Intravenous lacosamide or phenytoin for treatment of refractory status epilepticus.

Abstract:

OBJECTIVES:To compare intravenous phenytoin (PHT) and intravenous lacosamide (LCM) for treatment of status epilepticus after failure of the first and second drug. METHODS:We retrospectively identified patients from a large community hospital in northern Germany who had been diagnosed with SE between August 2008 and December 2010. Patients who had failed to respond to the first two drugs were selected for this analysis. RESULTS:Forty-six patients (23 female, median age 68 years) were identified. LCM was used as third drug in 21 patients (median bolus 400 mg) and PHT in 15 patients (median bolus 1500 mg). Pretreatment was similar regarding substance groups (benzodiazepine as first line, levetiracetam as second line drug) and bolus doses. Status epilepticus was terminated in six patients (40%) of the PHT group and in seven patients (33%) of the LCM group. Four patients (27%) of the PHT group and no patient of the LCM group suffered from a relevant, treatment-related side effect during administration of the third drug. CONCLUSION:Lacosamide and PHT showed similar success rates for treatment of SE when used after failure of benzodiazepines and levetiracetam. However, PHT was associated with relevant side effects that were not seen with LCM.

journal_name

Acta Neurol Scand

authors

Kellinghaus C,Berning S,Stögbauer F

doi

10.1111/ane.12174

subject

Has Abstract

pub_date

2014-05-01 00:00:00

pages

294-9

issue

5

eissn

0001-6314

issn

1600-0404

journal_volume

129

pub_type

杂志文章
  • Headache characteristics in obstructive sleep apnea syndrome and insomnia.

    abstract:OBJECTIVES:To determine headache characteristics in the obstructive sleep apnea syndrome (OSAS) and in insomnia. PATIENTS AND METHODS:Fifty-six OSAS patients and 50 insomnia patients were assessed in the same time period. Patients in both groups underwent an accurate interview to investigate headache occurrence and it...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0404.2005.00372.x

    authors: Alberti A,Mazzotta G,Gallinella E,Sarchielli P

    更新日期:2005-05-01 00:00:00

  • Influence of monoamine oxidase inhibitors and a dopamine uptake blocker on the distribution of 11C-N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, 11C-MPTP, in the head of the rhesus monkey.

    abstract::N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, MPTP, is a neurotoxic substance known to induce a parkinsonian syndrome in primates. The distribution of intravenously injected 11C-labelled MPTP (11C-MPTP) in the head of Rhesus monkeys was studied by means of positron emission tomography, PET. The influence of pretreatme...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0404.1986.tb04618.x

    authors: Hartvig P,Larsson BS,Lindberg BS,Oreland L,Gullberg P,Långström B,Rimland A,Lundqvist H,Malmborg P,Lindquist NG

    更新日期:1986-07-01 00:00:00

  • [(123) I]FP-CIT-SPECT asymmetry index to differentiate Parkinson's disease from vascular parkinsonism.

    abstract:OBJECTIVES:Differential diagnosis between vascular parkinsonism (VP) and Parkinson's Disease (PD) is often difficult, due to the overlap in clinical presentation and the lack of specificity at neuroimaging. Aim of the study was to identify a possible reliable marker at SPECT imaging useful to distinguish the two condit...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0404.2011.01583.x

    authors: Contrafatto D,Mostile G,Nicoletti A,Dibilio V,Raciti L,Lanzafame S,Luca A,Distefano A,Zappia M

    更新日期:2012-07-01 00:00:00

  • Efficacy of a soft hand brace and a wrist splint for carpal tunnel syndrome: a randomized controlled study.

    abstract:OBJECTIVE:To examine, in a randomized, controlled, single blinded trial, the efficacy of a soft hand brace and a wrist splint for carpal tunnel syndrome (CTS). METHODS:We randomized 120 patients with CTS into a group wearing the soft hand brace MANU and into another group wearing the wrist splint CAMP TIELLE at night ...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/j.1600-0404.2008.01072.x

    authors: De Angelis MV,Pierfelice F,Di Giovanni P,Staniscia T,Uncini A

    更新日期:2009-01-01 00:00:00

  • Cerebral hemodynamic patterns during stimuli tasks in multi-infarct and Alzheimer types of dementia.

    abstract:OBJECTIVES:To examine differences in cerebrovascular reactivity between multi-infarct and Alzheimer types of dementia. PATIENTS AND METHODS:Using transcranial Doppler, measurements of flow velocity in the middle cerebral arteries during apnea, thumb-to-finger opposition and verbal and design discrimination tasks were ...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0404.1998.tb05969.x

    authors: Matteis M,Silvestrini M,Troisi E,Bragoni M,Vernieri F,Caltagirone C

    更新日期:1998-06-01 00:00:00

  • Perampanel Study 207: long-term open-label evaluation in patients with epilepsy.

    abstract:OBJECTIVES:Evaluate interim long-term tolerability, safety and efficacy of adjunctive perampanel, a novel α-amino-3-hydroxy-5-methyl-5-isoxazolepropionic acid (AMPA)-receptor antagonist, in patients with refractory partial-onset seizures. MATERIALS AND METHODS:Study 207, an open-label extension (OLE) study (ClinicalTr...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1111/ane.12001

    authors: Rektor I,Krauss GL,Bar M,Biton V,Klapper JA,Vaiciene-Magistris N,Kuba R,Squillacote D,Gee M,Kumar D

    更新日期:2012-10-01 00:00:00

  • The value of CT angiography in patients with acute severe headache.

    abstract::Patients with acute severe headache may have a secondary form of headache. Standard head computer tomography (CT) and cerebrospinal fluid (CSF) examination are often performed in the absence of neurological deficits to exclude subarachnoid hemorrhage (SAH). Increasingly, patients undergo subsequent CT angiography (CTA...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/ane.12302

    authors: Alons IM,van den Wijngaard IR,Verheul RJ,Lycklama à Nijeholt G,Wermer MJ,Algra A,Jellema K

    更新日期:2015-03-01 00:00:00

  • Entrapment neuropathy in patients with spastic cerebral palsy.

    abstract:OBJECTIVES:We performed nerve conduction and needle electromyographic tests in 29 patients with spastic cerebral palsy (SCP) and severe limb deformities. Nerve conduction abnormalities were detected in 32 of 400 sensory or motor nerves, while 11 of 29 patients (37.9%) showed abnormal nerve conduction, indicating one or...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0404.2005.00468.x

    authors: Frascarelli M,Frascarelli F,Gentile MG,Serrao M,De Santis F,Pierelli F,Santilli V

    更新日期:2005-09-01 00:00:00

  • Myoclonus epilepsy and ragged-red fibers: blood mitochondrial DNA heteroplasmy in affected and asymptomatic members of a family.

    abstract::By a rapid PCR-based method to assess the 8344 mtDNA mutation associated with MERRF disease, we have studied DNA from blood samples of 10 individuals belonging to a family spanning four generations in which one patient showed the complete MERRF phenotype, three other members were less severely affected, while the rema...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0404.1993.tb05368.x

    authors: Piccolo G,Focher F,Verri A,Spadari S,Banfi P,Gerosa E,Mazzarello P

    更新日期:1993-12-01 00:00:00

  • Leber's hereditary optic neuropathy associated with a disorder indistinguishable from multiple sclerosis in a male harbouring the mitochondrial DNA 11778 mutation.

    abstract::This report describes a multiple sclerosis (MS)-like disorder in a male patient with Leber's hereditary optic neuropathy (LHON) harbouring the mitochondrial DNA 11778 base pair mutation. Given the population frequencies of MS and LHON, coincidental occurrence is unlikely. Hypothetically the mitochondrial mutation unde...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0404.1995.tb07016.x

    authors: Olsen NK,Hansen AW,Nørby S,Edal AL,Jørgensen JR,Rosenberg T

    更新日期:1995-05-01 00:00:00

  • Anterior ischaemic optic neuropathy secondary to cluster headache.

    abstract::This report describes a patient with cluster headache who developed anterior ischaemic optic neuropathy during an attack of headache, an association not previously described. A possible pathophysiologic mechanism based upon the understanding of optic disc physiology and ocular vascular pathology in headache syndromes ...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0404.1986.tb03266.x

    authors: Toshniwal P

    更新日期:1986-02-01 00:00:00

  • Autonomic dysfunction in experimental allergic neuritis.

    abstract::Beat-to-beat variation (R-R variation) in the electrocardiogram was studied in experimental allergic neuritis in the Sprague-Dawley rat. Reduced R-R variations were found in 2 of 10 animals, probably as a sign of autonomic dysfunction. The vagal nerves from these two animals, studied in vitro, showed disturbed conduct...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0404.1985.tb01542.x

    authors: Solders G,Persson A,Kristensson K,Hansson S

    更新日期:1985-07-01 00:00:00

  • Decreased plasma alanine and isoleucine in Huntington's disease.

    abstract::Amino acid concentrations in plasma of patients with Huntington's disease (HD) were determined in 16 patients and 21 age- and sex-matched healthy controls. Alanine and isoleucine were significantly decreased in HD plasma whereas arginine, histidine, leucine, lysine, ornithine, proline, serine, threonine, tyrosine, and...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0404.1995.tb00438.x

    authors: Reilmann R,Rolf LH,Lange HW

    更新日期:1995-03-01 00:00:00

  • Alterations in polyadenylic acid-containing messenger RNA synthesis of brain polysomes after seizures of seizure-susceptible E1 mice.

    abstract::The effect of seizures on synthesis of the polyadenylic acid (poly(A]-containing messenger RNA (mRNA) isolated from brain polysomes in a genetically seizure-susceptible E1 mouse was studied in vivo. The seizure in the E1 mice was induced by tossed-up stimulation. Immediately after the seizure ceased, the labeled oroti...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0404.1989.tb03888.x

    authors: Yamagami S,Onishi H,Kawakita Y

    更新日期:1989-10-01 00:00:00

  • ApoE polymorphism and acute stroke: a study with diffusion- and perfusion-weighted MRI and MR angiography.

    abstract:OBJECTIVES:We examined whether the apolipoprotein E (ApoE) allele epsilon4 influences imaging findings in stroke as assessed by diffusion- (DWI) and perfusion-weighted (PWI) magnetic resonance imaging, and MR angiography (MRA). METHODS:Eight ApoE epsilon4 carriers and 15 non-carriers with acute ischemic stroke in the ...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0404.2006.00654.x

    authors: Liu Y,Nuutinen J,Laakso MP,Karonen JO,Soimakallio S,Aronen HJ,Vanninen RL

    更新日期:2006-11-01 00:00:00

  • Circulating nociceptin and CGRP in medication-overuse headache.

    abstract:BACKGROUND:Previous studies found low serum levels of nociceptin in migraine patients but high serum levels of calcitonin gene-related peptide (CGRP). CGRP can elicit migraine-like headache. Medication-Overuse Headache (MOH) often has migraine features and can mimic chronic migraine. We therefore hypothesized that as i...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/ane.13053

    authors: Munksgaard SB,Ertsey C,Frandsen E,Bendtsen L,Tekes K,Jensen RH

    更新日期:2019-03-01 00:00:00

  • Cigarette smoking and risk of primary intracerebral haemorrhage. A population-based case-control study.

    abstract::From September 1985 to December 1989 a total of 158 patients had primary intracerebral haemorrhage in the population of 116,000 in the Jyväskylä Region, Central Finland. All had the diagnosis confirmed by either computerised tomography or necropsy, and information on cigarette smoking habits was available in 155 patie...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0404.1993.tb04119.x

    authors: Fogelholm R,Murros K

    更新日期:1993-05-01 00:00:00

  • Pain and allodynia in postherpetic neuralgia: role of somatic and sympathetic nervous systems.

    abstract::The immediate effects of selective sympathetic and somatic blockades on pain and tactile allodynia in 12 patients with long-standing ophthalmic or high cervical postherpetic neuralgia were compared. For the duration of the somatic blockade, pain was completely abolished in 11 patients and allodynia in 8 patients. In c...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0404.1991.tb04923.x

    authors: Nurmikko T,Wells C,Bowsher D

    更新日期:1991-08-01 00:00:00

  • Pre-traumatic conditions can influence cortisol levels before and after a brain injury.

    abstract:OBJECTIVE:Satisfactory anabolic reactions, including the activation of the hypothalamic-pituitary-adrenal (HPA) axis, are essential following severe traumatic brain injury (TBI) and aneurysmal subarachnoid hemorrhage (SAH). Many factors may influence this activation. This study aimed to investigate whether individuals ...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/ane.13212

    authors: Sörbo A,Eiving I,Theodorsson E,Rydenhag B,Jonsdottir IH

    更新日期:2020-04-01 00:00:00

  • Treatment of steroid-unresponsive optic neuritis with plasma exchange.

    abstract:OBJECTIVES:Until now, the significance of plasma exchange (PE) as a treatment for steroid-unresponsive optic neuritis (ON) is still unclear because placebo-controlled and larger studies are missing. We report our experience with 23 patients treated by PE due to steroid-unresponsive ON. MATERIALS AND METHODS:Patients w...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0404.2011.01612.x

    authors: Roesner S,Appel R,Gbadamosi J,Martin R,Heesen C

    更新日期:2012-08-01 00:00:00

  • The controversy of birth order as a risk factor for epilepsy: a study from Saudi Arabia.

    abstract:PURPOSE:To evaluate the relationship between people with epilepsy and birth order. METHODS:A case-control study of 336 epileptics, 15 years and above, and their 1961 full siblings. The data was analysed by birth order and then stratified by sibship size. The 95% confidence interval (CI) for each odds ratio (OR) was ob...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1034/j.1600-0404.2002.1o142.x

    authors: Obeid T,Awada A,Amene P,Oni G

    更新日期:2002-03-01 00:00:00

  • Prediction of length of stay for stroke patients.

    abstract:OBJECTIVES:To examine the factors that influence acute and total length of stay (LOS) for stroke patients. MATERIALS AND METHODS:The basis of this investigation was a population-based cohort of first-ever stroke patients (n = 388). Subjects were survivors of the initial hospitalization (n = 295). Age, sex, social fact...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0404.2006.00756.x

    authors: Appelros P

    更新日期:2007-07-01 00:00:00

  • Natural anticoagulants (antithrombin III, protein C, and protein S) in patients with mild to moderate ischemic stroke.

    abstract:BACKGROUND AND PURPOSE:The role of the natural anticoagulants, antithrombin III (AT III), protein C (PC), and protein S (PS), in patients with mild to moderate ischemic stroke remains uncertain. We aimed to find out whether their levels in peripheral blood correlated with the severity of neurological deficit or can pre...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1034/j.1600-0404.2002.1o112.x

    authors: Haapaniemi E,Tatlisumak T,Soinne L,Syrjälä M,Kaste M

    更新日期:2002-02-01 00:00:00

  • Epilepsy surgery in children with drug-resistant epilepsy, a long-term follow-up.

    abstract:OBJECTIVES:In this follow-up study, we wanted to present the long-term outcome (5-21 years) in terms of seizure freedom, seizure reduction, and the cognitive development in the first 47 children who underwent epilepsy surgery at the University Hospital in Lund from 1991 to 2007. MATERIALS AND METHODS:All children who ...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/ane.12154

    authors: Hallböök T,Tideman P,Rosén I,Lundgren J,Tideman E

    更新日期:2013-12-01 00:00:00

  • Evaluation of 110 consecutive patients with dementias: a prospective study.

    abstract::We prospectively investigated 131 consecutive cases (both in- and outpatients) of suspected dementia to evaluate the relative frequency of different types of dementia in Chinese patients. Dementia was confirmed in 110 cases (84.0%). In contrast to the Western series, vascular dementia (39.1%) was slightly more frequen...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0404.1991.tb04981.x

    authors: Liu HC,Tsou HK,Lin KN,Yan SH,Guo NW,Wang CL,Chiang BN

    更新日期:1991-11-01 00:00:00

  • Intrathecal origin of CSF ribonuclease. Differences between infectious processes of the nervous system and multiple sclerosis.

    abstract::A CSF Poly(C)-avid ribonuclease (RNase) activity was determined in serum and CSF of 11 controls and 75 neurological patients (34 multiple sclerosis (MS), 18 infectious processes and 23 other neurological diseases (OND]. In controls, the blood-CSF ratio of RNase activity is low. This fact and the absence of correlation...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:

    authors: Allinquant B,Musenger C,Schuller E

    更新日期:1984-07-01 00:00:00

  • "Numb, clumsy hands" and tactile agnosia secondary to high cervical spondylotic myelopathy: a clinical and electrophysiological correlation.

    abstract::Four patients presented with a distinctive syndrome of "numb, clumsy hand" and tactile agnosia. Myelography and computed tomographic myelography (CTM) of the cervical spine documented major spondylotic compressive lesions mainly between the C3 and C5 levels. The cortical responses of dermatomal somatosensory evoked po...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0404.1992.tb05499.x

    authors: Chang MH,Liao KK,Cheung SC,Kong KW,Chang SP

    更新日期:1992-12-01 00:00:00

  • Psychological characteristics of patients with myotonic dystrophy type 1.

    abstract:OBJECTIVES:Myotonic dystrophy type 1 (DM1) is the most common adult-onset muscular dystrophy. It is associated with motor symptoms but patients also display non-motor symptoms such as particular personality traits. Studies have reported mixed results about personality characteristics which may be attributable to small ...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/ane.12356

    authors: Bertrand JA,Jean S,Laberge L,Gagnon C,Mathieu J,Gagnon JF,Richer L

    更新日期:2015-07-01 00:00:00

  • Serum soluble interleukin-2 receptor levels in chronic progressive, stable and steroid-treated multiple sclerosis.

    abstract::Serum levels of the soluble interleukin-2 receptor (sIL-2R), an indicator of T cell activation, were significantly elevated in chronic progressive MS (CPMS) patients, clinically stable MS patients and in patients with other neurological diseases (OND) as compared to healthy controls. Levels of sIL-2R in steroid treate...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0404.1991.tb04955.x

    authors: Bansil S,Troiano R,Cook SD,Rohowsky-Kochan C

    更新日期:1991-10-01 00:00:00

  • In vivo microstructural white matter changes in early spinocerebellar ataxia 2.

    abstract:OBJECTIVE:White matter (WM) integrity of Spinocerebellar ataxia 2 (SCA2) is poorly understood, more so in the early stages of SCA2. In this study, we evaluated the microstructural integrity of the WM tracts with an emphasis on the nature of in vivo pathological involvement in early SCA2. MATERIALS AND METHODS:We evalu...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/ane.13359

    authors: Stezin A,Bhardwaj S,Khokhar S,Hegde S,Jain S,Bharath RD,Saini J,Pal PK

    更新日期:2020-10-08 00:00:00