Age at onset: the major determinant of outcome in Parkinson's disease.

abstract：:The effects of L-threo-3,4-dihydroxyphenylserine (L-threo-DOPS), an unnatural norepinephrine precursor, on alpha 2-adrenergic receptors in platelet membranes were investigated in a patient with familial amyloidotic polyneuropathy, two patients with multiple system atrophy, and two patients with Parkinson's disease. Ea...

journal_title：Acta neurologica Scandinavica

authors： Azuma T,Suzuki T,Sakoda S,Mizuno R,Tsujino S,Kobayashi T,Kishimoto S,Hiraga T,Matsubara T,Yoshida S

更新日期：1991-07-01 00:00:00

abstract：OBJECTIVE:Blepharoclonus (BLC) denotes a large amplitude, involuntary tremors of the orbicularis oculi muscles, observed during gentle closure of the eyelids. BLC may follow major head trauma. Four patients with Arnold-Chiari malformation (ACM) and BLC are described. MATERIALS AND METHODS:The first patient had facial ...

journal_title：Acta neurologica Scandinavica

authors： Jacome DE

更新日期：2001-08-01 00:00:00

abstract：INTRODUCTION:The objective of the study was to estimate the prevalence of parkinsonism in the Province of Rome using antiparkinsonian prescription histories from 1986 to 1991. METHODS:A subject was defined as a case of parkinsonism if he/she had received "specific" and "consistent" antiparkinsonian therapy in the stud...

journal_title：Acta neurologica Scandinavica

authors： Menniti-Ippolito F,Spila-Alegiani S,Vanacore N,Bonifati V,Diana G,Meco G,Raschetti R

更新日期：1995-07-01 00:00:00

abstract：BACKGROUND:The Multiple Sclerosis Functional Composite (MSFC) is a multidimensional measurement tool for multiple sclerosis (MS) including a measure of ambulation (Timed 25-foot Walk [TWT]), arm function (Nine-Hole Peg Test [9HPT]) and cognition (Paced Auditory Serial Addition Test [PASAT]). OBJECTIVES:To assess the r...

journal_title：Acta neurologica Scandinavica

authors： Rosti-Otajärvi E,Hämäläinen P,Koivisto K,Hokkanen L

更新日期：2008-06-01 00:00:00

abstract：:Rabbit antiserum to a citric acid extract of human skeletal muscle (CA) stained epithelial thymoma cells as well as skeletal muscle. Thymomas from two myasthenia gravis (MG) patients showing no circulating anti-CA antibodies prior to thymectomy were also stained by the antiserum. Thus, in these patients as well, the t...

journal_title：Acta neurologica Scandinavica

authors： Gilhus NE,Matre R,Aarli JA,Hofstad H,Thunold S

更新日期：1986-04-01 00:00:00

abstract：BACKGROUND:Thirty patients with glioblastoma multiforme (GBM) were treated by boron neutron capture therapy (BNCT) at the Studsvik facility in Sweden, in a clinical trial exploring a procedure in which 900 mg p-boronophenylalanine (BPA) per kilo body weight was infused in 6 h. OBJECTIVE:The present study was designed ...

journal_title：Acta neurologica Scandinavica

authors： H-Stenstam B,Pellettieri L,Sköld K,Rezaei A,Brun A

更新日期：2007-09-01 00:00:00

abstract：:Magnetic resonance imaging (MRI) has enabled ante mortem diagnosis of Hallervorden Spatz disease (HSD). Childhood-onset cases are the most common type and usually present with progressive dystonia and dementia. The duration of illness is 15 to 20 years, leading to death. Presentation in adulthood and infancy have also...

journal_title：Acta neurologica Scandinavica

authors： Hickman SJ,Ward NS,Surtees RA,Stevens JM,Farmer SF

更新日期：2001-03-01 00:00:00

abstract：BACKGROUND:Neuropsychiatric symptoms are common in Parkinson's disease and may precede onset of motor symptoms. They are also known to increase caregiver's burden. OBJECTIVE:The aim of this study was to assess neuropsychiatric symptoms in a cohort of Nigerian patients with idiopathic Parkinson's disease and compare wi...

journal_title：Acta neurologica Scandinavica

authors： Ojagbemi AA,Akinyemi RO,Baiyewu O

更新日期：2013-07-01 00:00:00

abstract：:The immediate effects of selective sympathetic and somatic blockades on pain and tactile allodynia in 12 patients with long-standing ophthalmic or high cervical postherpetic neuralgia were compared. For the duration of the somatic blockade, pain was completely abolished in 11 patients and allodynia in 8 patients. In c...

journal_title：Acta neurologica Scandinavica

authors： Nurmikko T,Wells C,Bowsher D

更新日期：1991-08-01 00:00:00

abstract：OBJECTIVES:Myotonic dystrophy type 1 (DM1) is the most common adult-onset muscular dystrophy. It is associated with motor symptoms but patients also display non-motor symptoms such as particular personality traits. Studies have reported mixed results about personality characteristics which may be attributable to small ...

journal_title：Acta neurologica Scandinavica

authors： Bertrand JA,Jean S,Laberge L,Gagnon C,Mathieu J,Gagnon JF,Richer L

更新日期：2015-07-01 00:00:00

abstract：BACKGROUND:Variants in genes encoding enzymes involved in production, aggregation or degradation of beta-amyloid are potential risk factors for sporadic Alzheimer's disease (AD). METHODS:Meta-analyses on AD association with BACE1 exon 5, BACE1 intron 5, FE65 intron 13, CYP46 intron 2, alpha(1)-antichymotrypsine Ala17T...

journal_title：Acta neurologica Scandinavica

authors： Llorca J,Rodríguez-Rodríguez E,Dierssen-Sotos T,Delgado-Rodríguez M,Berciano J,Combarros O

更新日期：2008-01-01 00:00:00

abstract：:A CSF Poly(C)-avid ribonuclease (RNase) activity was determined in serum and CSF of 11 controls and 75 neurological patients (34 multiple sclerosis (MS), 18 infectious processes and 23 other neurological diseases (OND]. In controls, the blood-CSF ratio of RNase activity is low. This fact and the absence of correlation...

journal_title：Acta neurologica Scandinavica

authors： Allinquant B,Musenger C,Schuller E

更新日期：1984-07-01 00:00:00

abstract：:A total of 158 recordings of brain stem auditory evoked potentials (BAEPs) were obtained in 121 patients with multiple sclerosis. A statistically significant increased incidence of abnormality and diffusely abnormal recordings was found with increasing duration and severity of symptoms. Alterations in follow-up record...

journal_title：Acta neurologica Scandinavica

authors： Kjaer M

更新日期：1980-03-01 00:00:00

abstract：:Using the macrophage electrophoretic mobility (MEM) test, the in vitro effects of oleic, linoleic and arachidonic acid, as well as Naudicell oil and methyl gamma-linolenate, on lymphocyte response to various antigens (PPD, thyroid antigen and EF) were studied in patients with mutiple sclerosis, patients with other neu...

journal_title：Acta neurologica Scandinavica

authors： Field EJ,Shenton BK

更新日期：1975-08-01 00:00:00

abstract：OBJECTIVES:The purpose of the study was to develop a simplified method for the acquisition and analysis of data from positron emission tomography (PET) using the ligand 11C-L-deuterium-deprenyl. This is motivated by an increased interest in methods to characterize gliosis in neurodegenerative diseases and epilepsy, whi...

journal_title：Acta neurologica Scandinavica

authors： Bergström M,Kumlien E,Lilja A,Tyrefors N,Westerberg G,Långström B

更新日期：1998-10-01 00:00:00

abstract：OBJECTIVES:To clarify the clinical variability, including central nervous system (CNS) involvement, in X-linked Charcot-Marie-Tooth disease (CMTX) patients. MATERIAL AND METHODS:We clinically, pathologically and genetically studied six CMTX patients with distinct symptoms and four different GJB1 mutations. RESULTS:On...

journal_title：Acta neurologica Scandinavica

authors： Takashima H,Nakagawa M,Umehara F,Hirata K,Suehara M,Mayumi H,Yoshishige K,Matsuyama W,Saito M,Jonosono M,Arimura K,Osame M

更新日期：2003-01-01 00:00:00

abstract：OBJECTIVE:To replicate the treatment study by Behan et al. (1990) using current research criteria for Chronic Fatigue Syndrome (CFS). METHOD:Fifty patients who fulfilled the Oxford Criteria for CFS were randomly allocated to treatment with either Efamol Marine or placebo for 3 months. They were seen monthly and comple...

journal_title：Acta neurologica Scandinavica

authors： Warren G,McKendrick M,Peet M

更新日期：1999-02-01 00:00:00

abstract：:A 54 year-old woman showed the unusual association of a Guillain-Barré syndrome and opsoclonus, a rare eye movement characterized by involuntary bursts of jerking, ataxic and multidirectional saccades, without an intersaccadic interval. Since opsoclonus is a phenomenon described exclusively in CNS diseases, the case r...

journal_title：Acta neurologica Scandinavica

authors： Nicolai A,Lazzarino LG

更新日期：1992-05-01 00:00:00

abstract：:In order to evaluate the prognosis and possible prognostic factors associated with a bening course, 118 cases of motor neuron disease diagnosed 1948-1975 were followed up. Survival curves, based on the actuarial method showed a survival rate of 18.7 per cent (95 per cent confidence limits: 11.4-26.0) and 7.6 per cent ...

journal_title：Acta neurologica Scandinavica

authors： Kristensen O,Melgaard B

更新日期：1977-10-01 00:00:00

abstract：BACKGROUND:Persons with multiple sclerosis (MS) engage in substantially less overall physical activity than healthy controls, but there is little information on public health rates of physical activity necessary for health benefits. PURPOSE:This study examined the rates of insufficient, moderate, and sufficient physic...

journal_title：Acta neurologica Scandinavica

authors： Motl RW,McAuley E,Sandroff BM,Hubbard EA

更新日期：2015-06-01 00:00:00

abstract：:In order to approach the mechanism of chronic or relapsing course in human chronic inflammatory demyelinating polyradiculoneuropathy, we established a chronic model of experimental allergic neuritis (EAN) in juvenile guinea pigs, and investigated the underlying cellular immune phenomenon in comparison with acute EAN i...

journal_title：Acta neurologica Scandinavica

authors： Suzumura A,Sobue G,Sugimura K,Matsuoka Y,Sobue I

更新日期：1985-05-01 00:00:00

abstract：:The influence of the rheological properties of the blood on cerebral perfusion is still unresolved. Data on normal subjects are lacking and difficulties arise regarding the effect of blood viscosity owing to its close relationship with hematocrit. For these reasons we have studied the relationship between two rheologi...

journal_title：Acta neurologica Scandinavica

authors： Cavestri R,Radice L,Ferrarini F,Longhini M,Longhini E

更新日期：1992-04-01 00:00:00

abstract：:The production of oxygen-free radicals and their subsequent peroxidative action on membrane unsaturated fatty acids could be enhanced after subarachnoid hemorrhage. High-dose methylprednisolone (30 mg/Kg i.v.) treatment can antagonize acute SAH-induced brain hypoperfusion and protect the ultrastructural integrity of e...

journal_title：Acta neurologica Scandinavica

authors： Marzatico F,Gaetani P,Buratti E,Messina AL,Ferlenga P,Rodriguez y Baena R

更新日期：1990-10-01 00:00:00

abstract：:Using organotypic cultures of ICR mouse cerebellum, we studied the effects of TNF-alpha on myelin formation, and its demyelinating effects. Mature, myelinated cultures were resistant to TNF-alpha, even at the highest concentration examined, 1 x 10(4) U/ml. However, when cultures were grown in medium containing TNF-alp...

journal_title：Acta neurologica Scandinavica

authors： Tsukamoto T,Ishikawa M,Yamamoto T

更新日期：1995-01-01 00:00:00

abstract：OBJECTIVE:Association of leuko-araiosis (LA) with certain risk factors has been reported in Western patients. This is a case-control study to determine the risk factors and the type of stroke associated with LA in Saudi patients. DESIGN AND SETTING:398 consecutive Saudi patients with the diagnosis of stroke admitted o...

journal_title：Acta neurologica Scandinavica

authors： Awada A,Omojola MF

更新日期：1996-12-01 00:00:00

abstract：:The present communication is devoted to investigating the possibility that in myotonic dystrophy (MyD) a decreased ATP utilization by the membrane may produce modifications in glycoprotein structure and/or in the supramolecular arrangement of some membrane proteins. The study was carried out a) by determining the memb...

journal_title：Acta neurologica Scandinavica

authors： Sandrini G,Bottiroli G,Nappi G,Balduini C,Brovelli A

更新日期：1982-06-01 00:00:00

abstract：:IgG and IgM concentrations in tears of multiple sclerosis patients (n = 38) are increased compared to normal controls (n = 23). The occurrence of oligoclonal tear IgG bands (7.9%)--as determined by immunoblotting--did not differ between groups. Our findings suggest an altered reactivity of the secretory immune system ...

journal_title：Acta neurologica Scandinavica

authors： Liedtke W,Weller M,Wiethölter H,Dichgans J

更新日期：1992-03-01 00:00:00

abstract：OBJECTIVES:To describe two patients with progressive external ophthalmoplegia (PEO) and mitochondrial myopathy associated with mutations in mitochondrial DNA, encoding the tRNAAsn gene (MT-TN), which have not previously been published with clinical descriptions. MATERIALS & METHODS:Two unrelated patients with PEO were...

journal_title：Acta neurologica Scandinavica

authors： Visuttijai K,Hedberg-Oldfors C,Lindgren U,Nordström S,Elíasdóttir Ó,Lindberg C,Oldfors A

更新日期：2020-08-31 00:00:00

abstract：BACKGROUND:Idiopathic Parkinson's disease (IPD) is characterized by the clinical motor symptoms of hypokinesia, rigidity, and tremor. Apart from these motor symptoms, cognitive deficits often occur in IPD. The positive effect of cholinesterase inhibitors on cognitive deficits in IPD and findings of earlier molecular im...

journal_title：Acta neurologica Scandinavica

authors： Lorenz R,Samnick S,Dillmann U,Schiller M,Ong MF,Faßbender K,Buck A,Spiegel J

更新日期：2014-09-01 00:00:00

abstract：:Cyclic adenosine 3',5'-monophosphate (cAMP) and cyclic guanosine 3',5'-monophosphate (cGMP) were measured in cerebrospinal fluid (CSF) and plasma from 7 patients with bacterial meningitis, 9 patients with serous meningitis, 5 patients with idiopathic polyneuritis and 15 reference patients. A significantly (P less than...

journal_title：Acta neurologica Scandinavica

authors： Lerche A,Svenson M,Wiik A

更新日期：1984-03-01 00:00:00