Abstract:
PURPOSE:Modern refractive surgery and follow up relies on a knowledge of corneal thickness (CT) and shape, and the reliability of modern instrumentation providing such data is important. This study sought to determine the performance of the TOPCON SP-2000P specular microscope in measuring CT. The aims of this study were: (a) to determine if there is any difference between the CT results obtained from the first image, the clearest of three images and the mean of measurements from three images; (b) to determine the correlation between central and peripheral CT and (c) to investigate the reliability (repeatability and reproducibility) of the SP-2000P in the determination of central and peripheral CT. METHODS:The central and peripheral CT measurements shown on the first (f), the clearest (c) of three images and the mean (m) CT shown in three images captured with the SP-2000P of 43 subjects were compared. All images were captured by the same examiner. Nineteen of the subjects (male) returned on another day and measurements were taken by two examiners. RESULTS:fCT, cCT and mCT were not significantly different from each other. The intraclass correlation coefficients (ICC) between the three values were> 0.9 for all corneal locations measured. However, the variability in the differences between fCT and cCT was relatively greater for peripheral CT (except temporal). The peripheral CT values obtained were all significantly greater than the central CT, and statistically significant correlations were found between the central and each of the peripheral thickness. There was no statistically significant between-visit or between-examiner differences in the central or peripheral CT. The ICC values for between-visit differences for central and temporal measurements were > 0.9 but for the other corneal locations, the ICC values were 0.81 to 0.88. For between-examiner differences, the ICC value was 0.82 for inferior CT and > 0.9 for the other four CT. CONCLUSIONS:Differences in CT measurements obtained from the first and clearest images captured by the SP-2000P were not statistically significant but can be clinically significant for peripheral CT. We therefore suggest the use of the CT value obtained from the clearest of three images. For every unit change in central CT, there is an approximately equivalent change in peripheral CT. Based on the ICC values, the SP-2000P showed very good repeatability and reproducibility in the determination of central CT. For the determination of peripheral CT, the repeatability and reproducibility of the SP-2000P were good and reasonably good respectively. These findings have relevance to the measurement of the cornea before and after refractive surgery.
journal_name
Curr Eye Resjournal_title
Current eye researchauthors
Cho P,Cheung SWdoi
10.1076/ceyr.21.4.799.5542subject
Has Abstractpub_date
2000-10-01 00:00:00pages
799-807issue
4eissn
0271-3683issn
1460-2202journal_volume
21pub_type
杂志文章abstract:PURPOSE:We recently demonstrated that direct subretinal (SR) injection of adeno-associated virus (AAV) type 8 (AAV8) into photoreceptor cells and retinal pigment epithelium (RPE) is a highly efficient model of gene delivery. The current study compared transduction efficiency and expression patterns associated with vari...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713683.2013.779720
更新日期:2013-05-01 00:00:00
abstract::We studied the effects of a forskolin suspension on intraocular pressure (IOP) in normal albino and pigmented rabbits and in alpha-chymotrypsin induced ocular hypertensive rabbits. Experimental-induced ocular hypertensive rabbits were produced by injecting of alpha-chymotrypsin (167 units) into the posterior chamber o...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713688809033195
更新日期:1988-07-01 00:00:00
abstract:PURPOSE:This study was performed to compare the positive predictive value of peripapillary retinal nerve fiber layer (RNFL) thickness measurements obtained using Cirrus high-definition optical coherence tomography (Cirrus HD-OCT; Carl Zeiss Meditec, Dublin, CA) and spectral OCT/scanning laser ophthalmoscopy (SLO) (OPKO...
journal_title:Current eye research
pub_type: 临床试验,杂志文章
doi:10.3109/02713683.2013.824989
更新日期:2014-01-01 00:00:00
abstract:PURPOSE:To examine the effects of nitric oxide synthase (NOS) inhibitors on intraocular pressure (IOP) and ocular inflammation following laser irradiation of the rabbit iris, and to investigate the involvement of nitric oxide (NO). METHODS:Thirty min after the intravenous administration of a nonselective inhibitor of ...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1076/ceyr.17.3.308.5225
更新日期:1998-03-01 00:00:00
abstract:PURPOSE:To determine whether environmental factors or bacterial viability affect the binding of two strains of P. aeruginosa to mouse cornea. METHODS:Scarified corneas were placed in organ culture and inoculated with P. aeruginosa cell suspensions containing either ATCC 19660 or PAO1 bacterial strains classed as cytot...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1076/ceyr.17.3.231.5226
更新日期:1998-03-01 00:00:00
abstract::The full length cDNA sequence for the lens-specific intermediate filament protein, CP49, from chicken is presented. The sequence contains features typical of the other intermediate filament proteins, including two major alpha-helical regions, helix I and II and appropriate linker regions. CP49 lacks a C-terminal non-a...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713689508998401
更新日期:1995-07-01 00:00:00
abstract:PURPOSE/AIM OF THE STUDY:Polarization-sensitive anterior-segmental optical coherence tomography (PS-OCT) is useful to evaluate the filtering blebs after trabeculectomy. However, the attenuation phenomenon of OCT signal disturbs the visibility of intra-bleb's structure and distribution of birefringence; a specific param...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713683.2020.1825749
更新日期:2020-10-04 00:00:00
abstract:PURPOSE:The expression of human leukocyte antigen (HLA) class II molecules on the cell surface is necessary for the presentation of peptide antigens to helper CD4 T lymphocytes of the immune system. We studied the immunoexpression of HLA class II antigen in conjunctival precursor lesions and conjunctival squamous cell ...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1076/ceyr.27.3.151.16052
更新日期:2003-09-01 00:00:00
abstract:PURPOSE:Corneal scarring is a common poor outcome of corneal trauma. Transforming growth factor β-1 plays a vital role in corneal fibrosis, inducing keratocyte transformation to myofibroblasts. Other than corneal transplantation, no other curative treatment methods for corneal scarring are currently available. Hypercap...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713683.2020.1820526
更新日期:2020-09-11 00:00:00
abstract:PURPOSE:Statins have been shown to reduce ocular inflammation in animal models of uveitis and to prevent development of uveitis in observational studies. There have been no experimental human studies evaluating statins' efficacy and safety in uveitis. In this study, we aimed to investigate efficacy and safety of simvas...
journal_title:Current eye research
pub_type: 杂志文章,随机对照试验
doi:10.1080/02713683.2017.1355468
更新日期:2017-12-01 00:00:00
abstract::This study reports on serum interleukin 2-receptor (IL-2R) levels in uveitis patients. IL-2R is the mediator protein of interleukin 2 (IL-2), a mitogenetic cytokine of primarily immune cell interaction. Stimulated T-cells readily express IL-2R on their cell surface and release a soluble form into serum. The measuremen...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713689008999415
更新日期:1990-01-01 00:00:00
abstract:PURPOSE:To determine the cellular mechanisms involved in the hypoxia-induced alteration of the retinal pigment epithelium (RPE) potentials and the light-evoked responses of the RPE in chicks. In addition, to determine the mechanisms involved in the recovery of the RPE during the post-hypoxic period. METHODS:In vitro p...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713689808951219
更新日期:1998-04-01 00:00:00
abstract:PURPOSE:To evaluate the effect of the birth weight and the postconceptional age on the tear production of preterm and term newborn infants and to evaluate the changes in tear production during the first two months of life. SUBJECTS--METHODS: Both eyes of medically stable term and preterm infants were included in the st...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1076/ceyr.28.2.145.26235
更新日期:2004-02-01 00:00:00
abstract::It has been hypothesized that an activator of Ca-ATPase co-exists with Ca-ATPase in the mouse lens. Though the Ca-ATPase activity could be measured from mouse lens homogenate, its activity could not be determined in individual soluble and insoluble fractions. The Ca-ATPase activity, however, could be detected when an ...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713688409065593
更新日期:1984-05-01 00:00:00
abstract:PURPOSE:Robo1, a member of the roundabout (Robo) family, serves as neuronal guidance receptors and has been reported to mediate tumor angiogenesis. In this study, we investigated the function of Robo1 and its possible role in retinal angiogenesis in vitro and in vivo. METHODS:Expression of Robo1 in relation to retinal...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713680903308495
更新日期:2009-12-01 00:00:00
abstract::Blood and lymphatic vessel proliferation into the cornea occurs after severe trauma. Whilst the events early in blood vessel growth are reasonably understood, little is known of the early events in lymphangiogenesis. In this study, a model for proliferating lymphatic vessels using tritiated-thymidine autoradiography a...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713688909013898
更新日期:1989-01-01 00:00:00
abstract:PURPOSE:To compare the quality of corneal endothelium of precut Descemet-stripping automated endothelial keratoplasty (DSAEK) tissue when transported with and without the anterior lamellar corneal tissue (ALCT) when organ-culture corneal storage methods are used. METHODS:After microkeratome-assisted excision of anteri...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713683.2011.648045
更新日期:2012-02-01 00:00:00
abstract:PURPOSE:To evaluate the length of the trabecular meshwork (TM) from the scleral spur (SS) to Schwalbe's line (SL) and assess the detectability of the SS in histopathology specimens. METHODS:This study included 158 angle images from 79 cross-sectional slides derived from eyes enucleated for melanoma. The slides were st...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713683.2012.700757
更新日期:2013-01-01 00:00:00
abstract:PURPOSE:Pigmentation of the iris is caused by varying amounts of melanin pigment granula in a constant number of melanocytes in the superficial stroma. Melanin has been shown to act as antioxidant. We have now investigated lipid peroxidation in dependence on stromal pigmentation in isolated porcine irises. METHODS:The...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1076/ceyr.22.3.229.5511
更新日期:2001-03-01 00:00:00
abstract::The acyclic nucleoside phosphonate analogue PMEA [9-(2-phosphonylmethoxyethyl)adenine] is a broad spectrum antiviral agent effective against DNA viruses and retroviruses. It is particularly active against the human immunodeficiency virus and, like other phosphonylmethoxyalkyl derivatives, it also inhibits HSV-1, TK- H...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713689109020370
更新日期:1991-01-01 00:00:00
abstract::An image analyser installed in a 16 bit personal computer was used to measure grey levels in red free photographs of normal and glaucomatous eyes. Regional photographic image intensity and density were correlated with Humphrey Field Analyser results for corresponding areas of visual field. Two methods for standardisin...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713688809033210
更新日期:1988-08-01 00:00:00
abstract:PURPOSE:Endothelial cells of different vascular systems may express site-specific adhesion molecules to attract leukocyte subsets. This study describes a method to visualize and compare leukocyte-endothelial interactions in three vascular beds within the same eye in mice. METHODS:Digital in vivo fluorescence microscop...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1076/ceyr.24.3.214.8303
更新日期:2002-03-01 00:00:00
abstract:PURPOSE:We investigated the impact of target properties on vertical fusion amplitude (VFA) using a 3D display platform; the performance of the subjects allowed us to assess how central and peripheral retina regions interact during the fusion process. MATERIAL AND METHODS:Fourteen subjects were involved in the test. VF...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713683.2016.1196704
更新日期:2017-03-01 00:00:00
abstract::Goggles that degrade the retinal image produce axial enlargement of the ocular globe and large myopic refractive errors. Many authors have assumed that visual image degradation itself leads to myopia. Hodos and co-authors have shown, however, that goggled eyes in chicks are considerably warmer than normal. Such temper...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713689308999467
更新日期:1993-03-01 00:00:00
abstract::Corneal acidosis has been shown to reduce corneal hydration control (CHC) as measured by the rate, expressed as the percent recovery per hour (PRPH), at which the thickness of the cornea decreases exponentially after an increased hydration load. Since the effect of pH on corneal function is of scientific interest and ...
journal_title:Current eye research
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.3109/02713689508999932
更新日期:1995-05-01 00:00:00
abstract:PURPOSE:To assess the potential impact of corneal crosslinking treatment (365 nm ultraviolet (UV)A irradiation with riboflavin) on the material properties of Intracorneal Rings Segments (ICRS). MATERIALS AND METHODS:Material properties were studied using FT-IR spectroscopy and UV-Vis spectroscopy. Rings were examined:...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713683.2014.941071
更新日期:2015-05-01 00:00:00
abstract:BACKGROUND:There is a clinical need for biomimetic corneas that are as effective, preferably superior, to cadaveric donor tissue. Decellularized tissues are advantageous compared to synthetic or semi-synthetic engineered tissues in that the native matrix ultrastructure and intrinsic biological cues including growth fac...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713683.2015.1062114
更新日期:2016-06-01 00:00:00
abstract::Lenses from normal Wistar rats and those from a Wistar strain with X-ray-induced cataract mutation were examined electron microscopically for morphological characterization and acid phosphatase (AcPase) localization. Ocular anlages of 11 through 18 days of gestation were included in the study. A late-separating or per...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713688409003064
更新日期:1984-04-01 00:00:00
abstract::We measured the relative solubility of collagen in acetic acid after pepsin digestion and tentatively identified the types of collagen present in corneas of rabbits of various ages and in corneal scar tissue, using hydroxyproline assays and polyacrylamide gel electrophoretic analyses. More than 80% of the collagen in ...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713688109019966
更新日期:1981-01-01 00:00:00
abstract::Papavarine, cholera toxin, and isoproterenol each elevated cyclic AMP in cultured rat retinal pigment epithelium and reduced the phagocytosis of isolated rod outer segments (38-66% of controls) during a 4 hour incubation. In addition, cultured pigment epithelium was preincubated with 25 mM exogenous cyclic AMP for two...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713688608995161
更新日期:1986-01-01 00:00:00