Motor neuron disease. Prognosis and epidemiology.

abstract：:Adenylate kinase (AK) was determined in a lumbo-cisternal cerebrospinal fluid (CSF) gradient and in CSF from patients with mental deterioration. AK activity was unchanged in the gradient and different from albumin and albumin ratio (alb CSF/albumin serum), a blood-brain barrier marker in the same gradient. No differen...

journal_title：Acta neurologica Scandinavica

authors： Ahlberg J,Blomstrand C,Ronquist G,Wikkelsö C

更新日期：1985-11-01 00:00:00

abstract：:Patients with aseptic meningitis (AM) were examined with the active T cell rosette test, which has been claimed to reflect cell-mediated immunocompetence more accurately than determination of total T cells. Higher percentages of active T cells were demonstrated in CSF compared to blood regardless if specimens were obt...

journal_title：Acta neurologica Scandinavica

authors： Frydén A,Kam-Hansen S,Maller R,Link H

更新日期：1980-05-01 00:00:00

abstract：:The purpose of this study was to test the improved sensitivity of P3 abnormality in the detection of dementia using a variety of auditory stimuli. Improved detection was obtained using auditory stimuli that differed in their cognitive attributes and by using several P3 measures. These measures included P3 latencies an...

journal_title：Acta neurologica Scandinavica

authors： Attias J,Huberman M,Cott E,Pratt H

更新日期：1995-07-01 00:00:00

abstract：:Only 15% of patients with severe epilepsy with frequent partial seizures achieve any improvement in their seizure frequency by further drug treatment. As we know that epileptic seizures result in neuron loss with early development of mental deterioration, that the mortality rate of patients with epilepsy is increased ...

journal_title：Acta neurologica Scandinavica

authors： Dam M

更新日期：1996-08-01 00:00:00

abstract：OBJECTIVE:To explore the relationship between motor subtypes and drooling, and other risk factors associated with drooling in a large cohort of Chinese patients with Parkinson's disease (PD). METHODS:A total of 586 PD patients were enrolled in this study. Unified Parkinson's disease rating scale (UPDRS) and Hoehn & Ya...

journal_title：Acta neurologica Scandinavica

authors： Mao CJ,Xiong YT,Wang F,Yang YP,Yuan W,Zhu C,Chen J,Liu CF

更新日期：2018-05-01 00:00:00

abstract：OBJECTIVES:Studies demonstrating reduced quality of life and psychological well-being in multiple sclerosis (MS) have typically investigated patients within more advanced stages of disease. The aim of the present paper was to evaluate the emotional burden and quality of life of recently diagnosed MS patients and their ...

journal_title：Acta neurologica Scandinavica

authors： Janssens AC,van Doorn PA,de Boer JB,van der Meché FG,Passchier J,Hintzen RQ

更新日期：2003-12-01 00:00:00

abstract：OBJECTIVES:This study aimed to investigate whether neurological disability status, heart rate variability (HRV), cardiorespiratory fitness (CRF) explained the variance in depressive symptoms in multiple sclerosis (MS). METHODS:Associations between CRF (via maximal oxygen uptake; VO2peak ), HRV indices of normalized ul...

journal_title：Acta neurologica Scandinavica

authors： Ensari I,Pilutti LA,Motl RW

更新日期：2017-11-01 00:00:00

abstract：INTRODUCTION:Cerebral small vessel disease (SVD) contributes to dementia and disability in the elderly, and may negatively affect stroke outcomes. We aimed to evaluate to what extent single features and global burden of SVD detected with magnetic resonance (MR) are associated with worse outcomes in patients with ischae...

journal_title：Acta neurologica Scandinavica

authors： Arba F,Inzitari D,Ali M,Warach SJ,Luby M,Lees KR,STIR\/VISTA Imaging Collaboration.

更新日期：2017-07-01 00:00:00

abstract：OBJECTIVES:To gain insight into the main advantages and disadvantages that might result from valproate being unavailable for women who intend to become pregnant. MATERIALS AND METHODS:Analysis of data from the Australian Pregnancy Register concerning pregnancies exposed to valproate (N = 501) and pregnancies where pre...

journal_title：Acta neurologica Scandinavica

authors： Vajda FJE,O'Brien TJ,Graham JE,Hitchcock AA,Lander CM,Eadie MJ

更新日期：2019-01-01 00:00:00

abstract：OBJECTIVES:We studied the in vitro production of variably MS-related cytokines from Sardinian MS and healthy donors bearing the two "Sardinian" MS-associated HLA-DR alleles: DR3 and DR4, with the purpose to evidentiate possible differences in their immune response. MATERIALS AND METHODS:ELISA were used for detection o...

journal_title：Acta neurologica Scandinavica

authors： Sotgiu S,Serra C,Marrosu MG,Dolei A,Pugliatti M,Murgia B,Aiello I,Rosati G

更新日期：1998-11-01 00:00:00

abstract：BACKGROUND:There has been a long-standing interest in the possible role of the hippocampus in autism and both postmortem brain and neuroimaging studies have documented varying abnormalities in this limbic system structure. AIMS:This study investigates the density of subsets of hippocampal interneurons, immunostained w...

journal_title：Acta neurologica Scandinavica

authors： Lawrence YA,Kemper TL,Bauman ML,Blatt GJ

更新日期：2010-02-01 00:00:00

abstract：OBJECTIVE:To assess seizure control and tolerability of eslicarbazepine acetate (ESL) as adjunctive therapy to one baseline antiepileptic drug (AED), in adults with partial-onset seizures (POS) with or without secondary generalization. METHODS:Multicenter, non-interventional, prospective cohort study conducted between...

journal_title：Acta neurologica Scandinavica

authors： Chaves J,Breia P,Pimentel J,Pelejão R,Carvalho M,Mateus P,Grebe H,Mestre A,Fernandes H,Sousa R,Gala A

更新日期：2017-11-01 00:00:00

abstract：:Two children are reported, who became diseased at the age of 4 and 2 years, respectively, with progressive upper motor neuron symptoms leading to severe disability within a few years. The boy died at age 10 and autopsy disclosed a severe gangliolipidosis throughout the central nervous system, maximal in the brain stem...

journal_title：Acta neurologica Scandinavica

authors： Brandt S,Clausen J,Diemer NH,Faurholt-Pedersen V,Jensen GE,Lademann A,Melchior JC

更新日期：1977-12-01 00:00:00

abstract：:The effect of seizures on synthesis of the polyadenylic acid (poly(A]-containing messenger RNA (mRNA) isolated from brain polysomes in a genetically seizure-susceptible E1 mouse was studied in vivo. The seizure in the E1 mice was induced by tossed-up stimulation. Immediately after the seizure ceased, the labeled oroti...

journal_title：Acta neurologica Scandinavica

authors： Yamagami S,Onishi H,Kawakita Y

更新日期：1989-10-01 00:00:00

abstract：OBJECTIVE:We examined whether the modulatory effect of pregnancy on multiple sclerosis (MS) is associated with changes in the apoptotic molecules in sera. SUBJECTS AND METHODS:The serum levels of tumor necrosis factor-related apoptosis-inducing ligand (sTRAIL), sFas, Fas ligand (sFasL) and macrophage migration inhibit...

journal_title：Acta neurologica Scandinavica

authors： Rinta S,Airas L,Elovaara I

更新日期：2010-09-01 00:00:00

abstract：OBJECTIVE:To validate the diagnosis of idiopathic intracranial hypertension (IIH) from the Swedish National Patient Register (NPR) and investigate the incidence of IIH, as well as co-morbidities and medication use in a large Swedish population-based sample. METHODS:We searched the NPR to find all patients ≥18 years ol...

journal_title：Acta neurologica Scandinavica

authors： Sundholm A,Burkill S,Sveinsson O,Piehl F,Bahmanyar S,Nilsson Remahl AIM

更新日期：2017-11-01 00:00:00

abstract：OBJECTIVES:To estimate the total costs of multiple sclerosis (MS) for all Canadians in 1994. METHODS:Prevalence-based study estimating disease-related societal costs for Canadians with MS in 1994. The human capital approach was used to estimate the value of lost productivity due to illness. Two components were reveale...

journal_title：Acta neurologica Scandinavica

authors： Asche CV,Ho E,Chan B,Coyte PC

更新日期：1997-05-01 00:00:00

abstract：INTRODUCTION:The objective of the study was to estimate the prevalence of parkinsonism in the Province of Rome using antiparkinsonian prescription histories from 1986 to 1991. METHODS:A subject was defined as a case of parkinsonism if he/she had received "specific" and "consistent" antiparkinsonian therapy in the stud...

journal_title：Acta neurologica Scandinavica

authors： Menniti-Ippolito F,Spila-Alegiani S,Vanacore N,Bonifati V,Diana G,Meco G,Raschetti R

更新日期：1995-07-01 00:00:00

abstract：INTRODUCTION:Because of the limited information on cervical spondylotic radiculopathy, we conducted a door-to-door two-phase survey in a Sicilian municipality. MATERIAL AND METHODS:We first screened for cervical spondylotic radiculopathy among the inhabitants of the municipality: (N = 7653, as of the prevalence day, N...

journal_title：Acta neurologica Scandinavica

authors： Salemi G,Savettieri G,Meneghini F,Di Benedetto ME,Ragonese P,Morgante L,Reggio A,Patti F,Grigoletto F,Di Perri R

更新日期：1996-02-01 00:00:00

abstract：:Out of a data pool of 1271 patients with Multiple Sclerosis (MS) a total of 109 cases are selected having a sole spinal symptomatology throughout the course of the disease. This group differs in three particular features from the non-spinal forms of MS: In this group there is a higher percentage of females, the age at...

journal_title：Acta neurologica Scandinavica

authors： Poser S,Herrmann-Gremmels I,Wikström J,Poser W

更新日期：1978-02-01 00:00:00

abstract：:Recurrent herpes zoster myelitis is very rare. However, a case was recently observed in our hospital. A 43-year-old woman developed myelitis 2 weeks after development of shingles. Her condition was improved by methylprednisolone. Seven months later, she developed myelitis after development of shingles again. Antibody ...

journal_title：Acta neurologica Scandinavica

authors： Nakano T,Awaki E,Araga S,Takai H,Inoue K,Takahashi K

更新日期：1992-05-01 00:00:00

abstract：BACKGROUND:The epidemiology, diagnosis, and treatment of motor neuron disease (MND) in Chinese patients are ill known. METHODS:A registered study of 461 MND patients was conducted across 10 facilities in 7 Chinese cities from February 2009 to March 2010. RESULTS:Patients were classified as amyotrophic lateral scleros...

journal_title：Acta neurologica Scandinavica

authors： Cui F,Liu M,Chen Y,Huang X,Cui L,Fan D,Pu C,Lu J,Zhou D,Zhang C,Yan C,Li C,Ding X,Liu Y,Li X,Jiang Y,Zhang J,Shang H,Yao X,Ding Y,Niu Q,Wang L

更新日期：2014-08-01 00:00:00

abstract：:In order to characterize the CSF (cerebrospinal fluid) lymphocytes in CNS (central nervous system) inflammation, we examined paired samples of CSF and PB (peripheral blood) of 19 patients with acute aseptic meningitis, performing the dual labelling method on flow cytometry. Significantly higher percentages of CD3+ (T ...

journal_title：Acta neurologica Scandinavica

authors： Uchihara T,Ikeda M,Takahashi H,Yoshida S,Tsukagoshi H

更新日期：1990-05-01 00:00:00

abstract：:A group of asymptomatic HIV-infected patients (CDC II and III) was followed-up over a two year period with semi-annual neuropsychological testing. Of the total sample of 36 subjects, all were retested at test two (T2), 19 at test three (T3) and 13 at test four (T4). A subgroup of subjects was further tested on a simpl...

journal_title：Acta neurologica Scandinavica

authors： Karlsen NR,Reinvang I,Frøland SS

更新日期：1993-02-01 00:00:00

abstract：:N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, MPTP, is a neurotoxic substance known to induce a parkinsonian syndrome in primates. The distribution of intravenously injected 11C-labelled MPTP (11C-MPTP) in the head of Rhesus monkeys was studied by means of positron emission tomography, PET. The influence of pretreatme...

journal_title：Acta neurologica Scandinavica

authors： Hartvig P,Larsson BS,Lindberg BS,Oreland L,Gullberg P,Långström B,Rimland A,Lundqvist H,Malmborg P,Lindquist NG

更新日期：1986-07-01 00:00:00

abstract：:Total lymphoid irradiation (TLI) has been reported to delay deterioration in patients with progressive multiple sclerosis and other autoimmune disorders. METHODS--In an open trial, the effect of TLI combined with a one year course of low dose prednisone was compared to the effect of sham TLI and TLI only in a prior do...

journal_title：Acta neurologica Scandinavica

authors： Cook SD,Devereux C,Troiano R,Bansil S,Zito G,Sheffet A,Jotkowitz A,Rohowsky-Kochan C,Dowling PC

更新日期：1995-01-01 00:00:00

abstract：:The production of oxygen-free radicals and their subsequent peroxidative action on membrane unsaturated fatty acids could be enhanced after subarachnoid hemorrhage. High-dose methylprednisolone (30 mg/Kg i.v.) treatment can antagonize acute SAH-induced brain hypoperfusion and protect the ultrastructural integrity of e...

journal_title：Acta neurologica Scandinavica

authors： Marzatico F,Gaetani P,Buratti E,Messina AL,Ferlenga P,Rodriguez y Baena R

更新日期：1990-10-01 00:00:00

abstract：:With the macrophage electrophoretic mobility (MEM) test of Field & Caspary, lymphocyte sensitization to thyroid antigen (F1-fraction) is demonstrable in all subjects--multiple sclerosis (MS) patients, those with other (destructive) neurological diseases (OND) and normals. The MEM-LAD test enables a further differentia...

journal_title：Acta neurologica Scandinavica

authors： Jenssen HL,Meyer-Rienecker HJ,Köhler H,Günther JK

更新日期：1976-01-01 00:00:00

abstract：:Eleven patients with presenile Alzheimer type dementia (ATD) were treated with N-terminal ACTH fragments for 14 days. No change in cognitive functions was observed during the treatment. A significant increase in CSF beta-endorphin (beta-EP) levels was found, while ACTH and beta-lipoprotein remain unaffected. The possi...

journal_title：Acta neurologica Scandinavica

authors： Nappi G,Facchinetti F,Martignoni E,Petraglia F,Sinforiani E,Bono G,Genazzani AR

更新日期：1988-08-01 00:00:00

abstract：OBJECTIVES:Focal brain ischemia induced in rodents by occlusion of the middle cerebral artery (MCA) is a widely used paradigm of human brain infarct. The objective of this study is to compare the effectiveness and reproducibility of MCA filament occlusion model in rats and mice. MATERIALS AND METHODS:A total of 140 ro...

journal_title：Acta neurologica Scandinavica

authors： Ardehali MR,Rondouin G

更新日期：2003-04-01 00:00:00