Molecular and physiological analysis of an OxyR-regulated ahpC promoter in Xanthomonas campestris pv. phaseoli.

abstract：:Listeria monocytogenes grows in the cytosol of mammalian cells and spreads from cell to cell without exiting the intracellular milieu. During cell-cell spread, bacteria become transiently entrapped in double-membrane vacuoles. Escape from these vacuoles is mediated in part by a bacterial phospholipase C (PC-PLC), whos...

journal_title：Molecular microbiology

authors： Marquis H,Hager EJ

更新日期：2000-01-01 00:00:00

abstract：:Pyruvoyl-dependent histidine decarboxylases are produced as proenzymes that mature by cleavage followed by formation of the pyruvoyl prosthetic group. The histidine decarboxylation pathway of Streptococcus thermophilus CHCC1524 that consists of the pyruvoyl-dependent histidine decarboxylase HdcA and the histidine/hist...

journal_title：Molecular microbiology

authors： Trip H,Mulder NL,Rattray FP,Lolkema JS

更新日期：2011-02-01 00:00:00

abstract：:The recently identified recA gene of the naturally transformable bacterium Streptococcus pneumoniae has been further characterized by constructing a recA null mutation and by investigating its regulation. The recA mutation has been shown to confer both DNA repair (as judged from sensitivity to u.v. and methyl methane ...

journal_title：Molecular microbiology

authors： Martin B,García P,Castanié MP,Claverys JP

更新日期：1995-01-01 00:00:00

abstract：:Sphingosine-1-phosphate (S1P), a bioactive sphingolipid metabolite, plays a critical role in the orchestration of immune responses. S1P levels within the mammalian host are tightly regulated, in part through the activity of S1P lyase (S1PL) which catalyses its irreversible degradation. Herein, we describe the identifi...

journal_title：Molecular microbiology

authors： Custódio R,McLean CJ,Scott AE,Lowther J,Kennedy A,Clarke DJ,Campopiano DJ,Sarkar-Tyson M,Brown AR

更新日期：2016-12-01 00:00:00

abstract：:Type VI secretion is critical for Vibrio cholerae to successfully combat phagocytic eukaryotes and to survive in the presence of competing bacterial species. V. cholerae type VI secretion system genes are encoded in one large and two small clusters. In V. cholerae, type VI secretion is controlled by quorum sensing, th...

journal_title：Molecular microbiology

authors： Shao Y,Bassler BL

更新日期：2014-06-01 00:00:00

abstract：:The largest subunit of RNA polymerase II, Rpb1, contains an unusual C-terminal domain (CTD) composed of numerous repeats of the YSPTSPS consensus sequence. This sequence is the target of post-translational modifications such as phosphorylation, glycosylation, methylation and transitions between stereoisomeric states, ...

journal_title：Molecular microbiology

authors： Drogat J,Hermand D

更新日期：2012-06-01 00:00:00

abstract：:Bactericidal/permeability-increasing protein (BPI) of neutrophils is a lipopolysaccharide (LPS)-binding antibacterial protein with specificity for Gram negative bacteria. BPI binding to the bacterial surface rapidly triggers potentially reversible bacterial growth inhibition and alterations of the outer membrane and, ...

journal_title：Molecular microbiology

authors： Prohinar P,Forst SA,Reed D,Mandic-Mulec I,Weiss J

更新日期：2002-03-01 00:00:00

abstract：:The diffusible factor synthase XanB2, originally identified in Xanthomonas campestris pv. campestris (Xcc), is highly conserved across a wide range of bacterial species, but its substrate and catalytic mechanism have not yet been investigated. Here, we show that XanB2 is a unique bifunctional chorismatase that hydroly...

journal_title：Molecular microbiology

authors： Zhou L,Wang JY,Wu J,Wang J,Poplawsky A,Lin S,Zhu B,Chang C,Zhou T,Zhang LH,He YW

更新日期：2013-01-01 00:00:00

abstract：:Type IV pili (T4P) are surface structures that undergo extension/retraction oscillations to generate cell motility. In Myxococcus xanthus, T4P are unipolarly localized and undergo pole-to-pole oscillations synchronously with cellular reversals. We investigated the mechanisms underlying these oscillations. We show that...

journal_title：Molecular microbiology

authors： Bulyha I,Schmidt C,Lenz P,Jakovljevic V,Höne A,Maier B,Hoppert M,Søgaard-Andersen L

更新日期：2009-11-01 00:00:00

abstract：:In Escherichia coli, after DNA damage, the SOS response increases the transcription (and protein levels) of approximately 50 genes. As DNA repair ensues, the level of transcription returns to homeostatic levels. ClpXP and other proteases return the high levels of several SOS proteins to homeostasis. When all SOS genes...

journal_title：Molecular microbiology

authors： Warr AR,Klimova AN,Nwaobasi AN,Sandler SJ

更新日期：2019-02-01 00:00:00

abstract：:In Salmonella enterica, an activated Rcs signalling system inhibits initiation of transcription of the flhD master operon. Under these conditions, where motility is shut down, microarray experiments showed an increased RNA signal for three flagellar genes -fliPQR- located upstream of rcsA. We show here that it is the ...

journal_title：Molecular microbiology

authors： Wang Q,Harshey RM

更新日期：2009-10-01 00:00:00

abstract：:Reversible phase variation between the rugose and smooth colony variants is predicted to be important for the survival of Vibrio cholerae in natural aquatic habitats. Microarray expression profiling studies of the rugose and smooth variants of the same strain led to the identification of 124 differentially regulated g...

journal_title：Molecular microbiology

authors： Yildiz FH,Liu XS,Heydorn A,Schoolnik GK

更新日期：2004-07-01 00:00:00

abstract：:Metabolic adaptations are critical to the ability of bacterial pathogens to grow within host cells and are normally preceded by sensing of host-specific metabolic signals, which in turn can influence the pathogen's virulence state. Previously, we reported that the intracellular bacterial pathogen Listeria monocytogene...

journal_title：Molecular microbiology

authors： Lobel L,Sigal N,Borovok I,Belitsky BR,Sonenshein AL,Herskovits AA

更新日期：2015-02-01 00:00:00

abstract：:OmpR activates expression of the two-component regulatory system located on Salmonella pathogenicity island 2 (SPI-2) that controls the expression of a type III secretion system, as well as many other genes required for systemic infection in mice. Measurements of SsrA and SsrB protein levels under different growth con...

journal_title：Molecular microbiology

authors： Feng X,Walthers D,Oropeza R,Kenney LJ

更新日期：2004-11-01 00:00:00

abstract：:Nitrogen metabolism in Aspergillus nidulans is regulated by AREA, a member of the GATA family of transcription factors. One mechanism that modulates AREA activity involves the rapid degradation of the areA transcript when sufficient NH4+ or Gln are available. This signalling mechanism has been shown to require a regio...

journal_title：Molecular microbiology

authors： Morozov IY,Martinez MG,Jones MG,Caddick MX

更新日期：2000-09-01 00:00:00

abstract：:Toxin-antitoxin loci have been identified in almost all free-living prokaryotes, often in high copy numbers. The biological function and molecular targets of the abundant vapBC loci are not yet known. Here we analyse the vapBC loci of Salmonella LT2 and Shigella plasmid pMYSH6000. Both loci encode putative PIN (PilT N...

journal_title：Molecular microbiology

authors： Winther KS,Gerdes K

更新日期：2009-05-01 00:00:00

abstract：:The PII protein has been considered pivotal to the dual cascade regulating ammonia assimilation through glutamine synthetase activity. Here we show that PII, encoded by the glnB gene, is not always essential; for instance upon ammonia deprivation of a glnB deletion strain, glutamine synthetase can be deadenylylated as...

journal_title：Molecular microbiology

authors： van Heeswijk WC,Hoving S,Molenaar D,Stegeman B,Kahn D,Westerhoff HV

更新日期：1996-07-01 00:00:00

abstract：:A major obstacle to tuberculosis (TB) control is the problem of chronic TB infection (CTBI). Here we report that 5'-adenosinephosphosulphate reductase (CysH), an enzyme essential for the production of reduced-sulphur-containing metabolites, is critical for Mycobacterium tuberculosis (Mtb) survival in chronic infection...

journal_title：Molecular microbiology

authors： Senaratne RH,De Silva AD,Williams SJ,Mougous JD,Reader JR,Zhang T,Chan S,Sidders B,Lee DH,Chan J,Bertozzi CR,Riley LW

更新日期：2006-03-01 00:00:00

abstract：:Three distinct types of terminal oxidases participate in the aerobic respiratory pathways of Paracoccus denitrificans. Two alternative genes encoding subunit I of the aa3-type cytochrome c oxidase have been isolated before, namely ctaDI and ctaDII. Each of these genes can be expressed separately to complement a double...

journal_title：Molecular microbiology

authors： de Gier JW,Lübben M,Reijnders WN,Tipker CA,Slotboom DJ,van Spanning RJ,Stouthamer AH,van der Oost J

更新日期：1994-07-01 00:00:00

abstract：:Folate metabolism in malaria parasites is a long-standing, clinical target for chemotherapy and prophylaxis. However, despite determination of the complete genome sequence of the lethal species Plasmodium falciparum, the pathway of de novo folate biosynthesis remains incomplete, as no candidate gene for dihydroneopter...

journal_title：Molecular microbiology

authors： Dittrich S,Mitchell SL,Blagborough AM,Wang Q,Wang P,Sims PF,Hyde JE

更新日期：2008-02-01 00:00:00

abstract：:Campylobacter jejuni, a prevalent cause of bacterial gastroenteritis, must adapt to different environments to be a successful pathogen. We previously identified a C. jejuni two-component regulatory system (Cj1226/7c) as upregulated during cell infections. Analyses described herein led us to designate the system CprRS ...

journal_title：Molecular microbiology

authors： Svensson SL,Davis LM,MacKichan JK,Allan BJ,Pajaniappan M,Thompson SA,Gaynor EC

更新日期：2009-01-01 00:00:00

abstract：:A series of internal deletions in the lktA gene of Pasteurella haemolytica has been constructed. All of the deletions eliminated the lytic activity of the leukotoxin towards the bovine lymphoma cell line, BL-3. Deletions removing segments of the amino-proximal hydrophobic region, which is thought to constitute an esse...

journal_title：Molecular microbiology

authors： Cruz WT,Young R,Chang YF,Struck DK

更新日期：1990-11-01 00:00:00

abstract：:For the rod-shaped Gram-negative bacterium Escherichia coli, changes in cell shape have critical consequences for motility, immune system evasion, proliferation and adhesion. For most bacteria, the peptidoglycan cell wall is both necessary and sufficient to determine cell shape. However, how the synthesis machinery as...

journal_title：Molecular microbiology

authors： Furchtgott L,Wingreen NS,Huang KC

更新日期：2011-07-01 00:00:00

abstract：:A 2.7 kb fragment of Helicobacter pylori UA802 chromosomal DNA was cloned and sequenced. Three open reading frames (designated ORF1, ORF2 and ORF3, respectively) were predicted from the DNA sequence, of which ORF1 and ORF2 appeared to be located within the same operon. The deduced 611-amino-acid sequence of ORF1, a P-...

journal_title：Molecular microbiology

authors： Ge Z,Hiratsuka K,Taylor DE

更新日期：1995-01-01 00:00:00

abstract：:Roughly 10% of all genes in Escherichia coli are controlled by the global transcription factor Lrp, which responds to nutrient availability. Bioinformatically, we identified lrp as one of several putative targets for the sRNA MicF, which is transcriptionally downregulated by Lrp. Deleting micF results in higher Lrp le...

journal_title：Molecular microbiology

authors： Holmqvist E,Unoson C,Reimegård J,Wagner EG

更新日期：2012-05-01 00:00:00

abstract：:The mobile insertion sequence, IS6110, is an important marker in tracking of Mycobacterium tuberculosis strains. Here, we demonstrate that IS6110 can upregulate downstream genes through an outward-directed promoter in its 3' end, thus adding to the significance of this element. Promoter activity was orientation depend...

journal_title：Molecular microbiology

authors： Safi H,Barnes PF,Lakey DL,Shams H,Samten B,Vankayalapati R,Howard ST

更新日期：2004-05-01 00:00:00

abstract：:The Bacillus subtilis genome encodes three apparent lipoyl ligase homologues: yhfJ, yqhM and ywfL, which we have renamed lplJ, lipM and lipL respectively. We show that LplJ encodes the sole lipoyl ligase of this bacterium. Physiological and biochemical characterization of a ΔlipM strain showed that LipM is absolutely ...

journal_title：Molecular microbiology

authors： Martin N,Christensen QH,Mansilla MC,Cronan JE,de Mendoza D

更新日期：2011-04-01 00:00:00

abstract：:The majority of characterized bacterial dipeptide permeases (Dpp) are membrane-associated complexes of five proteins belonging to the ABC-transporter family. They have been found to be involved in the uptake of essential amino acids, haem production, chemotaxis and sporulation. A 5.8 kb genomic DNA fragment of the ser...

journal_title：Molecular microbiology

authors： Podbielski A,Leonard BA

更新日期：1998-06-01 00:00:00

abstract：:Salmonella typhimurium responds to a variety of environmental stresses by accumulating the alternative sigma factor sigmaS. The repertoire of sigmaS -dependent genes that are subsequently expressed confers tolerance to a variety of potentially lethal conditions including low pH and stationary phase. The mechanism(s) r...

journal_title：Molecular microbiology

authors： Webb C,Moreno M,Wilmes-Riesenberg M,Curtiss R 3rd,Foster JW

更新日期：1999-10-01 00:00:00

abstract：:Transmission of Plasmodium species from a mammalian host to the mosquito vector requires the uptake, during an infected blood meal, of gametocytes, the precursor cells of the gametes. Relatively little is known about the molecular mechanisms involved in the developmental switch from asexual development to sexual diffe...

journal_title：Molecular microbiology

authors： Boisson B,Lacroix C,Bischoff E,Gueirard P,Bargieri DY,Franke-Fayard B,Janse CJ,Ménard R,Baldacci P

更新日期：2011-09-01 00:00:00