Cerebrospinal fluid Flt3 ligand level in patients with amyotrophic lateral sclerosis.

abstract：:Factors at presentation which influenced the course of the disease and response to treatment were assessed in 125 de novo patients with Parkinson's disease. Ninety-eight patients were available for re-assessment at 5 years. Older patients presented earlier after the onset of symptoms, deteriorated more rapidly, and we...

journal_title：Acta neurologica Scandinavica

authors： Hely MA,Morris JG,Reid WG,O'Sullivan DJ,Williamson PM,Broe GA,Adena MA

更新日期：1995-12-01 00:00:00

abstract：:Immunoglobulin G (IgG) band patterns were investigated in cerebrospinal fluid (CSF) from 19 patients with myasthenia gravis (MG) in a search for abnormalities indicating central nervous system (CNS) involvement in this disorder. Using the isoelectric focusing (IEF) technique and antiserum immunoblotting against IgG, w...

journal_title：Acta neurologica Scandinavica

authors： Mavra M,Apostolski S,Nikolic J,Thompson EJ

更新日期：1990-03-01 00:00:00

abstract：:Status epilepticus (SE) describes an enduring epileptic state during which seizures are unremitting and tend to be self-perpetuating. We describe the clinical phases of generalized convulsive SE, impending SE, established SE, and subtle SE. We discuss the physiological and biochemical cascades which characterize self-...

journal_title：Acta neurologica Scandinavica

authors： Chen JW,Naylor DE,Wasterlain CG

更新日期：2007-04-01 00:00:00

abstract：BACKGROUND:Delayed-release dimethyl fumarate (DMF) treatment can be associated with reduced lymphocyte and leucocyte counts, which might persist after DMF discontinuation. CASE PRESENTATION:We report the case of a patient with severe disease reactivation despite prolonged lymphopenia after DMF discontinuation. We desc...

journal_title：Acta neurologica Scandinavica

authors： Zecca C,Antozzi CG,Torri Clerici V,Ferrazzini M,Mantegazza RE,Rossi S,Gobbi C

更新日期：2018-06-01 00:00:00

abstract：OBJECTIVE:Machado-Joseph disease (MJD)/spinocerebellar ataxia type 3 is an autosomal dominant spinocerebellar degeneration, for which there is no effective treatment. PATIENTS AND METHODS:This study involved the clinical response of lamotrigine (LTG) on six MJD patients with early truncal ataxia and the effect of LTG ...

journal_title：Acta neurologica Scandinavica

authors： Liu CS,Hsu HM,Cheng WL,Hsieh M

更新日期：2005-06-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to determine the progression of cognitive dysfunction in primary Sjögren Syndrome (SS). METHODS:Twelve subjects with SS were compared with ten subjects with migraine and ten healthy controls on neuropsychological, mood and fatigue tests at baseline and 8 years later. RESULTS:At fol...

journal_title：Acta neurologica Scandinavica

authors： Martínez S,Cáceres C,Mataró M,Escudero D,Latorre P,Dávalos A

更新日期：2010-09-01 00:00:00

abstract：OBJECTIVES:Evaluate interim long-term tolerability, safety and efficacy of adjunctive perampanel, a novel α-amino-3-hydroxy-5-methyl-5-isoxazolepropionic acid (AMPA)-receptor antagonist, in patients with refractory partial-onset seizures. MATERIALS AND METHODS:Study 207, an open-label extension (OLE) study (ClinicalTr...

journal_title：Acta neurologica Scandinavica

authors： Rektor I,Krauss GL,Bar M,Biton V,Klapper JA,Vaiciene-Magistris N,Kuba R,Squillacote D,Gee M,Kumar D

更新日期：2012-10-01 00:00:00

abstract：OBJECTIVE:To compare the mortality rate in Parkinson's disease (PD) with a control group without PD, and to assess the relationship between mortality and features of PD. MATERIAL AND METHODS:Ninety PD patients and 50 controls, mortality ascertained at 11 years follow-up. RESULTS:The hazard ratio (HR) for mortality in...

journal_title：Acta neurologica Scandinavica

authors： Hughes TA,Ross HF,Mindham RH,Spokes EG

更新日期：2004-08-01 00:00:00

abstract：:The clinical features of multiple sclerosis (MS) in north-east Scotland have been examined along with an epidemiological study to determine the prevalence of the disease on 1st December, 1970. Patient information was collected from all available diagnostic indices, both retrospectively and prospectively from 1965. Eve...

journal_title：Acta neurologica Scandinavica

authors： Shepherd DI

更新日期：1979-10-01 00:00:00

abstract：:Serum levels of the soluble interleukin-2 receptor (sIL-2R), an indicator of T cell activation, were significantly elevated in chronic progressive MS (CPMS) patients, clinically stable MS patients and in patients with other neurological diseases (OND) as compared to healthy controls. Levels of sIL-2R in steroid treate...

journal_title：Acta neurologica Scandinavica

authors： Bansil S,Troiano R,Cook SD,Rohowsky-Kochan C

更新日期：1991-10-01 00:00:00

abstract：OBJECTIVE:We examined whether the modulatory effect of pregnancy on multiple sclerosis (MS) is associated with changes in the apoptotic molecules in sera. SUBJECTS AND METHODS:The serum levels of tumor necrosis factor-related apoptosis-inducing ligand (sTRAIL), sFas, Fas ligand (sFasL) and macrophage migration inhibit...

journal_title：Acta neurologica Scandinavica

authors： Rinta S,Airas L,Elovaara I

更新日期：2010-09-01 00:00:00

abstract：:To investigate the blood-brain barrier (BBB function), serum and cerebrospinal fluid (CSF) from 118 patients with Alzheimer's disease (AD) and 50 healthy controls was analyzed with regard to albumin concentrations. For the AD group, clinical vascular factors were also recorded. The CSF/serum albumin ratio was used as ...

journal_title：Acta neurologica Scandinavica

authors： Blennow K,Wallin A,Fredman P,Karlsson I,Gottfries CG,Svennerholm L

更新日期：1990-04-01 00:00:00

abstract：OBJECTIVES:To measure clinical and immunological parameters in a patient with myasthenia gravis (MG) treated with antibodies against CD25 (basiliximab, Simulect). Patient and methods - Injections of basiliximab were given repeatedly together with cyclosporin A and corticosteroids for 9 months to a patient with severe M...

journal_title：Acta neurologica Scandinavica

authors： Kakoulidou M,Pirskanen-Matell R,Lefvert AK

更新日期：2008-03-01 00:00:00

abstract：:The preventive and suppressive effects of methylprednisolone (MP) were investigated in 22 rabbits immunized with peripheral nerve myelin. Cellular reactivity to bovine P2 protein (P2) and anti-P2 antibody were also examined serially in these animals, using the lymphocyte proliferation test or enzyme-linked immunosorbe...

journal_title：Acta neurologica Scandinavica

authors： Ohno R,Hamaguchi K,Nomura K,Sowa K,Tanaka H,Negishi T,Yamashita T

更新日期：1988-06-01 00:00:00

abstract：:Taurine content of 199 clinical muscle biopsies was determined and correlated to histometric data of 121 cases. Taurine concentration in muscles was markedly dependent on fiber type distribution, taurine being more abundant in the slow, oxidative type 1 fibers than in the type 2 fibers. Taurine concentration rose slig...

journal_title：Acta neurologica Scandinavica

authors： Airaksinen EM,Paljärvi L,Partanen J,Collan Y,Laakso R,Pentikäinen T

更新日期：1990-01-01 00:00:00

abstract：OBJECTIVES:Patients with Parkinson's disease (PD) and essential tremor (ET) have a higher risk of cognitive impairment than age-matched controls. Only a few small studies (11-18 subjects per group) have directly compared the cognitive profile of these conditions. Our aim was to compare the cognitive profile of patients...

journal_title：Acta neurologica Scandinavica

authors： Sánchez-Ferro Á,Benito-León J,Louis ED,Contador I,Hernández-Gallego J,Puertas-Martín V,Bermejo-Pareja F

更新日期：2017-11-01 00:00:00

abstract：OBJECTIVE:We evaluated the differences in brain morphology among patients with juvenile myoclonic epilepsy according to the occurrence of absence seizures. MATERIALS AND METHODS:Twenty-one juvenile myoclonic epilepsy patients with (n = 6) and without (n = 15) absence seizures were enrolled. We analyzed whole-brain T1-...

journal_title：Acta neurologica Scandinavica

authors： Park KM,Kim TH,Han YH,Mun CW,Shin KJ,Ha SY,Park JS,Kim SE

更新日期：2016-02-01 00:00:00

abstract：:We studied a Becker muscular dystrophy (BMD) family with a manifesting carrier. Proximal muscle weakness, pseudohypertrophy of the calves, significantly elevated serum creatine kinase and dystrophic alterations in the muscle biopsy were the characteristic phenotypical features of this manifesting carrier. The recombin...

journal_title：Acta neurologica Scandinavica

authors： Ionasescu VV,Searby CC,Ionasescu R

更新日期：1989-06-01 00:00:00

abstract：OBJECTIVES:To determine if visual hallucinations in patients with Parkinson's disease are associated with an increased prevalence of white matter lesions. PATIENTS AND METHODS:Fifteen patients with (group 1) and 15 patients without (group 2) a history of visual hallucinations were studied. Both groups were matched for...

journal_title：Acta neurologica Scandinavica

authors： Kraft E,Winkelmann J,Trenkwalder C,Auer DP

更新日期：1999-06-01 00:00:00

abstract：:Patients with homocystinuria excrete a large amount of metal in their urine. Homocysteine similar to penicillamine, administration to methylmercury treated rats resulted in a large amount of urinary methylmercury excretion. These results suggested that the total metal amounts in the whole body of patients with homocys...

journal_title：Acta neurologica Scandinavica

authors： Yoshida Y,Nakano A,Hamada R,Kamitsuchibashi H,Yamamoto K,Akagi H,Kitazono M,Osame M

更新日期：1992-11-01 00:00:00

abstract：:Only 15% of patients with severe epilepsy with frequent partial seizures achieve any improvement in their seizure frequency by further drug treatment. As we know that epileptic seizures result in neuron loss with early development of mental deterioration, that the mortality rate of patients with epilepsy is increased ...

journal_title：Acta neurologica Scandinavica

authors： Dam M

更新日期：1996-08-01 00:00:00

abstract：OBJECTIVES:Clinical research has documented a range of evidence-based treatment approaches for spatial neglect (SN), but there is a lack of research on the implementation of treatment into clinical practice. The purpose of this study is to describe the current clinical practice of SN treatment across healthcare sectors...

journal_title：Acta neurologica Scandinavica

authors： Evald L,Wilms IL,Nordfang M

更新日期：2020-01-01 00:00:00

abstract：:The effects of L-threo-3,4-dihydroxyphenylserine (L-threo-DOPS), an unnatural norepinephrine precursor, on alpha 2-adrenergic receptors in platelet membranes were investigated in a patient with familial amyloidotic polyneuropathy, two patients with multiple system atrophy, and two patients with Parkinson's disease. Ea...

journal_title：Acta neurologica Scandinavica

authors： Azuma T,Suzuki T,Sakoda S,Mizuno R,Tsujino S,Kobayashi T,Kishimoto S,Hiraga T,Matsubara T,Yoshida S

更新日期：1991-07-01 00:00:00

abstract：BACKGROUND:Previous studies have shown that white matter lesions (WMLs) is an important risk factor for cognitive impairment, but the underlying mechanisms have not been clarified. OBJECTIVE:We tested the hypothesis that the cognitive impairments associated with periventricular white matter hyperintensities (PWMHs) on...

journal_title：Acta neurologica Scandinavica

authors： Zi W,Duan D,Zheng J

更新日期：2014-09-01 00:00:00

abstract：OBJECTIVES:To explore (1) effects of test and subject variables in determining euphoric and dysphoric responses during unilateral amobarbital anesthesia and (2) which cerebral areas contribute to the emotional responses. METHOD:Incidence of euphoric and dysphoric reactions during left- and right-sided amobarbital anes...

journal_title：Acta neurologica Scandinavica

authors： Stabell KE,Andresen S,Bakke SJ,Bjørnaes H,Borchgrevink HM,Heminghyt E,Røste GK

更新日期：2004-11-01 00:00:00

abstract：:We investigated the types of syndrome, location, size and presumed causes of 72 patients with acute capsular lacunar infarction. Clinical syndromes were classified into pure motor hemiparesis (PM), sensorimotor stroke (SM) and ataxic hemiparesis (AH). Lesion sizes of AH were significantly smaller than those of PM (p <...

journal_title：Acta neurologica Scandinavica

authors： Tei H,Uchiyama S,Maruyama S

更新日期：1993-10-01 00:00:00

abstract：:We studied clinically and electrophysiologically 8 patients affected by orthostatic tremor (OT), which is an unusual movement disorder consisting of shaking movements of the legs and trunk in the standing position. We failed to find any cause in 6 of the 8 cases. In 2 patients OT was clearly secondary to neurologic di...

journal_title：Acta neurologica Scandinavica

authors： Gabellini AS,Martinelli P,Gullì MR,Ambrosetto G,Ciucci G,Lugaresi E

更新日期：1990-02-01 00:00:00

abstract：:Intrathecal IgG synthesis and CSF oligoclonal bands were reexamined after 18-24 months in 66 patients with multiple sclerosis; 40 of them received azathioprine (AZA) 2.5 mg/Kg/die; all received a course of dexamethasone (DEXA) during clinical relapses. The IgG Index was significantly reduced in the group treated with ...

journal_title：Acta neurologica Scandinavica

authors： Caputo D,Zaffaroni M,Ghezzi A,Cazzullo CL

更新日期：1987-02-01 00:00:00

abstract：OBJECTIVES:The goal of this study was to evaluate the incidence of urological malignancies in MS patients using active screening. MATERIAL AND METHODS:A total of 495 MS patients (141 men, 354 women, age of 42±13.4) were included in the study. The duration of disease was 12.3±11 years, and the EDSS score was 4.3 (±2.5)...

journal_title：Acta neurologica Scandinavica

authors： Krhut J,Hradilek P,Nemec D,Tvrdik J,Zapletalova O,Zvara P

更新日期：2014-09-01 00:00:00

abstract：OBJECTIVES:Therapy of acute relapses in multiple sclerosis with corticosteroids (CC) remains uncertain with respect to route, dosage and effectiveness. This makes the treatment of relapses a clinical field where 'shared decision-making (SDM)' could be of advantage for the patients. A prerequisite for SDM is the provisi...

journal_title：Acta neurologica Scandinavica

authors： Köpke S,Heesen C,Kasper J,Mühlhauser I

更新日期：2004-07-01 00:00:00