Efficacy of 9-(2-phosphonylmethoxyethyl)adenine in the therapy of TK+ and TK- herpes simplex virus experimental keratitis.


:The acyclic nucleoside phosphonate analogue PMEA [9-(2-phosphonylmethoxyethyl)adenine] is a broad spectrum antiviral agent effective against DNA viruses and retroviruses. It is particularly active against the human immunodeficiency virus and, like other phosphonylmethoxyalkyl derivatives, it also inhibits HSV-1, TK- HSV-1 and HSV-2. We have evaluated the therapeutic efficacy of PMEA in the HSV-1 and TK- HSV-1 experimental keratitis models using BVDU (bromovinyldeoxyuridine) as the reference compound. As compared to placebo eyedrops, PMEA 0.2% and BVDU 0.2% eyedrops induced a rapid and significant healing (P less than 0.005) of keratitis caused by TK+ HSV-1. Treatment with PMEA 0.2% eyedrops also reduced the severity of keratitis caused by the TK- HSV-1 (P less than 0.05), whereas BVDU 0.2% eyedrops did not affect the course of TK- HSV-1 keratitis.


Curr Eye Res


Current eye research


Maudgal PC,De Clercq E




Has Abstract


1991-01-01 00:00:00








10 Suppl


  • Sodium/potassium ATPase in normal and cataractous human lenses.

    abstract::Na/K ATPase activity has been determined in normal and cataractous human lenses using labeled ATP as a substrate. The enzyme is distributed throughout the lens with approximately 1/3 of the total activity in the capsule-epithelium and 1/2 of the activity in the cortex. Furthermore, the activity of Na/K ATPase decrease...

    journal_title:Current eye research

    pub_type: 杂志文章


    authors: Kobatashi S,Roy D,Spector A

    更新日期:1982-01-01 00:00:00

  • Prevalence and Associations of Posterior Segment Manifestations in a Cohort of Egyptian Patients with Pathological Myopia.

    abstract::Purpose: To determine the prevalence of posterior segment manifestations among consecutive patients with pathological myopia attending our University Hospital general ophthalmology clinic and their association with age, refractive error, axial length and each other. Methods: Patients diagnosed with pathological myopia...

    journal_title:Current eye research

    pub_type: 杂志文章


    authors: Elnahry AG,Khafagy MM,Esmat SM,Mortada HA

    更新日期:2019-09-01 00:00:00

  • Associations among Socioeconomic Factors, Lag Time, and High-Risk Histopathologic Features in Eyes Primarily Enucleated for Retinoblastoma.

    abstract::Purpose/Aim: To determine the associations among socioeconomic factors, delay in management, and high-risk histopathologic features in eyes primarily enucleated for retinoblastoma. Materials and Methods: A single-site survey was conducted from January 2016 through January 2018. Eyes primarily enucleated for unilateral...

    journal_title:Current eye research

    pub_type: 杂志文章


    authors: Xiao W,Ye H,Zeng H,Tang L,Chen R,Gao Y,Mao Y,Yang H

    更新日期:2019-10-01 00:00:00

  • A platelet-activating factor antagonist reduces corneal allograft inflammation and neovascularization.

    abstract::We assessed the role of platelet-activating factor (PAF) in corneal allograft rejection and evaluated the effects of a PAF antagonist on corneal inflammation, cellular infiltration, vascularization, and edema. Rabbits with vascularized corneas served as recipients of allogeneic cornea grafts. Rabbits with normal corne...

    journal_title:Current eye research

    pub_type: 杂志文章


    authors: Cohen RA,Gebhardt BM,Bazan NG

    更新日期:1994-02-01 00:00:00

  • Protective effect of passive immunization on herpetic retinitis of newborn rabbits.

    abstract::We studied the protective effects of passive immunization with virus specific antibody in newborn rabbits inoculated subcutaneously with type 2 herpes simplex virus (HSV-2). Newborn rabbits given anti-HSV-2 antibody intraperitoneally (IP) on days 0, 2 and 4 post infection had smaller herpetic skin lesions and reduced ...

    journal_title:Current eye research

    pub_type: 杂志文章


    authors: Friedlaender RP,Oh JO,Minasi P,Ohashi Y

    更新日期:1987-01-01 00:00:00

  • Aberrant Epigenetic Alterations of Glutathione-S-Transferase P1 in Age-Related Nuclear Cataract.

    abstract:PURPOSE:Oxidative damage of lens tissue contributes to the formation of age-related cataract. Pi-class glutathione-S-transferase (GSTP1) plays a role in the removal of oxidative adducts by transferring them to glutathione. To assess epigenetic regulation of GSTP1 and its potential role in age-related nuclear cataract (...

    journal_title:Current eye research

    pub_type: 杂志文章


    authors: Chen J,Zhou J,Wu J,Zhang G,Kang L,Ben J,Wang Y,Qin B,Guan H

    更新日期:2017-03-01 00:00:00

  • Down-regulation of matrix metalloproteinase-9 by pyrrolidine dithiocarbamate prevented retinal ganglion cell death after transection of optic nerve in rats.

    abstract:PURPOSE:To investigate the effects of pyrrolidine dithiocarbamate (PDTC), a nuclear factor κ-light-chain-enhancer of activated B cells (NF-κB) inhibitor, on the expression of matrix metalloproteinases (MMP) and MMP-mediated apoptosis in retinal ganglion cells (RGCs) following the transection of the optic nerve (ON) in ...

    journal_title:Current eye research

    pub_type: 杂志文章


    authors: Sun MH,Chen KJ,Tsao YP,Kao LY,Han WH,Lin KK,Pang JH

    更新日期:2011-11-01 00:00:00

  • Characterization of the pupil light reflex, electroretinogram and tonometric parameters in healthy rat eyes.

    abstract:PURPOSE:To characterize the pupil light reflex (PLR), electroretinographic (ERG) and tonometric parameters in healthy rat eyes. METHODS:Brown Norway rats were used for experiments. The PLR was evaluated with a computerized pupillometer (n = 27), ERGs were recorded simultaneously from both eyes (n = 27) and IOP was mea...

    journal_title:Current eye research

    pub_type: 杂志文章


    authors: Grozdanic S,Sakaguchi DS,Kwon YH,Kardon RH,Sonea IM

    更新日期:2002-08-01 00:00:00

  • Efficacy of Polytetrafluoroethylene/Polylactide-co-glycolide (PTFE/PLGA) Laminate and PTFE/PLGA Laminate Containing Slow-Releasing Thalidomide in Delayed Adjustable Strabismus Surgery in a Rabbit Model.

    abstract::Purpose: To evaluate the efficacy of polytetrafluoroethylene/polylactide-co-glycolide (PTFE/PLGA) laminate containing sustained-release thalidomide for delayed adjustable strabismus surgery. Methods: This is a prospective, masked-observer, controlled study using 50 eyes of 25 rabbits. After superior rectus muscle (SRM...

    journal_title:Current eye research

    pub_type: 杂志文章


    authors: Han SB,Kim JH,Yang HK,Hwang JM

    更新日期:2019-07-01 00:00:00

  • Citicoline reduces upregulated clusterin following kainic acid injection in the rat retina.

    abstract:PURPOSE:To investigate the effects of citicoline on upregulated clusterin and retinal damage induced by kainic acid (KA). METHODS:KA was injected into the vitreous of rats. Effects of systemic citicoline treatments were estimated by measuring the thickness of the various retinal layers, immunoblotting, and immunohisto...

    journal_title:Current eye research

    pub_type: 杂志文章


    authors: Park CH,Kim YS,Lee HK,Kim YH,Choi MY,Jung DE,Yoo JM,Kang SS,Choi WS,Cho GJ

    更新日期:2007-12-01 00:00:00

  • Effect of ZnCl2 and chelation of zinc ions by N,N-diethyldithiocarbamate (DEDTC) on the ERG b-wave amplitude from the isolated superfused vertebrate retina.

    abstract:PURPOSE:NiCl(2) (15 microM) enhances the ERG b-wave amplitude of vertebrate retina, up to 1.5-fold by blocking E/R-type voltage-gated Ca(2+) channels, which is mediated by blocking the release of GABA onto ionotropic GABA-A and GABA-C receptors. In vivo, it is likely that zinc, rather than nickel ions, may be involved ...

    journal_title:Current eye research

    pub_type: 杂志文章


    authors: Siapich SA,Wrubel H,Albanna W,Alnawaiseh M,Hescheler J,Weiergräber M,Lüke M,Schneider T

    更新日期:2010-04-01 00:00:00

  • Calmodulin antagonists induce changes in lens permeability and transparency.

    abstract::Calmodulin has been shown to perform several important functions in the lens including regulation of the plasma membrane Ca(2+)-ATPase. This study investigated the effects of a variety of different CaM antagonists on rat lens membrane potential, membrane resistance, intracellular Na+ and Ca2+ content and transparency,...

    journal_title:Current eye research

    pub_type: 杂志文章


    authors: Sanderson J,Gandolfi SA,Duncan G

    更新日期:1994-03-01 00:00:00

  • Plasma Rich in Growth Factors for the Treatment of Ocular Surface Diseases.

    abstract:PURPOSE:The purpose of this work is to describe and review the technology of plasma rich in growth factors (PRGF), a novel blood derivative product, in the treatment of ocular surface disorders. METHODS:To demonstrate the importance of this technology in the treatment of ocular pathologies, a thorough review of the pr...

    journal_title:Current eye research

    pub_type: 杂志文章,评审


    authors: Anitua E,Muruzabal F,de la Fuente M,Merayo J,Durán J,Orive G

    更新日期:2016-07-01 00:00:00

  • The Association of Nailfold Capillaroscopy with Systemic Matrix Metalloproteinase-9 Concentration in Normal-Tension Glaucoma.

    abstract:PURPOSE:To investigate the association of nailfold capillaroscopy, heart rate variability (HRV), and clinical characteristics of glaucoma with the plasma matrix metalloproteinase-9 (MMP-9) level in normal-tension glaucoma (NTG). MATERIALS AND METHODS:We conducted a prospective, cross-sectional study on 25 patients wit...

    journal_title:Current eye research

    pub_type: 杂志文章


    authors: Lee NY,Park HY,Park SH,Park CK

    更新日期:2015-01-01 00:00:00

  • Ultrastructural and acid phosphatase histochemical analysis of developmental lens abnormalities in rats with X-ray-induced cataract mutation.

    abstract::Lenses from normal Wistar rats and those from a Wistar strain with X-ray-induced cataract mutation were examined electron microscopically for morphological characterization and acid phosphatase (AcPase) localization. Ocular anlages of 11 through 18 days of gestation were included in the study. A late-separating or per...

    journal_title:Current eye research

    pub_type: 杂志文章


    authors: Anderson JW,Gorthy WC

    更新日期:1984-04-01 00:00:00

  • Canaloplasty with Suprachoroidal Drainage in Patients with Pseudoexfoliation Glaucoma - Four Years Results.

    abstract::Purpose: To evaluate the long-term efficacy and safety of the modified canaloplasty technique with additional suprachoroidal drainage in patients with pseudoexfoliation glaucoma. Methods: This retrospective clinical trial included 131 patients with pseudoexfoliation glaucoma who underwent canaloplasty with suprachoroi...

    journal_title:Current eye research

    pub_type: 杂志文章


    authors: Seuthe AM,Szurman P,Januschowski K

    更新日期:2021-02-01 00:00:00

  • Cullin5 reduces retinal cell death induced by glutamate toxicity.

    abstract:PURPOSE:To investigate the expression in the mouse retina and the function in a retinal cell of cullin5 that is known as a protein that is associated with ubiquitilation. METHODS:The retinal sites of expressing cullin5 were determined by immunohistochemistry with a specific antibody for cullin5. Retinal cells were tra...

    journal_title:Current eye research

    pub_type: 杂志文章


    authors: Kanamoto T,Okumichi H,Rimayanti U,Kiuchi Y

    更新日期:2011-01-01 00:00:00

  • Experimental preretinal neovascularization by laser-induced venous thrombosis in rats.

    abstract:PURPOSE:Retinal ischemia and neovascularization (NV) are important components of many retinal disorders. To facilitate further investigation of retinal ischemia and neovascularization, we sought to develop a reproducible in vivo experimental model of venous occlusion by photodynamic thrombosis in rats. METHODS:After a...

    journal_title:Current eye research

    pub_type: 杂志文章


    authors: Saito Y,Park L,Skolik SA,Alfaro DV,Chaudhry NA,Barnstable CJ,Liggett PE

    更新日期:1997-01-01 00:00:00

  • Cone-mediated multifocal electroretinogram in early age-related maculopathy and its relationships with subjective macular function tests.

    abstract:PURPOSE:To investigate the multifocal electroretinogram (mfERG) and subjective function in early age-related maculopathy (ARM). METHODS:Seventeen subjects with early ARM with visual acuity (VA) of 6/12 or better and 20 age-matched control subjects were examined. We assessed mfERGs, high and low contrast distance VA, n...

    journal_title:Current eye research

    pub_type: 杂志文章


    authors: Feigl B,Brown B,Lovie-Kitchin J,Swann P

    更新日期:2004-10-01 00:00:00

  • A siRNA targeting vascular endothelial growth factor-A inhibiting experimental corneal neovascularization.

    abstract:PURPOSE:This study was designed to investigate whether synthetic small interference RNA (siRNA) targeting VEGF-A could inhibit mouse corneal neovascularization or not. METHODS:First, the effect of synthetic siRNA targeting VEGF-A on the expression of VEGF in human retinal pigment epithelial line ARPE-19 cells was exam...

    journal_title:Current eye research

    pub_type: 杂志文章


    authors: Zuo L,Fan Y,Wang F,Gu Q,Xu X

    更新日期:2010-05-01 00:00:00

  • Hydrogen peroxide localization in ocular tissue: an electron microscopic cytochemical study.

    abstract::A reduced nicotinamide adenine dinucleotide phosphate (NAD(P)H)-dependent hydrogen peroxide-generating activity of rat ocular tissue was investigated cytochemically utilizing the cerium method. NADPH or NADH oxidation resulted in electron-dense fine granular deposits on the corneal epithelial and endothelial plasma me...

    journal_title:Current eye research

    pub_type: 杂志文章


    authors: Atalla LR,Sevanian A,Rao NA

    更新日期:1988-09-01 00:00:00

  • Prostaglandins increase proMMP-1 and proMMP-3 secretion by human ciliary smooth muscle cells.

    abstract:PURPOSE:The mechanism by which prostaglandin(PG)F2 alpha increases uveoscleral outflow and lowers intraocular pressure in primates is not known. In cultured human ciliary muscle cells, PGF2 alpha induces the expression of the protooncogene c-fos which is known to induce the transcription of genes such as matrix metallo...

    journal_title:Current eye research

    pub_type: 杂志文章


    authors: Lindsey JD,Kashiwagi K,Boyle D,Kashiwagi F,Firestein GS,Weinreb RN

    更新日期:1996-08-01 00:00:00

  • Quantifying retinal irradiance levels in light damage experiments.

    abstract::From knowledge of the optical parameters of experimental animal eyes and radiometric parameters of the light source, it is possible to provide accurate retinal irradiances (dose rates). Examples are given for the rat, cat, monkey and other animals of interest. Fluorescent lamps and incandescent lamp radiances are prov...

    journal_title:Current eye research

    pub_type: 杂志文章


    authors: Sliney DH

    更新日期:1984-01-01 00:00:00

  • Inhibitory effects of oral disulfiram on endotoxin-induced uveitis in rats.

    abstract:PURPOSE:Disulfiram (DSF) exhibits a wide variety of biological activities, including an anti-inflammatory action, on which we focused our attention. The aim of the present study was to investigate the effect of oral DSF on endotoxin-induced uveitis (EIU) in rats. METHODS:We investigated its effect upon cellular infilt...

    journal_title:Current eye research

    pub_type: 杂志文章


    authors: Kanai K,Itoh N,Yoshioka K,Yonezawa T,Ikadai H,Hori Y,Ito Y,Nagai N,Chikazawa S,Hoshi F,Higuchi S

    更新日期:2010-10-01 00:00:00

  • Murine endotoxin-induced uveitis, but not immune complex-induced uveitis, is dependent on the IL-8 receptor homolog.

    abstract:PURPOSE:To determine the roles of the murine interleukin-8 receptor homolog (mIL-8Rh, neutrophil chemokine CXC receptor 2) and macrophage inflammatory protein-1alpha (MIP-1alpha, a CC chemokine) in two eye inflammation models: endotoxin-induced uveitis (EIU) and immune complex-induced uveitis (reverse passive Arthus re...

    journal_title:Current eye research

    pub_type: 杂志文章


    authors: Brito BE,O'Rourke LM,Pan Y,Huang X,Park JM,Zamora D,Cook DN,Planck SR,Rosenbaum JT

    更新日期:1999-07-01 00:00:00

  • Effect of Optical Defocus on the Kinetic Perimetry in Young Myopic Participants.

    abstract:PURPOSE:The prospective study evaluated the effects of optical defocus on kinetic sensitivity using automated kinetic perimetry. MATERIALS AND METHODS:The 17 eyes of 17 healthy young participants were evaluated. All of the participants had myopia (≥ -5.00 D) and mild to no astigmatism (<1.00 D). Automated kinetic peri...

    journal_title:Current eye research

    pub_type: 杂志文章


    authors: Hirasawa K,Shoji N

    更新日期:2015-01-01 00:00:00

  • Assessment of patient satisfaction following external versus transcanalicular dacryocystorhinostomy with a diode laser and evaluation if change in quality of life after simultaneous bilateral surgery in patients with bilateral nasolacrimal duct obstructio

    abstract:AIM:To compare patient satisfaction and experience after external dacryocystorhinostomy (EX-DCR) versus transcanalicular DCR (TC-DCR) with a diode laser and to evaluate the change in quality of life following simultaneous bilateral DCR. METHODS:Prospective evaluation of 38 eyes of 19 patients with bilateral nasolacrim...

    journal_title:Current eye research

    pub_type: 杂志文章


    authors: Yeniad B,Uludag G,Kozer-Bilgin L

    更新日期:2012-04-01 00:00:00

  • Corneal endothelial changes in diabetic dogs.

    abstract::The corneal endothelium of alloxan diabetic dogs was examined by wide-field specular microscopy and compared to that of age-matched non-diabetic dogs. Computer-assisted morphometry of individual cells showed that the diabetic dog endothelium had marked polymegethism and pleomorphism similar to that previously describe...

    journal_title:Current eye research

    pub_type: 杂志文章


    authors: Yee RW,Matsuda M,Kern TS,Engerman RL,Edelhauser HF

    更新日期:1985-07-01 00:00:00

  • Effects of hypoxia and post-hypoxic recovery on chick retinal pigment epithelium potentials and light-evoked responses in vitro.

    abstract:PURPOSE:To determine the cellular mechanisms involved in the hypoxia-induced alteration of the retinal pigment epithelium (RPE) potentials and the light-evoked responses of the RPE in chicks. In addition, to determine the mechanisms involved in the recovery of the RPE during the post-hypoxic period. METHODS:In vitro p...

    journal_title:Current eye research

    pub_type: 杂志文章


    authors: Nakazaki S,Nao-i N,Sawada A

    更新日期:1998-04-01 00:00:00

  • The Distinct Biometric Features of High Myopia Compared to Moderate Myopia.

    abstract:PURPOSE:To evaluate changes in biometric parameters in myopic eyes. MATERIALS AND METHODS:412 eyes of 412 young myopic patients underwent ophthalmic examinations including assessments of refractive error, axial length (AL), anterior chamber depth (ACD), and central corneal thickness (CCT). By using spectral domain opt...

    journal_title:Current eye research

    pub_type: 杂志文章


    authors: Chung HJ,Park CK

    更新日期:2016-12-01 00:00:00