids in brain tumors.

    abstract::The composition of the free amino acid pools in various brain tumors and in normal brains obtained at surgery or at autopsy is determined with an automatic amino acid analyzer and the results statistically evaluated. The tumors have lower ratios of GABA in the pools than the normal brain; tumors with higher GABA ratio...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0404.1979.tb02985.x

    authors: Shibasaki T,Uki J,Kanoh T,Kawafuchi J

    更新日期:1979-01-01 00:00:00

  • Assessment of the ophthalmic artery as a collateral to the cerebral circulation. A comparison of transorbital Doppler ultrasonography and regional cerebral blood flow measurements.

    abstract::The role of the ophthalmic artery (OA) as a collateral to the cerebral circulation in carotid occlusive disease is somewhat controversial. The aim of this study was to assess the importance of this collateral by comparing the results of transorbital Doppler ultrasonography and regional cerebral blood flow measurements...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0404.1996.tb00012.x

    authors: Kerty E,Nyberg-Hansen R,Dahl A,Bakke SJ,Russell D,Rootwelt K

    更新日期:1996-05-01 00:00:00

  • Myelin glycosphingolipid immunoreactivity and CSF levels in multiple sclerosis.

    abstract:OBJECTIVES:Patients with multiple sclerosis were reported to harbour antibodies not only against proteins and glycoproteins but also against glycolipids, including sulfatide and galactosylceramide (GalCer), the two major glycosphingolipids of myelin. However, previous results were inconsistent concerning glycosphingoli...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0404.2011.01554.x

    authors: Haghighi S,Lekman A,Nilsson S,Blomqvist M,Andersen O

    更新日期:2012-01-01 00:00:00

  • Phenotypes and mitochondrial DNA substitutions in families with A3243G mutation.

    abstract:OBJECTIVE:To clarify the relationship between mitochondrial DNA (mtDNA) sequence variations and phenotypes in patients with A3243G mutation. MATERIALS AND METHODS:We studied whole mtDNA sequences in two families with A3243G mutation and characteristic clinical features. Two brothers in Family 1 had shown thiamine defi...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1034/j.1600-0404.2002.01172.x

    authors: Morovvati S,Nakagawa M,Sato Y,Hamada K,Higuchi I,Osame M

    更新日期:2002-08-01 00:00:00