Diesel exhaust exposure and lung cancer: adjustment for the effect of smoking in a retrospective cohort study.

Abstract:

BACKGROUND:The extent that cigarette smoking may confound the relationship between diesel exhaust exposure and lung cancer was assessed in a retrospective cohort study of 55,395 U.S. railroad workers followed from 1959 to 1976. METHODS:The relative risk (RR) of lung cancer due to diesel exhaust was indirectly adjusted using job-specific smoking data from a case-control study of railroad workers who died between 1981-1982 and from a survey of 514 living workers from an active railroad in 1982. Adjustment factors were developed based on the distribution of job-specific smoking rates. RESULTS:The unadjusted RR for lung cancer was 1.58 (95% CI = 1.14-2. 20) for workers aged 40-44 in 1959, who experienced the longest possible duration of exposure, and the smoking adjusted RR was 1.44 (1.01-2.05). CONCLUSIONS:After considering differences in smoking rates between workers exposed and unexposed to diesel exhaust in a relatively large blue-collar cohort, there were still elevated risks of lung cancer in workers in jobs with diesel exhaust exposure.

journal_name

Am J Ind Med

authors

Larkin EK,Smith TJ,Stayner L,Rosner B,Speizer FE,Garshick E

doi

10.1002/1097-0274(200010)38:4<399::aid-ajim5>3.0.c

subject

Has Abstract

pub_date

2000-10-01 00:00:00

pages

399-409

issue

4

eissn

0271-3586

issn

1097-0274

pii

10.1002/1097-0274(200010)38:4<399::AID-AJIM5>3.0.C

journal_volume

38

pub_type

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