Ectopic production of VapCs from Enterobacteria inhibits translation and trans-activates YoeB mRNA interferase.

abstract：:Several Fusarium species produce the polyketide mycotoxin zearalenone (ZEA), a causative agent of hyperestrogenic syndrome in animals that is often found in F. graminearum-infected cereals in temperate regions. The ZEA biosynthetic cluster genes PKS4, PKS13, ZEB1 and ZEB2 encode a reducing polyketide synthase, a non-r...

journal_title：Molecular microbiology

authors： Park AR,Son H,Min K,Park J,Goo JH,Rhee S,Chae SK,Lee YW

更新日期：2015-09-01 00:00:00

abstract：:Changes in the mRNA levels of two Mycobacterium tuberculosis genes (fbpB known as antigen 85B, and hspX known as Acr) were studied in infected human monocytes. Antigen 85B is an enzyme involved in cell wall biosynthesis and is also a major target of the immune response. Acr is a stress protein believed to be involved ...

journal_title：Molecular microbiology

authors： Wilkinson RJ,DesJardin LE,Islam N,Gibson BM,Kanost RA,Wilkinson KA,Poelman D,Eisenach KD,Toossi Z

更新日期：2001-02-01 00:00:00

abstract：:Reactive oxygen species (ROS) are critical components of the antimicrobial repertoire of macrophages, yet the mechanisms by which ROS damage bacteria in the phagosome are unclear. The NADH-dependent phagocytic oxidase produces superoxide, which dismutes to form H(2)O(2). The Barras and Méresse labs use a GFP fusion to...

journal_title：Molecular microbiology

authors： Slauch JM

更新日期：2011-05-01 00:00:00

abstract：:Bacteria co-ordinate their social behaviour in a density-dependent manner by production of diffusible signal molecules by a process known as quorum sensing (QS). It is generally assumed that in homogenous environments and at high cell density, QS synchronizes cells in the population to perform collective social tasks ...

journal_title：Molecular microbiology

authors： Pradhan BB,Chatterjee S

更新日期：2014-05-01 00:00:00

abstract：:Bacteriophage D3 is capable of lysogenizing Pseudomonas aeruginosa PAO1 (serotype O5), converting the O-antigen from O5 to O16 and O-acetylating the N-acetylfucosamine moiety. To investigate the mechanism of lysogenic conversion, a 3.6 kb fragment from the D3 genome was isolated capable of mediating serotypic conversi...

journal_title：Molecular microbiology

authors： Newton GJ,Daniels C,Burrows LL,Kropinski AM,Clarke AJ,Lam JS

更新日期：2001-03-01 00:00:00

abstract：:The haemolysin of Haemophilus ducreyi is the newest member of the Proteus/Serratia family of pore-forming toxins. In order to assess the role of the haemolysin in virulence, we constructed an isogenic haemolysin-deficient mutant of H. ducreyi strain 35000 This strain, designated 35000-3, lacks detectable haemolytic ac...

journal_title：Molecular microbiology

authors： Palmer KL,Goldman WE,Munson RS Jr

更新日期：1996-07-01 00:00:00

abstract：:The translocation of proteins across the bacterial cell membrane is carried out by highly conserved components of the Sec system. Most bacterial species have a single copy of the genes encoding SecA and SecY, which are essential for viability. However, Streptococcus gordonii strain M99 encodes SecA and SecY homologues...

journal_title：Molecular microbiology

authors： Bensing BA,Sullam PM

更新日期：2002-05-01 00:00:00

abstract：:A family of nine Salmonella typhimurium type III secretion effectors with a conserved amino-terminus have been defined. Three family members (SifA, SifB and SseJ) have previously been demonstrated to localize to the Salmonella-containing vacuole and to Salmonella-induced filaments. In contrast, we demonstrate that two...

journal_title：Molecular microbiology

authors： Miao EA,Brittnacher M,Haraga A,Jeng RL,Welch MD,Miller SI

更新日期：2003-04-01 00:00:00

abstract：:Clusters of regularly interspaced short palindromic repeats (CRISPRs) of Sulfolobus fall into three main families based on their repeats, leader regions, associated cas genes and putative recognition sequences on viruses and plasmids. Spacer sequence matches to different viruses and plasmids of the Sulfolobales reveal...

journal_title：Molecular microbiology

authors： Lillestøl RK,Shah SA,Brügger K,Redder P,Phan H,Christiansen J,Garrett RA

更新日期：2009-04-01 00:00:00

abstract：:9 alpha-Hydroxylation of 4-androstene-3,17-dione (AD) and 1,4-androstadiene-3,17-dione (ADD) is catalysed by 3-ketosteroid 9 alpha-hydroxylase (KSH), a key enzyme in microbial steroid catabolism. Very limited knowledge is presently available on the KSH enzyme. Here, we report for the first time the identification and ...

journal_title：Molecular microbiology

authors： van der Geize R,Hessels GI,van Gerwen R,van der Meijden P,Dijkhuizen L

更新日期：2002-08-01 00:00:00

abstract：:Streptococcus pyogenes interacts with host fibronectin via distinct surface components. One of these components is the Sfbl protein (streptococcal fibronectin-binding protein, now specified as class I), an adhesin that represents a protein family with characteristic features. Here we present the complete structure of ...

journal_title：Molecular microbiology

authors： Kreikemeyer B,Talay SR,Chhatwal GS

更新日期：1995-07-01 00:00:00

abstract：:Although diminutive in size, bacteria possess highly diverse and spatially confined cellular structures. Two related alphaproteobacteria, Sinorhizobium meliloti and Caulobacter crescentus, serve as models for investigating the genetic basis of morphological variations. S. meliloti, a symbiont of leguminous plants, syn...

journal_title：Molecular microbiology

authors： Fields AT,Navarrete CS,Zare AZ,Huang Z,Mostafavi M,Lewis JC,Rezaeihaghighi Y,Brezler BJ,Ray S,Rizzacasa AL,Barnett MJ,Long SR,Chen EJ,Chen JC

更新日期：2012-06-01 00:00:00

abstract：:Micrococcus luteus secretes a small protein called Rpf, which has autocrine and paracrine signalling functions and is required for the resuscitation of dormant cells. Originally isolated from the supernatant of actively growing cultures, Rpf was also detected on the surface of actively growing bacteria. Most molecules...

journal_title：Molecular microbiology

authors： Mukamolova GV,Turapov OA,Kazarian K,Telkov M,Kaprelyants AS,Kell DB,Young M

更新日期：2002-11-01 00:00:00

abstract：:The esg locus is required for the formation of multicellular fruiting bodies and spores by the developmental bacterium Myxococcus xanthus. Studies have suggested that esg mutants are defective in the production of an essential signal (E-signal) used in cell-cell communication and that E-signalling is required for the ...

journal_title：Molecular microbiology

authors： Downard J,Toal D

更新日期：1995-04-01 00:00:00

abstract：:GspB is a large cell-surface glycoprotein expressed by Streptococcus gordonii M99 that mediates binding of this organism to human platelets. This adhesin is glycosylated in the cytoplasm, and is then transported to the cell surface via an accessory Sec system. To assess the structural features of GspB that are needed ...

journal_title：Molecular microbiology

authors： Bensing BA,Takamatsu D,Sullam PM

更新日期：2005-12-01 00:00:00

abstract：:A search with the proposed amino acid translation product from the new 'candidate gene' for human Menkes disease against protein sequence libraries showed a remarkable similarity to that for the cadmium efflux ATPase from Staphylococcus aureus resistance plasmids. The Menkes sequence appears closer to the CadA Cd2+ se...

journal_title：Molecular microbiology

authors： Silver S,Nucifora G,Phung LT

更新日期：1993-10-01 00:00:00

abstract：:A biochemical approach to identify proteins with high affinity for choline-containing pneumococcal cell walls has allowed the localization, cloning and sequencing of a gene (lytC ) coding for a protein that degrades the cell walls of Streptococcus pneumoniae. The lytC gene is 1506 bp long and encodes a protein (LytC) ...

journal_title：Molecular microbiology

authors： García P,Paz González M,García E,García JL,López R

更新日期：1999-07-01 00:00:00

abstract：:Mycelial fungi play a central role in element cycling in nature by degrading dead organic material such as wood. Fungal colonization of a substrate starts with the invasion of exploring hyphae. These hyphae secrete enzymes that convert the organic material into small molecules that can be taken up by the fungus to ser...

journal_title：Molecular microbiology

authors： Vinck A,Terlou M,Pestman WR,Martens EP,Ram AF,van den Hondel CA,Wösten HA

更新日期：2005-11-01 00:00:00

abstract：:Expression of the Saccharomyces cerevisiae nuclear gene CYB2 encoding the mitochondrial enzyme L-(+)-lactate-cytochrome c oxidoreductase (EC 1.2.2.3) is subject to several strict metabolic controls at the transcriptional level: repression due to glucose fermentation, derepression by ethanol, induction by lactate and i...

journal_title：Molecular microbiology

authors： Ramil E,Agrimonti C,Shechter E,Gervais M,Guiard B

更新日期：2000-09-01 00:00:00

abstract：:The plant pathogen Pseudomonas syringae pv. phaseolicola, which causes halo blight disease of beans, contains a 106 kb genomic island PPHGI-1. PPHGI-1 carries a gene, avrPphB, which encodes an effector protein that triggers a resistance response in certain bean cultivars. Previous studies have shown that when PPHGI-1 ...

journal_title：Molecular microbiology

authors： Neale HC,Jackson RW,Preston GM,Arnold DL

更新日期：2018-11-01 00:00:00

abstract：:Nitrogen metabolism genes of Bacillus subtilis are regulated by the availability of rapidly metabolizable nitrogen sources, but not by any mechanism analogous to the two-component Ntr regulatory system found in enteric bacteria. Instead, at least three regulatory proteins independently control the expression of gene p...

journal_title：Molecular microbiology

authors： Fisher SH

更新日期：1999-04-01 00:00:00

abstract：:Two so-called Ter sites, which bind the Escherichia coli Tus protein, are located near the replication origin of plasmid R1. Inactivation of the tus gene caused a large decrease in the stability of maintenance of the R1 mini-derivative pOU47 despite the presence of a functional partition system on the plasmid. Deletio...

journal_title：Molecular microbiology

authors： Krabbe M,Zabielski J,Bernander R,Nordström K

更新日期：1997-05-01 00:00:00

abstract：:We recently identified a gene (FTN_0818) required for Francisella virulence that seemed likely involved in biotin metabolism. However, the molecular function of this virulence determinant was unclear. Here we show that this protein named BioJ is the enzyme of the biotin biosynthesis pathway that determines the chain l...

journal_title：Molecular microbiology

authors： Feng Y,Napier BA,Manandhar M,Henke SK,Weiss DS,Cronan JE

更新日期：2014-01-01 00:00:00

abstract：:The MtrCDE multidrug pump, from Neisseria gonorrhoeae, is assembled from the inner and outer membrane proteins MtrD and MtrE, which are connected by the periplasmic membrane fusion protein MtrC. Although it is clear that MtrD delivers drugs to the channel of MtrE, it remains unclear how drug delivery and channel openi...

journal_title：Molecular microbiology

authors： Janganan TK,Bavro VN,Zhang L,Borges-Walmsley MI,Walmsley AR

更新日期：2013-05-01 00:00:00

abstract：:A new virus of halophilic Archaea is reported by Liu et al., and is remarkable in many ways. SNJ2 is the first temperate, pleomorphic virus (pleolipovirus) that integrates into the genome of its host. Analyses of the virus structure and its genome have provided an unexpected puzzle while at the same time solving anoth...

journal_title：Molecular microbiology

authors： Dyall-Smith M,Porter K

更新日期：2015-12-01 00:00:00

abstract：:The Escherichia coli fructose repressor, FruR, is known to regulate expression of several genes concerned with carbon utilization. Using a previously derived consensus sequence for FruR binding, additional potential operators were identified and tested for FruR binding in DNA band migration retardation assays. Operato...

journal_title：Molecular microbiology

authors： Ramseier TM,Bledig S,Michotey V,Feghali R,Saier MH Jr

更新日期：1995-06-01 00:00:00

abstract：:In May 2004, over 100 bacteriologists from 19 different countries discussed recent progress in identification and understanding of individual signal transfer mechanisms in bacteria and in the mutual interactions between these systems to form a functional living cell. The meeting was held in San Feliu and supported by ...

journal_title：Molecular microbiology

authors： Hellingwerf KJ

更新日期：2004-10-01 00:00:00

abstract：:The psaBCA locus of Streptococcus pneumoniae encodes a putative ABC Mn2+-permease complex. Downstream of the operon is psaD, which may be co-transcribed and encodes a thiol peroxidase. Previously, there has been discordance concerning the phenotypic impact of mutations in the psa locus, resolution of which has been co...

journal_title：Molecular microbiology

authors： McAllister LJ,Tseng HJ,Ogunniyi AD,Jennings MP,McEwan AG,Paton JC

更新日期：2004-08-01 00:00:00

abstract：:We used in vivo oxidative cross-linking of engineered cysteine pairs to assess conformational changes in the four-helix transmembrane domain of chemoreceptor Trg. Extending previous work, we searched for and found a fourth cross-linking pair that spanned the intrasubunit interface between transmembrane helix 1 (TM1) a...

journal_title：Molecular microbiology

authors： Beel BD,Hazelbauer GL

更新日期：2001-05-01 00:00:00

abstract：:A method of insertional mutagenesis for naturally transformable organisms has been adapted from Haemophilus influenzae and applied to the study of the pathogenesis of Campylobacter jejuni. A series of kanamycin-resistant insertional mutants of C. jejuni 81-176 has been generated and screened for loss of ability to inv...

journal_title：Molecular microbiology

authors： Yao R,Burr DH,Doig P,Trust TJ,Niu H,Guerry P

更新日期：1994-12-01 00:00:00