Direct comparison of administration routes for AAV8-mediated ocular gene therapy.

abstract：PURPOSE:Histidine is an indispensable amino acid with an imidazole ring and it is a precursor of histamine, carnosine, and anserine. Histidine has been proposed to act as a neurotransmitter or neuromodulator in mammalian central nervous system (CNS), including retina. In this study, we report histidine-like immunoreact...

journal_title：Current eye research

authors： Kusakari Y,Nishikawa S,Ishiguro S,Tamai M

更新日期：1997-06-01 00:00:00

abstract：PURPOSE:To explore the roles of interleukin (IL)-17A in alkali-induced corneal neovascularization (CRNV). METHODS:Induction of CRNV by alkali injury was performed and compared in recombinant mouse IL-17A protein or anti-mouse IL-17A neutralizing antibody (Ab)-treated mice. The expression of IL-17A, IL-17A receptor (IL...

journal_title：Current eye research

authors： Liu G,Wu H,Lu P,Zhang X

更新日期：2017-03-01 00:00:00

abstract：:Purpose: Dual wavelength retinal oximetry allows the quantification of oxygen saturation in the larger retinal vessels. However, the technique might be refined further by identifying factors that are responsible for the different oxygen saturations in first order arterioles from the same eye shortly after their branch...

journal_title：Current eye research

authors： Jeppesen SK,Bek T

更新日期：2019-01-01 00:00:00

abstract：PURPOSE/AIM OF THE STUDY:Polarization-sensitive anterior-segmental optical coherence tomography (PS-OCT) is useful to evaluate the filtering blebs after trabeculectomy. However, the attenuation phenomenon of OCT signal disturbs the visibility of intra-bleb's structure and distribution of birefringence; a specific param...

journal_title：Current eye research

authors： Kosugi M,Kokubun T,Tsuda S,Yamanari M,Nakazawa T

更新日期：2020-10-04 00:00:00

abstract：:Spontaneous ocular shedding and adrenergic induction of ocular shedding were examined in rabbits infected with ten strains of herpes simplex virus type 1 (HSV-1): McKrae, KOS, F, Rodanus, 17 Syn+, RE, E-43, SC-16, MacIntyre, and CGA-3. All ocular inoculations were with 50 microliter of HSV-1 with titers between 1-10 X...

journal_title：Current eye research

authors： Hill JM,Rayfield MA,Haruta Y

更新日期：1987-01-01 00:00:00

abstract：PURPOSE:The purpose of this work is to describe and review the technology of plasma rich in growth factors (PRGF), a novel blood derivative product, in the treatment of ocular surface disorders. METHODS:To demonstrate the importance of this technology in the treatment of ocular pathologies, a thorough review of the pr...

journal_title：Current eye research

authors： Anitua E,Muruzabal F,de la Fuente M,Merayo J,Durán J,Orive G

更新日期：2016-07-01 00:00:00

abstract：:Purpose: The goal of this work was to determine whether the retinal tissue perfusion (RTP) is impaired in patients with multiple sclerosis (MS). Methods: Seventy-four patients [66 relapsing-remitting MS (RRMS) and 8 clinically isolated syndrome (CIS)] and 74 age- and gender-matched healthy controls were recruited. RTP...

journal_title：Current eye research

authors： Liu Y,Delgado S,Jiang H,Lin Y,Hernandez J,Deng Y,Gameiro GR,Wang J

更新日期：2019-10-01 00:00:00

abstract：PURPOSE:To quantify levels of matricellular proteins in aqueous humor samples from acute primary angle closure (APAC) and non-glaucomatous cataract eyes and investigate their correlation with intraocular pressure (IOP) fluctuation. MATERIALS AND METHODS:Aqueous humor samples were collected from 63 eyes including 29 cu...

journal_title：Current eye research

authors： Wang J,Fu M,Liu K,Wang N,Zhang Z,Zhou M,Xu X

更新日期：2018-06-01 00:00:00

abstract：PURPOSE:The aim of this study was to investigate how glutathione reductase (GR) loses its activity during cataract formation and whether it is possible to revive it back to the normal levels. METHOD:In this study, endogenous as well as synthetic reducing systems (GSH, TTase, DTT, captopril) and alpha-crystallin at dif...

journal_title：Current eye research

authors： Rachdan D,Lou MF,Harding JJ

更新日期：2005-10-01 00:00:00

abstract：PURPOSE:To study retinal neovascularization (RNV) inhibition by intravitreal injections (IVs) of ranibizumab, sTie2 fusion protein (sTie2-Fc), and a combined therapy in an oxygen-induced retinopathy (OIR) model. MATERIALS AND METHODS:An OIR mouse model was used to simulate RNV in retinopathy of prematurity (ROP); and ...

journal_title：Current eye research

authors： Jiang C,Ruan L,Zhang J,Huang X

更新日期：2018-09-01 00:00:00

abstract：PURPOSE:To study the effect of Na-K pump and K(ATP) channel inhibition on the diameter and the adenosine-induced vasodilation of small retinal arterioles. METHODS:Thirty isolated porcine arterioles with a diameter of approximately 70 microm were mounted in a double-barrelled pipette system placed in an organ bath, and...

journal_title：Current eye research

authors： Jeppesen P,Aalkjaer C,Bek T

更新日期：2002-07-01 00:00:00

abstract：PURPOSE:To develop a standardized method for measuring from iris photographs, light and dark segments of areas and densities of iris color. METHODS:Computerized image analysis was used to measure the iris photographs. The reproducibility of this method was studied in 30 normal eyes with three different colored irides,...

journal_title：Current eye research

authors： Takamoto T,Schwartz B,Cantor LB,Hoop JS,Steffens T

更新日期：2001-06-01 00:00:00

abstract：BACKGROUND:This work compares the concentration of active ingredients and preservatives in commonly used brand name versus generic glaucoma medications. MATERIALS AND METHODS:Active ingredient and benzalkonium chloride (BAK) concentrations in brand name latanoprost and dorzolamide-timolol were each compared to two gen...

journal_title：Current eye research

authors： Kahook MY,Fechtner RD,Katz LJ,Noecker RJ,Ammar DA

更新日期：2012-02-01 00:00:00

abstract：:The ocular penetration pathways of three alpha 2-adrenergic agents (p-aminoclonidine, AGN 190342, and clonidine) were investigated in rabbits both in vitro and in vivo. The corneal permeabilities of the compounds correlated positively with their octanol/water distribution coefficients. The ocular drug absorption via c...

journal_title：Current eye research

authors： Chien DS,Homsy JJ,Gluchowski C,Tang-Liu DD

更新日期：1990-11-01 00:00:00

abstract：PURPOSE:Experiments were performed to evaluate the effect of various pro- and anti-inflammatory cytokines on the human fetal retinal pigment epithelium's (HFRPE) expression of major histocompatibility complex (MHC) and costimulatory molecules. METHODS:Pure cultures of HFRPE cells were isolated. HFRPE cells were incuba...

journal_title：Current eye research

authors： Farrokh-Siar L,Rezai KA,Palmer EM,Patel SC,Ernest TJ,van Seventer GA

更新日期：2001-10-01 00:00:00

abstract：:In the Royal College of Surgeons rat, the migration of phagocytic cells into the subretinal space accompanies photoreceptor cell death during the early stages of retinal dystrophy. These are followed closely by cellular alterations in the retinal pigment epithelium, Müller cells, and outer retinal vessels. We have ide...

journal_title：Current eye research

authors： Roque RS,Caldwell RB

更新日期：1993-03-01 00:00:00

abstract：:In earlier experiments on the role of the cytolytic toxin pneumolysin in ocular infections with pneumococcus, we found that a strain carrying a deletion in the gene encoding pneumolysin was considerably less virulent than wild type when tested in an intracorneal model of keratitis in the rabbit. To confirm this result...

journal_title：Current eye research

authors： Johnson MK,Hobden JA,O'Callaghan RJ,Hill JM

更新日期：1992-12-01 00:00:00

abstract：PURPOSE:To assess the incidence of cell proliferation and apoptosis in epiretinal membranes from eyes with proliferative vitreoretinopathy (PVR), proliferative diabetic retinopathy (PDR), and macular pucker (MP) and to further investigate the potential involvement of key executors of apoptosis. METHODS:Epiretinal memb...

journal_title：Current eye research

authors： Zhang X,Barile G,Chang S,Hays A,Pachydaki S,Schiff W,Sparrow J

更新日期：2005-05-01 00:00:00

abstract：:Glaucoma is increasingly recognized as a neurodegenerative disorder, characterized by the accelerated loss of retinal ganglion cells (RGCs) and their axons. Impaired axonal transport has been implicated as a pathogenic mechanism in a number of neurodegenerative diseases, including glaucoma. The long RGC axon, with its...

journal_title：Current eye research

authors： Fahy ET,Chrysostomou V,Crowston JG

更新日期：2016-01-01 00:00:00

abstract：PURPOSE:Psychiatric conditions and not just the treatments themselves might be involved in the pathophysiology of dry eye disease (DED). The aim of our study was to evaluate the association between depression and DED using objective and subjective tests in patients with newly diagnosed depressive disorder who were not ...

journal_title：Current eye research

authors： Tiskaoglu NS,Yazıcı A,Karlıdere T,Sari E,Oguz EY,Musaoglu M,Aslan S,Samet Ermiş S

更新日期：2017-05-01 00:00:00

abstract：PURPOSE/AIM:We aimed to characterize the connective tissue microanatomy, elastin abundance, and fiber orientation in the human optic nerve sheath, also known as the optic nerve dura mater, for correlation with its biomechanical properties. MATERIALS AND METHODS:Seven whole human orbits aged 4-93 years, and five isolat...

journal_title：Current eye research

authors： Le A,Shin A,Park J,Poukens V,Demer JL

更新日期：2020-07-01 00:00:00

abstract：:Purpose: To evaluate the effect of methylphenidate on visual field testing in healthy adults with abnormal visual field results. Methods: This prospective, randomized, controlled interventional clinical trial comprised all patients who had abnormal visual field test results and normal eye examination and ophthalmic hi...

journal_title：Current eye research

authors： Sternfeld A,Bialer OY,Keidar D,Megiddo E,Budnik I,Stiebel-Kalish H,Livnat T

更新日期：2020-12-21 00:00:00

abstract：PURPOSE:To assess the upper eyelid kinematics during spontaneous blinking in unilateral paralytic lagophthalmos before and after upper eyelid load with gold weight (GW) or autogenous temporalis fascia (TF) sling. DESIGN:Comparative case series. SUBJECTS:Patients with long-standing unresolved unilateral facial palsy w...

journal_title：Current eye research

authors： Wambier SP,Garcia DM,Cruz AA,Messias A

更新日期：2016-04-01 00:00:00

abstract：PURPOSE:To investigate glaucoma progression and its relationship with corrected and uncorrected intraocular pressure (IOP) in patients with a history of refractive corneal surgery (RCS). METHODS:Totally, 56 eyes of 56 primary open-angle glaucoma patients who had a history of RCS were included. Mean keratometry and cen...

journal_title：Current eye research

authors： Kwon J,Sung KR,Jo J,Yang SH

更新日期：2018-09-01 00:00:00

abstract：:Langerhans cells (LC) appear to have a role in the processing of antigens presented through cutaneous surfaces. In most species LC are found in the conjunctiva and limbal epithelium but are rarely found in the central cornea. A quantitative study of corneal LC was performed in guinea pigs and rabbits with HSV-1 kerati...

journal_title：Current eye research

authors： Asbell PA,Kamenar T

更新日期：1987-01-01 00:00:00

abstract：:Using phosphorus-31 nuclear magnetic resonance (P-31 NMR) spectroscopy the rat crystalline lens was evaluated as a potential animal model for the study of lens metabolic processes relevant to the human. The P-31 NMR spectra of intact rat lenses and rat lens PCA extracts provided comparable qualitative and quantitative...

journal_title：Current eye research

authors： Kopp SJ,Greiner JV,Glonek T

更新日期：1981-01-01 00:00:00

abstract：PURPOSE:The fibroblast growth factors (FGFs) are a family of 9 heparin binding proteins which have been proposed to play key roles in angiogenesis. Basic FGF (bFGF), acidic FGF (aFGF) and FGF5 have previously been demonstrated to be expressed in the normal retina and RPE. In this study, the expression of FGF5 was explo...

journal_title：Current eye research

authors： Kitaoka T,Morse LS,Schneeberger S,Ishigooka H,Hjelmeland LM

更新日期：1997-04-01 00:00:00

abstract：PURPOSE:To investigate the effect of topical iganidipine, a new dihydropyridine derivative calcium channel blocker, on impairment of the ocular circulation caused by endothelin-1 (ET-1), we examined modification of the effect of ET-1 on visual-evoked potential (VEP) in albino rabbits. METHODS:To clarify whether VEP co...

journal_title：Current eye research

authors： Oku H,Sugiyama T,Kojima S,Watanabe T,Ikeda T

更新日期：2000-02-01 00:00:00

abstract：PURPOSE:Acanthamoeba keratitis is a sight-threatening corneal infection. It is known that: (i) more amoebae bind to the surface of injured corneas than to the normal corneal surface and (ii) mannose-containing glycoproteins (GPs) possess binding sites for Acanthamoeba. The present study was undertaken to determine whet...

journal_title：Current eye research

authors： Jaison PL,Cao Z,Panjwani N

更新日期：1998-08-01 00:00:00

abstract：:Antifibrosis agents have improved the success of glaucoma filtration surgery, although undesired side effects are not readily reversible and may present a major limitation in the use of these agents. Our purpose was to study the efficacy of cytosine arabinoside (Ara-C) as an adjunctive antimetabolite in glaucoma surge...

journal_title：Current eye research

authors： Chu JL,Shields SR,Netland PA

更新日期：1994-11-01 00:00:00